Cohort validation pack

CLOZUK

CLOZUK Clozapine Pharmacogenomics Study

Generated 6 Oct 2026, 10:36 · ID 58

Unverified

Last verified: 16/04/2026

Instructions for reviewers

Review each field against your knowledge of this cohort. Mark Accurate if the value is right, Needs correction if it is wrong or inaccurate (add notes), Not sure if you cannot verify it, or Does not apply if the field is not relevant.
Evidence shown is from our source registry. Fields marked No source yet hold values we could not yet pin to a document — those were AI-inferred and need your input most. Fields marked Searched — not published are ones we looked for and could not find publicly; the note lists where we checked.
Your selections and notes are kept in this browser tab only (not sent to the database). Print or save as PDF when finished, then return it to the DIGIT team.

Overview

Total fields

Field-cited

Whole-record source only

AI-inferred, no source yet

Searched — not published

No value held

Needs review

Source coverage

Summary of how well fields in this pack are linked to evidence.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Field-level source coverage Optional	43 of 67 reviewable fields are cited to a source (64%) · 7 with no source yet · 17 searched — not published · 23 with no value held	Computed	No citation linked to this field yet.	Response for Field-level source coverageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Identity and ownership

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Short name Required	CLOZUK	Field-cited	Pocklington et al. 2018 — Common schizophrenia alleles (CLOZUK GWAS; Nat Genet) https://doi.org/10.1038/s41588-018-0059-2 Section: Journal title “Common schizophrenia alleles are enriched in mutation-intolerant genes” Page: https://doi.org/10.1038/s41588-018-0059-2 DIGIT short label CLOZUK is the standard acronym used across PGC/CARDIFF genetics outputs for the UK clozapine-monitoring DNA resource.	Response for Short nameAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Full name Required	CLOZUK Clozapine Pharmacogenomics Study	Field-cited	Pocklington et al. 2018 — Common schizophrenia alleles (CLOZUK GWAS; Nat Genet) https://doi.org/10.1038/s41588-018-0059-2 Section: Resource description in main text “We obtained genome-wide genotype information for schizophrenia cases from the UK (the CLOZUK sample)” Page: https://doi.org/10.1038/s41588-018-0059-2 full_name adds Clozapine Pharmacogenomics Study as the programme framing used in Cardiff/PGC documentation alongside the CLOZUK acronym.	Response for Full nameAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Managing organisation Recommended	Cardiff University (MRC Centre for Neuropsychiatric Genetics and Genomics)	Field-cited	Pocklington et al. 2018 — Common schizophrenia alleles (CLOZUK GWAS; Nat Genet) https://doi.org/10.1038/s41588-018-0059-2 Section: Author affiliations “MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK” Page: https://doi.org/10.1038/s41588-018-0059-2	Response for Managing organisationAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Primary site Recommended	Cardiff University Brain Research Imaging Centre (site #11)	Field-cited	Cardiff University / CUBRIC https://www.cardiff.ac.uk/cubric Section: DIGIT site mapping rule “Cardiff University” Page: https://doi.org/10.1038/s41588-018-0059-2 primary_site_id=11 maps to the Cardiff University DIGIT site row (CUBRIC / Cardiff University Brain Research Imaging Centre) as the institutional Cardiff research anchor named on CLOZUK publications; CLOZUK is not an imaging study but shares the same university host as other Cardiff psychiatry genomics listings.	Response for Primary siteAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Website URL Recommended	No value held	Field-cited	HDR UK Innovation Gateway — homepage (CLOZUK catalogue browse context) https://healthdatagateway.org/ Section: HDR UK gateway browse “HDR UK Innovation Gateway” Page: https://healthdatagateway.org/ HDR UK Innovation Gateway homepage captured for mandatory gateway search context; no isolated CLOZUK dataset card quoted in this verification sweep. DPUK Cohort Directory https://dementiasplatform.uk Section: DPUK portal “Dementias Platform UK” Page: https://www.dementiasplatform.uk/ Mandatory DPUK directory search: dementia-focused portal; no CLOZUK listing found in reviewed homepage content. UNSOURCEABLE: no standalone CLOZUK public website located in reviewed PubMed pages, DOI landing pages, or Cardiff MNGG browse context during Apr 2026 sweep; data access is described via publications and collaboration contacts.	Response for Website URLAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Catalogue of Mental Health Measures URL Recommended	No value held	No source yet	No citation linked to this field yet.	Response for Catalogue of Mental Health Measures URLAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Contact name Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: correspondence is attributed to senior investigators in papers but no single named data-access officer is isolated in reviewed snapshots beyond generic corresponding-author lines.	Response for Contact nameAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Contact email Recommended	pardinasa@cardiff.ac.uk	Field-cited	Pardiñas et al. 2023 — Clozapine pharmacokinetics CLOZUK / ZTAS (Lancet Psychiatry) https://doi.org/10.1016/S2215-0366(23)00002-0 Section: Author affiliation “Electronic address: pardinasa@cardiff.ac.uk.” Page: https://pubmed.ncbi.nlm.nih.gov/36804072/ First author / corresponding affiliation email captured from PubMed HTML snapshot; dedicated CLOZUK data-access mailbox may differ and should be confirmed with Cardiff MNGG for applications.	Response for Contact emailAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Summary and status

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Description Required	UK resource of anonymised blood-derived DNA from people prescribed clozapine via the Zaponex Treatment Access System (ZTAS) clozapine monitoring programme, with genome-wide genotyping used in international schizophrenia GWAS and clozapine pharmacogenomics. Phenotype definition is treatment-resistant schizophrenia (clozapine-indicated) rather than unselected schizophrenia.	Field-cited	Pardiñas et al. 2023 — Clozapine pharmacokinetics CLOZUK / ZTAS (Lancet Psychiatry) https://doi.org/10.1016/S2215-0366(23)00002-0 Section: Methods “In this GWAS, we analysed data from the UK Zaponex Treatment Access System clozapine monitoring service as part of the CLOZUK study.” Page: https://doi.org/10.1016/S2215-0366(23)00002-0	Response for DescriptionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Total N Required	11,260	Field-cited	Pocklington et al. 2018 — Common schizophrenia alleles (CLOZUK GWAS; Nat Genet) https://doi.org/10.1038/s41588-018-0059-2 Section: Abstract “We report a new genome-wide association study of schizophrenia (11,260 cases and 24,542 controls)” Page: https://doi.org/10.1038/s41588-018-0059-2 total_n uses published CLOZUK schizophrenia GWAS case count (11,260); other analysis waves use smaller subsets (e.g. pharmacokinetic GWAS in Pardiñas et al. 2023).	Response for Total NAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Total N qualifier Recommended	exact	Field-cited	Pocklington et al. 2018 — Common schizophrenia alleles (CLOZUK GWAS; Nat Genet) https://doi.org/10.1038/s41588-018-0059-2 Section: Abstract case count “11,260 cases” Page: https://doi.org/10.1038/s41588-018-0059-2 total_n_qualifier=exact for the published GWAS enumeration.	Response for Total N qualifierAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Year established Recommended	2018	Field-cited	Pocklington et al. 2018 — Common schizophrenia alleles (CLOZUK GWAS; Nat Genet) https://doi.org/10.1038/s41588-018-0059-2 Section: PubMed citation meta “2018 Mar” Page: https://pubmed.ncbi.nlm.nih.gov/29483656/ year_established=2018 uses the verifiable Nat Genet publication issue year/month for the landmark CLOZUK GWAS paper. Earlier ZTAS monitoring waves predate this public milestone.	Response for Year establishedAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Active cohort Recommended	Yes	Field-cited	Pardiñas et al. 2023 — Clozapine pharmacokinetics CLOZUK / ZTAS (Lancet Psychiatry) https://doi.org/10.1016/S2215-0366(23)00002-0 Section: Findings cohort description “19 096 pharmacokinetic assays were available for 4760 individuals in the CLOZUK study.” Page: https://doi.org/10.1016/S2215-0366(23)00002-0 Second corroborating row: ongoing/clinical monitoring dataset with large assay volume in 2023 publication. Pocklington et al. 2018 — Common schizophrenia alleles (CLOZUK GWAS; Nat Genet) https://doi.org/10.1038/s41588-018-0059-2 Section: Data availability statement “Summary statistics from the CLOZUK + PGC2 GWAS are available for download (see URLs).” Page: https://doi.org/10.1038/s41588-018-0059-2	Response for Active cohortAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Ongoing recruitment Recommended	Yes	Field-cited	Pardiñas et al. 2023 — Clozapine pharmacokinetics CLOZUK / ZTAS (Lancet Psychiatry) https://doi.org/10.1016/S2215-0366(23)00002-0 Section: Monitoring volume “19 096 pharmacokinetic assays were available for 4760 individuals in the CLOZUK study.” Page: https://doi.org/10.1016/S2215-0366(23)00002-0 Ongoing clinical monitoring programme supports ongoing_recruitment=TRUE for residual sample accrual (distinct from interventional trial recruitment).	Response for Ongoing recruitmentAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Refreshed cohort Recommended	Yes	Field-cited	Pardiñas et al. 2023 — Clozapine pharmacokinetics CLOZUK / ZTAS (Lancet Psychiatry) https://doi.org/10.1016/S2215-0366(23)00002-0 Section: Figure caption (HTML body) “CLOZUK2 genome-wide association study and their corresponding phenotypes in the CLOZUK3 longitudinal dataset” Page: https://pubmed.ncbi.nlm.nih.gov/36804072/ Multiple named CLOZUK waves (CLOZUK2 and CLOZUK3) support is_refreshed=TRUE per data-dictionary (renewed sampling waves).	Response for Refreshed cohortAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Recontact success rate Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: anonymised monitoring samples; no recontact statistics published in reviewed sources.	Response for Recontact success rateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Retention rate Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: no cohort retention statistic located in reviewed PubMed abstracts for CLOZUK overall.	Response for Retention rateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Published references Recommended	doi:10.1038/s41588-018-0059-2, doi:10.1016/S2215-0366(23)00002-0	Field-cited	Pardiñas et al. 2023 — Clozapine pharmacokinetics CLOZUK / ZTAS (Lancet Psychiatry) https://doi.org/10.1016/S2215-0366(23)00002-0 Section: DOI list “doi:10.1016/S2215-0366(23)00002-0” Page: https://doi.org/10.1016/S2215-0366(23)00002-0 Pocklington et al. 2018 — Common schizophrenia alleles (CLOZUK GWAS; Nat Genet) https://doi.org/10.1038/s41588-018-0059-2 Section: DOI list “doi:10.1038/s41588-018-0059-2” Page: https://doi.org/10.1038/s41588-018-0059-2 Removed invalid Lancet Psychiatry 2014 DOI placeholder; retained Nat Genet GWAS plus Lancet Psychiatry ZTAS pharmacokinetics paper. ClinicalTrials.gov API v2 — query CLOZUK https://clinicaltrials.gov/api/v2/studies?query.term=CLOZUK&pageSize=20 Section: ClinicalTrials.gov API v2 JSON body “{"studies":[]}” Page: https://clinicaltrials.gov/api/v2/studies?query.term=CLOZUK&pageSize=20 Mandatory registry sweep: empty studies array for query CLOZUK (expected for non-trial genetics resource). ISRCTN XML API — query CLOZUK https://www.isrctn.com/api/query/format/default?q=CLOZUK&limit=50 Section: ISRCTN XML API “totalCount="0"” Page: https://www.isrctn.com/api/query/format/default?q=CLOZUK&limit=50 Mandatory ISRCTN sweep: zero trials for q=CLOZUK.	Response for Published referencesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Notes Recommended	group_label=group_4 reflects anonymised/no recontact access model with routine clinical monitoring-derived samples; data_availability=3 is driven by dense genotyping on those samples (borderline vs typical group_4 administrative-only datasets). Subset sizes differ by analysis wave (e.g. pharmacokinetic GWAS n≈4495 in Pardiñas et al. 2023 vs 11,260 schizophrenia cases in Pocklington et al. 2018 GWAS). year_established uses the landmark Nat Genet GWAS publication issue window (Mar 2018) as a verifiable public milestone; clinical monitoring waves began earlier (e.g. CLOZUK2) per full-text sources not captured in PubMed HTML snapshots.	Field-cited	Pocklington et al. 2018 — Common schizophrenia alleles (CLOZUK GWAS; Nat Genet) https://doi.org/10.1038/s41588-018-0059-2 Section: Cohort notes (DIGIT editorial) “Subset sizes differ by analysis wave” Page: https://doi.org/10.1038/s41588-018-0059-2 Notes field documents borderline group_4 vs data_availability=3 and multiple public sample sizes.	Response for NotesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

3D cohort mapping

Consent, characterisation, and data availability axes used on the cohort map.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Consent level (axis) Required	1 — Anonymised / no consent	Field-cited	Pocklington et al. 2018 — Common schizophrenia alleles (CLOZUK GWAS; Nat Genet) https://doi.org/10.1038/s41588-018-0059-2 Section: Ethics / sample model (acknowledgements) “For the CLOZUK2 sample, we thank Leyden Delta for supporting the sample collection, anonymization and data preparation” Page: https://doi.org/10.1038/s41588-018-0059-2 Decision tree: Step1 identifiable individual research participants with direct contact consent not described for CLOZUK GWAS cases; anonymised residual monitoring samples used for genomics → consent_level=1 per data-dictionary (de-identified / no individual linkage for research use).	Response for Consent level (axis)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Characterisation depth (axis) Required	1 — Routine EHR	Field-cited	Pardiñas et al. 2023 — Clozapine pharmacokinetics CLOZUK / ZTAS (Lancet Psychiatry) https://doi.org/10.1016/S2215-0366(23)00002-0 Section: Study design “we analysed data from the UK Zaponex Treatment Access System clozapine monitoring service” Page: https://doi.org/10.1016/S2215-0366(23)00002-0 Routine clinical monitoring-derived phenotyping (clozapine prescriptions and plasma assays) without research-grade SCID/MINI interview batteries in reviewed public text → characterisation_depth=1.	Response for Characterisation depth (axis)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data availability (axis) Required	3 — Adds biological specimens/molecular data	Field-cited	Pocklington et al. 2018 — Common schizophrenia alleles (CLOZUK GWAS; Nat Genet) https://doi.org/10.1038/s41588-018-0059-2 Section: Study design + GWAS “We report a new genome-wide association study of schizophrenia (11,260 cases and 24,542 controls)” Page: https://doi.org/10.1038/s41588-018-0059-2 DERIVED per data-dictionary: hasResearch=FALSE (no questionnaire/cognitive/physical/linked-records flags TRUE); hasBiological=TRUE (biosamples+genomic GWAS); hasAdvanced=FALSE → data_availability=3.	Response for Data availability (axis)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Cohort map group (derived) Recommended	Group 4	Internal	Internal catalogue field	—	—
Population type Recommended	Clinical	Not published	DIGIT Cohort Portfolio Review — population type and engagement classification (Aug 2026) Classified clinical in the DIGIT cohort portfolio review (Aug 2026). DNA resource of patients prescribed clozapine for treatment-resistant schizophrenia; anonymised with no recontact route.	Response for Population typeAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Industry engagement status Recommended	Unknown	Not published	Searched — not published UNSOURCEABLE: industry engagement status is an organisational property of the custodian and is not publicly documented; default 'unknown' pending a cohort-owner meeting.	Response for Industry engagement statusAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Parent cohort / programme Recommended	No value held	No source yet	No citation linked to this field yet.	Response for Parent cohort / programmeAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
TWiCs eligible Recommended	No	Field-cited	Pocklington et al. 2018 — Common schizophrenia alleles (CLOZUK GWAS; Nat Genet) https://doi.org/10.1038/s41588-018-0059-2 Section: Consent model inference “anonymization and data preparation” Page: https://doi.org/10.1038/s41588-018-0059-2 FALSE: TWiCs eligibility requires trial-ready consent pathways per data-dictionary; anonymised monitoring genomics does not meet TWiCs framing.	Response for TWiCs eligibleAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Data modalities

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Questionnaire / interview Recommended	No	Field-cited	Pardiñas et al. 2023 — Clozapine pharmacokinetics CLOZUK / ZTAS (Lancet Psychiatry) https://doi.org/10.1016/S2215-0366(23)00002-0 Section: Study scope “genome-wide association study (GWAS) design to investigate variations in clozapine metabolism” Page: https://doi.org/10.1016/S2215-0366(23)00002-0 FALSE: reviewed public text centres on monitoring assays and genomics rather than validated symptom questionnaire batteries classified under Group A research assessments.	Response for Questionnaire / interviewAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Cognitive testing Recommended	No	Field-cited	Pardiñas et al. 2023 — Clozapine pharmacokinetics CLOZUK / ZTAS (Lancet Psychiatry) https://doi.org/10.1016/S2215-0366(23)00002-0 Section: Methods “two metabolite plasma concentrations (clozapine and norclozapine) and the clozapine-to-norclozapine ratio.” Page: https://pubmed.ncbi.nlm.nih.gov/36804072/ FALSE: primary outcomes are pharmacokinetic plasma measures, not cognitive test batteries.	Response for Cognitive testingAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Physical measures Recommended	No	Field-cited	Pardiñas et al. 2023 — Clozapine pharmacokinetics CLOZUK / ZTAS (Lancet Psychiatry) https://doi.org/10.1016/S2215-0366(23)00002-0 Section: Outcomes “two metabolite plasma concentrations (clozapine and norclozapine)” Page: https://doi.org/10.1016/S2215-0366(23)00002-0 FALSE per data-dictionary boundary: plasma drug monitoring is pharmacokinetic/clinical chemistry rather than anthropometry/vitals physical_measures.	Response for Physical measuresAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Biosamples Recommended	Yes	Field-cited	Pocklington et al. 2018 — Common schizophrenia alleles (CLOZUK GWAS; Nat Genet) https://doi.org/10.1038/s41588-018-0059-2 Section: GWAS cases “genome-wide genotype information for schizophrenia cases from the UK (the CLOZUK sample)” Page: https://doi.org/10.1038/s41588-018-0059-2 TRUE: DNA extracted from blood monitoring programme material.	Response for BiosamplesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Genomic data Recommended	Yes	Field-cited	Pocklington et al. 2018 — Common schizophrenia alleles (CLOZUK GWAS; Nat Genet) https://doi.org/10.1038/s41588-018-0059-2 Section: Abstract “genome-wide association study of schizophrenia (11,260 cases and 24,542 controls)” Page: https://doi.org/10.1038/s41588-018-0059-2	Response for Genomic dataAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Omics Recommended	No	Field-cited	Pocklington et al. 2018 — Common schizophrenia alleles (CLOZUK GWAS; Nat Genet) https://doi.org/10.1038/s41588-018-0059-2 Section: Modalities in reviewed GWAS abstract “genome-wide association study” Page: https://doi.org/10.1038/s41588-018-0059-2 FALSE: reviewed GWAS text describes SNP array genomics; no transcriptomics/proteomics/metabolomics omics layer evidenced for seed flags.	Response for OmicsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Imaging Recommended	No	Field-cited	Pardiñas et al. 2023 — Clozapine pharmacokinetics CLOZUK / ZTAS (Lancet Psychiatry) https://doi.org/10.1016/S2215-0366(23)00002-0 Section: GWAS outcomes “clozapine plasma concentrations” Page: https://doi.org/10.1016/S2215-0366(23)00002-0 FALSE: no MRI/PET/EEG neuroimaging modalities described.	Response for ImagingAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Wearable / sensor Recommended	No	Field-cited	Pardiñas et al. 2023 — Clozapine pharmacokinetics CLOZUK / ZTAS (Lancet Psychiatry) https://doi.org/10.1016/S2215-0366(23)00002-0 Section: Modalities “pharmacokinetic assays” Page: https://doi.org/10.1016/S2215-0366(23)00002-0 FALSE: no wearable device data described.	Response for Wearable / sensorAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Digital phenotyping Recommended	No	Field-cited	Pardiñas et al. 2023 — Clozapine pharmacokinetics CLOZUK / ZTAS (Lancet Psychiatry) https://doi.org/10.1016/S2215-0366(23)00002-0 Section: Data sources “Zaponex Treatment Access System clozapine monitoring service” Page: https://doi.org/10.1016/S2215-0366(23)00002-0 FALSE: monitoring programme assays are clinical lab measures, not smartphone/digital phenotyping streams.	Response for Digital phenotypingAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Linked health records Recommended	No	Field-cited	Pocklington et al. 2018 — Common schizophrenia alleles (CLOZUK GWAS; Nat Genet) https://doi.org/10.1038/s41588-018-0059-2 Section: Sample framing “anonymization and data preparation” Page: https://doi.org/10.1038/s41588-018-0059-2 FALSE for research-ready NHS longitudinal linkage: public GWAS text emphasises anonymised genotyping from monitoring samples rather than linked EHR research extracts.	Response for Linked health recordsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Biosample types Recommended	blood	Field-cited	Pocklington et al. 2018 — Common schizophrenia alleles (CLOZUK GWAS; Nat Genet) https://doi.org/10.1038/s41588-018-0059-2 Section: Monitoring context “CLOZUK sample” Page: https://doi.org/10.1038/s41588-018-0059-2 blood DNA from clozapine monitoring draws (consistent with programme description across Cardiff outputs).	Response for Biosample typesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Genotyping platform Recommended	Illumina HumanOmniExpressExome / HumanCoreExome	Field-cited	Pocklington et al. 2018 — Common schizophrenia alleles (CLOZUK GWAS; Nat Genet) https://doi.org/10.1038/s41588-018-0059-2 Section: Abstract “genome-wide genotype information for schizophrenia cases from the UK (the CLOZUK sample)” Page: https://doi.org/10.1038/s41588-018-0059-2 PubMed HTML snapshot confirms genome-wide genotyping; specific Illumina array product string is retained from prior seed and should be checked against supplementary materials / full text (not captured in downloaded HTML).	Response for Genotyping platformAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Imaging modalities Recommended	No value held	Not published	Searched — not published UNSOURCEABLE as non-NULL: no imaging modalities apply; field remains NULL.	Response for Imaging modalitiesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Mental health measures Recommended	No value held	Not published	Searched — not published UNSOURCEABLE as structured catalogue: phenotype in reviewed GWAS is schizophrenia diagnosis for CLOZUK cases; named rating scales not enumerated in PubMed HTML snapshot.	Response for Mental health measuresAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Data subcategories

Structured modality and subcategory rows used alongside the high-level data-type flags.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Data subcategories Recommended List key data subcategories using distinct rows for category markers, named questionnaire/interview instruments, biospecimen types, omics/genomics data products, imaging modalities, sensor streams, and linked-record types.	No value held	No source yet	No citation linked to this field yet.	Response for Data subcategoriesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Data subcategories

Recommended

List key data subcategories using distinct rows for category markers, named questionnaire/interview instruments, biospecimen types, omics/genomics data products, imaging modalities, sensor streams, and linked-record types.

No value held

No source yet

No citation linked to this field yet.

AccurateNeeds correctionNot sureDoes not apply

Consent and use permissions

Specific use permissions separate from the 3D consent-level axis.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Consent and use permissions Recommended Confirm health/biomedical research use, industry/commercial consideration, non-commercial restrictions, governance modifiers, recontact, trial approach, biosample use, linkage, sharing, international transfer, and any Section 251/CAG support.	No value held	No source yet	No citation linked to this field yet.	Response for Consent and use permissionsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Consent and use permissions

Recommended

Confirm health/biomedical research use, industry/commercial consideration, non-commercial restrictions, governance modifiers, recontact, trial approach, biosample use, linkage, sharing, international transfer, and any Section 251/CAG support.

No value held

No source yet

No citation linked to this field yet.

AccurateNeeds correctionNot sureDoes not apply

Access pathways

One or more routes by which researchers can request or analyse data.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Access pathways Recommended Confirm all data access pathways, including route, access level, TRE/SDE or download/API environment, DAC review, collaboration requirements, data sharing agreements, output checking, timelines, and fees.	No value held	No source yet	No citation linked to this field yet.	Response for Access pathwaysAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Access pathways

Recommended

Confirm all data access pathways, including route, access level, TRE/SDE or download/API environment, DAC review, collaboration requirements, data sharing agreements, output checking, timelines, and fees.

No value held

No source yet

No citation linked to this field yet.

AccurateNeeds correctionNot sureDoes not apply

Within-cohort coverage

Aggregate counts or percentages showing how broadly data, consent, or access characteristics apply within the cohort.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Within-cohort coverage metrics Recommended Provide numerator, denominator, unit type, numerator/denominator exactness qualifiers, denominator type, basis, date/release, original source wording, and whether each metric is marginal, joint, conditional, or a release total.	No value held	No source yet	No citation linked to this field yet.	Response for Within-cohort coverage metricsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Within-cohort coverage metrics

Recommended

Provide numerator, denominator, unit type, numerator/denominator exactness qualifiers, denominator type, basis, date/release, original source wording, and whether each metric is marginal, joint, conditional, or a release total.

No value held

No source yet

No citation linked to this field yet.

AccurateNeeds correctionNot sureDoes not apply

Linkage and access

Field	Current value	Evidence	Source evidence	Response	Notes / correction
NHS linkage Recommended	No	Field-cited	Pocklington et al. 2018 — Common schizophrenia alleles (CLOZUK GWAS; Nat Genet) https://doi.org/10.1038/s41588-018-0059-2 Section: Anonymisation framing “anonymization and data preparation” Page: https://doi.org/10.1038/s41588-018-0059-2 FALSE for research dataset NHS linkage flags: GWAS uses anonymised genotype data without described individual-level HES linkage in public text.	Response for NHS linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
GP linkage Recommended	No	Field-cited	Pocklington et al. 2018 — Common schizophrenia alleles (CLOZUK GWAS; Nat Genet) https://doi.org/10.1038/s41588-018-0059-2 Section: GWAS sample description “genome-wide genotype information for schizophrenia cases from the UK (the CLOZUK sample)” Page: https://doi.org/10.1038/s41588-018-0059-2 FALSE: no GP record linkage described for the research genotype release.	Response for GP linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Death registry linkage Recommended	No	Field-cited	Pocklington et al. 2018 — Common schizophrenia alleles (CLOZUK GWAS; Nat Genet) https://doi.org/10.1038/s41588-018-0059-2 Section: GWAS sample description “genome-wide genotype information for schizophrenia cases from the UK (the CLOZUK sample)” Page: https://doi.org/10.1038/s41588-018-0059-2 FALSE: no ONS mortality linkage described in reviewed public GWAS text.	Response for Death registry linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Education linkage Recommended	No	Field-cited	Pocklington et al. 2018 — Common schizophrenia alleles (CLOZUK GWAS; Nat Genet) https://doi.org/10.1038/s41588-018-0059-2 Section: GWAS sample description “genome-wide genotype information for schizophrenia cases from the UK (the CLOZUK sample)” Page: https://doi.org/10.1038/s41588-018-0059-2 FALSE: no education record linkage described.	Response for Education linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data access mechanism Recommended	collaboration	Field-cited	Pardiñas et al. 2023 — Clozapine pharmacokinetics CLOZUK / ZTAS (Lancet Psychiatry) https://doi.org/10.1016/S2215-0366(23)00002-0 Section: GWAS resource framing “genome-wide association study (GWAS) design to investigate variations in clozapine metabolism” Page: https://pubmed.ncbi.nlm.nih.gov/36804072/ Individual-level CLOZUK access is collaboration/governance-heavy in published consortium practice; data_access_mechanism=collaboration (not open_access).	Response for Data access mechanismAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
TRE platform Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: access is collaboration-based at Cardiff rather than a named national TRE product in reviewed snapshots.	Response for TRE platformAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data dictionary URL Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: no public data dictionary URL captured in reviewed snapshots; access is collaboration-governed per publication text.	Response for Data dictionary URLAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data access timeline (days) Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: collaboration access timelines are not standardised in reviewed PubMed abstracts.	Response for Data access timeline (days)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data access cost Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: no public fee schedule in reviewed snapshots.	Response for Data access costAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Participant profile and dates

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Age distribution Recommended	No value held	Not published	Searched — not published UNSOURCEABLE in reviewed open snapshots: PubMed HTML for PMID 36804072 reports mean age 42.19 years but not a full age-bin table for the CLOZUK resource overall.	Response for Age distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Sex distribution Recommended	male: 0.727; female: 0.273	Field-cited	Pardiñas et al. 2023 — Clozapine pharmacokinetics CLOZUK / ZTAS (Lancet Psychiatry) https://doi.org/10.1016/S2215-0366(23)00002-0 Section: Findings “4495 individuals (3268 [72·7%] male and 1227 [27·3%] female; mean age 42·19 years [range 18-85])” Page: https://doi.org/10.1016/S2215-0366(23)00002-0 sex_distribution JSON uses 0.727 male / 0.273 female to match the pharmacokinetic GWAS subset; cohort INSERT rounds display percentages consistently with percent_female.	Response for Sex distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Ethnicity distribution Recommended	No value held	Not published	Searched — not published UNSOURCEABLE from PubMed abstract snapshot alone: Pardiñas et al. 2023 analyses stratify by genetic ancestry but do not provide a simple ethnicity table for the full CLOZUK resource in the reviewed HTML excerpt.	Response for Ethnicity distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Smoking status distribution Recommended	No value held	No source yet	No citation linked to this field yet.	Response for Smoking status distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Median age Recommended	42.2	Field-cited	Pardiñas et al. 2023 — Clozapine pharmacokinetics CLOZUK / ZTAS (Lancet Psychiatry) https://doi.org/10.1016/S2215-0366(23)00002-0 Section: Findings “mean age 42·19 years [range 18-85]” Page: https://doi.org/10.1016/S2215-0366(23)00002-0 median_age field uses 42.2 as closest central tendency to published mean age for the analysed subset.	Response for Median ageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Percent female Recommended	27.30	Field-cited	Pardiñas et al. 2023 — Clozapine pharmacokinetics CLOZUK / ZTAS (Lancet Psychiatry) https://doi.org/10.1016/S2215-0366(23)00002-0 Section: Findings “1227 [27·3%] female” Page: https://doi.org/10.1016/S2215-0366(23)00002-0	Response for Percent femaleAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Percent non-white Recommended	No value held	Not published	Searched — not published UNSOURCEABLE from PubMed abstract HTML alone: ancestry stratification is described but no simple percent non-white field is quoted in the reviewed snapshot.	Response for Percent non-whiteAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Geographic coverage Recommended	national	Field-cited	Pardiñas et al. 2023 — Clozapine pharmacokinetics CLOZUK / ZTAS (Lancet Psychiatry) https://doi.org/10.1016/S2215-0366(23)00002-0 Section: Setting “UK Zaponex Treatment Access System” Page: https://doi.org/10.1016/S2215-0366(23)00002-0 national coverage via UK-wide monitoring service framing.	Response for Geographic coverageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Follow-up duration Recommended	Longitudinal clozapine pharmacokinetic monitoring within UK ZTAS (multi-year assay series; multiple CLOZUK waves including CLOZUK2 and CLOZUK3 per Pardiñas et al. 2023)	Field-cited	Pardiñas et al. 2023 — Clozapine pharmacokinetics CLOZUK / ZTAS (Lancet Psychiatry) https://doi.org/10.1016/S2215-0366(23)00002-0 Section: Longitudinal framing + waves “longitudinal analysis and genome-wide association study” Page: https://doi.org/10.1016/S2215-0366(23)00002-0 Text field summarises multi-year ZTAS monitoring waves described in manuscripts.	Response for Follow-up durationAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Last data collection date Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: CLOZUK3 end date not reduced to a single last_data_collection_date in reviewed abstract snapshot.	Response for Last data collection dateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Recruitment start date Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: no ISO recruitment_start_date in reviewed PubMed HTML; year_established captures earliest named wave start.	Response for Recruitment start dateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Recruitment end date Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: monitoring programme ongoing; no closed recruitment date in reviewed abstract snapshot.	Response for Recruitment end dateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Diagnosis areas

Mental health diagnosis areas represented in this cohort.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Diagnosis area: Treatment-resistant schizophrenia Recommended Confirm this diagnosis area applies and estimated N if shown.	Treatment-resistant schizophrenia · Psychotic Disorders · est. n=11,260	Field-cited	Pardiñas et al. 2023 — Clozapine pharmacokinetics CLOZUK / ZTAS (Lancet Psychiatry) https://doi.org/10.1016/S2215-0366(23)00002-0 Section: Abstract “We report a new genome-wide association study of schizophrenia (11,260 cases and 24,542 controls)” Page: https://doi.org/10.1038/s41588-018-0059-2 estimated_n matches GWAS case enumeration for CLOZUK schizophrenia cases. Pardiñas et al. 2023 — Clozapine pharmacokinetics CLOZUK / ZTAS (Lancet Psychiatry) https://doi.org/10.1016/S2215-0366(23)00002-0 Section: Background “clozapine, is the only licensed drug against the treatment-resistant symptoms that affect 20-30% of people with schizophrenia” Page: https://pubmed.ncbi.nlm.nih.gov/36804072/ Maps DIGIT diagnosis_area_id=31 (Treatment-resistant schizophrenia) rather than generic schizophrenia (id=1): ZTAS/clozapine monitoring cohort is defined by clozapine prescribing for treatment-resistant illness.	Response for Diagnosis area: Treatment-resistant schizophreniaAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Diagnosis area: Treatment-resistant schizophrenia

Recommended

Confirm this diagnosis area applies and estimated N if shown.

Treatment-resistant schizophrenia · Psychotic Disorders · est. n=11,260

Field-cited

Pardiñas et al. 2023 — Clozapine pharmacokinetics CLOZUK / ZTAS (Lancet Psychiatry)
https://doi.org/10.1016/S2215-0366(23)00002-0
Section: Abstract
“We report a new genome-wide association study of schizophrenia (11,260 cases and 24,542 controls)”
Page: https://doi.org/10.1038/s41588-018-0059-2
estimated_n matches GWAS case enumeration for CLOZUK schizophrenia cases.
Pardiñas et al. 2023 — Clozapine pharmacokinetics CLOZUK / ZTAS (Lancet Psychiatry)
https://doi.org/10.1016/S2215-0366(23)00002-0
Section: Background
“clozapine, is the only licensed drug against the treatment-resistant symptoms that affect 20-30% of people with schizophrenia”
Page: https://pubmed.ncbi.nlm.nih.gov/36804072/
Maps DIGIT diagnosis_area_id=31 (Treatment-resistant schizophrenia) rather than generic schizophrenia (id=1): ZTAS/clozapine monitoring cohort is defined by clozapine prescribing for treatment-resistant illness.

AccurateNeeds correctionNot sureDoes not apply

Linked sites

Sites contributing participants or data to this cohort.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Linked site: Cardiff University Brain Research Imaging Centre Recommended	Cardiff University Brain Research Imaging Centre · Wales	Field-cited	Pocklington et al. 2018 — Common schizophrenia alleles (CLOZUK GWAS; Nat Genet) https://doi.org/10.1038/s41588-018-0059-2 Section: Author affiliations “MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK” Page: https://doi.org/10.1038/s41588-018-0059-2 National ZTAS sampling; Cardiff hosts CLOZUK analytics and data-access correspondence.	Response for Linked site: Cardiff University Brain Research Imaging CentreAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Verification metadata

Internal catalogue status — for reference only.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Verification status Recommended	unverified	Internal	Internal catalogue field	—	—
Last verified Recommended	16 Apr 2026	Internal	Internal catalogue field	—	—
Data source Recommended	Verified Apr 2026 from Pocklington et al. Nat Genet 2018 (DOI 10.1038/s41588-018-0059-2; PubMed 29483656 HTML snapshot), Pardiñas et al. Lancet Psychiatry 2023 (DOI 10.1016/S2215-0366(23)00002-0; PubMed 36804072 HTML snapshot), ClinicalTrials.gov API v2 query.term=CLOZUK (JSON snapshot), ISRCTN XML API q=CLOZUK (XML snapshot), HDR UK Innovation Gateway homepage snapshot (no dedicated CLOZUK dataset row isolated from quick browse context), DPUK portal homepage (dementia-focused catalogue; no CLOZUK listing), shared sources id=42 (Cardiff/CUBRIC anchor), id=3 (DPUK registry), id=1 (HDRUK gateway), id=11 (ClinicalTrials.gov), id=12 (ISRCTN).	Internal	Internal catalogue field	—	—