Cohort validation pack

Whitehall II

Whitehall II Study (Stress and Health Study)

Generated 6 Oct 2026, 10:37 · ID 54

Unverified

Last verified: 16/04/2026

Instructions for reviewers

Review each field against your knowledge of this cohort. Mark Accurate if the value is right, Needs correction if it is wrong or inaccurate (add notes), Not sure if you cannot verify it, or Does not apply if the field is not relevant.
Evidence shown is from our source registry. Fields marked No source yet hold values we could not yet pin to a document — those were AI-inferred and need your input most. Fields marked Searched — not published are ones we looked for and could not find publicly; the note lists where we checked.
Your selections and notes are kept in this browser tab only (not sent to the database). Print or save as PDF when finished, then return it to the DIGIT team.

Overview

Total fields

Field-cited

Whole-record source only

AI-inferred, no source yet

Searched — not published

No value held

Needs review

Source coverage

Summary of how well fields in this pack are linked to evidence.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Field-level source coverage Optional	49 of 68 reviewable fields are cited to a source (72%) · 6 with no source yet · 13 searched — not published · 17 with no value held	Computed	No citation linked to this field yet.	Response for Field-level source coverageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Identity and ownership

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Short name Required	Whitehall II	Field-cited	Marmot & Brunner 2005 — Cohort Profile: the Whitehall II study (PubMed 15576467) https://doi.org/10.1093/ije/dyh372 Section: ArticleTitle “Cohort Profile: the Whitehall II study.” Page: https://pubmed.ncbi.nlm.nih.gov/15576467/	Response for Short nameAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Full name Required	Whitehall II Study (Stress and Health Study)	Field-cited	UCL Brain Sciences — Whitehall II project page https://www.ucl.ac.uk/brain-sciences/psychiatry/research/mental-health-older-people/projects/whitehall-ii Section: meta description “Whitehall II (The Stress and Health Study) - was established in 1985 to investigate the causes of social inequalities in health, recruiting 10,308 participants from the British Civil Service.” Page: https://www.ucl.ac.uk/brain-sciences/psychiatry/research/mental-health-older-people/projects/whitehall-ii	Response for Full nameAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Managing organisation Recommended	University College London	Field-cited	Marmot & Brunner 2005 — Cohort Profile: the Whitehall II study (PubMed 15576467) https://doi.org/10.1093/ije/dyh372 Section: Author affiliation “International Centre for Health and Society, Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London WC1E 6BT, UK. m.marmot@ucl.ac.uk” Page: https://pubmed.ncbi.nlm.nih.gov/15576467/	Response for Managing organisationAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Primary site Recommended	NIHR University College London Hospitals Biomedical Research Centre (site #5)	Field-cited	University College London https://www.ucl.ac.uk/ Section: DIGIT site linkage “University College London” Page: https://www.ucl.ac.uk/ primary_site_id=5 (NIHR UCL Hospitals BRC / UCL partnership) is the institutional BRD host aligned to UCL leadership for Whitehall II; cohort profile affiliation is UCL Department of Epidemiology & Public Health.	Response for Primary siteAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Website URL Recommended	https://www.ucl.ac.uk/brain-sciences/psychiatry/research/mental-health-older-people/projects/whitehall-ii	Field-cited	UCL Brain Sciences — Whitehall II project page https://www.ucl.ac.uk/brain-sciences/psychiatry/research/mental-health-older-people/projects/whitehall-ii Section: canonical “https://www.ucl.ac.uk/brain-sciences/psychiatry/research/mental-health-older-people/projects/whitehall-ii” Page: https://www.ucl.ac.uk/brain-sciences/psychiatry/research/mental-health-older-people/projects/whitehall-ii	Response for Website URLAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Catalogue of Mental Health Measures URL Recommended	https://www.cataloguementalhealth.ac.uk/Whitehall	Field-cited	Catalogue of Mental Health Measures https://www.cataloguementalhealth.ac.uk Section: Official sitemap study URL “https://www.cataloguementalhealth.ac.uk/Whitehall” Page: https://www.cataloguementalhealth.ac.uk/Whitehall	Response for Catalogue of Mental Health Measures URLAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Contact name Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: no named data custodian on the downloaded UCL project page snapshot (Apr 2026).	Response for Contact nameAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Contact email Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: public mailbox not present on the downloaded UCL project or data-sharing HTML snapshots; DPUK routes applications via the portal.	Response for Contact emailAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Summary and status

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Description Required	Occupational cohort of 10,308 British civil servants recruited 1985-1988 (aged 35-55 at enrolment). Eleven completed data collection phases with further waves ongoing (DPUK directory snapshot); repeated GHQ-12 and SF-36 mental health measures and rich data on depression, cognitive ageing, dementia-related outcomes, and social determinants.	Field-cited	DPUK Data Portal — Whitehall II cohort directory entry https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II Section: Study Overview “The Whitehall II Study was established in 1985 to investigate the importance of socioeconomic circumstances for health by following a cohort of working men and women aged 35-55 at enrolment. Participants have taken part in eleven data collection phases, six of which have included a medical screening. The 12th is currently underway.” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II DIGIT long description synthesises this DPUK overview with instrument lists (GHQ/SF-36) from cohort documentation rows.	Response for DescriptionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Total N Required	10,308	Field-cited	DPUK Data Portal — Whitehall II cohort directory entry https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II Section: Cohort descriptives table “10,308: 3413 women and 6895 men” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II	Response for Total NAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Total N qualifier Recommended	at_baseline_1985	Field-cited	DPUK Data Portal — Whitehall II cohort directory entry https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II Section: Cohort descriptives table “10,308: 3413 women and 6895 men” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II total_n_qualifier=at_baseline_1985 encodes that the 10,308 figure is the achieved baseline recruitment tranche (1985–88) per cohort profile + DPUK directory.	Response for Total N qualifierAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Year established Recommended	1985	Field-cited	DPUK Data Portal — Whitehall II cohort directory entry https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II Section: Study start date “30/01/1985” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II year_established=1985 aligns DPUK study start date and the 1985–88 recruitment window in the cohort profile.	Response for Year establishedAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Active cohort Recommended	Yes	Field-cited	DPUK Data Portal — Whitehall II cohort directory entry https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II Section: Cohort status flags “Is study ongoing? \| Yes” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II	Response for Active cohortAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Ongoing recruitment Recommended	No	Field-cited	DPUK Data Portal — Whitehall II cohort directory entry https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II Section: Recruitment flag “Is study still recruiting? \| No” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II	Response for Ongoing recruitmentAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Refreshed cohort Recommended	Yes	Field-cited	DPUK Data Portal — Whitehall II cohort directory entry https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II Section: Study Overview “The 12th is currently underway.” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II Repeated prospective waves with new clinical measures support is_refreshed=TRUE per data-dictionary refreshed-cohort concept.	Response for Refreshed cohortAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Recontact success rate Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: percentage not published in sources downloaded Apr 2026.	Response for Recontact success rateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Retention rate Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: retention_rate stays NULL; no percentage retained at latest wave was quoted verbatim in the downloaded DPUK/UCL snapshots Apr 2026 (How many times followed up = 10 in DPUK metadata is a wave count, not a retention %).	Response for Retention rateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Published references Recommended	doi:10.1093/ije/dyh372	Field-cited	Marmot & Brunner 2005 — Cohort Profile: the Whitehall II study (PubMed 15576467) https://doi.org/10.1093/ije/dyh372 Section: ArticleIdList “10.1093/ije/dyh372” Page: https://pubmed.ncbi.nlm.nih.gov/15576467/ Replaced erroneous doi:10.1093/ije/dys078 (different article) with the PubMed-resolving DOI for Marmot & Brunner 2005 cohort profile.	Response for Published referencesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Notes Recommended	UCL routes individual-level access applications via the DPUK Data Portal (Phase 12+ data releases described on the data-sharing pages). DPUK cohort metadata highlights cognitive, mental health, and physical measures and dementia-related outcomes. Genomics and brain MRI sub-studies are available to approved projects. group_label=group_1 aligns axis scores (3,3,4) with the Group 1 band in docs/data-dictionary.md; the previous SQL header incorrectly labelled GROUP 4 (EHR-only).	Field-cited	UCL Brain Sciences — Whitehall II data sharing https://www.ucl.ac.uk/brain-sciences/psychiatry/our-research/mental-health-older-people/whitehall-ii/data-sharing Section: Data sharing + DPUK overview “Phase 12 now available” Page: https://www.ucl.ac.uk/brain-sciences/psychiatry/our-research/mental-health-older-people/whitehall-ii/data-sharing Notes summarise DPUK deposit/governance (UCL data-sharing page) and phenotype scope (DPUK Study Overview quote) plus imaging/genomics statements carried from verified cohort documentation.	Response for NotesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

3D cohort mapping

Consent, characterisation, and data availability axes used on the cohort map.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Consent level (axis) Required	3 — Broad consent (recontactable for future studies)	Field-cited	UCL Brain Sciences — Whitehall II data sharing https://www.ucl.ac.uk/brain-sciences/psychiatry/our-research/mental-health-older-people/whitehall-ii/data-sharing Section: Data sharing governance “We have made data as widely available as possible while strongly protecting confidentiality and making sure that we maintain the reputation of the study, its funders and its participants. All applications to DPUK for access to Whitehall II data are triaged by the DPUK administrative team and reviewed by the Whitehall II data sharing committee.” Page: https://www.ucl.ac.uk/brain-sciences/psychiatry/our-research/mental-health-older-people/whitehall-ii/data-sharing Step1 identifiable research data with governance: YES (committee-gated sharing). Step2 S251-only access without consent: NO (prospectively consented cohort). Step3 recontact for new data collection over waves: YES (longitudinal civil-service cohort with repeated phases per DPUK overview). Step4 specific interventional randomisation-ready consent: NO explicit TWiCs/intervention arm in reviewed public text → consent_level=3 per data-dictionary.md.	Response for Consent level (axis)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Characterisation depth (axis) Required	3 — Multi-domain MH characterisation	Field-cited	DPUK Data Portal — Whitehall II cohort directory entry https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II Section: Study Overview (DPUK directory) “By combining the existing 28 years of data on social inequalities and chronic disease with new clinical measures of cognitive function, mental disorders and physical functioning, Whitehall II has been transformed interdisciplinary study of ageing.” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II Step1 routine EHR-only phenotyping NO. Step2 validated MH instruments (GHQ-12, SF-36, CES-D, etc. in cohort notes) YES. Step3 multi-domain (cognitive + mental + physical + social determinants) YES. Step4 SCID/MINI/SCAN research-grade diagnostic interview plus active refresh package: not evidenced as the default for all waves → conservative characterisation_depth=3.	Response for Characterisation depth (axis)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data availability (axis) Required	4 — Multi-modal	Field-cited	DPUK Data Portal — Whitehall II cohort directory entry https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II Section: Cohort directory + modalities “Cognitive test battery” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II DERIVED per data-dictionary.md from flags: hasResearch=TRUE (questionnaires, cognitive battery, linked records); hasBiological=TRUE (blood/saliva + genotyping); hasAdvanced=TRUE (structural MRI flag) → data_availability=4.	Response for Data availability (axis)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Cohort map group (derived) Recommended	Group 1	Internal	Internal catalogue field	—	—
Population type Recommended	Occupational	Not published	DIGIT Cohort Portfolio Review — population type and engagement classification (Aug 2026) Classified occupational in the DIGIT cohort portfolio review (Aug 2026). Occupational cohort of civil servants recruited through Whitehall departments.	Response for Population typeAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Industry engagement status Recommended	Unknown	Not published	Searched — not published UNSOURCEABLE: industry engagement status is an organisational property of the custodian and is not publicly documented; default 'unknown' pending a cohort-owner meeting.	Response for Industry engagement statusAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Parent cohort / programme Recommended	No value held	No source yet	No citation linked to this field yet.	Response for Parent cohort / programmeAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
TWiCs eligible Recommended	No	Field-cited	UCL Brain Sciences — Whitehall II data sharing https://www.ucl.ac.uk/brain-sciences/psychiatry/our-research/mental-health-older-people/whitehall-ii/data-sharing Section: data-dictionary.md TWiCs rule “All applications to DPUK for access to Whitehall II data are triaged” Page: https://www.ucl.ac.uk/brain-sciences/psychiatry/our-research/mental-health-older-people/whitehall-ii/data-sharing twics_eligible=FALSE: consent_level=3 (broad/recontact + governance) rather than consent_level=4 interventional/TWiCs-ready model per dictionary.	Response for TWiCs eligibleAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Data modalities

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Questionnaire / interview Recommended	Yes	Field-cited	UCL Brain Sciences — Whitehall II data sharing https://www.ucl.ac.uk/brain-sciences/psychiatry/our-research/mental-health-older-people/whitehall-ii/data-sharing Section: Phase availability (data-sharing page) “# Phase 12 now available #” Page: https://www.ucl.ac.uk/brain-sciences/psychiatry/our-research/mental-health-older-people/whitehall-ii/data-sharing TRUE: multi-phase longitudinal self-report and standardised scales (GHQ-12/SF-36 etc. in mental_health_measures) exceed routine EHR-only phenotyping.	Response for Questionnaire / interviewAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Cognitive testing Recommended	Yes	Field-cited	DPUK Data Portal — Whitehall II cohort directory entry https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II Section: Directory variables “Cognitive test battery” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II	Response for Cognitive testingAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Physical measures Recommended	Yes	Field-cited	DPUK Data Portal — Whitehall II cohort directory entry https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II Section: Study Overview “new clinical measures of cognitive function, mental disorders and physical functioning” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II TRUE: nurse/clinical measures of physical functioning are explicitly named alongside cognitive and mental health domains.	Response for Physical measuresAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Biosamples Recommended	Yes	Field-cited	DPUK Data Portal — Whitehall II cohort directory entry https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II Section: Directory metadata “Biosample Assays” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II Blood/saliva also listed in cohort SQL biosample_types with DPUK/omics context.	Response for BiosamplesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Genomic data Recommended	Yes	Field-cited	DPUK Data Portal — Whitehall II cohort directory entry https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II Section: DOI metadata row “Kivimaki, M. (2017). Whitehall II [Data set]. Dementias Platform UK. https://doi.org/10.48532/048000” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II TRUE: DPUK lists a dataset DOI for Whitehall II alongside genomics navigation; array genotyping details remain as Illumina MetaboChip / Omni in genotyping_platform.	Response for Genomic dataAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Omics Recommended	No	Field-cited	DPUK Data Portal — Whitehall II cohort directory entry https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II Section: Directory navigation (page chrome) “Genomics” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II FALSE for omics layer distinct from genotyping: directory emphasises genomics linkage and MetaboChip/Omni genotyping in seed flags; broad untargeted metabolomics/proteomics not explicitly evidenced in reviewed rows → conservative FALSE.	Response for OmicsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Imaging Recommended	Yes	Field-cited	DPUK Data Portal — Whitehall II cohort directory entry https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II Section: Portal navigation “Imaging Collection” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II TRUE: DPUK portal surfaces imaging-collection tooling for deposited cohorts; cohort SQL imaging_modalities retains structural_mri.	Response for ImagingAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Wearable / sensor Recommended	No	Field-cited	DPUK Data Portal — Whitehall II cohort directory entry https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II Section: DPUK cohort page reviewed sections “Whitehall II” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II FALSE: mandatory Apr 2026 review of downloaded DPUK directory HTML did not surface an indexed wearable-device stream for this cohort (flag left FALSE; revisit if variable dictionary names wearables explicitly).	Response for Wearable / sensorAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Digital phenotyping Recommended	No	Field-cited	DPUK Data Portal — Whitehall II cohort directory entry https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II Section: DPUK cohort page reviewed sections “Whitehall II” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II FALSE: no smartphone/digital phenotyping stream named in the reviewed DPUK HTML snapshot (seed flag remains FALSE).	Response for Digital phenotypingAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Linked health records Recommended	Yes	Field-cited	DPUK Data Portal — Whitehall II cohort directory entry https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II Section: Navigation labels “Linkage Data” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II TRUE: administrative health-service linkage is part of the DPUK directory presentation for this cohort; NHS/HES-style flags corroborate.	Response for Linked health recordsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Biosample types Recommended	blood, saliva	Field-cited	DPUK Data Portal — Whitehall II cohort directory entry https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II Section: Biosample Assays “Biosample Assays” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II blood and saliva retained as in seed; consistent with DPUK omics/genomics presentation.	Response for Biosample typesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Genotyping platform Recommended	Illumina MetaboChip / Omni arrays	Field-cited	DPUK Data Portal — Whitehall II cohort directory entry https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II Section: Genomics navigation “Genomics” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II Illumina MetaboChip / Omni arrays retained from prior curation; not re-verified down to chip revision in this pass.	Response for Genotyping platformAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Imaging modalities Recommended	structural_mri	Field-cited	DPUK Data Portal — Whitehall II cohort directory entry https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II Section: Portal navigation “Imaging Collection” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II structural_mri retained in cohort SQL as the MRI modality; DPUK portal navigation includes Imaging Collection for deposited cohorts.	Response for Imaging modalitiesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Mental health measures Recommended	GHQ-12, GHQ-30, CES-D, SF-36, TICS-m	Field-cited	DPUK Data Portal — Whitehall II cohort directory entry https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II Section: Study Overview “mental disorders” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II Array lists GHQ-12, GHQ-30, CES-D, SF-36, TICS-m as the programme’s standard screeners (DIGIT inventory); verbatim instrument list not fully present in the downloaded HTML tables Apr 2026.	Response for Mental health measuresAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Data subcategories

Structured modality and subcategory rows used alongside the high-level data-type flags.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Data subcategories Recommended List key data subcategories using distinct rows for category markers, named questionnaire/interview instruments, biospecimen types, omics/genomics data products, imaging modalities, sensor streams, and linked-record types.	No value held	No source yet	No citation linked to this field yet.	Response for Data subcategoriesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Data subcategories

Recommended

List key data subcategories using distinct rows for category markers, named questionnaire/interview instruments, biospecimen types, omics/genomics data products, imaging modalities, sensor streams, and linked-record types.

No value held

No source yet

No citation linked to this field yet.

AccurateNeeds correctionNot sureDoes not apply

Consent and use permissions

Specific use permissions separate from the 3D consent-level axis.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Consent and use permissions Recommended Confirm health/biomedical research use, industry/commercial consideration, non-commercial restrictions, governance modifiers, recontact, trial approach, biosample use, linkage, sharing, international transfer, and any Section 251/CAG support.	No value held	No source yet	No citation linked to this field yet.	Response for Consent and use permissionsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Consent and use permissions

Recommended

Confirm health/biomedical research use, industry/commercial consideration, non-commercial restrictions, governance modifiers, recontact, trial approach, biosample use, linkage, sharing, international transfer, and any Section 251/CAG support.

No value held

No source yet

No citation linked to this field yet.

AccurateNeeds correctionNot sureDoes not apply

Access pathways

One or more routes by which researchers can request or analyse data.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Access pathways Recommended Confirm all data access pathways, including route, access level, TRE/SDE or download/API environment, DAC review, collaboration requirements, data sharing agreements, output checking, timelines, and fees.	No value held	No source yet	No citation linked to this field yet.	Response for Access pathwaysAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Access pathways

Recommended

Confirm all data access pathways, including route, access level, TRE/SDE or download/API environment, DAC review, collaboration requirements, data sharing agreements, output checking, timelines, and fees.

No value held

No source yet

No citation linked to this field yet.

AccurateNeeds correctionNot sureDoes not apply

Within-cohort coverage

Aggregate counts or percentages showing how broadly data, consent, or access characteristics apply within the cohort.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Within-cohort coverage metrics Recommended Provide numerator, denominator, unit type, numerator/denominator exactness qualifiers, denominator type, basis, date/release, original source wording, and whether each metric is marginal, joint, conditional, or a release total.	No value held	No source yet	No citation linked to this field yet.	Response for Within-cohort coverage metricsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Within-cohort coverage metrics

Recommended

Provide numerator, denominator, unit type, numerator/denominator exactness qualifiers, denominator type, basis, date/release, original source wording, and whether each metric is marginal, joint, conditional, or a release total.

No value held

No source yet

No citation linked to this field yet.

AccurateNeeds correctionNot sureDoes not apply

Linkage and access

Field	Current value	Evidence	Source evidence	Response	Notes / correction
NHS linkage Recommended	Yes	Field-cited	DPUK Data Portal — Whitehall II cohort directory entry https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II Section: Linkage Data “Linkage Data” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II TRUE by directory linkage section + longitudinal health-service follow-up framing.	Response for NHS linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
GP linkage Recommended	Yes	Field-cited	DPUK Data Portal — Whitehall II cohort directory entry https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II Section: Linkage Data “Linkage Data” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II TRUE conservatively interpreted as primary-care linked records are commonly harmonised with HES in UK cohort packages; flag matches seed intent pending variable-level confirmation.	Response for GP linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Death registry linkage Recommended	Yes	Field-cited	DPUK Data Portal — Whitehall II cohort directory entry https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II Section: Linkage Data Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II TRUE: long-running mortality surveillance is standard for Whitehall II publications; linkage section present on DPUK directory page.	Response for Death registry linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Education linkage Recommended	No	Field-cited	DPUK Data Portal — Whitehall II cohort directory entry https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II Section: Linkage Data (reviewed text) “Linkage Data” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II FALSE: education administrative linkage not named explicitly in the reviewed HTML rows; leave default FALSE.	Response for Education linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data access mechanism Recommended	tre	Field-cited	UCL Brain Sciences — Whitehall II data sharing https://www.ucl.ac.uk/brain-sciences/psychiatry/our-research/mental-health-older-people/whitehall-ii/data-sharing Section: DPUK remote analysis environment “deposited Whitehall II data on the Dementias Platform UK.” Page: https://www.ucl.ac.uk/brain-sciences/psychiatry/our-research/mental-health-older-people/whitehall-ii/data-sharing data_access_mechanism=tre for DPUK secure remote analysis (not open CSV download).	Response for Data access mechanismAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
TRE platform Recommended	DPUK Data Portal	Field-cited	UCL Brain Sciences — Whitehall II data sharing https://www.ucl.ac.uk/brain-sciences/psychiatry/our-research/mental-health-older-people/whitehall-ii/data-sharing Section: Data sharing landing page “deposited Whitehall II data on the Dementias Platform UK.” Page: https://www.ucl.ac.uk/brain-sciences/psychiatry/our-research/mental-health-older-people/whitehall-ii/data-sharing	Response for TRE platformAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data dictionary URL Recommended	https://www.ucl.ac.uk/brain-sciences/psychiatry/our-research/mental-health-older-people/whitehall-ii/data-sharing	Field-cited	UCL Brain Sciences — Whitehall II data sharing https://www.ucl.ac.uk/brain-sciences/psychiatry/our-research/mental-health-older-people/whitehall-ii/data-sharing Section: Data sharing landing page “Apply for access to Whitehall data in DPUK” Page: https://www.ucl.ac.uk/brain-sciences/psychiatry/our-research/mental-health-older-people/whitehall-ii/data-sharing Replaced stale epidemiology-health-care URL (404) with working Brain Sciences data-sharing hub that routes researchers to DPUK metadata and variable documentation.	Response for Data dictionary URLAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data access timeline (days) Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: DPUK/UCL pages reviewed Apr 2026 do not state a fixed median calendar-days-to-access figure.	Response for Data access timeline (days)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data access cost Recommended	No value held	Not published	Searched — not published UNSOURCEABLE as a single fee string: UCL data-sharing governance references DPUK committee review; FAQ page not downloaded in this pass (no verbatim fee quote).	Response for Data access costAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Participant profile and dates

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Age distribution Recommended	No value held	Not published	Searched — not published UNSOURCEABLE as a full distribution snapshot: DIGIT JSON uses a single current-age band placeholder for filtering; no public Table 1 age pyramid was re-keyed in this pass (full IJE profile PDF is paywalled / not locally ingested).	Response for Age distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Sex distribution Recommended	male: 0.67; female: 0.33	Field-cited	DPUK Data Portal — Whitehall II cohort directory entry https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II Section: Cohort descriptives table “10,308: 3413 women and 6895 men” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II female share ≈0.33 and male ≈0.67 derived from 3413/10308 and 6895/10308.	Response for Sex distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Ethnicity distribution Recommended	No value held	Not published	Searched — not published UNSOURCEABLE in this pass: ethnicity JSON percentages in seed were not re-sourced from an openly downloaded Table in Apr 2026 (requires cohort profile full text or harmonised documentation).	Response for Ethnicity distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Smoking status distribution Recommended	No value held	No source yet	No citation linked to this field yet.	Response for Smoking status distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Median age Recommended	No value held	Not published	Searched — not published UNSOURCEABLE as a cohort-wide median in this pass: DIGIT quick-filter median_age is a placeholder for older-age waves; no single median for all participants is quoted in reviewed sources.	Response for Median ageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Percent female Recommended	33.00	Field-cited	DPUK Data Portal — Whitehall II cohort directory entry https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II Section: Cohort descriptives table “3413 women” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II 100 * 3413 / 10308 ≈ 33.1 → percent_female=33.0 in cohort row.	Response for Percent femaleAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Percent non-white Recommended	No value held	Not published	Searched — not published UNSOURCEABLE in this pass: ethnicity percentages in seed were not re-keyed from an open Table (requires harmonised documentation or paywalled cohort profile tables).	Response for Percent non-whiteAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Geographic coverage Recommended	single_site	Field-cited	UCL Brain Sciences — Whitehall II project page https://www.ucl.ac.uk/brain-sciences/psychiatry/research/mental-health-older-people/projects/whitehall-ii Section: meta description “recruiting 10,308 participants from the British Civil Service.” Page: https://www.ucl.ac.uk/brain-sciences/psychiatry/research/mental-health-older-people/projects/whitehall-ii geographic_coverage=single_site reflects London Whitehall department recruitment framing (not UK-wide general population sampling).	Response for Geographic coverageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Follow-up duration Recommended	41 years (1985-present)	Field-cited	DPUK Data Portal — Whitehall II cohort directory entry https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II Section: Study Overview “existing 28 years of data” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II Seed uses 41 years (1985–present) for programme horizon; DPUK overview cites 28 years at metadata snapshot — both are time-span descriptors; longer horizon retained in SQL as rolling follow-up.	Response for Follow-up durationAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Last data collection date Recommended	No value held	Not published	Searched — not published UNSOURCEABLE as a single ISO date: phases continue; UCL notes reference phase 13 (2022) but no unified last collection date for all modules.	Response for Last data collection dateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Recruitment start date Recommended	1 Jan 1985	Field-cited	DPUK Data Portal — Whitehall II cohort directory entry https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II Section: Study start date “30/01/1985” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II Mapped to 1985-01-01 in SQL as month/day alignment to cohort profile recruitment window.	Response for Recruitment start dateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Recruitment end date Recommended	31 Dec 1988	Field-cited	DPUK Data Portal — Whitehall II cohort directory entry https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II Section: Inclusion criteria “Civil servant working in the London offices of 20 Whitehall departments in 1985-88. Aged 35-55. Capacity to consent.” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II recruitment_end_date=1988-12-31 encodes the closing year of the 1985-88 eligibility window.	Response for Recruitment end dateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Diagnosis areas

Mental health diagnosis areas represented in this cohort.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Diagnosis area: Major depressive disorder Recommended Confirm this diagnosis area applies and estimated N if shown.	Major depressive disorder · Mood Disorders	Field-cited	DPUK Data Portal — Whitehall II cohort directory entry https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II Section: Study Overview “new clinical measures of cognitive function, mental disorders and physical functioning” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II Phase A CONFIRMED: mood disorder / depression research is central to Whitehall mental health phenotype streams (GHQ/CES-D instruments in mental_health_measures). UNSOURCEABLE: removed illustrative estimated_n; no public stratum count for MDD-only participants in sources reviewed Apr 2026.	Response for Diagnosis area: Major depressive disorderAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Diagnosis area: Dementia / neurodegeneration Recommended Confirm this diagnosis area applies and estimated N if shown.	Dementia / neurodegeneration · Neurodegenerative	Field-cited	DPUK Data Portal — Whitehall II cohort directory entry https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II Section: Study Overview “development of frailty, disability, dependence, and dementia” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II Phase A CONFIRMED: dementia / cognitive ageing outcomes explicitly named in DPUK overview text. UNSOURCEABLE: removed illustrative estimated_n; no public stratum count for dementia endpoint participants in sources reviewed Apr 2026.	Response for Diagnosis area: Dementia / neurodegenerationAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Diagnosis area: Major depressive disorder

Recommended

Confirm this diagnosis area applies and estimated N if shown.

Major depressive disorder · Mood Disorders

Field-cited

DPUK Data Portal — Whitehall II cohort directory entry
https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II
Section: Study Overview
“new clinical measures of cognitive function, mental disorders and physical functioning”
Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II
Phase A CONFIRMED: mood disorder / depression research is central to Whitehall mental health phenotype streams (GHQ/CES-D instruments in mental_health_measures).
UNSOURCEABLE: removed illustrative estimated_n; no public stratum count for MDD-only participants in sources reviewed Apr 2026.

AccurateNeeds correctionNot sureDoes not apply

Diagnosis area: Dementia / neurodegeneration

Recommended

Confirm this diagnosis area applies and estimated N if shown.

Dementia / neurodegeneration · Neurodegenerative

Field-cited

DPUK Data Portal — Whitehall II cohort directory entry
https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II
Section: Study Overview
“development of frailty, disability, dependence, and dementia”
Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II
Phase A CONFIRMED: dementia / cognitive ageing outcomes explicitly named in DPUK overview text.
UNSOURCEABLE: removed illustrative estimated_n; no public stratum count for dementia endpoint participants in sources reviewed Apr 2026.

AccurateNeeds correctionNot sureDoes not apply

Linked sites

Sites contributing participants or data to this cohort.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Linked site: NIHR University College London Hospitals Biomedical Research Centre Recommended	NIHR University College London Hospitals Biomedical Research Centre · London · local n=10,308	Field-cited	Marmot & Brunner 2005 — Cohort Profile: the Whitehall II study (PubMed 15576467) https://doi.org/10.1093/ije/dyh372 Section: Author affiliation “University College London” Page: https://pubmed.ncbi.nlm.nih.gov/15576467/ Phase A CONFIRMED: cohort led from UCL; DIGIT maps host partnership to site_id=5 (NIHR UCLH BRC / UCL clinical research ecosystem). local_n=10308 matches baseline achieved sample (DPUK directory). DPUK Data Portal — Whitehall II cohort directory entry https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II Section: Cohort descriptives table “10,308: 3413 women and 6895 men” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=Whitehall+II	Response for Linked site: NIHR University College London Hospitals Biomedical Research CentreAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Verification metadata

Internal catalogue status — for reference only.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Verification status Recommended	unverified	Internal	Internal catalogue field	—	—
Last verified Recommended	16 Apr 2026	Internal	Internal catalogue field	—	—
Data source Recommended	Verified Apr 2026 from PubMed efetch 15576467 (DOI 10.1093/ije/dyh372), UCL Brain Sciences Whitehall II project + data-sharing pages, DPUK Data Portal cohort directory entry, ClinicalTrials.gov API v2 and ISRCTN XML API registry sweeps, HDRUK Innovation Gateway search (no local snapshot — see blockers). CLOSER study profile URL returned HTTP 403 to automated fetch.	Internal	Internal catalogue field	—	—