Cohort validation pack

BIOPATH

Biomarkers in the Psychosis Pathway

Generated 6 Oct 2026, 10:36 · ID 65

Unverified

Last verified: 16/04/2026

Instructions for reviewers

Review each field against your knowledge of this cohort. Mark Accurate if the value is right, Needs correction if it is wrong or inaccurate (add notes), Not sure if you cannot verify it, or Does not apply if the field is not relevant.
Evidence shown is from our source registry. Fields marked No source yet hold values we could not yet pin to a document — those were AI-inferred and need your input most. Fields marked Searched — not published are ones we looked for and could not find publicly; the note lists where we checked.
Your selections and notes are kept in this browser tab only (not sent to the database). Print or save as PDF when finished, then return it to the DIGIT team.

Overview

Total fields

Field-cited

Whole-record source only

AI-inferred, no source yet

Searched — not published

No value held

Needs review

Source coverage

Summary of how well fields in this pack are linked to evidence.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Field-level source coverage Optional	21 of 69 reviewable fields are cited to a source (30%) · 7 with no source yet · 41 searched — not published · 33 with no value held	Computed	No citation linked to this field yet.	Response for Field-level source coverageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Identity and ownership

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Short name Required	BIOPATH	Field-cited	DIGIT — data-population-plan.md excerpt (BIOPATH / Group 1 / appendix) Section: §3.3 Cohorts Currently in the Database “Group 1 (8): MHM Mood, Early Psychosis, Born in Bradford, EIP 1000/yr, Psych-omics, NBR-MH, BIOPATH, UK Minds” Page: https://github.com/DIGIT-MHG/digit-capabilities-db/blob/main/docs/data-population-plan.md	Response for Short nameAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Full name Required	Biomarkers in the Psychosis Pathway	Field-cited	DIGIT — data-population-plan.md excerpt (BIOPATH / Group 1 / appendix) Section: Short name only in programme doc “BIOPATH” Page: https://github.com/DIGIT-MHG/digit-capabilities-db/blob/main/docs/data-population-plan.md The public programme excerpt on file documents the catalogue short label BIOPATH but not the expanded string “Biomarkers in the Psychosis Pathway”. The full_name value is therefore retained as an acronym expansion for UI consistency and is not asserted as an independently published cohort title. Primary naming evidence is the BIOPATH token in the Group 1 list (same file).	Response for Full nameAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Managing organisation Recommended	King's College London	Field-cited	KCL Institute of Psychiatry, Psychology & Neuroscience https://www.kcl.ac.uk/ioppn Section: Shared KCL IoPPN source (sources.sql id 44) “KCL Institute of Psychiatry, Psychology & Neuroscience” Page: https://www.kcl.ac.uk/ioppn managing_organisation is set to King's College London as the lead university; IoPPN is the faculty unit named on the shared KCL IoPPN website source.	Response for Managing organisationAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Primary site Recommended	NIHR Maudsley Biomedical Research Centre (site #1)	Field-cited	KCL IoPPN — Baseline Biomarker Check (BBC) Study (public comparator page) https://www.kcl.ac.uk/ioppn/research/biomarker-study Section: BBC study — collaboration paragraph “The study is a collaboration between the Department of Psychosis Studies in the Institute of Psychiatry, Psychology & Neuroscience at King's College London and the South London and Maudsley NHS Foundation Trust.” Page: https://www.kcl.ac.uk/ioppn/research/biomarker-study primary_site_id=1 maps to NIHR Maudsley BRC in this database (KCL + South London and Maudsley NHS FT partnership). The BBC page is a distinct public protocol but documents the same organisational locus used for KCL/SLaM psychosis biomarker research.	Response for Primary siteAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Website URL Recommended	No value held	Not published	DIGIT — registry search log (ClinicalTrials.gov, ISRCTN, PubMed) UNSOURCEABLE: No public site branding itself “BIOPATH” was found; website_url NULL.	Response for Website URLAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Catalogue of Mental Health Measures URL Recommended	No value held	No source yet	No citation linked to this field yet.	Response for Catalogue of Mental Health Measures URLAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Contact name Recommended	No value held	Not published	DIGIT — registry search log (ClinicalTrials.gov, ISRCTN, PubMed) UNSOURCEABLE: No public cohort-specific contact name for BIOPATH.	Response for Contact nameAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Contact email Recommended	No value held	Not published	DIGIT — registry search log (ClinicalTrials.gov, ISRCTN, PubMed) UNSOURCEABLE: No public BIOPATH email; BBC page lists different study contacts (not asserted as BIOPATH).	Response for Contact emailAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Summary and status

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Description Required	Psychosis biomarker programme led from King's College London and the South London and Maudsley NHS Foundation Trust partnership, catalogued in DIGIT as BIOPATH (data-population-plan.md §3.3 Group 1 list). No dedicated public cohort website or registry record using the name BIOPATH was located in Apr 2026. 3D scores follow DIGIT appendix examples that list BIOPATH under active consent and deep phenotyping tiers; data availability is derived from biological sampling plus research assessments per data-dictionary.md flags.	Field-cited	DIGIT — data-population-plan.md excerpt (BIOPATH / Group 1 / appendix) Section: §3.3 + Appendix examples “Group 1 (8): MHM Mood, Early Psychosis, Born in Bradford, EIP 1000/yr, Psych-omics, NBR-MH, BIOPATH, UK Minds” Page: https://github.com/DIGIT-MHG/digit-capabilities-db/blob/main/docs/data-population-plan.md Description synthesises (i) BIOPATH as a named Group 1 catalogue cohort, (ii) appendix placement under consent 4 and characterisation 4 example lists (same excerpt file), and (iii) registry negative findings from registry_search_log for absence of a public BIOPATH-titled protocol.	Response for DescriptionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Total N Required	No value held	Field-cited	DIGIT — registry search log (ClinicalTrials.gov, ISRCTN, PubMed) Page: https://www.kcl.ac.uk/ioppn/research/biomarker-study UNSOURCEABLE: No public enrolment total located. Searched: ClinicalTrials.gov API (empty for BIOPATH psychosis), ISRCTN API (empty), PubMed esearch (empty), KCL IoPPN BBC comparator page (different protocol; no BIOPATH N). total_n set NULL.	Response for Total NAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Total N qualifier Recommended	No value held	Not published	DIGIT — registry search log (ClinicalTrials.gov, ISRCTN, PubMed) UNSOURCEABLE: Qualifier only applies when total_n is non-NULL; left NULL.	Response for Total N qualifierAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Year established Recommended	No value held	Not published	DIGIT — registry search log (ClinicalTrials.gov, ISRCTN, PubMed) UNSOURCEABLE: No dated protocol or profile paper for BIOPATH located in registry search log; year_established set NULL pending primary protocol.	Response for Year establishedAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Active cohort Recommended	Yes	Field-cited	DIGIT — data-population-plan.md excerpt (BIOPATH / Group 1 / appendix) Section: Group 1 catalogue cohort “Group 1 (8): MHM Mood, Early Psychosis, Born in Bradford, EIP 1000/yr, Psych-omics, NBR-MH, BIOPATH, UK Minds” Page: https://github.com/DIGIT-MHG/digit-capabilities-db/blob/main/docs/data-population-plan.md Treated as an active programme cohort in the maintained DIGIT cohort checklist; is_active=TRUE.	Response for Active cohortAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Ongoing recruitment Recommended	No	Field-cited	DIGIT — registry search log (ClinicalTrials.gov, ISRCTN, PubMed) Page: https://www.kcl.ac.uk/ioppn/research/biomarker-study Set FALSE: BBC comparator page documents active recruitment for a different protocol; no BIOPATH-specific recruitment page found—conservative FALSE.	Response for Ongoing recruitmentAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Refreshed cohort Recommended	Yes	Field-cited	DIGIT — data-population-plan.md excerpt (BIOPATH / Group 1 / appendix) Section: Appendix characterisation_depth Level 4 examples “BIOPATH” Page: https://github.com/DIGIT-MHG/digit-capabilities-db/blob/main/docs/data-population-plan.md data-population-plan appendix lists BIOPATH among deep phenotyping / refreshed example cohorts (same row as GLAD-omics, SMILE). is_refreshed=TRUE to align with that programme classification.	Response for Refreshed cohortAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Recontact success rate Recommended	No value held	Not published	DIGIT — registry search log (ClinicalTrials.gov, ISRCTN, PubMed) UNSOURCEABLE: NULL.	Response for Recontact success rateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Retention rate Recommended	No value held	Not published	DIGIT — registry search log (ClinicalTrials.gov, ISRCTN, PubMed) UNSOURCEABLE: NULL.	Response for Retention rateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Published references Recommended	No value held	Not published	DIGIT — registry search log (ClinicalTrials.gov, ISRCTN, PubMed) UNSOURCEABLE: No cohort profile paper or DOI specifically for BIOPATH located; NULL.	Response for Published referencesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Notes Recommended	Identity: “BIOPATH” is the DIGIT short label from docs/data-population-plan.md §3.3. The expanded full name is an acronym interpretation for display and is not verified as a standalone public cohort title. Comparator: the KCL IoPPN “Baseline Biomarker Check (BBC)” page describes a distinct public protocol (first-episode psychosis biomarker treatment prediction); it uses different branding and is not treated as the same entity name. Registries: ClinicalTrials.gov and ISRCTN returned no study titled BIOPATH; PubMed returned no BIOPATH+KCL paper (Apr 2026). HDR UK Innovation Gateway could not be queried in the verification environment (network failure).	Field-cited	DIGIT — data-population-plan.md excerpt (BIOPATH / Group 1 / appendix) Section: Identity resolution (synthesised) “BIOPATH” Page: https://github.com/DIGIT-MHG/digit-capabilities-db/blob/main/docs/data-population-plan.md Notes field documents: (i) BIOPATH token sourced from data-population-plan §3.3 Group 1 list (local excerpt); (ii) distinction from the publicly titled KCL IoPPN Baseline Biomarker Check study (165000 HTML) which is a separate protocol name; (iii) registry negative findings (165003 log). KCL IoPPN — Baseline Biomarker Check (BBC) Study (public comparator page) https://www.kcl.ac.uk/ioppn/research/biomarker-study Section: BBC Study page — public title “<h1>Baseline Biomarker Check (BBC) Study</h1>” Page: https://www.kcl.ac.uk/ioppn/research/biomarker-study Comparator evidence: the publicly advertised KCL IoPPN psychosis biomarker protocol uses the BBC name and recruitment copy, not the catalogue label BIOPATH. Sourced HTML snapshot.	Response for NotesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

3D cohort mapping

Consent, characterisation, and data availability axes used on the cohort map.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Consent level (axis) Required	4 — Active research consent (interventions, TWiCs-eligible)	Field-cited	DIGIT — data-population-plan.md excerpt (BIOPATH / Group 1 / appendix) Section: Appendix consent_level examples “\| 4 \| Active research consent \| Specific informed consent for ongoing active research participation, including potential randomisation. Supports TWiCs. \| Specific informed consent; HRA-approved protocol \| MHM Mood, Early Psychosis, GBIT, BIOPATH, Psych-omics \|” Page: https://github.com/DIGIT-MHG/digit-capabilities-db/blob/main/docs/data-population-plan.md Step1: programme classifies BIOPATH under active research consent examples (Level 4). Step2: not S251-only. Step3–4: appendix explicitly lists BIOPATH in the Level 4 example row. Score=4 per maintained DIGIT rubric.	Response for Consent level (axis)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Characterisation depth (axis) Required	4 — Deep phenotyping, refreshed	Field-cited	DIGIT — data-population-plan.md excerpt (BIOPATH / Group 1 / appendix) Section: Appendix characterisation_depth examples “\| 4 \| Deep phenotyping, refreshed \| Comprehensive multi-domain characterisation with research-grade psychiatric diagnosis (SCID/MINI/SCAN) + cohort actively renewed/refreshed. \| MHM Mood, Early Psychosis, GBIT, BDRN, BIOPATH, GLAD-omics, SMILE \|” Page: https://github.com/DIGIT-MHG/digit-capabilities-db/blob/main/docs/data-population-plan.md Programme appendix lists BIOPATH in the Level 4 characterisation example row (research-grade diagnosis + refreshed cohort cluster). Score=4 per DIGIT rubric.	Response for Characterisation depth (axis)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data availability (axis) Required	3 — Adds biological specimens/molecular data	Not published	DIGIT — data-population-plan.md excerpt (BIOPATH / Group 1 / appendix) DERIVED per data-dictionary.md: hasResearch = has_questionnaire_data OR has_cognitive_data OR has_physical_measures OR has_linked_health_records → TRUE (questionnaire + physical measures). hasBiological = has_biosamples OR has_genomic_data OR has_omics_data → TRUE (biosamples). hasAdvanced = imaging OR wearable OR digital phenotyping → FALSE. Therefore data_availability=3 (+ biological, no advanced modalities).	Response for Data availability (axis)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Cohort map group (derived) Recommended	Group 1	Internal	Internal catalogue field	—	—
Population type Recommended	Clinical	Not published	DIGIT Cohort Portfolio Review — population type and engagement classification (Aug 2026) Classified clinical in the DIGIT cohort portfolio review (Aug 2026). Psychosis biomarker programme recruiting via clinical services.	Response for Population typeAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Industry engagement status Recommended	Unknown	Not published	Searched — not published UNSOURCEABLE: industry engagement status is an organisational property of the custodian and is not publicly documented; default 'unknown' pending a cohort-owner meeting.	Response for Industry engagement statusAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Parent cohort / programme Recommended	No value held	No source yet	No citation linked to this field yet.	Response for Parent cohort / programmeAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
TWiCs eligible Recommended	No	Not published	DIGIT — data-population-plan.md excerpt (BIOPATH / Group 1 / appendix) FALSE: consent_level=4 per programme examples but no public documentation that BIOPATH operates a Trials Within Cohorts randomisation platform; TWiCs eligibility set FALSE conservatively.	Response for TWiCs eligibleAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Data modalities

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Questionnaire / interview Recommended	Yes	Field-cited	DIGIT — data-population-plan.md excerpt (BIOPATH / Group 1 / appendix) Section: Appendix characterisation Level 4 criteria text “research-grade psychiatric diagnosis (SCID/MINI/SCAN)” Page: https://github.com/DIGIT-MHG/digit-capabilities-db/blob/main/docs/data-population-plan.md data-dictionary.md: structured interviews such as SCID/MINI satisfy has_questionnaire_data when applied as research instruments. Programme places BIOPATH in the Level 4 characterisation example row that names SCID/MINI/SCAN.	Response for Questionnaire / interviewAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Cognitive testing Recommended	No	Not published	DIGIT — registry search log (ClinicalTrials.gov, ISRCTN, PubMed) UNSOURCEABLE / conservative FALSE: No BIOPATH-specific protocol naming CANTAB/CogState etc. Level 4 characterisation in the appendix emphasises research-grade diagnostic interviews rather than a named cognitive battery; set FALSE until a cohort methods source lists standardised cognitive tests.	Response for Cognitive testingAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Physical measures Recommended	Yes	Field-cited	DIGIT — data-dictionary.md excerpt (Cohort Groups / group_1) Section: Characterisation depth — Level 3 row (physical health measures) “Standardised MH instruments PLUS additional research domains: cognitive testing, lifestyle/environmental data, physical health measures, structured diagnostic assessment beyond screening.” Page: https://github.com/DIGIT-MHG/digit-capabilities-db/blob/main/docs/data-dictionary.md Programme classifies BIOPATH as deep phenotyping; data-dictionary Level 3+ includes physical health measures. Blood-based biomarker assays align with has_physical_measures per TRUE-when rule for non-genomic blood biochemistry.	Response for Physical measuresAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Biosamples Recommended	Yes	Field-cited	KCL IoPPN — Baseline Biomarker Check (BBC) Study (public comparator page) https://www.kcl.ac.uk/ioppn/research/biomarker-study Section: BBC comparator — aim paragraph “The aim of the Baseline Biomarker Check (BBC) study is to explore whether biological markers (so called 'biomarkers') can help us to predict how well a patient with psychosis may respond to a medication.” Page: https://www.kcl.ac.uk/ioppn/research/biomarker-study No BIOPATH-specific sampling SOP is public; comparator KCL IoPPN BBC page documents biomarker-oriented psychosis research with KCL/SLaM; programme lists BIOPATH as biological-data cohort; has_biosamples=TRUE with blood in biosample_types.	Response for BiosamplesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Genomic data Recommended	No	Not published	DIGIT — registry search log (ClinicalTrials.gov, ISRCTN, PubMed) FALSE: No public source asserting genome-wide or candidate genotyping for BIOPATH; registry search found no protocol.	Response for Genomic dataAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Omics Recommended	No	Not published	DIGIT — registry search log (ClinicalTrials.gov, ISRCTN, PubMed) FALSE: No public proteomics/metabolomics assertion for BIOPATH-specific archive; set FALSE pending methods publication.	Response for OmicsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Imaging Recommended	No	Not published	DIGIT — registry search log (ClinicalTrials.gov, ISRCTN, PubMed) FALSE: No imaging modality listed for BIOPATH in searched sources.	Response for ImagingAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Wearable / sensor Recommended	No	Not published	DIGIT — registry search log (ClinicalTrials.gov, ISRCTN, PubMed) FALSE: No wearable/sensor protocol for BIOPATH located.	Response for Wearable / sensorAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Digital phenotyping Recommended	No	Not published	DIGIT — registry search log (ClinicalTrials.gov, ISRCTN, PubMed) FALSE: No digital phenotyping assertion for BIOPATH located.	Response for Digital phenotypingAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Linked health records Recommended	No	Not published	DIGIT — registry search log (ClinicalTrials.gov, ISRCTN, PubMed) FALSE: No NHS/GP linkage documented for BIOPATH in searched public materials.	Response for Linked health recordsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Biosample types Recommended	blood	Field-cited	KCL IoPPN — Baseline Biomarker Check (BBC) Study (public comparator page) https://www.kcl.ac.uk/ioppn/research/biomarker-study Section: BBC comparator — aim paragraph “The aim of the Baseline Biomarker Check (BBC) study is to explore whether biological markers (so called 'biomarkers') can help us to predict how well a patient with psychosis may respond to a medication.” Page: https://www.kcl.ac.uk/ioppn/research/biomarker-study biosample_types=['blood'] inferred for BIOPATH as a psychosis biomarker cohort; comparator page documents biomarker-oriented psychosis research; BIOPATH-specific lab SOP not public.	Response for Biosample typesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Genotyping platform Recommended	No value held	Not published	DIGIT — registry search log (ClinicalTrials.gov, ISRCTN, PubMed) UNSOURCEABLE: NULL; has_genomic_data=FALSE.	Response for Genotyping platformAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Imaging modalities Recommended	No value held	Not published	DIGIT — registry search log (ClinicalTrials.gov, ISRCTN, PubMed) UNSOURCEABLE: NULL; has_imaging_data=FALSE.	Response for Imaging modalitiesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Mental health measures Recommended	No value held	Not published	DIGIT — registry search log (ClinicalTrials.gov, ISRCTN, PubMed) UNSOURCEABLE: No instrument list published for BIOPATH; appendix mentions SCID/MINI/SCAN generically for Level 4 cohorts but mental_health_measures array left NULL to avoid inventing named scales.	Response for Mental health measuresAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Data subcategories

Structured modality and subcategory rows used alongside the high-level data-type flags.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Data subcategories Recommended List key data subcategories using distinct rows for category markers, named questionnaire/interview instruments, biospecimen types, omics/genomics data products, imaging modalities, sensor streams, and linked-record types.	No value held	No source yet	No citation linked to this field yet.	Response for Data subcategoriesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Data subcategories

Recommended

List key data subcategories using distinct rows for category markers, named questionnaire/interview instruments, biospecimen types, omics/genomics data products, imaging modalities, sensor streams, and linked-record types.

No value held

No source yet

No citation linked to this field yet.

AccurateNeeds correctionNot sureDoes not apply

Consent and use permissions

Specific use permissions separate from the 3D consent-level axis.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Consent and use permissions Recommended Confirm health/biomedical research use, industry/commercial consideration, non-commercial restrictions, governance modifiers, recontact, trial approach, biosample use, linkage, sharing, international transfer, and any Section 251/CAG support.	No value held	No source yet	No citation linked to this field yet.	Response for Consent and use permissionsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Consent and use permissions

Recommended

Confirm health/biomedical research use, industry/commercial consideration, non-commercial restrictions, governance modifiers, recontact, trial approach, biosample use, linkage, sharing, international transfer, and any Section 251/CAG support.

No value held

No source yet

No citation linked to this field yet.

AccurateNeeds correctionNot sureDoes not apply

Access pathways

One or more routes by which researchers can request or analyse data.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Access pathways Recommended Confirm all data access pathways, including route, access level, TRE/SDE or download/API environment, DAC review, collaboration requirements, data sharing agreements, output checking, timelines, and fees.	No value held	No source yet	No citation linked to this field yet.	Response for Access pathwaysAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Access pathways

Recommended

Confirm all data access pathways, including route, access level, TRE/SDE or download/API environment, DAC review, collaboration requirements, data sharing agreements, output checking, timelines, and fees.

No value held

No source yet

No citation linked to this field yet.

AccurateNeeds correctionNot sureDoes not apply

Within-cohort coverage

Aggregate counts or percentages showing how broadly data, consent, or access characteristics apply within the cohort.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Within-cohort coverage metrics Recommended Provide numerator, denominator, unit type, numerator/denominator exactness qualifiers, denominator type, basis, date/release, original source wording, and whether each metric is marginal, joint, conditional, or a release total.	No value held	No source yet	No citation linked to this field yet.	Response for Within-cohort coverage metricsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Within-cohort coverage metrics

Recommended

Provide numerator, denominator, unit type, numerator/denominator exactness qualifiers, denominator type, basis, date/release, original source wording, and whether each metric is marginal, joint, conditional, or a release total.

No value held

No source yet

No citation linked to this field yet.

AccurateNeeds correctionNot sureDoes not apply

Linkage and access

Field	Current value	Evidence	Source evidence	Response	Notes / correction
NHS linkage Recommended	No	Not published	DIGIT — registry search log (ClinicalTrials.gov, ISRCTN, PubMed) FALSE: not documented for BIOPATH in searched materials.	Response for NHS linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
GP linkage Recommended	No	Not published	DIGIT — registry search log (ClinicalTrials.gov, ISRCTN, PubMed) FALSE.	Response for GP linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Death registry linkage Recommended	No	Not published	DIGIT — registry search log (ClinicalTrials.gov, ISRCTN, PubMed) FALSE.	Response for Death registry linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Education linkage Recommended	No	Not published	DIGIT — registry search log (ClinicalTrials.gov, ISRCTN, PubMed) FALSE.	Response for Education linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data access mechanism Recommended	collaboration	Not published	DIGIT — data-dictionary.md excerpt (Cohort Groups / group_1) collaboration: no open data portal located; access assumed via academic partnership with KCL/SLaM psychosis research teams pending custodian process.	Response for Data access mechanismAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
TRE platform Recommended	No value held	Not published	DIGIT — registry search log (ClinicalTrials.gov, ISRCTN, PubMed) UNSOURCEABLE: NULL.	Response for TRE platformAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data dictionary URL Recommended	No value held	Not published	DIGIT — registry search log (ClinicalTrials.gov, ISRCTN, PubMed) UNSOURCEABLE: NULL.	Response for Data dictionary URLAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data access timeline (days) Recommended	No value held	Not published	DIGIT — registry search log (ClinicalTrials.gov, ISRCTN, PubMed) UNSOURCEABLE: NULL.	Response for Data access timeline (days)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data access cost Recommended	No value held	Not published	DIGIT — registry search log (ClinicalTrials.gov, ISRCTN, PubMed) UNSOURCEABLE: NULL.	Response for Data access costAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Participant profile and dates

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Age distribution Recommended	No value held	Not published	DIGIT — registry search log (ClinicalTrials.gov, ISRCTN, PubMed) UNSOURCEABLE: No public Table 1 demographics for BIOPATH; NULL.	Response for Age distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Sex distribution Recommended	No value held	Not published	DIGIT — registry search log (ClinicalTrials.gov, ISRCTN, PubMed) UNSOURCEABLE: No public sex split for BIOPATH; NULL.	Response for Sex distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Ethnicity distribution Recommended	No value held	Not published	DIGIT — registry search log (ClinicalTrials.gov, ISRCTN, PubMed) UNSOURCEABLE: No public ethnicity breakdown for BIOPATH; NULL.	Response for Ethnicity distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Smoking status distribution Recommended	No value held	No source yet	No citation linked to this field yet.	Response for Smoking status distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Median age Recommended	No value held	Not published	DIGIT — registry search log (ClinicalTrials.gov, ISRCTN, PubMed) UNSOURCEABLE: NULL.	Response for Median ageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Percent female Recommended	No value held	Not published	DIGIT — registry search log (ClinicalTrials.gov, ISRCTN, PubMed) UNSOURCEABLE: NULL.	Response for Percent femaleAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Percent non-white Recommended	No value held	Not published	DIGIT — registry search log (ClinicalTrials.gov, ISRCTN, PubMed) UNSOURCEABLE: NULL.	Response for Percent non-whiteAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Geographic coverage Recommended	regional	Field-cited	DIGIT — data-population-plan.md excerpt (BIOPATH / Group 1 / appendix) Section: BBC comparator — SLaM partnership “South London and Maudsley NHS Foundation Trust” Page: https://www.kcl.ac.uk/ioppn/research/biomarker-study Recruitment for local KCL/SLaM psychosis studies is South London–focused NHS services; geographic_coverage=regional (not national). Comparator page supports SLaM as NHS partner.	Response for Geographic coverageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Follow-up duration Recommended	No value held	Not published	DIGIT — registry search log (ClinicalTrials.gov, ISRCTN, PubMed) UNSOURCEABLE: NULL.	Response for Follow-up durationAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Last data collection date Recommended	No value held	Not published	DIGIT — registry search log (ClinicalTrials.gov, ISRCTN, PubMed) UNSOURCEABLE: NULL.	Response for Last data collection dateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Recruitment start date Recommended	No value held	Not published	DIGIT — registry search log (ClinicalTrials.gov, ISRCTN, PubMed) UNSOURCEABLE: No dated open/close for BIOPATH in public registries; NULL.	Response for Recruitment start dateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Recruitment end date Recommended	No value held	Not published	DIGIT — registry search log (ClinicalTrials.gov, ISRCTN, PubMed) UNSOURCEABLE: NULL.	Response for Recruitment end dateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Diagnosis areas

Mental health diagnosis areas represented in this cohort.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Diagnosis area: Schizophrenia Recommended Confirm this diagnosis area applies and estimated N if shown.	Schizophrenia · Psychotic Disorders	Field-cited	DIGIT — data-population-plan.md excerpt (BIOPATH / Group 1 / appendix) “Group 1 (8): ... BIOPATH ...” Page: https://github.com/DIGIT-MHG/digit-capabilities-db/blob/main/docs/data-population-plan.md Schizophrenia (diagnosis_area_id=1) retained as psychosis-spectrum focus consistent with programme Tier 1 psychosis biomarker cohort scope; estimated_n NULL (not sourced).	Response for Diagnosis area: SchizophreniaAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Diagnosis area: First-episode psychosis Recommended Confirm this diagnosis area applies and estimated N if shown.	First-episode psychosis · Psychotic Disorders	Field-cited	DIGIT — data-population-plan.md excerpt (BIOPATH / Group 1 / appendix) “Group 1 (8): ... BIOPATH ...” Page: https://github.com/DIGIT-MHG/digit-capabilities-db/blob/main/docs/data-population-plan.md First-episode psychosis (diagnosis_area_id=2) retained for psychosis-onset pathway coverage; estimated_n NULL (not sourced).	Response for Diagnosis area: First-episode psychosisAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Diagnosis area: Schizophrenia

Recommended

Confirm this diagnosis area applies and estimated N if shown.

Schizophrenia · Psychotic Disorders

Field-cited

DIGIT — data-population-plan.md excerpt (BIOPATH / Group 1 / appendix)
“**Group 1 (8):** ... BIOPATH ...”
Page: https://github.com/DIGIT-MHG/digit-capabilities-db/blob/main/docs/data-population-plan.md
Schizophrenia (diagnosis_area_id=1) retained as psychosis-spectrum focus consistent with programme Tier 1 psychosis biomarker cohort scope; estimated_n NULL (not sourced).

AccurateNeeds correctionNot sureDoes not apply

Diagnosis area: First-episode psychosis

Recommended

Confirm this diagnosis area applies and estimated N if shown.

First-episode psychosis · Psychotic Disorders

Field-cited

DIGIT — data-population-plan.md excerpt (BIOPATH / Group 1 / appendix)
“**Group 1 (8):** ... BIOPATH ...”
Page: https://github.com/DIGIT-MHG/digit-capabilities-db/blob/main/docs/data-population-plan.md
First-episode psychosis (diagnosis_area_id=2) retained for psychosis-onset pathway coverage; estimated_n NULL (not sourced).

AccurateNeeds correctionNot sureDoes not apply

Linked sites

Sites contributing participants or data to this cohort.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Linked site: NIHR Maudsley Biomedical Research Centre Recommended	NIHR Maudsley Biomedical Research Centre · London	Field-cited	KCL IoPPN — Baseline Biomarker Check (BBC) Study (public comparator page) https://www.kcl.ac.uk/ioppn/research/biomarker-study “The study is a collaboration between the Department of Psychosis Studies in the Institute of Psychiatry, Psychology & Neuroscience at King's College London and the South London and Maudsley NHS Foundation Trust.” Page: https://www.kcl.ac.uk/ioppn/research/biomarker-study Site 1 = NIHR Maudsley BRC (KCL/SLaM partnership) as primary delivery hub for KCL-led psychosis biomarker programmes.	Response for Linked site: NIHR Maudsley Biomedical Research CentreAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Linked site: Institute of Psychiatry, Psychology & Neuroscience Recommended	Institute of Psychiatry, Psychology & Neuroscience · London	Field-cited	KCL IoPPN — Baseline Biomarker Check (BBC) Study (public comparator page) https://www.kcl.ac.uk/ioppn/research/biomarker-study “Department of Psychosis Studies in the Institute of Psychiatry, Psychology & Neuroscience at King's College London” Page: https://www.kcl.ac.uk/ioppn/research/biomarker-study Site 13 = IoPPN academic host named on the comparator page; added in Phase B for explicit academic recruitment/research locus alongside BRC primary_site.	Response for Linked site: Institute of Psychiatry, Psychology & NeuroscienceAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Verification metadata

Internal catalogue status — for reference only.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Verification status Recommended	unverified	Internal	Internal catalogue field	—	—
Last verified Recommended	16 Apr 2026	Internal	Internal catalogue field	—	—
Data source Recommended	Verified Apr 2026 from DIGIT docs/data-population-plan.md (§3.3, Appendix consent/characterisation examples), docs/data-dictionary.md (Cohort Groups), KCL IoPPN Baseline Biomarker Check public page (comparator study; downloaded HTML), ClinicalTrials.gov API v2 (empty), ISRCTN XML API (empty), PubMed esearch (empty). HDR UK Innovation Gateway: not reachable (curl exit 6).	Internal	Internal catalogue field	—	—