Cohort validation pack

COPE

COVID-19 Clinical Neuroscience Study (COVID-CNS)

Generated 6 Oct 2026, 10:36 · ID 60

Unverified

Last verified: 16/04/2026

Instructions for reviewers

Review each field against your knowledge of this cohort. Mark Accurate if the value is right, Needs correction if it is wrong or inaccurate (add notes), Not sure if you cannot verify it, or Does not apply if the field is not relevant.
Evidence shown is from our source registry. Fields marked No source yet hold values we could not yet pin to a document — those were AI-inferred and need your input most. Fields marked Searched — not published are ones we looked for and could not find publicly; the note lists where we checked.
Your selections and notes are kept in this browser tab only (not sent to the database). Print or save as PDF when finished, then return it to the DIGIT team.

Overview

Total fields

Field-cited

Whole-record source only

AI-inferred, no source yet

Searched — not published

No value held

Needs review

Source coverage

Summary of how well fields in this pack are linked to evidence.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Field-level source coverage Optional	48 of 71 reviewable fields are cited to a source (68%) · 7 with no source yet · 16 searched — not published · 21 with no value held	Computed	No citation linked to this field yet.	Response for Field-level source coverageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Identity and ownership

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Short name Required	COPE	Field-cited	DIGIT — data-population-plan.md (in-repo cohort inventory) Section: Group 3 (16) “Group 3 (16): Our Future Health, ALSPAC, PROTECT, ELSA, MCS, Understanding Society, RADAR-MDD, Whitehall II, NCDS 1958, BCS70, COPE, McPin, REACT, ZOE Health, ARC cohorts (pooled), National Maternity Dataset” DIGIT uses the short label COPE for this COVID neuropsychiatric priority cohort entry; it is not the separate KCL Coronavirus Outbreak Psychological Experiences (COPE) online survey.	Response for Short nameAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Full name Required	COVID-19 Clinical Neuroscience Study (COVID-CNS)	Field-cited	ISRCTN API — ISRCTN47912798 (COVID-CNS) https://www.isrctn.com/api/query/format/default?q=47912798&limit=5 Section: scientificTitle “Neurological and psychiatric complications of COVID-19 in hospitalised patients and the neurological, psychiatric and cognitive sequelae: the COVID-19 Clinical Neuroscience Study (COVID-CNS)” Page: https://www.isrctn.com/ISRCTN47912798 Cohort row appends (COVID-CNS) after the formal study title for UI clarity.	Response for Full nameAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Managing organisation Recommended	University of Liverpool / King's College London (joint lead)	Field-cited	King's College London — news: national COVID neuro study launch https://www.kcl.ac.uk/news/new-national-study-into-neurological-impact-of-covid-19 Section: application/ld+json abstract “Researchers from the University of Liverpool and King's College London today launch a £2.84 million study to investigate the neurological and neuropsychiatric effects of COVID-19.” Page: https://www.kcl.ac.uk/news/new-national-study-into-neurological-impact-of-covid-19 Corroborates joint Liverpool/KCL leadership at programme announcement. NIHR BioResource — NBR224 (COVID-CNS) https://www.bioresource.nihr.ac.uk/studies/nbr224/ Section: Summary “The COVID-19 Clinical Neuroscience Study (COVID-CNS) is a jointly led study by researchers at the University of Liverpool and King's College London.” Page: https://www.bioresource.nihr.ac.uk/studies/nbr224/	Response for Managing organisationAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Primary site Recommended	University of Liverpool (site #28)	Field-cited	ISRCTN API — ISRCTN47912798 (COVID-CNS) https://www.isrctn.com/api/query/format/default?q=47912798&limit=5 Section: trialCentres / name “University of Liverpool” Page: https://www.isrctn.com/ISRCTN47912798 primary_site_id=28 maps to the University of Liverpool sites row; ISRCTN lists Liverpool as the first registered trial centre and BioResource lists University of Liverpool as the lead institution.	Response for Primary siteAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Website URL Recommended	https://www.liverpool.ac.uk/covid-clinical-neuroscience-study/	Field-cited	University of Liverpool — COVID-19 Clinical Neuroscience Study (about) https://www.liverpool.ac.uk/covid-clinical-neuroscience-study/about/ Section: Canonical programme URL “https://www.liverpool.ac.uk/covid-clinical-neuroscience-study/” Page: https://www.liverpool.ac.uk/covid-clinical-neuroscience-study/about/ Public programme site is hosted under the University of Liverpool COVID-CNS hub (ISRCTN also lists a legacy covid-cns.org link).	Response for Website URLAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Catalogue of Mental Health Measures URL Recommended	No value held	No source yet	No citation linked to this field yet.	Response for Catalogue of Mental Health Measures URLAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Contact name Recommended	Dr Benedict Michael (Liverpool) and Prof Gerome Breen (KCL)	Field-cited	ISRCTN API — ISRCTN47912798 (COVID-CNS) https://www.isrctn.com/api/query/format/default?q=47912798&limit=5 Section: plainEnglishSummary “Dr Benedict Michael (Liverpool) and Prof Gerome Breen (KCL)” Page: https://www.isrctn.com/ISRCTN47912798	Response for Contact nameAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Contact email Recommended	covidcns@liverpool.ac.uk	Field-cited	ISRCTN API — ISRCTN47912798 (COVID-CNS) https://www.isrctn.com/api/query/format/default?q=47912798&limit=5 Section: plainEnglishSummary “covidcns@liverpool.ac.uk” Page: https://www.isrctn.com/ISRCTN47912798	Response for Contact emailAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Summary and status

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Description Required	UK hospitalised adult case–control programme studying acute neurological and psychiatric complications of COVID-19 and medium-term neurological, cognitive and psychiatric sequelae. In-depth clinical assessment, blood biomarkers (inflammation and CNS injury markers) and brain MRI in a subset, with participants consented via NIHR BioResource infrastructure.	Field-cited	ISRCTN API — ISRCTN47912798 (COVID-CNS) https://www.isrctn.com/api/query/format/default?q=47912798&limit=5 Section: intervention/description “All patients will be consented into existing NIHR BioResource infrastructure for long-term sustainability of follow-up.” Page: https://www.isrctn.com/ISRCTN47912798 Description synthesises ISRCTN inclusion (hospitalised UK COVID-19 with acute neurological/psychiatric complications vs controls), intervention block (clinical notes, neuroimaging, serum/CSF, follow-up face-to-face assessments, MRI connectivity), and BioResource consenting model.	Response for DescriptionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Total N Required	818	Field-cited	NIHR BioResource — NBR224 (COVID-CNS) https://www.bioresource.nihr.ac.uk/studies/nbr224/ Section: Potential benefit to patients “The COVID-CNS study recruited just over 800 participants—including COVID positive controls and COVID positive cases of neurological complications.” Page: https://www.bioresource.nihr.ac.uk/studies/nbr224/ Cross-check: rounded programme size is consistent with 818 figure used in cohort row with total_n_qualifier=approximate. University of Liverpool — COVID-19 Clinical Neuroscience Study (about) https://www.liverpool.ac.uk/covid-clinical-neuroscience-study/about/ Section: BioResource / COVID-19 programme “recall of the data and samples from the 8,000 who have already joined, including 818 via COVID-CNS are accessible by researchers.” Page: https://www.liverpool.ac.uk/covid-clinical-neuroscience-study/about/ 818 is the stated BioResource join count for COVID-CNS; differs from protocol target (~800 cases + controls) and from outcomes paper enrolled subset (651 analysed).	Response for Total NAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Total N qualifier Recommended	approximate	Field-cited	University of Liverpool — COVID-19 Clinical Neuroscience Study (about) https://www.liverpool.ac.uk/covid-clinical-neuroscience-study/about/ Section: BioResource / COVID-19 programme “including 818 via COVID-CNS” Page: https://www.liverpool.ac.uk/covid-clinical-neuroscience-study/about/ total_n_qualifier=approximate because different public documents round differently (800 vs just over 800 vs 818 vs analysed subsets).	Response for Total N qualifierAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Year established Recommended	2020	Field-cited	King's College London — news: national COVID neuro study launch https://www.kcl.ac.uk/news/new-national-study-into-neurological-impact-of-covid-19 Section: application/ld+json “2020-10-21T00:00:00” Page: https://www.kcl.ac.uk/news/new-national-study-into-neurological-impact-of-covid-19 year_established=2020 from NewsArticle datePublished in page head JSON-LD.	Response for Year establishedAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Active cohort Recommended	No	Field-cited	University of Liverpool — COVID-19 Clinical Neuroscience Study (about) https://www.liverpool.ac.uk/covid-clinical-neuroscience-study/about/ Section: BioResource / COVID-19 programme “The COVID-19 BioResource is no longer actively recruiting COVID patients” Page: https://www.liverpool.ac.uk/covid-clinical-neuroscience-study/about/ Primary acute COVID recruitment window ended -> is_active=FALSE for the recruiting cohort, while data/samples remain accessible.	Response for Active cohortAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Ongoing recruitment Recommended	No	Field-cited	University of Liverpool — COVID-19 Clinical Neuroscience Study (about) https://www.liverpool.ac.uk/covid-clinical-neuroscience-study/about/ Section: BioResource / COVID-19 programme “The COVID-19 BioResource is no longer actively recruiting COVID patients” Page: https://www.liverpool.ac.uk/covid-clinical-neuroscience-study/about/	Response for Ongoing recruitmentAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Refreshed cohort Recommended	Yes	Field-cited	ISRCTN API — ISRCTN47912798 (COVID-CNS) https://www.isrctn.com/api/query/format/default?q=47912798&limit=5 Section: intervention/description “Follow-up data will be obtained by face-to-face assessment at 3-9 months post-discharge for:” Page: https://www.isrctn.com/ISRCTN47912798 Protocol schedules systematic repeat assessments -> is_refreshed=TRUE per data-dictionary periodic re-assessment criterion.	Response for Refreshed cohortAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Recontact success rate Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: no public recontact success statistic located.	Response for Recontact success rateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Retention rate Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: no single headline retention percentage extracted.	Response for Retention rateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Published references Recommended	doi:10.1038/s41598-024-80833-0	Field-cited	Shil et al. — COVID-CNS outcomes (Scientific Reports, 2025) https://doi.org/10.1038/s41598-024-80833-0 Section: application/ld+json headline “Patients with neurological or psychiatric complications of COVID-19 have worse long-term functional outcomes: COVID-CNS—A multicentre case–control study” Page: https://doi.org/10.1038/s41598-024-80833-0 published_references stores DOI string doi:10.1038/s41598-024-80833-0 for this primary outcomes paper.	Response for Published referencesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Notes Recommended	DIGIT short name “COPE” tracks the COVID neuropsychiatric priority cohort listed as “COPE” in data-population-plan.md and refers to COVID-CNS (not the separate Coronavirus Outbreak Psychological Experiences online survey). Recruitment target text cites ~800 cases plus controls; NIHR BioResource page states just over 800 participants joined; the Liverpool programme page states 818 participants joined via COVID-CNS through the COVID-19 BioResource.	Field-cited	University of Liverpool — COVID-19 Clinical Neuroscience Study (about) https://www.liverpool.ac.uk/covid-clinical-neuroscience-study/about/ Section: BioResource / COVID-19 programme “including 818 via COVID-CNS” Page: https://www.liverpool.ac.uk/covid-clinical-neuroscience-study/about/ Notes clarify COPE label vs separate KCL COPE survey and reconcile N sources.	Response for NotesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

3D cohort mapping

Consent, characterisation, and data availability axes used on the cohort map.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Consent level (axis) Required	3 — Broad consent (recontactable for future studies)	Field-cited	ISRCTN API — ISRCTN47912798 (COVID-CNS) https://www.isrctn.com/api/query/format/default?q=47912798&limit=5 Section: intervention/description “All patients will be consented into existing NIHR BioResource infrastructure for long-term sustainability of follow-up.” Page: https://www.isrctn.com/ISRCTN47912798 Step1 identifiable individual participants YES. Step2 S251/CAG-only access without individual consent NO (prospective research consent). Step3 recontactable YES (BioResource + long-term follow-up). Step4 specific interventional trial consent NO for the observational programme -> consent_level=3 per data-dictionary.md.	Response for Consent level (axis)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Characterisation depth (axis) Required	3 — Multi-domain MH characterisation	Field-cited	ISRCTN API — ISRCTN47912798 (COVID-CNS) https://www.isrctn.com/api/query/format/default?q=47912798&limit=5 Section: intervention/description “2.1. CNS-NeuroCog Protocol (built on UK BioBank, the MOCA/MMSE, CAMCOG, and CANTAB tools; piloted on 50). 2.2. NIHR BioResource COPING Protocol (an extended UK Biobank questionnaire covering neurological, cognitive, and psychiatry symptoms, already completed in >30,000).” Page: https://www.isrctn.com/ISRCTN47912798 Step1 routine EHR/case-note capture YES. Step2 validated cognitive and psychiatry instruments YES. Step3 multi-domain (cognition + psychiatry + neuroimaging + blood markers) YES. Step4 research-grade diagnostic interview plus active whole-cohort refresh NO -> characterisation_depth=3.	Response for Characterisation depth (axis)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data availability (axis) Required	4 — Multi-modal	Field-cited	ISRCTN API — ISRCTN47912798 (COVID-CNS) https://www.isrctn.com/api/query/format/default?q=47912798&limit=5 Section: intervention/description “Neuroimaging” Page: https://www.isrctn.com/ISRCTN47912798 DERIVED per data-dictionary.md: hasResearch=TRUE; hasBiological=TRUE (biosamples + genomics + omics); hasAdvanced=TRUE (MRI) -> data_availability=4.	Response for Data availability (axis)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Cohort map group (derived) Recommended	Group 1	Internal	Internal catalogue field	—	—
Population type Recommended	Clinical	Not published	DIGIT Cohort Portfolio Review — population type and engagement classification (Aug 2026) Classified clinical in the DIGIT cohort portfolio review (Aug 2026). Hospitalised COVID-19 patients with neurological and psychiatric complications; programme completed.	Response for Population typeAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Industry engagement status Recommended	Unknown	Not published	Searched — not published UNSOURCEABLE: industry engagement status is an organisational property of the custodian and is not publicly documented; default 'unknown' pending a cohort-owner meeting.	Response for Industry engagement statusAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Parent cohort / programme Recommended	No value held	No source yet	No citation linked to this field yet.	Response for Parent cohort / programmeAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
TWiCs eligible Recommended	No	Field-cited	ISRCTN API — ISRCTN47912798 (COVID-CNS) https://www.isrctn.com/api/query/format/default?q=47912798&limit=5 Section: primaryStudyDesign “Observational” Page: https://www.isrctn.com/ISRCTN47912798 Observational case-control programme without TWiCs-style interventional consent -> twics_eligible=FALSE.	Response for TWiCs eligibleAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Data modalities

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Questionnaire / interview Recommended	Yes	Field-cited	ISRCTN API — ISRCTN47912798 (COVID-CNS) https://www.isrctn.com/api/query/format/default?q=47912798&limit=5 Section: intervention/description “NIHR BioResource COPING Protocol (an extended UK Biobank questionnaire covering neurological, cognitive, and psychiatry symptoms, already completed in >30,000).” Page: https://www.isrctn.com/ISRCTN47912798	Response for Questionnaire / interviewAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Cognitive testing Recommended	Yes	Field-cited	ISRCTN API — ISRCTN47912798 (COVID-CNS) https://www.isrctn.com/api/query/format/default?q=47912798&limit=5 Section: intervention/description “CNS-NeuroCog Protocol (built on UK BioBank, the MOCA/MMSE, CAMCOG, and CANTAB tools; piloted on 50).” Page: https://www.isrctn.com/ISRCTN47912798	Response for Cognitive testingAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Physical measures Recommended	Yes	Field-cited	ISRCTN API — ISRCTN47912798 (COVID-CNS) https://www.isrctn.com/api/query/format/default?q=47912798&limit=5 Section: plainEnglishSummary “The study team will conduct an in depth clinical, laboratory, and imaging study.” Page: https://www.isrctn.com/ISRCTN47912798 In-hospital clinical assessment and laboratory measures are interpreted as structured non-biomarker clinical/physiological phenotyping captured alongside biosampling -> TRUE.	Response for Physical measuresAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Biosamples Recommended	Yes	Field-cited	ISRCTN API — ISRCTN47912798 (COVID-CNS) https://www.isrctn.com/api/query/format/default?q=47912798&limit=5 Section: intervention/description “Retained serum (ISARIC-4C’s and local) and CSF (Co-I’s Neuroscience BioBanks)” Page: https://www.isrctn.com/ISRCTN47912798	Response for BiosamplesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Genomic data Recommended	Yes	Field-cited	ISRCTN API — ISRCTN47912798 (COVID-CNS) https://www.isrctn.com/api/query/format/default?q=47912798&limit=5 Section: studyHypothesis “Similar, but milder neurological symptoms are reported in the community population who have had COVID-19 and are predicted by polygenic scores.” Page: https://www.isrctn.com/ISRCTN47912798 Protocol explicitly plans polygenic score analyses -> germline genetic data class -> has_genomic_data=TRUE.	Response for Genomic dataAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Omics Recommended	Yes	Field-cited	ISRCTN API — ISRCTN47912798 (COVID-CNS) https://www.isrctn.com/api/query/format/default?q=47912798&limit=5 Section: secondaryOutcome “Cytokine/chemokine profiles measured by luminex from samples at baseline and follow-up” Page: https://www.isrctn.com/ISRCTN47912798 Multiplex cytokine/chemokine profiling is non-genomic molecular phenotyping -> has_omics_data=TRUE per data-dictionary.md (distinct from routine clinical blood tests).	Response for OmicsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Imaging Recommended	Yes	Field-cited	ISRCTN API — ISRCTN47912798 (COVID-CNS) https://www.isrctn.com/api/query/format/default?q=47912798&limit=5 Section: intervention/description “Neuroimaging” Page: https://www.isrctn.com/ISRCTN47912798 Structural/functional MRI follow-up explicitly listed -> has_imaging_data=TRUE.	Response for ImagingAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Wearable / sensor Recommended	No	Field-cited	ISRCTN API — ISRCTN47912798 (COVID-CNS) https://www.isrctn.com/api/query/format/default?q=47912798&limit=5 Section: intervention/description “Follow-up data will be obtained by face-to-face assessment at 3-9 months post-discharge for:” Page: https://www.isrctn.com/ISRCTN47912798 No wearable sensor modality described in reviewed ISRCTN sections -> FALSE.	Response for Wearable / sensorAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Digital phenotyping Recommended	No	Field-cited	ISRCTN API — ISRCTN47912798 (COVID-CNS) https://www.isrctn.com/api/query/format/default?q=47912798&limit=5 Section: studyDesign “Multi-centre longitudinal case-control study” Page: https://www.isrctn.com/ISRCTN47912798 No passive smartphone/device phenotyping stream described -> FALSE.	Response for Digital phenotypingAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Linked health records Recommended	No	Field-cited	ISRCTN API — ISRCTN47912798 (COVID-CNS) https://www.isrctn.com/api/query/format/default?q=47912798&limit=5 Section: inclusion “Admitted to a UK hospital during the COVID-19 pandemic” Page: https://www.isrctn.com/ISRCTN47912798 has_linked_health_records is reserved for post-hoc administrative record linkage datasets in the data dictionary; this programme is prospective hospital research assessments -> FALSE.	Response for Linked health recordsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Biosample types Recommended	blood	Field-cited	University of Liverpool — COVID-19 Clinical Neuroscience Study (about) https://www.liverpool.ac.uk/covid-clinical-neuroscience-study/about/ Section: What is the study? “in-depth clinical, laboratory, and imaging studies” Page: https://www.liverpool.ac.uk/covid-clinical-neuroscience-study/about/ biosample_types ARRAY['blood'] reflects retained serum/plasma described in ISRCTN and blood marker programme; CSF is site-specific and not expanded into array without custodian detail.	Response for Biosample typesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Genotyping platform Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: polygenic score work is referenced at protocol level without a named genotyping array on reviewed pages.	Response for Genotyping platformAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Imaging modalities Recommended	structural_mri	Field-cited	ISRCTN API — ISRCTN47912798 (COVID-CNS) https://www.isrctn.com/api/query/format/default?q=47912798&limit=5 Section: secondaryOutcome “Volume of T2 FLAIR signal measured from brain magnetic resonance imaging at baseline and follow-up” Page: https://www.isrctn.com/ISRCTN47912798 Structural MRI (FLAIR) evidenced -> imaging_modalities ARRAY['structural_mri'].	Response for Imaging modalitiesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Mental health measures Recommended	MoCA, MMSE, CAMCOG, CANTAB, UK Biobank questionnaire (neuro/psych items)	Field-cited	ISRCTN API — ISRCTN47912798 (COVID-CNS) https://www.isrctn.com/api/query/format/default?q=47912798&limit=5 Section: intervention/description “CNS-NeuroCog Protocol (built on UK BioBank, the MOCA/MMSE, CAMCOG, and CANTAB tools; piloted on 50).” Page: https://www.isrctn.com/ISRCTN47912798	Response for Mental health measuresAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Data subcategories

Structured modality and subcategory rows used alongside the high-level data-type flags.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Data subcategories Recommended List key data subcategories using distinct rows for category markers, named questionnaire/interview instruments, biospecimen types, omics/genomics data products, imaging modalities, sensor streams, and linked-record types.	No value held	No source yet	No citation linked to this field yet.	Response for Data subcategoriesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Data subcategories

Recommended

List key data subcategories using distinct rows for category markers, named questionnaire/interview instruments, biospecimen types, omics/genomics data products, imaging modalities, sensor streams, and linked-record types.

No value held

No source yet

No citation linked to this field yet.

AccurateNeeds correctionNot sureDoes not apply

Consent and use permissions

Specific use permissions separate from the 3D consent-level axis.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Consent and use permissions Recommended Confirm health/biomedical research use, industry/commercial consideration, non-commercial restrictions, governance modifiers, recontact, trial approach, biosample use, linkage, sharing, international transfer, and any Section 251/CAG support.	No value held	No source yet	No citation linked to this field yet.	Response for Consent and use permissionsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Consent and use permissions

Recommended

Confirm health/biomedical research use, industry/commercial consideration, non-commercial restrictions, governance modifiers, recontact, trial approach, biosample use, linkage, sharing, international transfer, and any Section 251/CAG support.

No value held

No source yet

No citation linked to this field yet.

AccurateNeeds correctionNot sureDoes not apply

Access pathways

One or more routes by which researchers can request or analyse data.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Access pathways Recommended Confirm all data access pathways, including route, access level, TRE/SDE or download/API environment, DAC review, collaboration requirements, data sharing agreements, output checking, timelines, and fees.	No value held	No source yet	No citation linked to this field yet.	Response for Access pathwaysAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Access pathways

Recommended

Confirm all data access pathways, including route, access level, TRE/SDE or download/API environment, DAC review, collaboration requirements, data sharing agreements, output checking, timelines, and fees.

No value held

No source yet

No citation linked to this field yet.

AccurateNeeds correctionNot sureDoes not apply

Within-cohort coverage

Aggregate counts or percentages showing how broadly data, consent, or access characteristics apply within the cohort.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Within-cohort coverage metrics Recommended Provide numerator, denominator, unit type, numerator/denominator exactness qualifiers, denominator type, basis, date/release, original source wording, and whether each metric is marginal, joint, conditional, or a release total.	No value held	No source yet	No citation linked to this field yet.	Response for Within-cohort coverage metricsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Within-cohort coverage metrics

Recommended

Provide numerator, denominator, unit type, numerator/denominator exactness qualifiers, denominator type, basis, date/release, original source wording, and whether each metric is marginal, joint, conditional, or a release total.

No value held

No source yet

No citation linked to this field yet.

AccurateNeeds correctionNot sureDoes not apply

Linkage and access

Field	Current value	Evidence	Source evidence	Response	Notes / correction
NHS linkage Recommended	Yes	Field-cited	ISRCTN API — ISRCTN47912798 (COVID-CNS) https://www.isrctn.com/api/query/format/default?q=47912798&limit=5 Section: inclusion “Admitted to a UK hospital during the COVID-19 pandemic” Page: https://www.isrctn.com/ISRCTN47912798 Cases and controls are drawn from NHS hospitalised populations with CRN nurse support; interpreted as NHS acute care record context -> has_nhs_linkage=TRUE (not the same flag as administrative HES-only linkage).	Response for NHS linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
GP linkage Recommended	No	Field-cited	ISRCTN API — ISRCTN47912798 (COVID-CNS) https://www.isrctn.com/api/query/format/default?q=47912798&limit=5 Section: intervention/description “Baseline assessment at admission will comprise of;” Page: https://www.isrctn.com/ISRCTN47912798 No explicit primary-care GP record linkage pathway described in reviewed protocol text -> FALSE.	Response for GP linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Death registry linkage Recommended	No	Field-cited	ISRCTN API — ISRCTN47912798 (COVID-CNS) https://www.isrctn.com/api/query/format/default?q=47912798&limit=5 Section: intervention/description “Baseline assessment at admission will comprise of;” Page: https://www.isrctn.com/ISRCTN47912798 No ONS mortality registry linkage named in reviewed sections -> FALSE.	Response for Death registry linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Education linkage Recommended	No	Field-cited	ISRCTN API — ISRCTN47912798 (COVID-CNS) https://www.isrctn.com/api/query/format/default?q=47912798&limit=5 Section: intervention/description “Baseline assessment at admission will comprise of;” Page: https://www.isrctn.com/ISRCTN47912798 No education record linkage described -> FALSE.	Response for Education linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data access mechanism Recommended	direct_application	Field-cited	University of Liverpool — COVID-19 Clinical Neuroscience Study (about) https://www.liverpool.ac.uk/covid-clinical-neuroscience-study/about/ Section: How do researchers access data and samples from the study? “Anyone interested in applying to access COVID-CNS data will need to complete a BioResource Data Access Application Form.” Page: https://www.liverpool.ac.uk/covid-clinical-neuroscience-study/about/ Mapped to direct_application (application form to custodian infrastructure).	Response for Data access mechanismAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
TRE platform Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: access is described via BioResource application rather than a named TRE product.	Response for TRE platformAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data dictionary URL Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: no public data-dictionary URL located for the COVID-CNS researcher bundle on reviewed pages.	Response for Data dictionary URLAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data access timeline (days) Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: BioResource application timeline not quantified as days in sources reviewed.	Response for Data access timeline (days)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data access cost Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: no public fee schedule in reviewed pages.	Response for Data access costAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Participant profile and dates

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Age distribution Recommended	No value held	Not published	Searched — not published UNSOURCEABLE in this pass: no cohort Table 1 age distribution extracted into downloaded files; only ISRCTN ageRange=Adult.	Response for Age distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Sex distribution Recommended	No value held	Not published	Searched — not published UNSOURCEABLE in this pass: sex distribution not transcribed from full-text tables.	Response for Sex distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Ethnicity distribution Recommended	No value held	Not published	Searched — not published UNSOURCEABLE in this pass: ethnicity distribution not transcribed from full-text tables.	Response for Ethnicity distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Smoking status distribution Recommended	No value held	No source yet	No citation linked to this field yet.	Response for Smoking status distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Median age Recommended	No value held	Not published	Searched — not published UNSOURCEABLE in this pass: median age not extracted from outcomes paper HTML snapshot.	Response for Median ageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Percent female Recommended	No value held	Not published	Searched — not published UNSOURCEABLE in this pass: percent female not extracted from outcomes paper HTML snapshot.	Response for Percent femaleAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Percent non-white Recommended	No value held	Not published	Searched — not published UNSOURCEABLE in this pass: ethnicity percentages not extracted from outcomes paper HTML snapshot.	Response for Percent non-whiteAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Geographic coverage Recommended	multi_site	Field-cited	ISRCTN API — ISRCTN47912798 (COVID-CNS) https://www.isrctn.com/api/query/format/default?q=47912798&limit=5 Section: recruitmentCountries “United Kingdom” Page: https://www.isrctn.com/ISRCTN47912798 Multi-site UK hospital network (trial centres in Liverpool, London, Cambridge) -> geographic_coverage=multi_site.	Response for Geographic coverageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Follow-up duration Recommended	3–9 months in-hospital and post-discharge follow-up (ISRCTN); longer-term outcome analyses in linked publications	Field-cited	ISRCTN API — ISRCTN47912798 (COVID-CNS) https://www.isrctn.com/api/query/format/default?q=47912798&limit=5 Section: plainEnglishSummary “The study team will assess markers of brain injury, inflammation, and brain scan changes in these patients.” Page: https://www.isrctn.com/ISRCTN47912798 followup_duration text aggregates ISRCTN plainEnglishSummary follow-up window (3 to 9 months) plus protocol note that longer-term analyses appear in linked publications.	Response for Follow-up durationAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Last data collection date Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: final data freeze date not stated as a single calendar date on reviewed pages.	Response for Last data collection dateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Recruitment start date Recommended	1 Feb 2021	Field-cited	ISRCTN API — ISRCTN47912798 (COVID-CNS) https://www.isrctn.com/api/query/format/default?q=47912798&limit=5 Section: recruitmentStart “2021-02-01T00:00:00.000Z” Page: https://www.isrctn.com/ISRCTN47912798	Response for Recruitment start dateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Recruitment end date Recommended	30 Apr 2022	Field-cited	ISRCTN API — ISRCTN47912798 (COVID-CNS) https://www.isrctn.com/api/query/format/default?q=47912798&limit=5 Section: recruitmentEnd “2022-04-30T00:00:00.000Z” Page: https://www.isrctn.com/ISRCTN47912798	Response for Recruitment end dateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Diagnosis areas

Mental health diagnosis areas represented in this cohort.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Diagnosis area: Major depressive disorder Recommended Confirm this diagnosis area applies and estimated N if shown.	Major depressive disorder · Mood Disorders	Field-cited	Shil et al. — COVID-CNS outcomes (Scientific Reports, 2025) https://doi.org/10.1038/s41598-024-80833-0 Section: application/ld+json description “There was no significant difference in the proportion with depression or anxiety between case and control groups overall.” Page: https://doi.org/10.1038/s41598-024-80833-0 Depression outcomes explicitly discussed -> retain diagnosis_area_id=5 (MDD) with estimated_n NULL.	Response for Diagnosis area: Major depressive disorderAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Diagnosis area: Generalised anxiety disorder Recommended Confirm this diagnosis area applies and estimated N if shown.	Generalised anxiety disorder · Anxiety Disorders	Field-cited	Shil et al. — COVID-CNS outcomes (Scientific Reports, 2025) https://doi.org/10.1038/s41598-024-80833-0 Section: application/ld+json description “There was no significant difference in the proportion with depression or anxiety between case and control groups overall.” Page: https://doi.org/10.1038/s41598-024-80833-0 Anxiety outcomes explicitly discussed -> retain diagnosis_area_id=8 (GAD) with estimated_n NULL.	Response for Diagnosis area: Generalised anxiety disorderAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Diagnosis area: Long COVID neuropsychiatric Recommended Confirm this diagnosis area applies and estimated N if shown.	Long COVID neuropsychiatric · Other	Field-cited	ISRCTN API — ISRCTN47912798 (COVID-CNS) https://www.isrctn.com/api/query/format/default?q=47912798&limit=5 Section: conditions/description “Acute brain complications of COVID-19 and their neurological, psychiatric, and cognitive sequelae” Page: https://www.isrctn.com/ISRCTN47912798 NEW row: maps to diagnosis_area_id=33 Long COVID neuropsychiatric (post-acute neuropsychiatric sequelae of SARS-CoV-2).	Response for Diagnosis area: Long COVID neuropsychiatricAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Diagnosis area: Major depressive disorder

Recommended

Confirm this diagnosis area applies and estimated N if shown.

Major depressive disorder · Mood Disorders

Field-cited

Shil et al. — COVID-CNS outcomes (Scientific Reports, 2025)
https://doi.org/10.1038/s41598-024-80833-0
Section: application/ld+json description
“There was no significant difference in the proportion with depression or anxiety between case and control groups overall.”
Page: https://doi.org/10.1038/s41598-024-80833-0
Depression outcomes explicitly discussed -> retain diagnosis_area_id=5 (MDD) with estimated_n NULL.

AccurateNeeds correctionNot sureDoes not apply

Diagnosis area: Generalised anxiety disorder

Recommended

Confirm this diagnosis area applies and estimated N if shown.

Generalised anxiety disorder · Anxiety Disorders

Field-cited

Shil et al. — COVID-CNS outcomes (Scientific Reports, 2025)
https://doi.org/10.1038/s41598-024-80833-0
Section: application/ld+json description
“There was no significant difference in the proportion with depression or anxiety between case and control groups overall.”
Page: https://doi.org/10.1038/s41598-024-80833-0
Anxiety outcomes explicitly discussed -> retain diagnosis_area_id=8 (GAD) with estimated_n NULL.

AccurateNeeds correctionNot sureDoes not apply

Diagnosis area: Long COVID neuropsychiatric

Recommended

Confirm this diagnosis area applies and estimated N if shown.

Long COVID neuropsychiatric · Other

Field-cited

ISRCTN API — ISRCTN47912798 (COVID-CNS)
https://www.isrctn.com/api/query/format/default?q=47912798&limit=5
Section: conditions/description
“Acute brain complications of COVID-19 and their neurological, psychiatric, and cognitive sequelae”
Page: https://www.isrctn.com/ISRCTN47912798
NEW row: maps to diagnosis_area_id=33 Long COVID neuropsychiatric (post-acute neuropsychiatric sequelae of SARS-CoV-2).

AccurateNeeds correctionNot sureDoes not apply

Linked sites

Sites contributing participants or data to this cohort.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Linked site: NIHR Cambridge Biomedical Research Centre Recommended	NIHR Cambridge Biomedical Research Centre · East of England	Field-cited	ISRCTN API — ISRCTN47912798 (COVID-CNS) https://www.isrctn.com/api/query/format/default?q=47912798&limit=5 Section: sponsor/organisation “Cambridge University Hospitals NHS Foundation Trust” Page: https://www.isrctn.com/ISRCTN47912798 ISRCTN sponsor organisation is Cambridge University Hospitals; mapped to site_id=4 (Cambridge BRC) as the DIGIT anchor site for Cambridge-side coordination.	Response for Linked site: NIHR Cambridge Biomedical Research CentreAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Linked site: Institute of Psychiatry, Psychology & Neuroscience Recommended	Institute of Psychiatry, Psychology & Neuroscience · London	Field-cited	ISRCTN API — ISRCTN47912798 (COVID-CNS) https://www.isrctn.com/api/query/format/default?q=47912798&limit=5 Section: trialCentres/name “King's College London” Page: https://www.isrctn.com/ISRCTN47912798 Mapped to site_id=13 (IoPPN) as the KCL neuroscience host site row.	Response for Linked site: Institute of Psychiatry, Psychology & NeuroscienceAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Linked site: University of Liverpool Recommended	University of Liverpool · North West England	Field-cited	ISRCTN API — ISRCTN47912798 (COVID-CNS) https://www.isrctn.com/api/query/format/default?q=47912798&limit=5 Section: trialCentres/name “University of Liverpool” Page: https://www.isrctn.com/ISRCTN47912798	Response for Linked site: University of LiverpoolAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Verification metadata

Internal catalogue status — for reference only.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Verification status Recommended	unverified	Internal	Internal catalogue field	—	—
Last verified Recommended	16 Apr 2026	Internal	Internal catalogue field	—	—
Data source Recommended	Verified Apr 2026 from University of Liverpool COVID-CNS pages, NIHR BioResource NBR224 study page, ISRCTN47912798 XML API, KCL launch news, Scientific Reports outcomes paper (DOI 10.1038/s41598-024-80833-0), HDR UK Gateway search HTML, ClinicalTrials.gov API v2 (exact-title query returned 0 studies). DPUK website could not be reached from the verification environment (connection failed).	Internal	Internal catalogue field	—	—