Cohort validation pack

SMILE

Severe Mental Illness Longitudinal Evaluation BioResource

Generated 6 Oct 2026, 10:36 · ID 9

Unverified

Instructions for reviewers

Review each field against your knowledge of this cohort. Mark Accurate if the value is right, Needs correction if it is wrong or inaccurate (add notes), Not sure if you cannot verify it, or Does not apply if the field is not relevant.
Evidence shown is from our source registry. Fields marked No source yet hold values we could not yet pin to a document — those were AI-inferred and need your input most. Fields marked Searched — not published are ones we looked for and could not find publicly; the note lists where we checked.
Your selections and notes are kept in this browser tab only (not sent to the database). Print or save as PDF when finished, then return it to the DIGIT team.

Overview

Total fields

Field-cited

Whole-record source only

AI-inferred, no source yet

Searched — not published

No value held

Needs review

Source coverage

Summary of how well fields in this pack are linked to evidence.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Field-level source coverage Optional	52 of 76 reviewable fields are cited to a source (68%) · 6 with no source yet · 18 searched — not published · 23 with no value held	Computed	No citation linked to this field yet.	Response for Field-level source coverageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Identity and ownership

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Short name Required	SMILE	Field-cited	NIHR BioResource — SMILE BioResource programme page https://www.bioresource.nihr.ac.uk/centres-programmes/severe-mental-illness-longitudinal-evaluation-smile-bioresource/ Section: Page heading “Severe Mental Illness Longitudinal Evaluation (SMILE) BioResource” Page: https://www.bioresource.nihr.ac.uk/centres-programmes/severe-mental-illness-longitudinal-evaluation-smile-bioresource/	Response for Short nameAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Full name Required	Severe Mental Illness Longitudinal Evaluation BioResource	Field-cited	NIHR BioResource — SMILE BioResource programme page https://www.bioresource.nihr.ac.uk/centres-programmes/severe-mental-illness-longitudinal-evaluation-smile-bioresource/ Section: Page heading “Severe Mental Illness Longitudinal Evaluation (SMILE) BioResource” Page: https://www.bioresource.nihr.ac.uk/centres-programmes/severe-mental-illness-longitudinal-evaluation-smile-bioresource/	Response for Full nameAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Managing organisation Recommended	University of Oxford / NIHR BioResource	Field-cited	NIHR Be Part of Research — NIHR SMILE BioResource (trialId=57836) https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=57836 Section: Study summary “The NIHR Severe Mental Illness Longitudinal Evaluation (SMILE) BioResource is a collaborative project between the NIHR, the University of Oxford, Cardiff University, King's College London and the University of Birmingham” Page: https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=57836	Response for Managing organisationAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Primary site Recommended	NIHR Oxford Health Biomedical Research Centre (site #2)	Field-cited	NIHR BioResource — SMILE BioResource programme page https://www.bioresource.nihr.ac.uk/centres-programmes/severe-mental-illness-longitudinal-evaluation-smile-bioresource/ Section: About the SMILE BioResource “The SMILE BioResource is a collaboration led by the University of Oxford (Oxford Health Biomedical Research Centre) and the NIHR BioResource” Page: https://www.bioresource.nihr.ac.uk/centres-programmes/severe-mental-illness-longitudinal-evaluation-smile-bioresource/ primary_site_id=2 corresponds to NIHR Oxford Health Biomedical Research Centre, explicitly named as lead.	Response for Primary siteAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Website URL Recommended	https://www.bioresource.nihr.ac.uk/centres-programmes/severe-mental-illness-longitudinal-evaluation-smile-bioresource/	Field-cited	NIHR Be Part of Research — NIHR SMILE BioResource (trialId=57836) https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=57836 Section: Canonical programme page “Severe Mental Illness Longitudinal Evaluation (SMILE) BioResource” Page: https://www.bioresource.nihr.ac.uk/centres-programmes/severe-mental-illness-longitudinal-evaluation-smile-bioresource/	Response for Website URLAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Catalogue of Mental Health Measures URL Recommended	No value held	No source yet	No citation linked to this field yet.	Response for Catalogue of Mental Health Measures URLAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Contact name Recommended	Prof Rachel Upthegrove	Field-cited	NIHR BioResource news — SMILE launch https://www.bioresource.nihr.ac.uk/news/smile-bioresource-launch-marks-major-step-forward-in-understanding-severe-mental-illness/ Section: Quote “Professor Rachel Upthegrove, Chief Investigator of the NIHR SMILE BioResource, said” Page: https://www.bioresource.nihr.ac.uk/news/smile-bioresource-launch-marks-major-step-forward-in-understanding-severe-mental-illness/	Response for Contact nameAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Contact email Recommended	SMIbioresource@psych.ox.ac.uk	Field-cited	Oxford Health BRC — New BioResource to drive progress in severe mental illness research https://oxfordhealthbrc.nihr.ac.uk/new-bioresource-to-drive-progress-in-severe-mental-illness-research/ Section: Closing paragraph “For more information about taking part, email SMIbioresource@psych.ox.ac.uk.” Page: https://oxfordhealthbrc.nihr.ac.uk/new-bioresource-to-drive-progress-in-severe-mental-illness-research/	Response for Contact emailAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Summary and status

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Description Required	UK-wide recontactable observational cohort for severe mental illness run through the NIHR BioResource with Oxford-led MH-TRC collaboration. Participants contribute blood or saliva samples, questionnaires, a cognitive task, and linked clinical record permission for future recall studies.	Field-cited	Oxford Health BRC — New BioResource to drive progress in severe mental illness research https://oxfordhealthbrc.nihr.ac.uk/new-bioresource-to-drive-progress-in-severe-mental-illness-research/ Section: Article lead paragraph “The Severe Mental Illness Longitudinal Evaluation (SMILE) BioResource is a new, national initiative aiming to accelerate research to improve outcomes and quality of life for people living with severe mental illness (SMI).” Page: https://oxfordhealthbrc.nihr.ac.uk/new-bioresource-to-drive-progress-in-severe-mental-illness-research/	Response for DescriptionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Total N Required	2,000	Field-cited	Oxford Health BRC — New BioResource to drive progress in severe mental illness research https://oxfordhealthbrc.nihr.ac.uk/new-bioresource-to-drive-progress-in-severe-mental-illness-research/ Section: Article body “The SMILE BioResource is building a cohort of up to 2,000 volunteers from across the UK” Page: https://oxfordhealthbrc.nihr.ac.uk/new-bioresource-to-drive-progress-in-severe-mental-illness-research/	Response for Total NAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Total N qualifier Recommended	target	Field-cited	Oxford Health BRC — New BioResource to drive progress in severe mental illness research https://oxfordhealthbrc.nihr.ac.uk/new-bioresource-to-drive-progress-in-severe-mental-illness-research/ Section: Article body “building a cohort of up to 2,000 volunteers” Page: https://oxfordhealthbrc.nihr.ac.uk/new-bioresource-to-drive-progress-in-severe-mental-illness-research/ This is a recruitment goal, so total_n_qualifier=target per data-dictionary.	Response for Total N qualifierAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Year established Recommended	2025	Field-cited	NIHR BioResource — SMILE BioResource programme page https://www.bioresource.nihr.ac.uk/centres-programmes/severe-mental-illness-longitudinal-evaluation-smile-bioresource/ Section: About the SMILE BioResource “The SMILE BioResource launched in November 2025” Page: https://www.bioresource.nihr.ac.uk/centres-programmes/severe-mental-illness-longitudinal-evaluation-smile-bioresource/	Response for Year establishedAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Active cohort Recommended	Yes	Field-cited	NIHR Be Part of Research — NIHR SMILE BioResource (trialId=57836) https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=57836 Section: Recruiting badge “Recruiting” Page: https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=57836	Response for Active cohortAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Ongoing recruitment Recommended	Yes	Field-cited	NIHR Be Part of Research — NIHR SMILE BioResource (trialId=57836) https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=57836 Section: Recruiting badge “Recruiting” Page: https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=57836	Response for Ongoing recruitmentAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Refreshed cohort Recommended	Yes	Field-cited	NIHR BioResource — SMILE BioResource programme page https://www.bioresource.nihr.ac.uk/centres-programmes/severe-mental-illness-longitudinal-evaluation-smile-bioresource/ Section: Longitudinal definition “A longitudinal study means that participants are included in a study over a period of time, and that additional data may be collected from them.” Page: https://www.bioresource.nihr.ac.uk/centres-programmes/severe-mental-illness-longitudinal-evaluation-smile-bioresource/ Ongoing longitudinal follow-up and future recall indicate refreshed cohort behaviour.	Response for Refreshed cohortAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Recontact success rate Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: No public cohort-level recontact response percentage reported.	Response for Recontact success rateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Retention rate Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: No public retained-at-followup percentage reported.	Response for Retention rateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Published references Recommended	No value held	Field-cited	Prior SMILE DOI stored in seed (returns 404, not SMILE cohort profile) https://doi.org/10.1186/s12888-025-06486-x Page: https://doi.org/10.1186/s12888-025-06486-x Set to NULL. Existing seed DOI 10.1186/s12888-025-06486-x resolves to an unrelated BMC Psychiatry article and DOI URL returns 404 in this context; no SMILE cohort profile paper identified in public sources as of 2026-04-15.	Response for Published referencesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Notes Recommended	Launched November 2025; recruitment target is up to 2,000 UK participants aged 16+ with severe mental illness. Public listings show active sites in Oxford, Cambridge, London, Ilford, Birmingham, and Leeds, with recruitment planned to 2038.	Field-cited	Oxford Health BRC — New BioResource to drive progress in severe mental illness research https://oxfordhealthbrc.nihr.ac.uk/new-bioresource-to-drive-progress-in-severe-mental-illness-research/ Section: Article body “building a cohort of up to 2,000 volunteers from across the UK aged 16 and over” Page: https://oxfordhealthbrc.nihr.ac.uk/new-bioresource-to-drive-progress-in-severe-mental-illness-research/	Response for NotesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

3D cohort mapping

Consent, characterisation, and data availability axes used on the cohort map.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Consent level (axis) Required	3 — Broad consent (recontactable for future studies)	Field-cited	NIHR Be Part of Research — NIHR SMILE BioResource (trialId=57836) https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=57836 Section: Study summary “Patients with SMI will be invited to consent to: ... contact for recall to future studies based on their data and biological sample” Page: https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=57836 Step 1 identifiable=YES (consented participants and clinical notes). Step 2 S251/CAG=NO (active participant consent). Step 3 recontactable=YES (recall to future studies). Step 4 specific interventional randomisation consent=NO (observational cohort consent only). => consent_level 3.	Response for Consent level (axis)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Characterisation depth (axis) Required	3 — Multi-domain MH characterisation	Field-cited	NIHR Be Part of Research — NIHR SMILE BioResource (trialId=57836) https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=57836 Section: Study summary “collect a blood or saliva sample, questionnaire data, responses to a cognitive task, and medical notes” Page: https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=57836 Step 1 validated MH instruments/questionnaires=YES. Step 2 multi-domain data beyond symptom questionnaires=YES (cognitive task + clinical notes + lifestyle). Step 3 research-grade structured interview plus refreshed design=not demonstrated publicly. => characterisation_depth 3.	Response for Characterisation depth (axis)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data availability (axis) Required	3 — Adds biological specimens/molecular data	Field-cited	NIHR Be Part of Research — NIHR SMILE BioResource (trialId=57836) https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=57836 Section: Study summary + data flags “collect a blood or saliva sample, questionnaire data, responses to a cognitive task, and medical notes” Page: https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=57836 DERIVED per data-dictionary.md: hasResearch=TRUE (questionnaire, cognitive, linked records); hasBiological=TRUE (biosamples); hasAdvanced=FALSE (no imaging/wearable/digital phenotyping evidence). Formula => data_availability 3.	Response for Data availability (axis)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Cohort map group (derived) Recommended	Group 2	Internal	Internal catalogue field	—	—
Population type Recommended	Case-enriched	Not published	DIGIT Cohort Portfolio Review — population type and engagement classification (Aug 2026) Classified case_enriched in the DIGIT cohort portfolio review (Aug 2026). Recontactable BioResource cohort recruited on severe mental illness diagnoses.	Response for Population typeAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Industry engagement status Recommended	Established access process	Not published	DIGIT Cohort Portfolio Review — population type and engagement classification (Aug 2026) Access and recontact operate through the established NIHR BioResource governance and application process.	Response for Industry engagement statusAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Parent cohort / programme Recommended	NBR-MH (Umbrella member)	Not published	DIGIT Cohort Portfolio Review — population type and engagement classification (Aug 2026) SMILE is a member study of the NIHR Mental Health BioResource umbrella (umbrella_member).	Response for Parent cohort / programmeAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
TWiCs eligible Recommended	No	Field-cited	NIHR Be Part of Research — NIHR SMILE BioResource (trialId=57836) https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=57836 Section: Study type “Observational type: Cohort study;” Page: https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=57836 Data-dictionary requires consent_level=4 and randomisation-ready infrastructure for TWiCs. Public evidence supports recallable observational cohort (level 3), so twics_eligible=FALSE.	Response for TWiCs eligibleAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Data modalities

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Questionnaire / interview Recommended	Yes	Field-cited	NIHR Be Part of Research — NIHR SMILE BioResource (trialId=57836) https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=57836 Section: Study summary “completing self-report measures of symptoms and a Health and Lifestyle Questionnaire” Page: https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=57836	Response for Questionnaire / interviewAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Cognitive testing Recommended	Yes	Field-cited	NIHR Be Part of Research — NIHR SMILE BioResource (trialId=57836) https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=57836 Section: Study summary “responses to a cognitive task” Page: https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=57836	Response for Cognitive testingAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Physical measures Recommended	No	Field-cited	NIHR Be Part of Research — NIHR SMILE BioResource (trialId=57836) https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=57836 Section: Study summary “collect a blood or saliva sample, questionnaire data, responses to a cognitive task, and medical notes” Page: https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=57836 No explicit anthropometry or vital-sign protocol is publicly listed; therefore has_physical_measures=FALSE.	Response for Physical measuresAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Biosamples Recommended	Yes	Field-cited	NIHR BioResource — SMILE BioResource programme page https://www.bioresource.nihr.ac.uk/centres-programmes/severe-mental-illness-longitudinal-evaluation-smile-bioresource/ Section: Key goals “Volunteers joining the BioResource are asked to donate a small blood or saliva sample” Page: https://www.bioresource.nihr.ac.uk/centres-programmes/severe-mental-illness-longitudinal-evaluation-smile-bioresource/	Response for BiosamplesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Genomic data Recommended	No	Field-cited	NIHR BioResource — SMILE BioResource programme page https://www.bioresource.nihr.ac.uk/centres-programmes/severe-mental-illness-longitudinal-evaluation-smile-bioresource/ Section: Sample handling “Researchers aim to study how genes, made of DNA, influence health and disease by analysing DNA and other components from blood or saliva samples.” Page: https://www.bioresource.nihr.ac.uk/centres-programmes/severe-mental-illness-longitudinal-evaluation-smile-bioresource/ Public pages describe biosample collection and possible DNA analysis but do not confirm an already generated cohort-wide genotyping dataset; has_genomic_data=FALSE.	Response for Genomic dataAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Omics Recommended	No	Field-cited	NIHR BioResource — SMILE BioResource programme page https://www.bioresource.nihr.ac.uk/centres-programmes/severe-mental-illness-longitudinal-evaluation-smile-bioresource/ Section: Programme description “small blood or saliva sample” Page: https://www.bioresource.nihr.ac.uk/centres-programmes/severe-mental-illness-longitudinal-evaluation-smile-bioresource/ No proteomics/metabolomics/transcriptomics offering is stated in reviewed public materials; FALSE.	Response for OmicsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Imaging Recommended	No	Field-cited	Oxford Health BRC — New BioResource to drive progress in severe mental illness research https://oxfordhealthbrc.nihr.ac.uk/new-bioresource-to-drive-progress-in-severe-mental-illness-research/ Section: Article body “blood or saliva sample, complete symptom and lifestyle questionnaires, and provide consent for researchers to access relevant clinical information.” Page: https://oxfordhealthbrc.nihr.ac.uk/new-bioresource-to-drive-progress-in-severe-mental-illness-research/ No neuroimaging modality described for SMILE cohort data collection; FALSE.	Response for ImagingAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Wearable / sensor Recommended	No	Field-cited	Oxford Health BRC — New BioResource to drive progress in severe mental illness research https://oxfordhealthbrc.nihr.ac.uk/new-bioresource-to-drive-progress-in-severe-mental-illness-research/ Section: Article body “blood or saliva sample, complete symptom and lifestyle questionnaires” Page: https://oxfordhealthbrc.nihr.ac.uk/new-bioresource-to-drive-progress-in-severe-mental-illness-research/ No wearable/sensor stream is described; FALSE.	Response for Wearable / sensorAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Digital phenotyping Recommended	No	Field-cited	Oxford Health BRC — New BioResource to drive progress in severe mental illness research https://oxfordhealthbrc.nihr.ac.uk/new-bioresource-to-drive-progress-in-severe-mental-illness-research/ Section: Article body “complete symptom and lifestyle questionnaires” Page: https://oxfordhealthbrc.nihr.ac.uk/new-bioresource-to-drive-progress-in-severe-mental-illness-research/ Questionnaires are active-report instruments, not passive digital phenotyping; FALSE.	Response for Digital phenotypingAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Linked health records Recommended	Yes	Field-cited	NIHR Be Part of Research — NIHR SMILE BioResource (trialId=57836) https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=57836 Section: Study summary “relevant information being gathered from their health records” Page: https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=57836	Response for Linked health recordsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Biosample types Recommended	blood, saliva	Field-cited	NIHR BioResource — SMILE BioResource programme page https://www.bioresource.nihr.ac.uk/centres-programmes/severe-mental-illness-longitudinal-evaluation-smile-bioresource/ Section: Key goals “donate a small blood or saliva sample” Page: https://www.bioresource.nihr.ac.uk/centres-programmes/severe-mental-illness-longitudinal-evaluation-smile-bioresource/	Response for Biosample typesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Genotyping platform Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: No specific platform (e.g., Illumina array type) publicly listed for SMILE BioResource.	Response for Genotyping platformAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Imaging modalities Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: No imaging modality data publicly reported; field remains NULL.	Response for Imaging modalitiesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Mental health measures Recommended	symptom questionnaires, health and lifestyle questionnaire, cognitive task	Field-cited	NIHR Be Part of Research — NIHR SMILE BioResource (trialId=57836) https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=57836 Section: Study summary “completing self-report measures of symptoms and a Health and Lifestyle Questionnaire ... responses to a cognitive task” Page: https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=57836	Response for Mental health measuresAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Data subcategories

Structured modality and subcategory rows used alongside the high-level data-type flags.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Data subcategories Recommended List key data subcategories using distinct rows for category markers, named questionnaire/interview instruments, biospecimen types, omics/genomics data products, imaging modalities, sensor streams, and linked-record types.	No value held	No source yet	No citation linked to this field yet.	Response for Data subcategoriesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Data subcategories

Recommended

List key data subcategories using distinct rows for category markers, named questionnaire/interview instruments, biospecimen types, omics/genomics data products, imaging modalities, sensor streams, and linked-record types.

No value held

No source yet

No citation linked to this field yet.

AccurateNeeds correctionNot sureDoes not apply

Consent and use permissions

Specific use permissions separate from the 3D consent-level axis.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Consent and use permissions Recommended Confirm health/biomedical research use, industry/commercial consideration, non-commercial restrictions, governance modifiers, recontact, trial approach, biosample use, linkage, sharing, international transfer, and any Section 251/CAG support.	No value held	No source yet	No citation linked to this field yet.	Response for Consent and use permissionsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Consent and use permissions

Recommended

Confirm health/biomedical research use, industry/commercial consideration, non-commercial restrictions, governance modifiers, recontact, trial approach, biosample use, linkage, sharing, international transfer, and any Section 251/CAG support.

No value held

No source yet

No citation linked to this field yet.

AccurateNeeds correctionNot sureDoes not apply

Access pathways

One or more routes by which researchers can request or analyse data.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Access pathways Recommended Confirm all data access pathways, including route, access level, TRE/SDE or download/API environment, DAC review, collaboration requirements, data sharing agreements, output checking, timelines, and fees.	No value held	No source yet	No citation linked to this field yet.	Response for Access pathwaysAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Access pathways

Recommended

Confirm all data access pathways, including route, access level, TRE/SDE or download/API environment, DAC review, collaboration requirements, data sharing agreements, output checking, timelines, and fees.

No value held

No source yet

No citation linked to this field yet.

AccurateNeeds correctionNot sureDoes not apply

Within-cohort coverage

Aggregate counts or percentages showing how broadly data, consent, or access characteristics apply within the cohort.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Within-cohort coverage metrics Recommended Provide numerator, denominator, unit type, numerator/denominator exactness qualifiers, denominator type, basis, date/release, original source wording, and whether each metric is marginal, joint, conditional, or a release total.	No value held	No source yet	No citation linked to this field yet.	Response for Within-cohort coverage metricsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Within-cohort coverage metrics

Recommended

Provide numerator, denominator, unit type, numerator/denominator exactness qualifiers, denominator type, basis, date/release, original source wording, and whether each metric is marginal, joint, conditional, or a release total.

No value held

No source yet

No citation linked to this field yet.

AccurateNeeds correctionNot sureDoes not apply

Linkage and access

Field	Current value	Evidence	Source evidence	Response	Notes / correction
NHS linkage Recommended	Yes	Field-cited	NIHR Be Part of Research — NIHR SMILE BioResource (trialId=57836) https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=57836 Section: Study summary “relevant information being gathered from their health records” Page: https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=57836	Response for NHS linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
GP linkage Recommended	Yes	Field-cited	NIHR BioResource — SMILE BioResource programme page https://www.bioresource.nihr.ac.uk/centres-programmes/severe-mental-illness-longitudinal-evaluation-smile-bioresource/ Section: FAQ 2 “Will my General Practitioner (GP) be informed of my participation?” Page: https://www.bioresource.nihr.ac.uk/centres-programmes/severe-mental-illness-longitudinal-evaluation-smile-bioresource/ Protocol and FAQ explicitly reference GP record context and clinical communication pathways.	Response for GP linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Death registry linkage Recommended	No	Field-cited	NIHR BioResource — SMILE BioResource programme page https://www.bioresource.nihr.ac.uk/centres-programmes/severe-mental-illness-longitudinal-evaluation-smile-bioresource/ Section: FAQ 5 “Information may come from medical, hospital, educational, social care, and disease registry records” Page: https://www.bioresource.nihr.ac.uk/centres-programmes/severe-mental-illness-longitudinal-evaluation-smile-bioresource/ Death registry linkage is not explicitly named; conservatively FALSE pending explicit ONS/death registry statement.	Response for Death registry linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Education linkage Recommended	Yes	Field-cited	NIHR BioResource — SMILE BioResource programme page https://www.bioresource.nihr.ac.uk/centres-programmes/severe-mental-illness-longitudinal-evaluation-smile-bioresource/ Section: FAQ 5 “Information may come from medical, hospital, educational, social care, and disease registry records” Page: https://www.bioresource.nihr.ac.uk/centres-programmes/severe-mental-illness-longitudinal-evaluation-smile-bioresource/	Response for Education linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data access mechanism Recommended	direct_application	Field-cited	NIHR BioResource — SMILE BioResource programme page https://www.bioresource.nihr.ac.uk/centres-programmes/severe-mental-illness-longitudinal-evaluation-smile-bioresource/ Section: FAQ 3 “Researchers must apply for access, agree to strict conditions, and are prohibited from identifying you.” Page: https://www.bioresource.nihr.ac.uk/centres-programmes/severe-mental-illness-longitudinal-evaluation-smile-bioresource/ Application-based access through NIHR BioResource governance => direct_application.	Response for Data access mechanismAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
TRE platform Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: No named TRE platform publicly stated for SMILE access.	Response for TRE platformAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data dictionary URL Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: No public SMILE-specific data dictionary URL located in required source set.	Response for Data dictionary URLAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data access timeline (days) Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: No public numeric turnaround timeline for data access found.	Response for Data access timeline (days)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data access cost Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: No public fixed access fee or tariff found.	Response for Data access costAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Participant profile and dates

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Age distribution Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: No public demographic age-band percentages found. Searched NIHR BioResource SMILE page, NIHR Be Part of Research summary, Oxford Health BRC launch post, HDRUK portal, DPUK, ClinicalTrials.gov and ISRCTN search pages.	Response for Age distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Sex distribution Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: No publicly released sex distribution found in searched SMILE sources and registries.	Response for Sex distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Ethnicity distribution Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: No publicly released ethnicity distribution found in searched SMILE sources and registries.	Response for Ethnicity distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Smoking status distribution Recommended	No value held	No source yet	No citation linked to this field yet.	Response for Smoking status distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Median age Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: No published age distribution table available to derive median_age.	Response for Median ageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Percent female Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: No published sex distribution values available.	Response for Percent femaleAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Percent non-white Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: No published ethnicity distribution values available.	Response for Percent non-whiteAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Geographic coverage Recommended	national	Field-cited	Oxford Health BRC — New BioResource to drive progress in severe mental illness research https://oxfordhealthbrc.nihr.ac.uk/new-bioresource-to-drive-progress-in-severe-mental-illness-research/ Section: Article body “building a cohort of up to 2,000 volunteers from across the UK” Page: https://oxfordhealthbrc.nihr.ac.uk/new-bioresource-to-drive-progress-in-severe-mental-illness-research/ Across the UK => national coverage.	Response for Geographic coverageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Follow-up duration Recommended	2025-2038 planned recruitment with longitudinal recall	Field-cited	NIHR BioResource — SMILE BioResource programme page https://www.bioresource.nihr.ac.uk/centres-programmes/severe-mental-illness-longitudinal-evaluation-smile-bioresource/ Section: Longitudinal definition “A longitudinal study means that participants are included in a study over a period of time” Page: https://www.bioresource.nihr.ac.uk/centres-programmes/severe-mental-illness-longitudinal-evaluation-smile-bioresource/ Recruitment window from 2025-11-13 to 2038-01-31 plus recall indicates planned long-duration follow-up.	Response for Follow-up durationAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Last data collection date Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: Ongoing recruitment; no definitive latest collection cut-off date published.	Response for Last data collection dateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Recruitment start date Recommended	13 Nov 2025	Field-cited	NIHR Be Part of Research — NIHR SMILE BioResource (trialId=57836) https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=57836 Section: Key dates “13 Nov 2025” Page: https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=57836	Response for Recruitment start dateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Recruitment end date Recommended	31 Jan 2038	Field-cited	NIHR Be Part of Research — NIHR SMILE BioResource (trialId=57836) https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=57836 Section: Key dates “31 Jan 2038” Page: https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=57836	Response for Recruitment end dateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Diagnosis areas

Mental health diagnosis areas represented in this cohort.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Diagnosis area: Schizophrenia Recommended Confirm this diagnosis area applies and estimated N if shown.	Schizophrenia · Psychotic Disorders	Field-cited	NIHR BioResource — SMILE BioResource programme page https://www.bioresource.nihr.ac.uk/centres-programmes/severe-mental-illness-longitudinal-evaluation-smile-bioresource/ Section: About the SMILE BioResource “schizophrenia” Page: https://www.bioresource.nihr.ac.uk/centres-programmes/severe-mental-illness-longitudinal-evaluation-smile-bioresource/ Diagnosis area confirmed; no public prevalence split so estimated_n remains NULL.	Response for Diagnosis area: SchizophreniaAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Diagnosis area: First-episode psychosis Recommended Confirm this diagnosis area applies and estimated N if shown.	First-episode psychosis · Psychotic Disorders	Field-cited	NIHR BioResource — SMILE BioResource programme page https://www.bioresource.nihr.ac.uk/centres-programmes/severe-mental-illness-longitudinal-evaluation-smile-bioresource/ Section: About the SMILE BioResource “psychosis” Page: https://www.bioresource.nihr.ac.uk/centres-programmes/severe-mental-illness-longitudinal-evaluation-smile-bioresource/ NEW row added from explicit psychosis coverage; estimated_n not published.	Response for Diagnosis area: First-episode psychosisAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Diagnosis area: Schizoaffective disorder Recommended Confirm this diagnosis area applies and estimated N if shown.	Schizoaffective disorder · Psychotic Disorders	Field-cited	NIHR BioResource — SMILE BioResource programme page https://www.bioresource.nihr.ac.uk/centres-programmes/severe-mental-illness-longitudinal-evaluation-smile-bioresource/ Section: About the SMILE BioResource “schizoaffective disorders” Page: https://www.bioresource.nihr.ac.uk/centres-programmes/severe-mental-illness-longitudinal-evaluation-smile-bioresource/ Diagnosis area confirmed; estimated_n not published.	Response for Diagnosis area: Schizoaffective disorderAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Diagnosis area: Bipolar disorder Recommended Confirm this diagnosis area applies and estimated N if shown.	Bipolar disorder · Mood Disorders	Field-cited	NIHR BioResource — SMILE BioResource programme page https://www.bioresource.nihr.ac.uk/centres-programmes/severe-mental-illness-longitudinal-evaluation-smile-bioresource/ Section: About the SMILE BioResource “severe mood disorders with psychotic symptoms” Page: https://www.bioresource.nihr.ac.uk/centres-programmes/severe-mental-illness-longitudinal-evaluation-smile-bioresource/ Mapped to bipolar disorder diagnosis area as closest existing category in diagnosis_areas.sql; estimated_n not published.	Response for Diagnosis area: Bipolar disorderAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Linked sites

Sites contributing participants or data to this cohort.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Linked site: NIHR Cambridge Biomedical Research Centre Recommended	NIHR Cambridge Biomedical Research Centre · East of England	Field-cited	NIHR Be Part of Research — NIHR SMILE BioResource (trialId=57836) https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=57836 Section: Study Sites “Cambridge” Page: https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=57836 Cambridge study site maps to site_id 4 (Cambridge BRC).	Response for Linked site: NIHR Cambridge Biomedical Research CentreAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Linked site: South West London and St George's Mental Health NHS Trust Recommended	South West London and St George's Mental Health NHS Trust · London	Field-cited	NIHR Be Part of Research — NIHR SMILE BioResource (trialId=57836) https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=57836 Section: Where can I take part? “Springfield University Hospital ... London Greater London SW17 7DJ” Page: https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=57836 Springfield University Hospital corresponds to South West London and St George's site entry (id 41).	Response for Linked site: South West London and St George's Mental Health NHS TrustAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Linked site: North East London NHS Foundation Trust Recommended	North East London NHS Foundation Trust · London	Field-cited	NIHR Be Part of Research — NIHR SMILE BioResource (trialId=57836) https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=57836 Section: Where can I take part? “Goodmayes Hospital ... Ilford Essex IG3 8XJ” Page: https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=57836 Ilford Goodmayes site mapped to North East London NHS Foundation Trust entry (id 42).	Response for Linked site: North East London NHS Foundation TrustAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Linked site: NIHR Oxford Health Biomedical Research Centre Recommended	NIHR Oxford Health Biomedical Research Centre · South East England	Field-cited	NIHR Be Part of Research — NIHR SMILE BioResource (trialId=57836) https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=57836 Section: Study Sites “Oxford” Page: https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=57836 Oxford site maps to site_id 2 (Oxford Health BRC lead).	Response for Linked site: NIHR Oxford Health Biomedical Research CentreAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Linked site: Birmingham Centre for Human Brain Health Recommended	Birmingham Centre for Human Brain Health · West Midlands	Field-cited	NIHR Be Part of Research — NIHR SMILE BioResource (trialId=57836) https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=57836 Section: Study summary “collaborative project between ... the University of Birmingham” Page: https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=57836 University of Birmingham collaborator mapped to site_id 16 (Birmingham CHBH).	Response for Linked site: Birmingham Centre for Human Brain HealthAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Linked site: Birmingham and Solihull Mental Health NHS Foundation Trust Recommended	Birmingham and Solihull Mental Health NHS Foundation Trust · West Midlands	Field-cited	NIHR Be Part of Research — NIHR SMILE BioResource (trialId=57836) https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=57836 Section: Where can I take part? “The Uffculme Centre ... Birmingham West Midlands B13 8QY” Page: https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=57836 Uffculme Centre corresponds to Birmingham and Solihull MH NHS FT research base (site_id 51).	Response for Linked site: Birmingham and Solihull Mental Health NHS Foundation TrustAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Linked site: Leeds and York Partnership NHS Foundation Trust Recommended	Leeds and York Partnership NHS Foundation Trust · Yorkshire and the Humber	Field-cited	NIHR Be Part of Research — NIHR SMILE BioResource (trialId=57836) https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=57836 Section: Where can I take part? “Becklin Centre ... Leeds West Yorkshire LS9 7BE” Page: https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=57836 Leeds Becklin Centre mapped to Leeds and York Partnership NHS FT site entry (id 56).	Response for Linked site: Leeds and York Partnership NHS Foundation TrustAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Verification metadata

Internal catalogue status — for reference only.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Verification status Recommended	unverified	Internal	Internal catalogue field	—	—
Last verified Recommended	No value held	Internal	Internal catalogue field	—	—
Data source Recommended	Verified Apr 2026 from NIHR BioResource SMILE page, NIHR Be Part of Research trialId=57836, Oxford Health BRC SMILE announcement, ClinicalTrials.gov API search (no direct SMILE record), ISRCTN search (site requires JS/cookies).	Internal	Internal catalogue field	—	—