Cohort validation pack

HCS

Hertfordshire Cohort Study

Generated 6 Oct 2026, 10:36 · ID 78

AI inferred

Last verified: 16/04/2026

Instructions for reviewers

Review each field against your knowledge of this cohort. Mark Accurate if the value is right, Needs correction if it is wrong or inaccurate (add notes), Not sure if you cannot verify it, or Does not apply if the field is not relevant.
Evidence shown is from our source registry. Fields marked No source yet hold values we could not yet pin to a document — those were AI-inferred and need your input most. Fields marked Searched — not published are ones we looked for and could not find publicly; the note lists where we checked.
Your selections and notes are kept in this browser tab only (not sent to the database). Print or save as PDF when finished, then return it to the DIGIT team.

Overview

Total fields

Field-cited

Whole-record source only

AI-inferred, no source yet

Searched — not published

No value held

Needs review

Source coverage

Summary of how well fields in this pack are linked to evidence.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Field-level source coverage Optional	42 of 69 reviewable fields are cited to a source (61%) · 7 with no source yet · 20 searched — not published · 19 with no value held	Computed	No citation linked to this field yet.	Response for Field-level source coverageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Identity and ownership

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Short name Required	HCS	Field-cited	Catalogue of Mental Health Measures — Hertfordshire Cohort Study (HCS) https://cataloguementalhealth.ac.uk/HCS Section: Page title “Hertfordshire Cohort Study (HCS)” Page: https://cataloguementalhealth.ac.uk/HCS DIGIT short label HCS is the established acronym used alongside the full cohort name on the Catalogue study page.	Response for Short nameAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Full name Required	Hertfordshire Cohort Study	Field-cited	Europe PMC API — IJE dyi127 metadata (cohort profile) https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI:10.1093/ije/dyi127&format=json Section: Europe PMC lite JSON “Cohort profile: the Hertfordshire cohort study.” Page: https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI:10.1093/ije/dyi127&format=json	Response for Full nameAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Managing organisation Recommended	MRC Lifecourse Epidemiology Centre, University of Southampton	Field-cited	Catalogue of Mental Health Measures — Hertfordshire Cohort Study (HCS) https://cataloguementalhealth.ac.uk/HCS Section: Overview card “MRC Lifecourse Epidemiology Centre, University of Southampton” Page: https://cataloguementalhealth.ac.uk/HCS	Response for Managing organisationAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Primary site Recommended	University of Southampton — Centre for Innovation in Mental Health (site #74)	Not published	NULL: no University of Southampton / MRC LEU site row exists in db/seed/sites/ to reference as primary_site_id in this seed pass.	Response for Primary siteAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Website URL Recommended	https://www.mrc.soton.ac.uk/herts/	Field-cited	Catalogue of Mental Health Measures — Hertfordshire Cohort Study (HCS) https://cataloguementalhealth.ac.uk/HCS Section: Additional information “mrc.soton.ac.uk/herts” Page: https://cataloguementalhealth.ac.uk/HCS DIGIT website_url stores the HTTPS canonical form https://www.mrc.soton.ac.uk/herts/ aligned to the Catalogue link target.	Response for Website URLAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Catalogue of Mental Health Measures URL Recommended	https://www.cataloguementalhealth.ac.uk/HCS	Field-cited	Catalogue of Mental Health Measures https://www.cataloguementalhealth.ac.uk Section: Official sitemap study URL “https://www.cataloguementalhealth.ac.uk/HCS” Page: https://www.cataloguementalhealth.ac.uk/HCS	Response for Catalogue of Mental Health Measures URLAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Contact name Recommended	Cyrus Cooper	Field-cited	Syddall HE et al. 2019 — The Hertfordshire Cohort Study: an overview (F1000Research) https://doi.org/10.12688/f1000research.17457.1 Section: Corresponding author “Corresponding author: Cyrus Cooper (cc@mrc.soton.ac.uk)” Page: https://doi.org/10.12688/f1000research.17457.1 Used as the public scientific correspondence contact for the overview manuscript; dedicated operations inbox may differ.	Response for Contact nameAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Contact email Recommended	cc@mrc.soton.ac.uk	Field-cited	Syddall HE et al. 2019 — The Hertfordshire Cohort Study: an overview (F1000Research) https://doi.org/10.12688/f1000research.17457.1 Section: Corresponding author “cc@mrc.soton.ac.uk” Page: https://doi.org/10.12688/f1000research.17457.1	Response for Contact emailAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Summary and status

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Description Required	Nationally unique UK ageing cohort of men and women born in Hertfordshire in 1931–1939, traced from historic health-visitor ledgers through NHS registers with baseline home interviews and research clinics (1998–2004) and repeated follow-up waves collecting lifestyle, medical, biological, imaging, and (in substudies) wearable accelerometry data; mental health is captured with validated instruments including HADS and MMSE across sweeps, with NHS Digital hospital episode linkage and mortality notification on the NHS Central Register.	Field-cited	Syddall HE et al. 2019 — The Hertfordshire Cohort Study: an overview (F1000Research) https://doi.org/10.12688/f1000research.17457.1 Section: Abstract “The Hertfordshire Cohort Study is a nationally unique study of men and women born in the English county of Hertfordshire in the early part of the 20th century.” Page: https://doi.org/10.12688/f1000research.17457.1 DIGIT description extends the abstract with baseline/follow-up modalities summarised elsewhere in the same overview PDF (home interview, clinics, HES linkage, accelerometry substudy).	Response for DescriptionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Total N Required	3,225	Field-cited	Syddall HE et al. 2019 — The Hertfordshire Cohort Study: an overview (F1000Research) https://doi.org/10.12688/f1000research.17457.1 Section: Recruitment “3225 (53%) agreed to a home interview with a trained research nurse.” Page: https://doi.org/10.12688/f1000research.17457.1 Corroborates the Catalogue baseline count with the same numeric total in the open-access overview text. Catalogue of Mental Health Measures — Hertfordshire Cohort Study (HCS) https://cataloguementalhealth.ac.uk/HCS Section: Sample size at recruitment “3,225 (HCS Baseline)” Page: https://cataloguementalhealth.ac.uk/HCS	Response for Total NAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Total N qualifier Recommended	No value held	Not published	Syddall HE et al. 2019 — The Hertfordshire Cohort Study: an overview (F1000Research) https://doi.org/10.12688/f1000research.17457.1 NULL: 3225 is an enumerated recruited-participant total in primary sources, not an approximate/target figure requiring a data-dictionary qualifier.	Response for Total N qualifierAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Year established Recommended	1998	Field-cited	Catalogue of Mental Health Measures — Hertfordshire Cohort Study (HCS) https://cataloguementalhealth.ac.uk/HCS Section: Start date “HCS: 1998” Page: https://cataloguementalhealth.ac.uk/HCS year_established uses the Catalogue HCS programme start year for baseline fieldwork.	Response for Year establishedAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Active cohort Recommended	Yes	Field-cited	Syddall HE et al. 2019 — The Hertfordshire Cohort Study: an overview (F1000Research) https://doi.org/10.12688/f1000research.17457.1 Section: Abstract + follow-up narrative “This paper provides an overview of the study since its inception in the 1980s, including its methods, findings, and plans for its future.” Page: https://doi.org/10.12688/f1000research.17457.1 Ongoing programme maintenance and future plans described → is_active=TRUE.	Response for Active cohortAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Ongoing recruitment Recommended	No	Not published	Syddall HE et al. 2019 — The Hertfordshire Cohort Study: an overview (F1000Research) https://doi.org/10.12688/f1000research.17457.1 FALSE: baseline traced cohort with closed recruitment window; later activity is follow-up of existing participants rather than open population recruitment.	Response for Ongoing recruitmentAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Refreshed cohort Recommended	Yes	Field-cited	Syddall HE et al. 2019 — The Hertfordshire Cohort Study: an overview (F1000Research) https://doi.org/10.12688/f1000research.17457.1 Section: Follow-up studies 2004 to 2018 “Since their first contact in 1998–2004, HCS cohort members have generously agreed to take part in various follow-up postal questionnaires, face-to-face interviews, clinics, intervention studies, and focus groups” Page: https://doi.org/10.12688/f1000research.17457.1	Response for Refreshed cohortAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Recontact success rate Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: headline recontact response percentage not quoted in the cited F1000 overview or Catalogue cards.	Response for Recontact success rateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Retention rate Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: single cohort-wide retention percentage not extracted from cited sources in this pass.	Response for Retention rateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Published references Recommended	doi:10.1093/ije/dyi127, doi:10.12688/f1000research.17457.1	Field-cited	Syddall HE et al. 2019 — The Hertfordshire Cohort Study: an overview (F1000Research) https://doi.org/10.12688/f1000research.17457.1 Section: How to cite this article “https://doi.org/10.12688/f1000research.17457.1” Page: https://doi.org/10.12688/f1000research.17457.1 Second published_references element for the open-access overview DOI string as printed in the manuscript citation box. Europe PMC API — IJE dyi127 metadata (cohort profile) https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI:10.1093/ije/dyi127&format=json Section: Europe PMC lite JSON “"doi":"10.1093/ije/dyi127"” Page: https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI:10.1093/ije/dyi127&format=json	Response for Published referencesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Notes Recommended	Primary site set to the University of Southampton — Centre for Innovation in Mental Health row (site 74) as the closest registered University of Southampton site; the study is coordinated by the MRC Lifecourse Epidemiology Centre at the same university (Southampton), which is not separately listed in the sites seed. Musculoskeletal and cardiometabolic phenotypes dominate published outputs; MH measures are explicitly catalogued and collected in several sweeps per F1000 overview and Catalogue of Mental Health Measures entry.	Field-cited	Syddall HE et al. 2019 — The Hertfordshire Cohort Study: an overview (F1000Research) https://doi.org/10.12688/f1000research.17457.1 Section: Principal objective “The principal objective of the HCS is to evaluate interactions between the intra-uterine and early postnatal environment, adult diet and lifestyle, and genetics, in the aetiology of chronic disorders of ageing (osteoporosis, osteoarthritis, sarcopenia, obesity, cardiometabolic disease and type II diabetes mellitus).” Page: https://doi.org/10.12688/f1000research.17457.1 DIGIT notes additionally record the missing primary_site_id rationale stated in the cohort SQL comment. Syddall HE et al. 2019 — The Hertfordshire Cohort Study: an overview (F1000Research) https://doi.org/10.12688/f1000research.17457.1 Section: Table 2 “Anxiety and depression (HAD) scores” Page: https://doi.org/10.12688/f1000research.17457.1 Syddall HE et al. 2019 — The Hertfordshire Cohort Study: an overview (F1000Research) https://doi.org/10.12688/f1000research.17457.1 Section: Table 2 “Anxiety and depression (HAD) scores” Page: https://doi.org/10.12688/f1000research.17457.1 Syddall HE et al. 2019 — The Hertfordshire Cohort Study: an overview (F1000Research) https://doi.org/10.12688/f1000research.17457.1 Section: Later questionnaire list “Mini mental state examination (MMSE)” Page: https://doi.org/10.12688/f1000research.17457.1	Response for NotesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

3D cohort mapping

Consent, characterisation, and data availability axes used on the cohort map.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Consent level (axis) Required	3 — Broad consent (recontactable for future studies)	Field-cited	Syddall HE et al. 2019 — The Hertfordshire Cohort Study: an overview (F1000Research) https://doi.org/10.12688/f1000research.17457.1 Section: Ethical permission and informed consent “The HCS baseline investigations had ethical approval from the North and East Hertfordshire Local Research Ethics Committee and all subjects gave written informed consent.” Page: https://doi.org/10.12688/f1000research.17457.1 Step1 identifiable=YES (named participants in research). Step2 S251/CAG-only access=NO. Step3 recontactable=YES ("have generously agreed to take part in various follow-up postal questionnaires, face-to-face interviews, clinics"). Step4 interventional-ready randomisation consent for whole cohort=NO → consent_level=3 per data-dictionary.md.	Response for Consent level (axis)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Characterisation depth (axis) Required	3 — Multi-domain MH characterisation	Field-cited	Syddall HE et al. 2019 — The Hertfordshire Cohort Study: an overview (F1000Research) https://doi.org/10.12688/f1000research.17457.1 Section: Table 2. Hertfordshire Cohort Study Baseline “Anxiety and depression (HAD) scores” Page: https://doi.org/10.12688/f1000research.17457.1 Validated HADS plus multi-domain clinic phenotyping (cognition, physical measures) supports ≥L3; no cohort-wide SCID/MINI/SCAN described as the default MH diagnostic gold standard → characterisation_depth=3 (not L4) per data-dictionary.md tree.	Response for Characterisation depth (axis)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data availability (axis) Required	4 — Multi-modal	Field-cited	Syddall HE et al. 2019 — The Hertfordshire Cohort Study: an overview (F1000Research) https://doi.org/10.12688/f1000research.17457.1 Section: Multiple data domains in overview “DNA extracted from whole blood” Page: https://doi.org/10.12688/f1000research.17457.1 DERIVED per data-dictionary.md: hasResearch=TRUE (questionnaires, cognitive tests, physical measures, NHS record linkage flags set TRUE); hasBiological=TRUE (blood/DNA + omics substudy text); hasAdvanced=TRUE (MRI + accelerometry) → data_availability=4.	Response for Data availability (axis)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Cohort map group (derived) Recommended	Group 1	Internal	Internal catalogue field	—	—
Population type Recommended	General population	Not published	DIGIT Cohort Portfolio Review — population type and engagement classification (Aug 2026) Classified general_population in the DIGIT cohort portfolio review (Aug 2026). Ageing cohort traced from historic Hertfordshire birth records; population sample.	Response for Population typeAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Industry engagement status Recommended	Unknown	Not published	Searched — not published UNSOURCEABLE: industry engagement status is an organisational property of the custodian and is not publicly documented; default 'unknown' pending a cohort-owner meeting.	Response for Industry engagement statusAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Parent cohort / programme Recommended	No value held	No source yet	No citation linked to this field yet.	Response for Parent cohort / programmeAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
TWiCs eligible Recommended	No	Not published	Syddall HE et al. 2019 — The Hertfordshire Cohort Study: an overview (F1000Research) https://doi.org/10.12688/f1000research.17457.1 FALSE: consent_level=3 (broad written consent / follow-up participation) rather than cohort-wide active interventional randomisation-ready consent per data-dictionary TWiCs rule.	Response for TWiCs eligibleAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Data modalities

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Questionnaire / interview Recommended	Yes	Field-cited	Syddall HE et al. 2019 — The Hertfordshire Cohort Study: an overview (F1000Research) https://doi.org/10.12688/f1000research.17457.1 Section: Table 2. Hertfordshire Cohort Study Baseline “SF-36 health related quality of life” Page: https://doi.org/10.12688/f1000research.17457.1 Multiple named questionnaires including SF-36 and HADS family instruments in the same baseline table.	Response for Questionnaire / interviewAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Cognitive testing Recommended	Yes	Field-cited	Syddall HE et al. 2019 — The Hertfordshire Cohort Study: an overview (F1000Research) https://doi.org/10.12688/f1000research.17457.1 Section: Table 2. Hertfordshire Cohort Study Baseline — Clinic Visit “Cognitive function (AH4 intelligence quotient, Mill Hill vocabulary test)” Page: https://doi.org/10.12688/f1000research.17457.1	Response for Cognitive testingAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Physical measures Recommended	Yes	Field-cited	Syddall HE et al. 2019 — The Hertfordshire Cohort Study: an overview (F1000Research) https://doi.org/10.12688/f1000research.17457.1 Section: Clinic Visit “Grip strength (Jamar hand-grip dynamometer)” Page: https://doi.org/10.12688/f1000research.17457.1 Also includes anthropometry and DXA elsewhere in the same overview tables.	Response for Physical measuresAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Biosamples Recommended	Yes	Field-cited	Syddall HE et al. 2019 — The Hertfordshire Cohort Study: an overview (F1000Research) https://doi.org/10.12688/f1000research.17457.1 Section: Clinic Visit “Venous blood samples after overnight fast: Glucose” Page: https://doi.org/10.12688/f1000research.17457.1 DNA extraction sentence in the same document supports stored genetic material.	Response for BiosamplesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Genomic data Recommended	Yes	Field-cited	Syddall HE et al. 2019 — The Hertfordshire Cohort Study: an overview (F1000Research) https://doi.org/10.12688/f1000research.17457.1 Section: Genetics and epigenetics “more recently HCS has been an important contributor to many genome wide association studies conducted by worldwide consortia” Page: https://doi.org/10.12688/f1000research.17457.1	Response for Genomic dataAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Omics Recommended	Yes	Field-cited	Syddall HE et al. 2019 — The Hertfordshire Cohort Study: an overview (F1000Research) https://doi.org/10.12688/f1000research.17457.1 Section: Genetics and epigenetics “deep sequencing of RNA as well as high coverage methylation arrays to be completed in a subset of participants.” Page: https://doi.org/10.12688/f1000research.17457.1	Response for OmicsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Imaging Recommended	Yes	Field-cited	Syddall HE et al. 2019 — The Hertfordshire Cohort Study: an overview (F1000Research) https://doi.org/10.12688/f1000research.17457.1 Section: Clinic Visit “MRI scans of liver and muscle composition (Siemens 3T Tim Trio scanner)” Page: https://doi.org/10.12688/f1000research.17457.1 DXA and radiographs are described in the same overview document for bone and joint imaging outcomes.	Response for ImagingAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Wearable / sensor Recommended	Yes	Field-cited	Syddall HE et al. 2019 — The Hertfordshire Cohort Study: an overview (F1000Research) https://doi.org/10.12688/f1000research.17457.1 Section: Methodology “Wearable physical activity accelerometers were delivered and returned by post.” Page: https://doi.org/10.12688/f1000research.17457.1 Also lists "7-day hip-worn triaxial accelerometer assessment of physical activity" in key data availability bullets in the same PDF.	Response for Wearable / sensorAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Digital phenotyping Recommended	No	Not published	Syddall HE et al. 2019 — The Hertfordshire Cohort Study: an overview (F1000Research) https://doi.org/10.12688/f1000research.17457.1 FALSE: reviewed F1000 overview sections cite app-style passive smartphone phenotyping streams (GPS/metadata) only generically via related themes elsewhere; no passive digital phenotyping module is described for HCS in the cited PDF text.	Response for Digital phenotypingAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Linked health records Recommended	Yes	Field-cited	Syddall HE et al. 2019 — The Hertfordshire Cohort Study: an overview (F1000Research) https://doi.org/10.12688/f1000research.17457.1 Section: Follow-up studies 2004 to 2018 “With their consent, data on hospital admissions experienced by the cohort members across a decade have been obtained from NHS Digital” Page: https://doi.org/10.12688/f1000research.17457.1	Response for Linked health recordsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Biosample types Recommended	blood, plasma, serum, DNA, muscle_biopsy	Field-cited	Syddall HE et al. 2019 — The Hertfordshire Cohort Study: an overview (F1000Research) https://doi.org/10.12688/f1000research.17457.1 Section: Genetics and epigenetics “Furthermore, muscle cells obtained from biopsies of older men and women have been cultured in vitro” Page: https://doi.org/10.12688/f1000research.17457.1 ARRAY also encodes venous blood/plasma/serum/DNA alongside the muscle biopsy programme described here and venous blood sampling elsewhere in the same PDF.	Response for Biosample typesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Genotyping platform Recommended	No value held	Not published	Searched — not published UNSOURCEABLE in cited open materials: GWAS participation is asserted but no single array chip / sequencing platform string is named in the F1000 overview PDF or Catalogue cards used for this pass.	Response for Genotyping platformAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Imaging modalities Recommended	dexa, peripheral_qct, xray, structural_mri	Field-cited	Syddall HE et al. 2019 — The Hertfordshire Cohort Study: an overview (F1000Research) https://doi.org/10.12688/f1000research.17457.1 Section: Clinic Visit “MRI scans of liver and muscle composition (Siemens 3T Tim Trio scanner)” Page: https://doi.org/10.12688/f1000research.17457.1 ARRAY also encodes DXA, peripheral QCT, and plain radiographs described in the osteoporosis discussion and Table 2 context within the same PDF.	Response for Imaging modalitiesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Mental health measures Recommended	Hospital Anxiety and Depression Scale (HADS), Mini-Mental State Examination (MMSE), Warwick-Edinburgh Mental Well-Being Scale (WEMWBS), Pittsburgh Sleep Quality Index (PSQI)	Field-cited	Syddall HE et al. 2019 — The Hertfordshire Cohort Study: an overview (F1000Research) https://doi.org/10.12688/f1000research.17457.1 Section: Table 6 / later questionnaire lists “Warwick-Edinburgh Mental Well-being Scale” Page: https://doi.org/10.12688/f1000research.17457.1 ARRAY rows also align to HADS/HAD, MMSE, and Pittsburgh Sleep Quality questionnaire text in the same overview PDF.	Response for Mental health measuresAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Data subcategories

Structured modality and subcategory rows used alongside the high-level data-type flags.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Data subcategories Recommended List key data subcategories using distinct rows for category markers, named questionnaire/interview instruments, biospecimen types, omics/genomics data products, imaging modalities, sensor streams, and linked-record types.	No value held	No source yet	No citation linked to this field yet.	Response for Data subcategoriesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Data subcategories

Recommended

List key data subcategories using distinct rows for category markers, named questionnaire/interview instruments, biospecimen types, omics/genomics data products, imaging modalities, sensor streams, and linked-record types.

No value held

No source yet

No citation linked to this field yet.

AccurateNeeds correctionNot sureDoes not apply

Consent and use permissions

Specific use permissions separate from the 3D consent-level axis.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Consent and use permissions Recommended Confirm health/biomedical research use, industry/commercial consideration, non-commercial restrictions, governance modifiers, recontact, trial approach, biosample use, linkage, sharing, international transfer, and any Section 251/CAG support.	No value held	No source yet	No citation linked to this field yet.	Response for Consent and use permissionsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Consent and use permissions

Recommended

Confirm health/biomedical research use, industry/commercial consideration, non-commercial restrictions, governance modifiers, recontact, trial approach, biosample use, linkage, sharing, international transfer, and any Section 251/CAG support.

No value held

No source yet

No citation linked to this field yet.

AccurateNeeds correctionNot sureDoes not apply

Access pathways

One or more routes by which researchers can request or analyse data.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Access pathways Recommended Confirm all data access pathways, including route, access level, TRE/SDE or download/API environment, DAC review, collaboration requirements, data sharing agreements, output checking, timelines, and fees.	No value held	No source yet	No citation linked to this field yet.	Response for Access pathwaysAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Access pathways

Recommended

Confirm all data access pathways, including route, access level, TRE/SDE or download/API environment, DAC review, collaboration requirements, data sharing agreements, output checking, timelines, and fees.

No value held

No source yet

No citation linked to this field yet.

AccurateNeeds correctionNot sureDoes not apply

Within-cohort coverage

Aggregate counts or percentages showing how broadly data, consent, or access characteristics apply within the cohort.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Within-cohort coverage metrics Recommended Provide numerator, denominator, unit type, numerator/denominator exactness qualifiers, denominator type, basis, date/release, original source wording, and whether each metric is marginal, joint, conditional, or a release total.	No value held	No source yet	No citation linked to this field yet.	Response for Within-cohort coverage metricsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Within-cohort coverage metrics

Recommended

Provide numerator, denominator, unit type, numerator/denominator exactness qualifiers, denominator type, basis, date/release, original source wording, and whether each metric is marginal, joint, conditional, or a release total.

No value held

No source yet

No citation linked to this field yet.

AccurateNeeds correctionNot sureDoes not apply

Linkage and access

Field	Current value	Evidence	Source evidence	Response	Notes / correction
NHS linkage Recommended	Yes	Field-cited	Syddall HE et al. 2019 — The Hertfordshire Cohort Study: an overview (F1000Research) https://doi.org/10.12688/f1000research.17457.1 Section: Health services research “HCS was one of the first English cohorts to link with HES data” Page: https://doi.org/10.12688/f1000research.17457.1	Response for NHS linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
GP linkage Recommended	No	Not published	Syddall HE et al. 2019 — The Hertfordshire Cohort Study: an overview (F1000Research) https://doi.org/10.12688/f1000research.17457.1 FALSE: overview emphasises NHS Digital hospital admissions linkage and self-reported health service use items; no explicit research linkage to primary-care administrative records is named in the cited PDF excerpts.	Response for GP linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Death registry linkage Recommended	Yes	Field-cited	Syddall HE et al. 2019 — The Hertfordshire Cohort Study: an overview (F1000Research) https://doi.org/10.12688/f1000research.17457.1 Section: Follow-up studies 2004 to 2018 “cohort members remain flagged on the National Health Service Central Register for ongoing notification of mortality.” Page: https://doi.org/10.12688/f1000research.17457.1	Response for Death registry linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Education linkage Recommended	No	Not published	Syddall HE et al. 2019 — The Hertfordshire Cohort Study: an overview (F1000Research) https://doi.org/10.12688/f1000research.17457.1 FALSE: administrative education-record linkage is not described; educational attainment appears only as questionnaire fields (e.g. age left full-time education) in the overview tables.	Response for Education linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data access mechanism Recommended	tre	Field-cited	DPUK Data Portal — Dementias Platform UK https://www.dementiasplatform.uk/data-portal Section: Lead paragraph “Researchers can identify which cohorts and data are relevant to their proposed research question or area of study, apply for access to the data, and then analyse it in a secure, remote environment complete with data linkage, analytical software packages, and multi-cohort capability.” Page: https://www.dementiasplatform.uk/data-portal Mechanism classified as tre (trusted/secure research environment) per data-dictionary definitions.	Response for Data access mechanismAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
TRE platform Recommended	DPUK Data Portal (SeRP / Secure eResearch Platform)	Field-cited	DPUK Data Portal — Dementias Platform UK https://www.dementiasplatform.uk/data-portal Section: SeRP footer callout “SeRP – the Secure eResearch Platform’” Page: https://www.dementiasplatform.uk/data-portal Anchor text copied verbatim from the DPUK Data Portal HTML; combined with secure remote analysis wording in the same page for tre_platform labelling.	Response for TRE platformAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data dictionary URL Recommended	https://doi.org/10.1093/ije/dyi127	Field-cited	Europe PMC API — IJE dyi127 metadata (cohort profile) https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI:10.1093/ije/dyi127&format=json Section: Europe PMC lite JSON “"doi":"10.1093/ije/dyi127"” Page: https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI:10.1093/ije/dyi127&format=json DIGIT data_dictionary_url points to the DOI resolver for the published cohort profile as the canonical variable overview entry point.	Response for Data dictionary URLAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data access timeline (days) Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: the fetched DPUK marketing HTML pages saved locally do not contain a verbatim numeric turnaround string for days-to-access in extractable plain text; cohort-specific timelines are handled via study team / portal application workflows.	Response for Data access timeline (days)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data access cost Recommended	No value held	Not published	Searched — not published UNSOURCEABLE for HCS-specific pricing: DPUK page describes free-to-use portal infrastructure but does not quote study-specific fees.	Response for Data access costAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Participant profile and dates

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Age distribution Recommended	baseline_age_range_years: 59-73	Field-cited	Catalogue of Mental Health Measures — Hertfordshire Cohort Study (HCS) https://cataloguementalhealth.ac.uk/HCS Section: Age at recruitment “59-73 years at HCS Baseline (1998-2004)” Page: https://cataloguementalhealth.ac.uk/HCS JSON placeholder encodes the published baseline age span for DIGIT filters.	Response for Age distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Sex distribution Recommended	No value held	Not published	Searched — not published UNSOURCEABLE in cited snapshots: sex ratio tables for the 3225 baseline participants are not present in the Catalogue HTML cards or the F1000 overview excerpts used for this pass.	Response for Sex distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Ethnicity distribution Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: ethnicity JSON breakdown not present in the cited Catalogue overview cards or F1000 abstract/overview sections used here.	Response for Ethnicity distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Smoking status distribution Recommended	No value held	No source yet	No citation linked to this field yet.	Response for Smoking status distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Median age Recommended	No value held	Not published	NULL: baseline age is published as a broad 59–73 year band rather than a single median for the analysed sample in cited cards.	Response for Median ageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Percent female Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: sex percentages not present in the cited Catalogue overview cards or F1000 abstract/table excerpts used here.	Response for Percent femaleAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Percent non-white Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: ethnicity percentages not present in cited sources for this pass.	Response for Percent non-whiteAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Geographic coverage Recommended	regional	Field-cited	Catalogue of Mental Health Measures — Hertfordshire Cohort Study (HCS) https://cataloguementalhealth.ac.uk/HCS Section: Geographic coverage - Regions “Hertfordshire” Page: https://cataloguementalhealth.ac.uk/HCS geographic_coverage=regional per data-dictionary (county-restricted recruitment frame).	Response for Geographic coverageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Follow-up duration Recommended	25+ years (baseline fieldwork 1998–2004; follow-up substudies through at least 2018 per F1000 overview; programme ongoing)	Field-cited	Syddall HE et al. 2019 — The Hertfordshire Cohort Study: an overview (F1000Research) https://doi.org/10.12688/f1000research.17457.1 Section: Follow-up studies 2004 to 2018 “Follow-up studies 2004 to 2018” Page: https://doi.org/10.12688/f1000research.17457.1 free-text field extends beyond 2018 where later substudies are referenced in the same overview.	Response for Follow-up durationAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Last data collection date Recommended	No value held	Not published	Searched — not published UNSOURCEABLE as a single DATE: multiple overlapping sweeps and substudies continue across years; Catalogue lists a 2021 substudy size without a single closure date for all data collection.	Response for Last data collection dateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Recruitment start date Recommended	1 Jan 1998	Field-cited	Catalogue of Mental Health Measures — Hertfordshire Cohort Study (HCS) https://cataloguementalhealth.ac.uk/HCS Section: Start date “HCS: 1998” Page: https://cataloguementalhealth.ac.uk/HCS Anchored to 1998-01-01 as the programme start year cited on the Catalogue page.	Response for Recruitment start dateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Recruitment end date Recommended	31 Dec 2004	Field-cited	Catalogue of Mental Health Measures — Hertfordshire Cohort Study (HCS) https://cataloguementalhealth.ac.uk/HCS Section: Age at recruitment “59-73 years at HCS Baseline (1998-2004)” Page: https://cataloguementalhealth.ac.uk/HCS recruitment_end_date set to 2004-12-31 to match the cited baseline fieldwork window end year.	Response for Recruitment end dateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Diagnosis areas

Mental health diagnosis areas represented in this cohort.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Diagnosis area: Major depressive disorder Recommended Confirm this diagnosis area applies and estimated N if shown.	Major depressive disorder · Mood Disorders · est. n=3,225	Field-cited	Syddall HE et al. 2019 — The Hertfordshire Cohort Study: an overview (F1000Research) https://doi.org/10.12688/f1000research.17457.1 Section: Table 2 “Anxiety and depression (HAD) scores” Page: https://doi.org/10.12688/f1000research.17457.1 Syddall HE et al. 2019 — The Hertfordshire Cohort Study: an overview (F1000Research) https://doi.org/10.12688/f1000research.17457.1 Section: Table 2. Hertfordshire Cohort Study Baseline “Anxiety and depression (HAD) scores” Page: https://doi.org/10.12688/f1000research.17457.1 HADS depression scale supports mapping to Major depressive disorder (diagnosis_area_id=5) as symptom-level coverage in a general older cohort. Catalogue of Mental Health Measures — Hertfordshire Cohort Study (HCS) https://cataloguementalhealth.ac.uk/HCS Section: Sample size at recruitment “3,225 (HCS Baseline)” Page: https://cataloguementalhealth.ac.uk/HCS Uses recruited baseline n as an upper-bound exposure for mood symptom phenotyping (not treated MDD counts). NULL: no published within-cohort MDD prevalence suitable for prevalence_rate encoding was extracted in this pass.	Response for Diagnosis area: Major depressive disorderAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Diagnosis area: Generalised anxiety disorder Recommended Confirm this diagnosis area applies and estimated N if shown.	Generalised anxiety disorder · Anxiety Disorders · est. n=3,225	Field-cited	Syddall HE et al. 2019 — The Hertfordshire Cohort Study: an overview (F1000Research) https://doi.org/10.12688/f1000research.17457.1 Section: Table 2 “Anxiety and depression (HAD) scores” Page: https://doi.org/10.12688/f1000research.17457.1 Syddall HE et al. 2019 — The Hertfordshire Cohort Study: an overview (F1000Research) https://doi.org/10.12688/f1000research.17457.1 Section: Table 2. Hertfordshire Cohort Study Baseline “Anxiety and depression (HAD) scores” Page: https://doi.org/10.12688/f1000research.17457.1 HADS anxiety scale supports mapping to Generalised anxiety disorder (diagnosis_area_id=8) as symptom-level coverage. Catalogue of Mental Health Measures — Hertfordshire Cohort Study (HCS) https://cataloguementalhealth.ac.uk/HCS Section: Sample size at recruitment “3,225 (HCS Baseline)” Page: https://cataloguementalhealth.ac.uk/HCS Uses recruited baseline n as an upper-bound exposure for anxiety symptom phenotyping. NULL: no published within-cohort GAD prevalence suitable for prevalence_rate encoding was extracted in this pass.	Response for Diagnosis area: Generalised anxiety disorderAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Diagnosis area: Dementia / neurodegeneration Recommended Confirm this diagnosis area applies and estimated N if shown.	Dementia / neurodegeneration · Neurodegenerative · est. n=3,225	Field-cited	Syddall HE et al. 2019 — The Hertfordshire Cohort Study: an overview (F1000Research) https://doi.org/10.12688/f1000research.17457.1 Section: Later questionnaire list “Mini mental state examination (MMSE)” Page: https://doi.org/10.12688/f1000research.17457.1 Syddall HE et al. 2019 — The Hertfordshire Cohort Study: an overview (F1000Research) https://doi.org/10.12688/f1000research.17457.1 Section: Later questionnaire list “Mini mental state examination (MMSE)” Page: https://doi.org/10.12688/f1000research.17457.1 MMSE plus cognitive test battery and dementia-research platform visibility motivate mapping to Dementia / neurodegeneration (diagnosis_area_id=20). Catalogue of Mental Health Measures — Hertfordshire Cohort Study (HCS) https://cataloguementalhealth.ac.uk/HCS Section: Sample size at recruitment “3,225 (HCS Baseline)” Page: https://cataloguementalhealth.ac.uk/HCS Uses recruited baseline n as the analysed ageing/cognition sample frame. NULL: dementia case prevalence not extracted from cited sources in this pass.	Response for Diagnosis area: Dementia / neurodegenerationAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Diagnosis area: Major depressive disorder

Recommended

Confirm this diagnosis area applies and estimated N if shown.

Major depressive disorder · Mood Disorders · est. n=3,225

Field-cited

Syddall HE et al. 2019 — The Hertfordshire Cohort Study: an overview (F1000Research)
https://doi.org/10.12688/f1000research.17457.1
Section: Table 2
“Anxiety and depression (HAD) scores”
Page: https://doi.org/10.12688/f1000research.17457.1
Syddall HE et al. 2019 — The Hertfordshire Cohort Study: an overview (F1000Research)
https://doi.org/10.12688/f1000research.17457.1
Section: Table 2. Hertfordshire Cohort Study Baseline
“Anxiety and depression (HAD) scores”
Page: https://doi.org/10.12688/f1000research.17457.1
HADS depression scale supports mapping to Major depressive disorder (diagnosis_area_id=5) as symptom-level coverage in a general older cohort.
Catalogue of Mental Health Measures — Hertfordshire Cohort Study (HCS)
https://cataloguementalhealth.ac.uk/HCS
Section: Sample size at recruitment
“3,225 (HCS Baseline)”
Page: https://cataloguementalhealth.ac.uk/HCS
Uses recruited baseline n as an upper-bound exposure for mood symptom phenotyping (not treated MDD counts).
NULL: no published within-cohort MDD prevalence suitable for prevalence_rate encoding was extracted in this pass.

AccurateNeeds correctionNot sureDoes not apply

Diagnosis area: Generalised anxiety disorder

Recommended

Confirm this diagnosis area applies and estimated N if shown.

Generalised anxiety disorder · Anxiety Disorders · est. n=3,225

Field-cited

Syddall HE et al. 2019 — The Hertfordshire Cohort Study: an overview (F1000Research)
https://doi.org/10.12688/f1000research.17457.1
Section: Table 2
“Anxiety and depression (HAD) scores”
Page: https://doi.org/10.12688/f1000research.17457.1
Syddall HE et al. 2019 — The Hertfordshire Cohort Study: an overview (F1000Research)
https://doi.org/10.12688/f1000research.17457.1
Section: Table 2. Hertfordshire Cohort Study Baseline
“Anxiety and depression (HAD) scores”
Page: https://doi.org/10.12688/f1000research.17457.1
HADS anxiety scale supports mapping to Generalised anxiety disorder (diagnosis_area_id=8) as symptom-level coverage.
Catalogue of Mental Health Measures — Hertfordshire Cohort Study (HCS)
https://cataloguementalhealth.ac.uk/HCS
Section: Sample size at recruitment
“3,225 (HCS Baseline)”
Page: https://cataloguementalhealth.ac.uk/HCS
Uses recruited baseline n as an upper-bound exposure for anxiety symptom phenotyping.
NULL: no published within-cohort GAD prevalence suitable for prevalence_rate encoding was extracted in this pass.

AccurateNeeds correctionNot sureDoes not apply

Diagnosis area: Dementia / neurodegeneration

Recommended

Confirm this diagnosis area applies and estimated N if shown.

Dementia / neurodegeneration · Neurodegenerative · est. n=3,225

Field-cited

Syddall HE et al. 2019 — The Hertfordshire Cohort Study: an overview (F1000Research)
https://doi.org/10.12688/f1000research.17457.1
Section: Later questionnaire list
“Mini mental state examination (MMSE)”
Page: https://doi.org/10.12688/f1000research.17457.1
Syddall HE et al. 2019 — The Hertfordshire Cohort Study: an overview (F1000Research)
https://doi.org/10.12688/f1000research.17457.1
Section: Later questionnaire list
“Mini mental state examination (MMSE)”
Page: https://doi.org/10.12688/f1000research.17457.1
MMSE plus cognitive test battery and dementia-research platform visibility motivate mapping to Dementia / neurodegeneration (diagnosis_area_id=20).
Catalogue of Mental Health Measures — Hertfordshire Cohort Study (HCS)
https://cataloguementalhealth.ac.uk/HCS
Section: Sample size at recruitment
“3,225 (HCS Baseline)”
Page: https://cataloguementalhealth.ac.uk/HCS
Uses recruited baseline n as the analysed ageing/cognition sample frame.
NULL: dementia case prevalence not extracted from cited sources in this pass.

AccurateNeeds correctionNot sureDoes not apply

Linked sites

Sites contributing participants or data to this cohort.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Linked sites Optional	No value held	No source yet	No citation linked to this field yet.	Response for Linked sitesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Verification metadata

Internal catalogue status — for reference only.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Verification status Recommended	ai_inferred	Internal	Internal catalogue field	—	—
Last verified Recommended	16 Apr 2026	Internal	Internal catalogue field	—	—
Data source Recommended	Populated Apr 2026 from Syddall HE et al. (F1000Research 2019, DOI 10.12688/f1000research.17457.1; open-access PDF), Catalogue of Mental Health Measures HCS page (cataloguementalhealth.ac.uk/HCS), DPUK Data Portal description (dementiasplatform.uk/data-portal), Europe PMC lite JSON for DOI 10.1093/ije/dyi127, and docs/data-dictionary.md scoring ladders.	Internal	Internal catalogue field	—	—