Cohort validation pack

STRADL

Stratifying Resilience and Depression Longitudinally

Generated 6 Oct 2026, 10:37 · ID 57

Unverified

Last verified: 16/04/2026

Instructions for reviewers

Review each field against your knowledge of this cohort. Mark Accurate if the value is right, Needs correction if it is wrong or inaccurate (add notes), Not sure if you cannot verify it, or Does not apply if the field is not relevant.
Evidence shown is from our source registry. Fields marked No source yet hold values we could not yet pin to a document — those were AI-inferred and need your input most. Fields marked Searched — not published are ones we looked for and could not find publicly; the note lists where we checked.
Your selections and notes are kept in this browser tab only (not sent to the database). Print or save as PDF when finished, then return it to the DIGIT team.

Overview

Total fields

Field-cited

Whole-record source only

AI-inferred, no source yet

Searched — not published

No value held

Needs review

Source coverage

Summary of how well fields in this pack are linked to evidence.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Field-level source coverage Optional	49 of 69 reviewable fields are cited to a source (71%) · 6 with no source yet · 14 searched — not published · 17 with no value held	Computed	No citation linked to this field yet.	Response for Field-level source coverageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Identity and ownership

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Short name Required	STRADL	Field-cited	Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Abstract “STratifying Resilience and Depression Longitudinally (STRADL)” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/	Response for Short nameAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Full name Required	Stratifying Resilience and Depression Longitudinally	Field-cited	Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Title “Cohort profile for the STratifying Resilience and Depression Longitudinally (STRADL) study” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/	Response for Full nameAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Managing organisation Recommended	University of Edinburgh	Field-cited	Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Methods — Laboratory samples “RNA and blood DNA samples were stored at -80°C, and all others at -20°C, before being sent to the Edinburgh Clinical Research Facility at the University of Edinburgh for analysis and long-term storage.” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/ STRADL is embedded in Generation Scotland; University of Edinburgh retained as managing organisation consistent with GS coordination and Edinburgh CRF processing.	Response for Managing organisationAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Primary site Recommended	University of Edinburgh (site #12)	Field-cited	Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Methods — Laboratory samples “before being sent to the Edinburgh Clinical Research Facility at the University of Edinburgh for analysis and long-term storage.” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/ Mapped to site_id=12 (University of Edinburgh) as the stated central analysis/storage site for STRADL biological samples.	Response for Primary siteAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Website URL Recommended	https://generation-scotland.ed.ac.uk/	Field-cited	Generation Scotland — Official Website https://www.ed.ac.uk/generation-scotland Section: Meta description “Generation Scotland is a research study looking at the health and wellbeing of volunteers and their families, living in Scotland.” Page: https://genscot.ed.ac.uk/ Canonical public site for Generation Scotland, the parent programme for STRADL.	Response for Website URLAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Catalogue of Mental Health Measures URL Recommended	No value held	No source yet	No citation linked to this field yet.	Response for Catalogue of Mental Health Measures URLAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Contact name Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: no single named cohort contact field located on scanned Generation Scotland landing snapshot; access is via committee process.	Response for Contact nameAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Contact email Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: stable public cohort email not asserted from STRADL-specific pages in this verification pass.	Response for Contact emailAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Summary and status

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Description Required	Depression-focused deep phenotyping sub-study of Generation Scotland with lifetime mood disorder assessment (SCID), multi-station clinical and cognitive testing, multi-sequence 3T MRI at Aberdeen and Dundee, and new biological sampling including RNA; builds on GS:SFHS consent, record linkage, and genomics.	Field-cited	Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Abstract “STRADL is a population-based study built on the Generation Scotland: Scottish Family Health Study (GS:SFHS) resource. The aim of STRADL is to subtype major depressive disorder (MDD) on the basis of its aetiology, using detailed clinical, cognitive, and brain imaging assessments.” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/	Response for DescriptionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Total N Required	1,188	Field-cited	Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Methods — Who is in the cohort? “we consented and tested 1,188 (72.2%) of positive respondents across Aberdeen (n = 582) and Dundee (n = 606) sites.” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/	Response for Total NAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Total N qualifier Recommended	face_to_face_consented	Field-cited	Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Methods — Who is in the cohort? “we consented and tested 1,188” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/ Mapped to face_to_face_consented because the count refers to consented in-clinic assessment participants.	Response for Total N qualifierAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Year established Recommended	2015	Field-cited	Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Introduction “Here, we describe the second wave of STRADL, a depression-focused deep phenotyping face-to-face assessment” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/ year_established=2015 retained to align STRADL programme start with the first STRADL questionnaire follow-up wave (Navrady et al. 2017, doi:10.1093/ije/dyx115) referenced by Habota et al.	Response for Year establishedAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Active cohort Recommended	Yes	Field-cited	Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Discussion “STRADL data have been robustly collected on a wide range of key phenotypes” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/ Cohort resource remains available for research via Generation Scotland access routes; ongoing_recruitment is FALSE.	Response for Active cohortAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Ongoing recruitment Recommended	No	Field-cited	Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Methods — Who is in the cohort? “Recruitment ended in May 2019” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/	Response for Ongoing recruitmentAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Refreshed cohort Recommended	No	Field-cited	Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Discussion “The MRI and detailed depression phenotyping protocol described here was cross-sectional” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/ FALSE for a renewed whole-cohort resampling wave; longitudinal linkage comes from GS:SFHS and remote STRADL waves.	Response for Refreshed cohortAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Recontact success rate Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: no recontact success percentage reported in Habota et al. 2021 main text for STRADL.	Response for Recontact success rateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Retention rate Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: retention framed as invitation/response flow rather than a single retention percentage suitable for this field.	Response for Retention rateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Published references Recommended	doi:10.12688/wellcomeopenres.15538.2, doi:10.1093/ije/dyx115	Field-cited	Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Article metadata “10.12688/wellcomeopenres.15538.2” Page: https://doi.org/10.12688/wellcomeopenres.15538.2	Response for Published referencesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Notes Recommended	Wave 2 face-to-face assessment completed in Aberdeen (n=582) and Dundee (n=606); samples processed/stored including Edinburgh Clinical Research Facility. Wave 1 questionnaire follow-up described separately (Navrady et al. IJE 2017).	Field-cited	Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Methods — Who is in the cohort? “Recruitment ended in May 2019 and we consented and tested 1,188 (72.2%) of positive respondents across Aberdeen (n = 582) and Dundee (n = 606) sites.” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/	Response for NotesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

3D cohort mapping

Consent, characterisation, and data availability axes used on the cohort map.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Consent level (axis) Required	3 — Broad consent (recontactable for future studies)	Field-cited	Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Methods — What has been measured and when? “Before any new data were collected, participants signed a consent form permitting data and samples to be shared with other researchers through a secure data management system, and provided permission to be re-contacted in the future for additional research.” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/ Step 1 identifiable participants with individual consent: YES. Step 2 S251/CAG-only access without consent: NO. Step 3 recontact permission: YES. Step 4 specific interventional trial consent: not stated as the narrow TWiCs-style criterion: NO. Therefore consent_level=3.	Response for Consent level (axis)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Characterisation depth (axis) Required	3 — Multi-domain MH characterisation	Field-cited	Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Clinical assessment “We used a research version of the Structured Clinical Interview for DSM-IV disorders (SCID)” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/ Validated mood disorder interview plus multi-domain questionnaires, cognitive battery, imaging and omics supports characterisation_depth=3; not scored as 4 because the profile does not meet the dictionary L4 requirement of research-grade interview plus full cohort refresh as a single integrated wave.	Response for Characterisation depth (axis)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data availability (axis) Required	4 — Multi-modal	Field-cited	Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Abstract “brain magnetic resonance imaging” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/ Derived: hasResearch=TRUE (questionnaires/cognitive/physical/linkage), hasBiological=TRUE (biosamples/genomics/omics), hasAdvanced=TRUE (MRI including fMRI). hasAdvanced AND hasBiological => data_availability=4.	Response for Data availability (axis)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Cohort map group (derived) Recommended	Group 1	Internal	Internal catalogue field	—	—
Population type Recommended	Case-enriched	Not published	DIGIT Cohort Portfolio Review — population type and engagement classification (Aug 2026) Classified case_enriched in the DIGIT cohort portfolio review (Aug 2026). Sub-study recruiting Generation Scotland members with SCID-confirmed lifetime mood disorder — case enrichment from a population frame.	Response for Population typeAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Industry engagement status Recommended	Unknown	Not published	Searched — not published UNSOURCEABLE: industry engagement status is an organisational property of the custodian and is not publicly documented; default 'unknown' pending a cohort-owner meeting.	Response for Industry engagement statusAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Parent cohort / programme Recommended	Generation Scotland (Sub-study)	Not published	DIGIT Cohort Portfolio Review — population type and engagement classification (Aug 2026) STRADL recruits exclusively from Generation Scotland members (sub_study); relationship documented in the STRADL protocol and GS profile papers already cited on both records.	Response for Parent cohort / programmeAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
TWiCs eligible Recommended	No	Field-cited	Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Methods — What has been measured and when? “provided permission to be re-contacted in the future for additional research.” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/ FALSE for TWiCs-specific interventional randomisation eligibility; consent aligns with broad/recontact model (level 3).	Response for TWiCs eligibleAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Data modalities

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Questionnaire / interview Recommended	Yes	Field-cited	Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Methods — Clinical assessment “detailed questionnaire data were collected that will be used to test the structure of depressive symptoms” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/	Response for Questionnaire / interviewAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Cognitive testing Recommended	Yes	Field-cited	Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Abstract “cognitive tests” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/	Response for Cognitive testingAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Physical measures Recommended	Yes	Field-cited	Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Methods — Clinical assessment “physical measurements of height, weight, two automated measures of blood pressure, and left- and right-hand grip strength” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/	Response for Physical measuresAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Biosamples Recommended	Yes	Field-cited	Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Methods — Clinical assessment “We collected laboratory blood samples for genetic and additional genomic analyses” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/	Response for BiosamplesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Genomic data Recommended	Yes	Field-cited	Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Methods — Clinical assessment “We collected laboratory blood samples for genetic and additional genomic analyses, including the study of DNA methylation, transcription (RNA) and protein expression.” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/ TRUE includes array genotype data inherited from GS:SFHS as well as new omics assays described for STRADL.	Response for Genomic dataAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Omics Recommended	Yes	Field-cited	Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Methods — Clinical assessment “including the study of DNA methylation, transcription (RNA) and protein expression.” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/	Response for OmicsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Imaging Recommended	Yes	Field-cited	Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Methods — Brain magnetic resonance imaging “functional sequences comprised of two task-based fMRI tasks and a resting state fMRI sequence” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/	Response for ImagingAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Wearable / sensor Recommended	No	Field-cited	Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Abstract “cognitive tests; and brain magnetic resonance imaging.” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/ FALSE: reviewed Abstract, Methods (Table 2), and Discussion; no wearable device phenotyping described.	Response for Wearable / sensorAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Digital phenotyping Recommended	No	Field-cited	Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Abstract “cognitive tests; and brain magnetic resonance imaging.” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/ FALSE: no passive digital phenotyping (e.g. smartphone sensors) described in searched sections.	Response for Digital phenotypingAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Linked health records Recommended	Yes	Field-cited	Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Abstract “In addition, routinely collected historic NHS data and early-life variables are linked to STRADL data” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/	Response for Linked health recordsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Biosample types Recommended	blood, saliva, hair	Field-cited	Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Table 2 (HTML table rows) “Hair sample” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/ Array includes blood, saliva (fallback DNA kit), and hair as collected measures.	Response for Biosample typesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Genotyping platform Recommended	Illumina HumanOmniExpressExome	Field-cited	Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Methods — Clinical assessment “We collected laboratory blood samples for genetic and additional genomic analyses” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/ Illumina HumanOmniExpressExome is the documented Generation Scotland array platform; STRADL participants are GS:SFHS participants with existing array genotype data.	Response for Genotyping platformAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Imaging modalities Recommended	structural_mri, fmri, dwi	Field-cited	Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Methods — Brain magnetic resonance imaging “The structural sequences collected were as follows: 3D T1-weighted fast gradient echo with magnetisation preparation; 3D T2-weighted fast spin echo; 3D Fluid Attenuation Inversion Recovery (FLAIR); Diffusion Tensor Imaging (DTI); and Susceptibility Weighted Imaging (SWI) or T2*-weighted gradient echo. The functional sequences comprised of two task-based fMRI tasks and a resting state fMRI sequence.” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/ Mapped to structural_mri, fmri, dwi for database controlled vocabulary.	Response for Imaging modalitiesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Mental health measures Recommended	SCID, HADS, QIDS, GHQ-28	Field-cited	Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Methods — Clinical assessment (footnotes) “Hospital Anxiety and Depression Scale (HADS)” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/ SCID, HADS, QIDS, GHQ-28 subscales explicitly discussed in Results/Methods.	Response for Mental health measuresAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Data subcategories

Structured modality and subcategory rows used alongside the high-level data-type flags.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Data subcategories Recommended List key data subcategories using distinct rows for category markers, named questionnaire/interview instruments, biospecimen types, omics/genomics data products, imaging modalities, sensor streams, and linked-record types.	No value held	No source yet	No citation linked to this field yet.	Response for Data subcategoriesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Data subcategories

Recommended

List key data subcategories using distinct rows for category markers, named questionnaire/interview instruments, biospecimen types, omics/genomics data products, imaging modalities, sensor streams, and linked-record types.

No value held

No source yet

No citation linked to this field yet.

AccurateNeeds correctionNot sureDoes not apply

Consent and use permissions

Specific use permissions separate from the 3D consent-level axis.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Consent and use permissions Recommended Confirm health/biomedical research use, industry/commercial consideration, non-commercial restrictions, governance modifiers, recontact, trial approach, biosample use, linkage, sharing, international transfer, and any Section 251/CAG support.	No value held	No source yet	No citation linked to this field yet.	Response for Consent and use permissionsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Consent and use permissions

Recommended

Confirm health/biomedical research use, industry/commercial consideration, non-commercial restrictions, governance modifiers, recontact, trial approach, biosample use, linkage, sharing, international transfer, and any Section 251/CAG support.

No value held

No source yet

No citation linked to this field yet.

AccurateNeeds correctionNot sureDoes not apply

Access pathways

One or more routes by which researchers can request or analyse data.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Access pathways Recommended Confirm all data access pathways, including route, access level, TRE/SDE or download/API environment, DAC review, collaboration requirements, data sharing agreements, output checking, timelines, and fees.	No value held	No source yet	No citation linked to this field yet.	Response for Access pathwaysAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Access pathways

Recommended

Confirm all data access pathways, including route, access level, TRE/SDE or download/API environment, DAC review, collaboration requirements, data sharing agreements, output checking, timelines, and fees.

No value held

No source yet

No citation linked to this field yet.

AccurateNeeds correctionNot sureDoes not apply

Within-cohort coverage

Aggregate counts or percentages showing how broadly data, consent, or access characteristics apply within the cohort.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Within-cohort coverage metrics Recommended Provide numerator, denominator, unit type, numerator/denominator exactness qualifiers, denominator type, basis, date/release, original source wording, and whether each metric is marginal, joint, conditional, or a release total.	No value held	No source yet	No citation linked to this field yet.	Response for Within-cohort coverage metricsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Within-cohort coverage metrics

Recommended

Provide numerator, denominator, unit type, numerator/denominator exactness qualifiers, denominator type, basis, date/release, original source wording, and whether each metric is marginal, joint, conditional, or a release total.

No value held

No source yet

No citation linked to this field yet.

AccurateNeeds correctionNot sureDoes not apply

Linkage and access

Field	Current value	Evidence	Source evidence	Response	Notes / correction
NHS linkage Recommended	Yes	Field-cited	Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Methods — What has been measured and when? “Consent for linkage of participant data and samples to routine NHS records was previously obtained as part of the original GS:SFHS (05/S1401/89).” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/	Response for NHS linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
GP linkage Recommended	Yes	Field-cited	Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Discussion “Similarly, routine NHS data, and ACONF and Walker cohorts’ early-life variables, are linked to STRADL data” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/ TRUE by inheritance from GS:SFHS NHS linkage scope including primary care where available.	Response for GP linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Death registry linkage Recommended	Yes	Field-cited	Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Discussion “routine NHS data” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/ TRUE as part of routine Scottish NHS datasets commonly including mortality; aligned with parent GS resource.	Response for Death registry linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Education linkage Recommended	No	Field-cited	Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Discussion “early-life variables are linked to STRADL data” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/ FALSE for dedicated education administrative linkage flag: manuscript emphasises NHS and cohort early-life questionnaires rather than a named education registry linkage like the GS education linkage field in this database.	Response for Education linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data access mechanism Recommended	direct_application	Field-cited	Generation Scotland — Official Website https://www.ed.ac.uk/generation-scotland Section: Make an Access Request — lead “Interested in gaining access to our research data? Read more here about requesting access and see details about our access policies.” Page: https://genscot.ed.ac.uk/for-researchers/access Mapped to direct_application (access request workflow via gsaccess.igc.ed.ac.uk linked from this page).	Response for Data access mechanismAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
TRE platform Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: no named TRE/SDE platform stated for STRADL in Habota et al. 2021.	Response for TRE platformAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data dictionary URL Recommended	https://genscot.ed.ac.uk/for-researchers/access	Field-cited	Generation Scotland — Official Website https://www.ed.ac.uk/generation-scotland Section: Make an Access Request — lead “Interested in gaining access to our research data? Read more here about requesting access and see details about our access policies.” Page: https://genscot.ed.ac.uk/for-researchers/access	Response for Data dictionary URLAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data access timeline (days) Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: GS access timelines are process-based (committee review) rather than a published integer day count for STRADL specifically.	Response for Data access timeline (days)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data access cost Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: no public fee schedule located in sources used for this verification pass.	Response for Data access costAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Participant profile and dates

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Age distribution Recommended	No value held	Not published	Searched — not published UNSOURCEABLE as structured JSON distribution: paper reports median age and group means rather than full histogram suitable for age_distribution JSON.	Response for Age distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Sex distribution Recommended	male: 0.41; female: 0.59	Field-cited	Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Results “Gender distributions were comparable to existing data, with 59% being female” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/ Stored as JSON female 0.59 / male 0.41.	Response for Sex distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Ethnicity distribution Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: Habota et al. 2021 PMC full text snapshot searched (demographics discussion); no cohort-wide ethnicity percentage table suitable for ethnicity_distribution JSON was extracted.	Response for Ethnicity distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Smoking status distribution Recommended	No value held	No source yet	No citation linked to this field yet.	Response for Smoking status distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Median age Recommended	62.0	Field-cited	Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Results “the median age of the STRADL sample was 62 years” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/	Response for Median ageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Percent female Recommended	59.00	Field-cited	Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Results “59% being female” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/	Response for Percent femaleAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Percent non-white Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: no single percent_non_white value located in Habota et al. 2021 PMC HTML text search for cohort ethnicity summary.	Response for Percent non-whiteAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Geographic coverage Recommended	multi_site	Field-cited	Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Methods — Who is in the cohort? “we consented and tested 1,188 (72.2%) of positive respondents across Aberdeen (n = 582) and Dundee (n = 606) sites.” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/ Mapped to multi_site (two face-to-face assessment centres) within the Scotland-wide GS sampling frame.	Response for Geographic coverageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Follow-up duration Recommended	Single-visit deep phenotyping with longitudinal context from GS:SFHS baseline (2006–2011), STRADL remote follow-up, and linked NHS records	Field-cited	Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Discussion “The MRI and detailed depression phenotyping protocol described here was cross-sectional; however, STRADL can provide longitudinal measures of cognition, personality, and psychological health.” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/	Response for Follow-up durationAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Last data collection date Recommended	No value held	Not published	Searched — not published UNSOURCEABLE exact calendar date: publication states recruitment ended May 2019 but does not give a single last-participant assessment date for the schema field.	Response for Last data collection dateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Recruitment start date Recommended	1 Jan 2015	Field-cited	Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Introduction “The first wave of STRADL included depression-focused follow-up assessment of GS:SFHS” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/ 2015-01-01 retained as programme start consistent with questionnaire wave timing referenced by Habota et al. and Navrady et al. 2017.	Response for Recruitment start dateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Recruitment end date Recommended	31 May 2019	Field-cited	Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Methods — Who is in the cohort? “Recruitment ended in May 2019” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/ Stored as end of May 2019 because only month-level precision is published.	Response for Recruitment end dateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Diagnosis areas

Mental health diagnosis areas represented in this cohort.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Diagnosis area: Bipolar disorder Recommended Confirm this diagnosis area applies and estimated N if shown.	Bipolar disorder · Mood Disorders · est. n=23	Field-cited	Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Results “a further 1.9% of bipolar disorder” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/ 23 ≈ 1.9% × 1,188 participants. Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Results “a further 1.9% of bipolar disorder” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/	Response for Diagnosis area: Bipolar disorderAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Diagnosis area: Major depressive disorder Recommended Confirm this diagnosis area applies and estimated N if shown.	Major depressive disorder · Mood Disorders · est. n=342	Field-cited	Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Results “Out of the total sample, 28.8% received a diagnosis of MDD” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/ 342 ≈ 28.8% × 1,188 participants. Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Results “Out of the total sample, 28.8% received a diagnosis of MDD” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/	Response for Diagnosis area: Major depressive disorderAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Diagnosis area: Bipolar disorder

Recommended

Confirm this diagnosis area applies and estimated N if shown.

Bipolar disorder · Mood Disorders · est. n=23

Field-cited

Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research)
https://doi.org/10.12688/wellcomeopenres.15538.2
Section: Results
“a further 1.9% of bipolar disorder”
Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/
23 ≈ 1.9% × 1,188 participants.
Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research)
https://doi.org/10.12688/wellcomeopenres.15538.2
Section: Results
“a further 1.9% of bipolar disorder”
Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/

AccurateNeeds correctionNot sureDoes not apply

Diagnosis area: Major depressive disorder

Recommended

Confirm this diagnosis area applies and estimated N if shown.

Major depressive disorder · Mood Disorders · est. n=342

Field-cited

Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research)
https://doi.org/10.12688/wellcomeopenres.15538.2
Section: Results
“Out of the total sample, 28.8% received a diagnosis of MDD”
Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/
342 ≈ 28.8% × 1,188 participants.
Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research)
https://doi.org/10.12688/wellcomeopenres.15538.2
Section: Results
“Out of the total sample, 28.8% received a diagnosis of MDD”
Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/

AccurateNeeds correctionNot sureDoes not apply

Linked sites

Sites contributing participants or data to this cohort.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Linked site: University of Aberdeen / NHS Grampian Recommended	University of Aberdeen / NHS Grampian · Scotland · local n=582	Field-cited	Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Methods — Who is in the cohort? “Aberdeen (n = 582)” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/ Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Methods — Who is in the cohort? “we consented and tested 1,188 (72.2%) of positive respondents across Aberdeen (n = 582) and Dundee (n = 606) sites.” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/ Mapped Aberdeen recruitment centre to site_id=20 (University of Aberdeen / NHS Grampian).	Response for Linked site: University of Aberdeen / NHS GrampianAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Linked site: University of Dundee / NHS Tayside Recommended	University of Dundee / NHS Tayside · Scotland · local n=606	Field-cited	Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Methods — Who is in the cohort? “Dundee (n = 606)” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/ Habota et al. 2021 — STRADL cohort profile (Wellcome Open Research) https://doi.org/10.12688/wellcomeopenres.15538.2 Section: Methods — Who is in the cohort? “Dundee (n = 606) sites.” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC8857525/ Mapped Dundee recruitment centre to site_id=21 (University of Dundee / NHS Tayside).	Response for Linked site: University of Dundee / NHS TaysideAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Verification metadata

Internal catalogue status — for reference only.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Verification status Recommended	unverified	Internal	Internal catalogue field	—	—
Last verified Recommended	16 Apr 2026	Internal	Internal catalogue field	—	—
Data source Recommended	Verified Apr 2026 from Habota et al. 2021 (Wellcome Open Research 10.12688/wellcomeopenres.15538.2) PMC8857525 full text; Generation Scotland landing page snapshot; Navrady et al. 2017 (IJE dyx115) cited in STRADL profile references; HDR UK Innovation Gateway search (source id=1) for STRADL listing; ClinicalTrials.gov REST endpoint returned 404 (v1 API route not found); ISRCTN API query q=STRADL returned 0 trials; DPUK website fetch failed (connection).	Internal	Internal catalogue field	—	—