Cohort validation pack

CFAS

Medical Research Council Cognitive Function and Ageing Study (CFAS)

Generated 6 Oct 2026, 10:36 · ID 77

AI inferred

Last verified: 16/04/2026

Instructions for reviewers

Review each field against your knowledge of this cohort. Mark Accurate if the value is right, Needs correction if it is wrong or inaccurate (add notes), Not sure if you cannot verify it, or Does not apply if the field is not relevant.
Evidence shown is from our source registry. Fields marked No source yet hold values we could not yet pin to a document — those were AI-inferred and need your input most. Fields marked Searched — not published are ones we looked for and could not find publicly; the note lists where we checked.
Your selections and notes are kept in this browser tab only (not sent to the database). Print or save as PDF when finished, then return it to the DIGIT team.

Overview

Total fields

Field-cited

Whole-record source only

AI-inferred, no source yet

Searched — not published

No value held

Needs review

Source coverage

Summary of how well fields in this pack are linked to evidence.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Field-level source coverage Optional	48 of 68 reviewable fields are cited to a source (71%) · 4 with no source yet · 16 searched — not published · 20 with no value held	Computed	No citation linked to this field yet.	Response for Field-level source coverageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Identity and ownership

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Short name Required	CFAS	Field-cited	Europe PMC EBI web services — CFAS cohort profile DOI metadata (JSON) https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=doi:10.1093/ije/dyl199&format=json&resultType=core Section: result[0].title “Cohort profile: the Medical Research Council Cognitive Function and Ageing Study (CFAS).” Page: https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=doi:10.1093/ije/dyl199&format=json&resultType=core DIGIT short label CFAS is the programme acronym used in the indexed title string.	Response for Short nameAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Full name Required	Medical Research Council Cognitive Function and Ageing Study (CFAS)	Field-cited	Europe PMC EBI web services — CFAS cohort profile DOI metadata (JSON) https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=doi:10.1093/ije/dyl199&format=json&resultType=core Section: result[0].title “Cohort profile: the Medical Research Council Cognitive Function and Ageing Study (CFAS).” Page: https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=doi:10.1093/ije/dyl199&format=json&resultType=core full_name expands MRC and CFAS to match the formal programme naming in the cohort profile title; description field documents CFAS I/II/Wales as one catalogue family.	Response for Full nameAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Managing organisation Recommended	University of Cambridge (Department of Public Health and Primary Care)	Field-cited	DPUK Data Portal — Cognitive Function and Ageing Study (CFAS) cohort directory https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Section: Cohort Descriptives “University of Cambridge” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS	Response for Managing organisationAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Primary site Recommended	NIHR Cambridge Biomedical Research Centre (site #4)	Field-cited	DPUK Data Portal — Cognitive Function and Ageing Study (CFAS) cohort directory https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Section: Cohort Descriptives “University of Cambridge” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Mapped to site_id=4 (NIHR Cambridge BRC) as the closest DIGIT site row for the Cambridge-listed lead institution.	Response for Primary siteAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Website URL Recommended	http://www.cfas.ac.uk/cfas-i/	Field-cited	DPUK Data Portal — Cognitive Function and Ageing Study (CFAS) cohort directory https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Section: Study/Database Website “http://www.cfas.ac.uk/cfas-i/” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS	Response for Website URLAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Catalogue of Mental Health Measures URL Recommended	https://www.cataloguementalhealth.ac.uk/MRC%20CFAS	Field-cited	Catalogue of Mental Health Measures https://www.cataloguementalhealth.ac.uk Section: Official sitemap study URL “https://www.cataloguementalhealth.ac.uk/MRC%20CFAS” Page: https://www.cataloguementalhealth.ac.uk/MRC%20CFAS	Response for Catalogue of Mental Health Measures URLAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Contact name Recommended	Prof Carol Brayne	Field-cited	DPUK Data Portal — Cognitive Function and Ageing Study (CFAS) cohort directory https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Section: Principal Investigator (PI) “Prof Carol Brayne” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS	Response for Contact nameAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Contact email Recommended	Carol.Brayne@medschl.cam.ac.uk	Field-cited	NCBI E-utilities — PubMed XML record PMID 16980700 (CFAS cohort profile) https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pubmed&id=16980700&retmode=xml Section: PubMed author affiliation “Carol.Brayne@medschl.cam.ac.uk” Page: https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pubmed&id=16980700&retmode=xml Email appears on indexed cohort profile metadata; may be historical.	Response for Contact emailAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Summary and status

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Description Required	UK population-based programme on cognitive function, dementia, depression and disability in people aged 65+ since the late 1980s, spanning original MRC CFAS centres, CFAS II (mid-life/older cohort refresh in English centres), and CFAS Wales. This catalogue row treats CFAS I, II and Wales as one resource family with a shared phenotype archive and coordinated leadership from Cambridge.	Field-cited	DPUK Data Portal — Cognitive Function and Ageing Study (CFAS) cohort directory https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Section: Study Overview “CFAS started in the late 1980s with the initilal aim of investigating dementia and cognitive decline in a representative sample of more than 18,000 people over 65 years.” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS DIGIT description summarises the DPUK overview and adds CFAS II/Wales as later programme waves named in public programme summaries.	Response for DescriptionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Total N Required	18,005	Field-cited	DPUK Data Portal — Cognitive Function and Ageing Study (CFAS) cohort directory https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Section: Cohort Descriptives “18005” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Taken from #Subjects at Baseline table cell adjacent to label in archived DPUK HTML.	Response for Total NAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Total N qualifier Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: DPUK gives a numeric baseline count without an explicit approximate/ceiling qualifier token; left NULL rather than guessing.	Response for Total N qualifierAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Year established Recommended	1989	Field-cited	DPUK Data Portal — Cognitive Function and Ageing Study (CFAS) cohort directory https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Section: Cohort Descriptives “01/01/1989 00:00:00” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS year_established=1989 from Study start date field.	Response for Year establishedAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Active cohort Recommended	Yes	Field-cited	DPUK Data Portal — Cognitive Function and Ageing Study (CFAS) cohort directory https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Section: Cohort Descriptives “Yes” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Is study ongoing? row value Yes.	Response for Active cohortAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Ongoing recruitment Recommended	No	Field-cited	DPUK Data Portal — Cognitive Function and Ageing Study (CFAS) cohort directory https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Section: Cohort Descriptives “No” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Is study still recruiting? row value No.	Response for Ongoing recruitmentAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Refreshed cohort Recommended	Yes	Field-cited	DPUK Data Portal — Cognitive Function and Ageing Study (CFAS) cohort directory https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Section: How many times followed up? “11” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Multiple follow-up waves plus later CFAS II/Wales programme extensions support is_refreshed=TRUE per data-dictionary (renewed waves beyond one-off follow-up).	Response for Refreshed cohortAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Recontact success rate Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: No public recontact success percentage located in reviewed sources.	Response for Recontact success rateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Retention rate Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: Follow-up counts are not converted to a single retention_rate in reviewed sources.	Response for Retention rateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Published references Recommended	doi:10.1093/ije/dyl199	Field-cited	Europe PMC EBI web services — CFAS cohort profile DOI metadata (JSON) https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=doi:10.1093/ije/dyl199&format=json&resultType=core Section: result[0].doi “10.1093/ije/dyl199” Page: https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=doi:10.1093/ije/dyl199&format=json&resultType=core	Response for Published referencesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Notes Recommended	DPUK directory lists 18,005 subjects at baseline for the umbrella CFAS resource; programme includes multiple waves (directory reports 11 follow-ups) and later CFAS II / Wales extensions — see cohort profile paper and portal metadata for study design.	Field-cited	DPUK Data Portal — Cognitive Function and Ageing Study (CFAS) cohort directory https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Section: Study Overview “To date there have been in the region of 47,000 interviews with participants in the study.” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS	Response for NotesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

3D cohort mapping

Consent, characterisation, and data availability axes used on the cohort map.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Consent level (axis) Required	3 — Broad consent (recontactable for future studies)	Field-cited	DPUK Data Portal — Cognitive Function and Ageing Study (CFAS) cohort directory https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Section: Study Overview “In 2002/3 all survivors were approached by the study and re-interviewed.” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Step 1 identifiable=YES (longitudinal interviews). Step 2 S251/CAG=NO (prospective cohort consent model). Step 3 recontactable=YES (re-interview waves). Step 4 interventional randomisation-ready consent=NO in reviewed sources. => consent_level 3 per data-dictionary.md.	Response for Consent level (axis)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Characterisation depth (axis) Required	3 — Multi-domain MH characterisation	Field-cited	DPUK Data Portal — Cognitive Function and Ageing Study (CFAS) cohort directory https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Section: Study Overview “The range of information collected has allowed the study to investigate depression and physical disability in the older population and also look at the healthy active life expectancy.” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Step 1 validated MH-related phenotyping beyond ICD codes=YES (depression domain and dementia focus). Step 2 multi-domain=YES (cognition, disability, physical/life expectancy framing). Step 3 research-grade SCID/MINI/SCAN plus refreshed deep phenotyping not evidenced for broad MH diagnoses. => characterisation_depth 3.	Response for Characterisation depth (axis)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data availability (axis) Required	3 — Adds biological specimens/molecular data	Field-cited	DPUK Data Portal — Cognitive Function and Ageing Study (CFAS) cohort directory https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Section: Study Overview + biosampling context “although a number of research nurses have taken blood.” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS DERIVED: hasResearch=TRUE (questionnaires/interviews, cognitive tests per variable tabs, blood measures). hasBiological=TRUE (blood; brain donations in overview). hasAdvanced=FALSE (no imaging/wearable/digital phenotyping evidence in reviewed capture). => data_availability 3.	Response for Data availability (axis)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Cohort map group (derived) Recommended	Group 2	Internal	Internal catalogue field	—	—
Population type Recommended	General population	Not published	DIGIT Cohort Portfolio Review — population type and engagement classification (Aug 2026) Classified general_population in the DIGIT cohort portfolio review (Aug 2026). Population-based cognitive ageing programme recruiting adults 65+.	Response for Population typeAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Industry engagement status Recommended	Unknown	Not published	Searched — not published UNSOURCEABLE: industry engagement status is an organisational property of the custodian and is not publicly documented; default 'unknown' pending a cohort-owner meeting.	Response for Industry engagement statusAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Parent cohort / programme Recommended	No value held	Whole-record	Brayne et al. 2006 — Cohort profile: the Medical Research Council Cognitive Function and Ageing Study (CFAS) (Int J Epidemiol) https://doi.org/10.1093/ije/dyl199 Page: https://doi.org/10.1093/ije/dyl199 Primary cohort profile publication anchor (DOI 10.1093/ije/dyl199; PMID 16980700).	Response for Parent cohort / programmeAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
TWiCs eligible Recommended	No	Field-cited	DPUK Data Portal — Cognitive Function and Ageing Study (CFAS) cohort directory https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Section: Is study still recruiting? “No” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS consent_level=3 and no evidence of embedded randomisation-ready governance => twics_eligible FALSE per dictionary.	Response for TWiCs eligibleAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Data modalities

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Questionnaire / interview Recommended	Yes	Field-cited	DPUK Data Portal — Cognitive Function and Ageing Study (CFAS) cohort directory https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Section: Study Overview “To date there have been in the region of 47,000 interviews with participants in the study.” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Structured interview programme with depression among studied outcomes implies questionnaire/screening instruments beyond routine care documentation.	Response for Questionnaire / interviewAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Cognitive testing Recommended	Yes	Field-cited	DPUK Data Portal — Cognitive Function and Ageing Study (CFAS) cohort directory https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Section: Cohort variable matrix (Cognition tab excerpt in HTML) “Cambridge Cognitive Examination (CAMCOG)” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS	Response for Cognitive testingAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Physical measures Recommended	Yes	Field-cited	DPUK Data Portal — Cognitive Function and Ageing Study (CFAS) cohort directory https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Section: Who carries out data collection? “Interviewers: Mainly research interviewers, although a number of research nurses have taken blood.” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS	Response for Physical measuresAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Biosamples Recommended	Yes	Field-cited	DPUK Data Portal — Cognitive Function and Ageing Study (CFAS) cohort directory https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Section: Study Overview “Currently there have been over 500 donations of participant's brains after death.” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Blood draws plus brain donations satisfy stored biosamples definition.	Response for BiosamplesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Genomic data Recommended	No	Field-cited	DPUK Data Portal — Cognitive Function and Ageing Study (CFAS) cohort directory https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Section: Study Overview “molecular epidemiology” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS The overview lists molecular epidemiology as an evolved aim but does not state array/WGS/genotyping availability for researcher access; conservative=FALSE pending a genomics-specific inventory source.	Response for Genomic dataAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Omics Recommended	No	Field-cited	DPUK Data Portal — Cognitive Function and Ageing Study (CFAS) cohort directory https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Section: Study Overview “molecular epidemiology” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS No explicit proteomics/metabolomics/transcriptomics dataset flag found in reviewed DPUK descriptives; molecular epidemiology alone is insufficient to set omics=TRUE per dictionary.	Response for OmicsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Imaging Recommended	No	Field-cited	DPUK Data Portal — Cognitive Function and Ageing Study (CFAS) cohort directory https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Section: Study Overview “descriptive epidemiology, neuropathy, policy, molecular epidemiology and ethics.” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS No structural/functional MRI/PET/EEG research imaging archive described in reviewed overview text => FALSE.	Response for ImagingAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Wearable / sensor Recommended	No	Field-cited	DPUK Data Portal — Cognitive Function and Ageing Study (CFAS) cohort directory https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Section: How is data collected? “In person” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS No wearable sensor stream described in reviewed descriptives => FALSE.	Response for Wearable / sensorAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Digital phenotyping Recommended	No	Field-cited	DPUK Data Portal — Cognitive Function and Ageing Study (CFAS) cohort directory https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Section: How is data collected? “In person” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Passive smartphone/sensor phenotyping not described => FALSE.	Response for Digital phenotypingAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Linked health records Recommended	No	Field-cited	DPUK Data Portal — Cognitive Function and Ageing Study (CFAS) cohort directory https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Section: Cohort Descriptives reviewed “Is there follow-up data available?” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Archived DPUK descriptives table reviewed for this capture did not include an explicit NHS/HES/GP administrative linkage field populated; cohort is interview-led with follow-up interviews => has_linked_health_records=FALSE per conservative reading.	Response for Linked health recordsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Biosample types Recommended	blood, brain tissue	Field-cited	DPUK Data Portal — Cognitive Function and Ageing Study (CFAS) cohort directory https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Section: Study Overview + blood collection “although a number of research nurses have taken blood.” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Array also includes brain tissue from brain donation sentence in same overview paragraph.	Response for Biosample typesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Genotyping platform Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: No genotyping chip/sequencer platform named in reviewed sources.	Response for Genotyping platformAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Imaging modalities Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: No research imaging modality inventory in reviewed sources (brain donation pathology is not imaging_modalities).	Response for Imaging modalitiesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Mental health measures Recommended	Cambridge Cognitive Examination (CAMCOG), Extended Mental State Examination (EMSE)	Field-cited	DPUK Data Portal — Cognitive Function and Ageing Study (CFAS) cohort directory https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Section: Cognition variable matrix “Cambridge Cognitive Examination (CAMCOG)” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS The same DPUK cognition matrix row immediately below CAMCOG lists Extended Mental State Examination (EMSE) as verbatim instrument text in the archived HTML.	Response for Mental health measuresAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Data subcategories

Structured modality and subcategory rows used alongside the high-level data-type flags.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Data subcategories Recommended List key data subcategories using distinct rows for category markers, named questionnaire/interview instruments, biospecimen types, omics/genomics data products, imaging modalities, sensor streams, and linked-record types.	No value held	No source yet	No citation linked to this field yet.	Response for Data subcategoriesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Data subcategories

Recommended

List key data subcategories using distinct rows for category markers, named questionnaire/interview instruments, biospecimen types, omics/genomics data products, imaging modalities, sensor streams, and linked-record types.

No value held

No source yet

No citation linked to this field yet.

AccurateNeeds correctionNot sureDoes not apply

Consent and use permissions

Specific use permissions separate from the 3D consent-level axis.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Consent and use permissions Recommended Confirm health/biomedical research use, industry/commercial consideration, non-commercial restrictions, governance modifiers, recontact, trial approach, biosample use, linkage, sharing, international transfer, and any Section 251/CAG support.	No value held	No source yet	No citation linked to this field yet.	Response for Consent and use permissionsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Consent and use permissions

Recommended

Confirm health/biomedical research use, industry/commercial consideration, non-commercial restrictions, governance modifiers, recontact, trial approach, biosample use, linkage, sharing, international transfer, and any Section 251/CAG support.

No value held

No source yet

No citation linked to this field yet.

AccurateNeeds correctionNot sureDoes not apply

Access pathways

One or more routes by which researchers can request or analyse data.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Access pathways Recommended Confirm all data access pathways, including route, access level, TRE/SDE or download/API environment, DAC review, collaboration requirements, data sharing agreements, output checking, timelines, and fees.	No value held	No source yet	No citation linked to this field yet.	Response for Access pathwaysAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Access pathways

Recommended

Confirm all data access pathways, including route, access level, TRE/SDE or download/API environment, DAC review, collaboration requirements, data sharing agreements, output checking, timelines, and fees.

No value held

No source yet

No citation linked to this field yet.

AccurateNeeds correctionNot sureDoes not apply

Within-cohort coverage

Aggregate counts or percentages showing how broadly data, consent, or access characteristics apply within the cohort.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Within-cohort coverage metrics Recommended Provide numerator, denominator, unit type, numerator/denominator exactness qualifiers, denominator type, basis, date/release, original source wording, and whether each metric is marginal, joint, conditional, or a release total.	No value held	No source yet	No citation linked to this field yet.	Response for Within-cohort coverage metricsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Within-cohort coverage metrics

Recommended

Provide numerator, denominator, unit type, numerator/denominator exactness qualifiers, denominator type, basis, date/release, original source wording, and whether each metric is marginal, joint, conditional, or a release total.

No value held

No source yet

No citation linked to this field yet.

AccurateNeeds correctionNot sureDoes not apply

Linkage and access

Field	Current value	Evidence	Source evidence	Response	Notes / correction
NHS linkage Recommended	No	Field-cited	DPUK Data Portal — Cognitive Function and Ageing Study (CFAS) cohort directory https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Section: Cohort Descriptives reviewed “Is there follow-up data available?” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS No explicit NHS administrative linkage field captured in reviewed DPUK descriptives table => FALSE alongside has_linked_health_records=FALSE.	Response for NHS linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
GP linkage Recommended	No	Field-cited	DPUK Data Portal — Cognitive Function and Ageing Study (CFAS) cohort directory https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Section: Cohort Descriptives reviewed “Is there follow-up data available?” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS No explicit GP record linkage field captured => FALSE.	Response for GP linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Death registry linkage Recommended	No	Field-cited	DPUK Data Portal — Cognitive Function and Ageing Study (CFAS) cohort directory https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Section: Cohort Descriptives reviewed “Is there follow-up data available?” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Mortality follow-up may exist scientifically but no ONS/GRO linkage field text in this capture => conservative FALSE.	Response for Death registry linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Education linkage Recommended	No	Field-cited	DPUK Data Portal — Cognitive Function and Ageing Study (CFAS) cohort directory https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Section: Cohort Descriptives reviewed “Inclusion criteria” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS No DfE/administrative education record linkage described in reviewed descriptives => FALSE.	Response for Education linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data access mechanism Recommended	direct_application	Field-cited	DPUK Data Portal — Cognitive Function and Ageing Study (CFAS) cohort directory https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Section: DPUK portal navigation “Apply for Access” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS DPUK uses a researcher application workflow => direct_application per dictionary.	Response for Data access mechanismAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
TRE platform Recommended	Dementias Platform UK (DPUK) Data Portal	Field-cited	DPUK Data Portal — Cognitive Function and Ageing Study (CFAS) cohort directory https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Section: Portal branding “DPUK Data Portal” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Metadata hosted on Dementias Platform UK Data Portal; exact TRE product name for analysis may differ by access route.	Response for TRE platformAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data dictionary URL Recommended	https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS	Field-cited	DPUK Data Portal — Cognitive Function and Ageing Study (CFAS) cohort directory https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Section: Document title “CFAS Cohort - DPUK Data Portal” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS data_dictionary_url set to the archived DPUK cohort directory URL for variable-level metadata.	Response for Data dictionary URLAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data access timeline (days) Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: DPUK application timelines are process-dependent and not expressed as a single days integer in reviewed capture.	Response for Data access timeline (days)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data access cost Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: Access fees not enumerated in archived cohort directory HTML reviewed for this seed.	Response for Data access costAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Participant profile and dates

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Age distribution Recommended	65_plus: 1	Field-cited	DPUK Data Portal — Cognitive Function and Ageing Study (CFAS) cohort directory https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Section: Inclusion criteria “65 years and over, speaks English proficiently. Lives in the cohort catchment area.” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS JSON summarises recruited age band as 65+ only.	Response for Age distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Sex distribution Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: Archived DPUK descriptives table in this capture did not include sex split percentages.	Response for Sex distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Ethnicity distribution Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: No ethnicity distribution table found in reviewed archived DPUK descriptives.	Response for Ethnicity distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Smoking status distribution Recommended	No value held	Whole-record	Brayne et al. 2006 — Cohort profile: the Medical Research Council Cognitive Function and Ageing Study (CFAS) (Int J Epidemiol) https://doi.org/10.1093/ije/dyl199 Page: https://doi.org/10.1093/ije/dyl199 Primary cohort profile publication anchor (DOI 10.1093/ije/dyl199; PMID 16980700).	Response for Smoking status distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Median age Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: Minimum age 65+ is stated but median age not published in reviewed descriptives.	Response for Median ageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Percent female Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: Sex percentages not present in reviewed archived DPUK descriptives.	Response for Percent femaleAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Percent non-white Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: Ethnicity percentages not present in reviewed archived DPUK descriptives.	Response for Percent non-whiteAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Geographic coverage Recommended	national	Field-cited	DPUK Data Portal — Cognitive Function and Ageing Study (CFAS) cohort directory https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Section: MeshHeadingList (PubMed XML) “United Kingdom” Page: https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pubmed&id=16980700&retmode=xml UK-wide multicentre programme mapped to geographic_coverage=national per data-dictionary (UK-spanning cohort resource).	Response for Geographic coverageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Follow-up duration Recommended	35+ years (1989–present; multiple interview waves per DPUK directory)	Field-cited	DPUK Data Portal — Cognitive Function and Ageing Study (CFAS) cohort directory https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Section: How many times followed up? “11” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Eleven follow-up waves plus 1989 study start date support the multi-decade follow-up_duration string in the cohort seed.	Response for Follow-up durationAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Last data collection date Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: Portal lists study end date 2011 for a programme phase but not a single last_data_collection_date for the umbrella resource.	Response for Last data collection dateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Recruitment start date Recommended	1 Jan 1989	Field-cited	DPUK Data Portal — Cognitive Function and Ageing Study (CFAS) cohort directory https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Section: Study start date “01/01/1989 00:00:00” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS	Response for Recruitment start dateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Recruitment end date Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: Ongoing study flag conflicts with a single recruitment closure date for the umbrella catalogue row.	Response for Recruitment end dateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Diagnosis areas

Mental health diagnosis areas represented in this cohort.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Diagnosis area: Major depressive disorder Recommended Confirm this diagnosis area applies and estimated N if shown.	Major depressive disorder · Mood Disorders	Field-cited	DPUK Data Portal — Cognitive Function and Ageing Study (CFAS) cohort directory https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Section: Study Overview “investigate depression and physical disability in the older population” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS No MDD-specific case count published in reviewed sources; estimated_n NULL. DPUK Data Portal — Cognitive Function and Ageing Study (CFAS) cohort directory https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Section: Study Overview “investigate depression and physical disability in the older population” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS	Response for Diagnosis area: Major depressive disorderAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Diagnosis area: Dementia / neurodegeneration Recommended Confirm this diagnosis area applies and estimated N if shown.	Dementia / neurodegeneration · Neurodegenerative	Field-cited	DPUK Data Portal — Cognitive Function and Ageing Study (CFAS) cohort directory https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Section: Dementia prevalence “Dementia cases ascertained as part of study:” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS No diagnosis-specific participant count in reviewed sources; estimated_n NULL. DPUK Data Portal — Cognitive Function and Ageing Study (CFAS) cohort directory https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Section: Dementia cases ascertained “Yes” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS	Response for Diagnosis area: Dementia / neurodegenerationAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Diagnosis area: Major depressive disorder

Recommended

Confirm this diagnosis area applies and estimated N if shown.

Major depressive disorder · Mood Disorders

Field-cited

DPUK Data Portal — Cognitive Function and Ageing Study (CFAS) cohort directory
https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS
Section: Study Overview
“investigate depression and physical disability in the older population”
Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS
No MDD-specific case count published in reviewed sources; estimated_n NULL.
DPUK Data Portal — Cognitive Function and Ageing Study (CFAS) cohort directory
https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS
Section: Study Overview
“investigate depression and physical disability in the older population”
Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS

AccurateNeeds correctionNot sureDoes not apply

Diagnosis area: Dementia / neurodegeneration

Recommended

Confirm this diagnosis area applies and estimated N if shown.

Dementia / neurodegeneration · Neurodegenerative

Field-cited

DPUK Data Portal — Cognitive Function and Ageing Study (CFAS) cohort directory
https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS
Section: Dementia prevalence
“Dementia cases ascertained as part of study:”
Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS
No diagnosis-specific participant count in reviewed sources; estimated_n NULL.
DPUK Data Portal — Cognitive Function and Ageing Study (CFAS) cohort directory
https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS
Section: Dementia cases ascertained
“Yes”
Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS

AccurateNeeds correctionNot sureDoes not apply

Linked sites

Sites contributing participants or data to this cohort.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Linked site: NIHR Cambridge Biomedical Research Centre Recommended	NIHR Cambridge Biomedical Research Centre · East of England	Field-cited	DPUK Data Portal — Cognitive Function and Ageing Study (CFAS) cohort directory https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS Section: Institution Name “University of Cambridge” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=CFAS primary_site_id and cohort_sites link map the listed lead institution to DIGIT site_id 4 (Cambridge BRC). NCBI E-utilities — PubMed XML record PMID 16980700 (CFAS cohort profile) https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pubmed&id=16980700&retmode=xml Section: MeshHeadingList “Multicenter Studies as Topic” Page: https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pubmed&id=16980700&retmode=xml Per-site participant counts are not published in reviewed sources; local_n NULL despite multicentre design.	Response for Linked site: NIHR Cambridge Biomedical Research CentreAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Verification metadata

Internal catalogue status — for reference only.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Verification status Recommended	ai_inferred	Internal	Internal catalogue field	—	—
Last verified Recommended	16 Apr 2026	Internal	Internal catalogue field	—	—
Data source Recommended	Populated Apr 2026 from DPUK Data Portal cohort directory (CFAS), PubMed PMID 16980700 XML, Europe PMC EBI web services JSON (DOI 10.1093/ije/dyl199), and docs/data-dictionary.md scoring rules.	Internal	Internal catalogue field	—	—