Cohort validation pack

GLAD

Genetic Links to Anxiety and Depression

Generated 6 Oct 2026, 10:35 · ID 5

Unverified

Instructions for reviewers

Review each field against your knowledge of this cohort. Mark Accurate if the value is right, Needs correction if it is wrong or inaccurate (add notes), Not sure if you cannot verify it, or Does not apply if the field is not relevant.
Evidence shown is from our source registry. Fields marked No source yet hold values we could not yet pin to a document — those were AI-inferred and need your input most. Fields marked Searched — not published are ones we looked for and could not find publicly; the note lists where we checked.
Your selections and notes are kept in this browser tab only (not sent to the database). Print or save as PDF when finished, then return it to the DIGIT team.

Overview

Total fields

Field-cited

Whole-record source only

AI-inferred, no source yet

Searched — not published

No value held

Needs review

Source coverage

Summary of how well fields in this pack are linked to evidence.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Field-level source coverage Optional	81 of 92 reviewable fields are cited to a source (88%) · 0 with no source yet · 11 searched — not published · 9 with no value held	Computed	No citation linked to this field yet.	Response for Field-level source coverageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Identity and ownership

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Short name Required	GLAD	Field-cited	GLAD Study — Official Website https://gladstudy.org.uk/ Section: Page title “Genetic Links to Anxiety and Depression \| GLAD Study” Page: https://gladstudy.org.uk/	Response for Short nameAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Full name Required	Genetic Links to Anxiety and Depression	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: Abstract “The Genetic Links to Anxiety and Depression (GLAD) Study (www.gladstudy.org.uk) recruits individuals with depression or anxiety into the NIHR Mental Health BioResource.” Page: https://doi.org/10.1016/j.brat.2019.103503	Response for Full nameAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Managing organisation Recommended	King's College London / NIHR BioResource	Field-cited	NIHR BioResource https://bioresource.nihr.ac.uk Section: Page heading “Mental Health BioResource” Page: https://bioresource.nihr.ac.uk/centres-programmes/mental-health-bioresource/ Supplementary: GLAD operates within NIHR Mental Health BioResource governance (shared registry source id 2). GLAD Study — About the Study https://gladstudy.org.uk/about/ Section: Who runs GLAD? “GLAD is led by researchers at the National Institute for Health and Care Research (NIHR) Mental Health BioResource (part of the NIHR BioResource) at King's College London, in collaboration with Queen's University Belfast, University of Edinburgh, and Cardiff University.” Page: https://gladstudy.org.uk/about/	Response for Managing organisationAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Primary site Recommended	NIHR Maudsley Biomedical Research Centre (site #1)	Field-cited	NIHR Maudsley BRC — GLAD study story https://www.maudsleybrc.nihr.ac.uk/stories-of-research/genetic-links-to-anxiety-and-depression-glad-study/ Section: GLAD study story “Data and sample collection is organised by the BioResource for Mental Health theme at the Maudsley BRC and the central NIHR BioResource.” Page: https://www.maudsleybrc.nihr.ac.uk/stories-of-research/genetic-links-to-anxiety-and-depression-glad-study/ primary_site_id=1 (NIHR Maudsley BRC) is the operational hub named alongside central NIHR BioResource.	Response for Primary siteAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Website URL Recommended	https://gladstudy.org.uk/	Field-cited	GLAD Study — Official Website https://gladstudy.org.uk/ Section: Browser address “https://gladstudy.org.uk/” Page: https://gladstudy.org.uk/	Response for Website URLAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Catalogue of Mental Health Measures URL Recommended	https://www.cataloguementalhealth.ac.uk/GLAD	Field-cited	Catalogue of Mental Health Measures https://www.cataloguementalhealth.ac.uk Section: Official sitemap study URL “https://www.cataloguementalhealth.ac.uk/GLAD” Page: https://www.cataloguementalhealth.ac.uk/GLAD	Response for Catalogue of Mental Health Measures URLAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Contact name Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: No individually named public study coordinator required on Be Part of Research listing; team roster on website without assigning a single contact_name field.	Response for Contact nameAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Contact email Recommended	GLADstudy@kcl.ac.uk	Field-cited	NIHR Be Part of Research — GLAD (CPMS 40136) https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=21684 Section: Contact Information “GLADstudy@kcl.ac.uk” Page: https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=21684	Response for Contact emailAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Summary and status

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Description Required	UK-wide online cohort for anxiety and depression led by the NIHR Mental Health BioResource at King's College London, with academic collaborators in Belfast, Edinburgh, and Cardiff. Participants join via gladstudy.org.uk, complete questionnaires, provide saliva for DNA, and consent to record linkage and recontact for further studies.	Field-cited	GLAD Study — About the Study https://gladstudy.org.uk/about/ Section: What is GLAD? “The Genetic Links to Anxiety and Depression (GLAD) Study is a project set up to support studies exploring risk factors for depression and/or anxiety.” Page: https://gladstudy.org.uk/about/	Response for DescriptionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Total N Required	79,831	Field-cited	GLAD Study — Official Website https://gladstudy.org.uk/ Section: Homepage counter “79,831 people have signed up so far” Page: https://gladstudy.org.uk/ Counter reflects website sign-ups as of 2026-04-15, not audited consented N.	Response for Total NAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Total N qualifier Recommended	approximate	Field-cited	GLAD Study — Official Website https://gladstudy.org.uk/ Section: Homepage counter “79,831 people have signed up so far” Page: https://gladstudy.org.uk/ total_n_qualifier=approximate per data-dictionary.md (rolling website counter, not a formal audited census).	Response for Total N qualifierAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Year established Recommended	2018	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: Participants “The GLAD Study was launched in September 2018 to recruit a large, re-contactable sample of individuals with anxiety and/or depression to facilitate mental health research.” Page: https://doi.org/10.1186/s12888-023-04890-x	Response for Year establishedAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Active cohort Recommended	Yes	Field-cited	GLAD Study — About the Study https://gladstudy.org.uk/about/ Section: Eligibility / ongoing “The Genetic Links to Anxiety and Depression (GLAD) Study is currently only recruiting individuals over the age of 16.” Page: https://gladstudy.org.uk/	Response for Active cohortAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Ongoing recruitment Recommended	Yes	Field-cited	GLAD Study — About the Study https://gladstudy.org.uk/about/ Section: Can I take part “The Genetic Links to Anxiety and Depression (GLAD) Study is currently only recruiting individuals over the age of 16.” Page: https://gladstudy.org.uk/	Response for Ongoing recruitmentAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Refreshed cohort Recommended	Yes	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: 2.3.2. Optional questionnaires “Additional follow-up questionnaires will be sent to participants annually to provide longitudinal data on symptoms and outcomes.” Page: https://doi.org/10.1016/j.brat.2019.103503	Response for Refreshed cohortAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Recontact success rate Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: COPING participation paper reports recontact uptake for one sub-study, not a cohort-wide recontact_success_rate metric.	Response for Recontact success rateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Retention rate Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: No single retention_rate published for entire GLAD cohort across all waves in sources reviewed.	Response for Retention rateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Published references Recommended	doi:10.1016/j.brat.2019.103503, doi:10.1186/s12888-023-04890-x	Field-cited	Bright et al. — Participation after re-contact (GLAD subset), BMC Psychiatry 2023 https://doi.org/10.1186/s12888-023-04890-x Section: Citation “doi:10.1186/s12888-023-04890-x” Page: https://doi.org/10.1186/s12888-023-04890-x Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: Citation “doi:10.1016/j.brat.2019.103503” Page: https://doi.org/10.1016/j.brat.2019.103503	Response for Published referencesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Notes Recommended	Homepage counter (Apr 2026): 79,831 people signed up. Healthy control arm (about 10,000) in progress per GLAD About page. NHS primary care sites also participate via NIHR Be Part of Research listings; hub sites in cohort_sites reflect named university/BRC leads.	Field-cited	GLAD Study — Official Website https://gladstudy.org.uk/ Section: Homepage + About “79,831 people have signed up so far ... We also want to recruit 10,000 individuals without any history of” Page: https://gladstudy.org.uk/about/	Response for NotesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

3D cohort mapping

Consent, characterisation, and data availability axes used on the cohort map.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Consent level (axis) Required	3 — Broad consent (recontactable for future studies)	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: 2.2. Sign-up process “As part of the consenting process participants agree to long-term storage of their sample, requests to complete follow-up questionnaires, anonymised data sharing, recontact for future research studies based on their phenotype/genotype information, and access to their full medical and health related records.” Page: https://doi.org/10.1016/j.brat.2019.103503 Step 1 identifiable=YES. Step 2 S251/CAG access=NO (voluntary consent). Step 3 recontact=YES (quote). Step 4 specific interventional consent for randomisation=NO (broad recontact and linkage). -> consent_level 3 per data-dictionary.md.	Response for Consent level (axis)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Characterisation depth (axis) Required	3 — Multi-domain MH characterisation	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: 2.3.1. Sign-up questionnaire “The sign-up questionnaire was designed to assess core demographic, mental and physical health, comorbidities, and personal information as well as detailed psychological and behavioural phenotyping relevant to anxiety and depression (for full measure names see Table 1).” Page: https://doi.org/10.1016/j.brat.2019.103503 Step 1 validated MH instruments YES (PHQ-9, GAD-7, adapted CIDI-SF items). Step 2 multiple domains beyond symptom scales YES (lifestyle, trauma, physical comorbidity, optional modules). Step 3 research-grade SCID/MINI plus active refresh=NO (online adapted measures; not Level 4). -> characterisation_depth 3.	Response for Characterisation depth (axis)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data availability (axis) Required	3 — Adds biological specimens/molecular data	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: Data type flags + derivation “Detailed online phenotyping combined with genetic and clinical data.” Page: https://doi.org/10.1016/j.brat.2019.103503 DERIVED per data-dictionary.md: hasResearch=TRUE (questionnaires, linked records consent); hasBiological=TRUE (saliva/DNA, genotyping); hasAdvanced=FALSE (no imaging/wearables/digital phenotyping flags). Formula -> data availability level 3.	Response for Data availability (axis)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Cohort map group (derived) Recommended	Group 2	Internal	Internal catalogue field	—	—
Population type Recommended	Case-enriched	Not published	DIGIT Cohort Portfolio Review — population type and engagement classification (Aug 2026) Classified case_enriched in the DIGIT cohort portfolio review (Aug 2026). Volunteers self-select on lifetime anxiety/depression via the gladstudy.org.uk sign-up criteria — case-enriched by design.	Response for Population typeAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Industry engagement status Recommended	Established access process	Not published	DIGIT Cohort Portfolio Review — population type and engagement classification (Aug 2026) Access and recontact operate through the established NIHR BioResource governance and application process.	Response for Industry engagement statusAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Parent cohort / programme Recommended	NBR-MH (Umbrella member)	Not published	DIGIT Cohort Portfolio Review — population type and engagement classification (Aug 2026) GLAD is a member study of the NIHR Mental Health BioResource umbrella (umbrella_member); membership stated on the BioResource programme page cited on both records.	Response for Parent cohort / programmeAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
TWiCs eligible Recommended	No	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: Data dictionary cross-check “recontact for future research studies” Page: https://doi.org/10.1016/j.brat.2019.103503 TWiCs eligibility requires consent_level=4 per data-dictionary.md; GLAD is broad consent recontact (level 3) -> twics_eligible=FALSE.	Response for TWiCs eligibleAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Data modalities

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Questionnaire / interview Recommended	Yes	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: 2.3.1. Sign-up questionnaire “Current depressive symptoms (PHQ-9 ...). Current general anxiety symptoms (GAD-7 ...).” Page: https://doi.org/10.1016/j.brat.2019.103503	Response for Questionnaire / interviewAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Cognitive testing Recommended	No	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: 2.3.1. Sign-up questionnaire “Current depressive symptoms (PHQ-9 (Kroenke, Spitzer, & Williams, 2001)), and those with a score of five or above on the PHQ 9 ... Other measures of current psychopathology included ... current general anxiety symptoms (GAD-7 ...)” Page: https://doi.org/10.1016/j.brat.2019.103503 Instruments are self-report questionnaires and adapted diagnostic screeners, not computerised cognitive test batteries (CANTAB/CogState). Per data-dictionary.md -> has_cognitive_data=FALSE.	Response for Cognitive testingAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Physical measures Recommended	No	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: 2.3.1 (physical health) “Participants self-reported physical health conditions by responding yes or no to prior diagnoses of: asthma, emphysema or chronic bronchitis, heart attack or angina, cancer ...” Page: https://doi.org/10.1016/j.brat.2019.103503 Self-reported morbidity checklist only; no objective anthropometry/vitals/blood panel collection described -> has_physical_measures=FALSE.	Response for Physical measuresAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Biosamples Recommended	Yes	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: 2.2. Sign-up process “Those who were eligible through screening were then sent a saliva kit through the post for DNA analysis.” Page: https://doi.org/10.1016/j.brat.2019.103503	Response for BiosamplesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Genomic data Recommended	Yes	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: Highlights “Detailed online phenotyping combined with genetic and clinical data.” Page: https://doi.org/10.1016/j.brat.2019.103503	Response for Genomic dataAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Omics Recommended	No	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: 2.3.1 / biological material “Those who were eligible through screening were then sent a saliva kit through the post for DNA analysis.” Page: https://doi.org/10.1016/j.brat.2019.103503 Protocol describes genotyping/DNA from saliva; no separate proteomics/metabolomics/transcriptomics data offering beyond genomics per data-dictionary Group B definitions -> has_omics_data=FALSE.	Response for OmicsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Imaging Recommended	No	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: Protocol “Personal information and phenotypic data are collected entirely online through the GLAD Study website” Page: https://doi.org/10.1016/j.brat.2019.103503 No neuroimaging acquisition described in core protocol -> FALSE.	Response for ImagingAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Wearable / sensor Recommended	No	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: Protocol “collected entirely online” Page: https://doi.org/10.1016/j.brat.2019.103503 No wearable sensor data stream described in protocol overview -> FALSE.	Response for Wearable / sensorAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Digital phenotyping Recommended	No	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: Protocol “collected entirely online” Page: https://doi.org/10.1016/j.brat.2019.103503 Online questionnaires are active digital data collection but not passive smartphone/sensor digital phenotyping per data-dictionary boundary -> FALSE.	Response for Digital phenotypingAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Linked health records Recommended	Yes	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: 2.2. Sign-up process “access to their full medical and health related records” Page: https://doi.org/10.1016/j.brat.2019.103503	Response for Linked health recordsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Biosample types Recommended	saliva	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: 2.2. Sign-up process “sent a saliva kit through the post for DNA analysis.” Page: https://doi.org/10.1016/j.brat.2019.103503	Response for Biosample typesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Genotyping platform Recommended	Illumina genotyping arrays (e.g. Global Screening Array; array version may vary by analysis wave)	Field-cited	NIHR Maudsley BRC — GLAD study story https://www.maudsleybrc.nihr.ac.uk/stories-of-research/genetic-links-to-anxiety-and-depression-glad-study/ Section: GLAD study story “Participants answer questionnaires and give saliva DNA sample.” Page: https://www.maudsleybrc.nihr.ac.uk/stories-of-research/genetic-links-to-anxiety-and-depression-glad-study/ Specific Illumina array revision not quoted on this page; cohort SQL uses cautious wording; confirm from BioResource data release notes.	Response for Genotyping platformAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Imaging modalities Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: NULL array; no imaging modality applicable.	Response for Imaging modalitiesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Mental health measures Recommended	PHQ-9, GAD-7, AUDIT, WEMWBS, PCL-6, MDQ, WSAS	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: Table 1 (excerpt) “Current depressive symptoms \| Patient Health Questionnaire 9-items (PHQ-9)” Page: https://doi.org/10.1016/j.brat.2019.103503	Response for Mental health measuresAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Data subcategories

Structured modality and subcategory rows used alongside the high-level data-type flags.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Data modality: DNA sample Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · biosamples · biospecimen type · parent: Biospecimen collection · DNA derived from saliva sample	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: Pilot modality classification “DNA derived from saliva sample” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: DNA sampleAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: Saliva sample Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · biosamples · biospecimen type · parent: Biospecimen collection · Postal saliva kit	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: Pilot modality classification “Postal saliva kit” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: Saliva sampleAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: Biospecimen collection Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · biosamples · category marker · Saliva sample for DNA analysis	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: Pilot modality classification “Saliva sample for DNA analysis” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: Biospecimen collectionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: Genotyping array Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available on application · genomics · derived genomic data · Genetic data available through NIHR BioResource collaboration routes	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: Pilot modality classification “Genetic data available through NIHR BioResource collaboration routes” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: Genotyping arrayAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: Linked NHS records Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available on application · linked health records · category marker · Consent includes access to full medical and health-related records	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: Pilot modality classification “Consent includes access to full medical and health-related records” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: Linked NHS recordsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: Linked GP records Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available on application · linked health records · linked record type · parent: Linked NHS records · Consent wording covers medical and health-related records; exact data cuts require custodian confirmation	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: Pilot modality classification “Consent wording covers medical and health-related records; exact data cuts require custodian confirmation” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: Linked GP recordsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: Questionnaire / interview data Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · questionnaires · category marker · Online sign-up and follow-up questionnaires	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: Pilot modality classification “Online sign-up and follow-up questionnaires” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: Questionnaire / interview dataAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: AUDIT Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · questionnaires · questionnaire instrument · parent: Questionnaire / interview data · AUDIT captured as part of mental health/lifestyle questionnaire content	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: Pilot modality classification “AUDIT captured as part of mental health/lifestyle questionnaire content” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: AUDITAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: GAD-7 Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · questionnaires · questionnaire instrument · parent: Questionnaire / interview data · GAD-7 collected in sign-up questionnaire	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: Pilot modality classification “GAD-7 collected in sign-up questionnaire” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: GAD-7AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: PHQ-9 Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · questionnaires · questionnaire instrument · parent: Questionnaire / interview data · PHQ-9 collected in sign-up questionnaire	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: Pilot modality classification “PHQ-9 collected in sign-up questionnaire” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: PHQ-9AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: CIDI-SF Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · questionnaires · structured interview · parent: Questionnaire / interview data · Adapted CIDI-SF lifetime diagnostic modules	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: Pilot modality classification “Adapted CIDI-SF lifetime diagnostic modules” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: CIDI-SFAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Consent and use permissions

Specific use permissions separate from the 3D consent-level axis.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Consent/use: Biosample research use Recommended Confirm status, population scope, whether the permission is a DUO-style restriction/permission or a local operational permission, and whether academic and industry/commercial use differ.	permitted · biosample use · local operational permission · Eligible participants with returned saliva kits · Consent includes long-term sample storage.	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: Pilot consent/use permission classification “Consent includes long-term sample storage.” Structured consent/use row derived from existing sourced consent and access statements. Status captures whether the permission is explicit, restricted, or unknown in public sources.	Response for Consent/use: Biosample research useAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Consent/use: Industry / commercial research considered Recommended Confirm status, population scope, whether the permission is a DUO-style restriction/permission or a local operational permission, and whether academic and industry/commercial use differ.	unknown · commercial use · local operational permission · Consented participants · Industry use is not represented as a structured public permission in the current seed source set.	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: Pilot consent/use permission classification “Industry use is not represented as a structured public permission in the current seed source set.” Structured consent/use row derived from existing sourced consent and access statements. Status captures whether the permission is explicit, restricted, or unknown in public sources.	Response for Consent/use: Industry / commercial research consideredAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Consent/use: Health record linkage permitted Recommended Confirm status, population scope, whether the permission is a DUO-style restriction/permission or a local operational permission, and whether academic and industry/commercial use differ.	permitted · data linkage · local operational permission · Consented participants · Consent includes access to full medical and health-related records.	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: Pilot consent/use permission classification “Consent includes access to full medical and health-related records.” Structured consent/use row derived from existing sourced consent and access statements. Status captures whether the permission is explicit, restricted, or unknown in public sources.	Response for Consent/use: Health record linkage permittedAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Consent/use: Data sharing permitted Recommended Confirm status, population scope, whether the permission is a DUO-style restriction/permission or a local operational permission, and whether academic and industry/commercial use differ.	permitted · data sharing · local operational permission · Consented participants · Protocol states anonymised data sharing within consent terms.	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: Pilot consent/use permission classification “Protocol states anonymised data sharing within consent terms.” Structured consent/use row derived from existing sourced consent and access statements. Status captures whether the permission is explicit, restricted, or unknown in public sources.	Response for Consent/use: Data sharing permittedAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Consent/use: Collaboration required Recommended Confirm status, population scope, whether the permission is a DUO-style restriction/permission or a local operational permission, and whether academic and industry/commercial use differ.	restricted · governance · duo modifier · Consented participants · Research use normally proceeds through NIHR BioResource governance and collaboration routes.	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: Pilot consent/use permission classification “Research use normally proceeds through NIHR BioResource governance and collaboration routes.” Structured consent/use row derived from existing sourced consent and access statements. Status captures whether the permission is explicit, restricted, or unknown in public sources.	Response for Consent/use: Collaboration requiredAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Consent/use: Participant recontact permitted Recommended Confirm status, population scope, whether the permission is a DUO-style restriction/permission or a local operational permission, and whether academic and industry/commercial use differ.	permitted · recontact · local operational permission · Consented participants · Participants consent to recontact for future research based on phenotype/genotype.	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: Pilot consent/use permission classification “Participants consent to recontact for future research based on phenotype/genotype.” Structured consent/use row derived from existing sourced consent and access statements. Status captures whether the permission is explicit, restricted, or unknown in public sources.	Response for Consent/use: Participant recontact permittedAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Consent/use: Health / medical / biomedical research use Recommended Confirm status, population scope, whether the permission is a DUO-style restriction/permission or a local operational permission, and whether academic and industry/commercial use differ.	permitted · research use · duo permission · DUO:0000002 · Consented participants · Subject to NIHR BioResource governance and collaboration approval.	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: Pilot consent/use permission classification “Subject to NIHR BioResource governance and collaboration approval.” Structured consent/use row derived from existing sourced consent and access statements. Status captures whether the permission is explicit, restricted, or unknown in public sources.	Response for Consent/use: Health / medical / biomedical research useAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Consent/use: Approach for trials permitted Recommended Confirm status, population scope, whether the permission is a DUO-style restriction/permission or a local operational permission, and whether academic and industry/commercial use differ.	restricted · trial approach · local operational permission · Consented participants · Participants can be recontacted for future research; trial-specific consent still required.	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: Pilot consent/use permission classification “Participants can be recontacted for future research; trial-specific consent still required.” Structured consent/use row derived from existing sourced consent and access statements. Status captures whether the permission is explicit, restricted, or unknown in public sources.	Response for Consent/use: Approach for trials permittedAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Access pathways

One or more routes by which researchers can request or analyse data.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Access pathway: Collaboration required Recommended Confirm route, access level, environment type, DAC review, collaboration, data sharing agreement, output checking, platform, timeline, cost, URL, and whether multiple routes are possible.	available on application · access level: custodian review · environment: other · collaboration required · data sharing agreement required · NIHR BioResource · https://gladstudy.org.uk/for-researchers/ · Researchers submit data/sample access requests and normally collaborate through NIHR BioResource governance.	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: Pilot data access pathway classification “Researchers submit data/sample access requests and normally collaborate through NIHR BioResource governance.” Structured access pathway row derived from existing sourced access mechanism, TRE, cost, and route fields.	Response for Access pathway: Collaboration requiredAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Access pathway: Managed access / DAC Recommended Confirm route, access level, environment type, DAC review, collaboration, data sharing agreement, output checking, platform, timeline, cost, URL, and whether multiple routes are possible.	available on application · access level: custodian review · environment: other · DAC review required · collaboration required · data sharing agreement required · NIHR BioResource · https://gladstudy.org.uk/for-researchers/ · Access approval and feasibility are governed by the BioResource access process.	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: Pilot data access pathway classification “Access approval and feasibility are governed by the BioResource access process.” Structured access pathway row derived from existing sourced access mechanism, TRE, cost, and route fields.	Response for Access pathway: Managed access / DACAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Access pathway: Collaboration required

Recommended

Confirm route, access level, environment type, DAC review, collaboration, data sharing agreement, output checking, platform, timeline, cost, URL, and whether multiple routes are possible.

available on application · access level: custodian review · environment: other · collaboration required · data sharing agreement required · NIHR BioResource · https://gladstudy.org.uk/for-researchers/ · Researchers submit data/sample access requests and normally collaborate through NIHR BioResource governance.

Field-cited

Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text)
https://doi.org/10.1016/j.brat.2019.103503
Section: Pilot data access pathway classification
“Researchers submit data/sample access requests and normally collaborate through NIHR BioResource governance.”
Structured access pathway row derived from existing sourced access mechanism, TRE, cost, and route fields.

AccurateNeeds correctionNot sureDoes not apply

Access pathway: Managed access / DAC

Recommended

Confirm route, access level, environment type, DAC review, collaboration, data sharing agreement, output checking, platform, timeline, cost, URL, and whether multiple routes are possible.

available on application · access level: custodian review · environment: other · DAC review required · collaboration required · data sharing agreement required · NIHR BioResource · https://gladstudy.org.uk/for-researchers/ · Access approval and feasibility are governed by the BioResource access process.

Field-cited

Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text)
https://doi.org/10.1016/j.brat.2019.103503
Section: Pilot data access pathway classification
“Access approval and feasibility are governed by the BioResource access process.”
Structured access pathway row derived from existing sourced access mechanism, TRE, cost, and route fields.

AccurateNeeds correctionNot sureDoes not apply

Within-cohort coverage

Aggregate counts or percentages showing how broadly data, consent, or access characteristics apply within the cohort.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Coverage: Questionnaire responses submitted Recommended Confirm numerator, denominator, unit type, exactness qualifiers, denominator type, basis, as-of date/release, source wording, and whether the metric is marginal, joint, conditional, or a release total.	>= 50,000 / >= 91,000 (54.95% indicative) · unit: participants · denominator: consented participants · basis: completed · status: available · release: NIHR BioResource public count · as of 16 Apr 2026 · scope: marginal · source value: 50,000+ questionnaire responses of 91,000+ GLAD participants · Both numerator and denominator are lower-bound public counts; computed percentage should be read as indicative only.	Field-cited	NIHR BioResource — Mental Health BioResource programme page https://www.bioresource.nihr.ac.uk/centres-programmes/mental-health-bioresource/ Section: GLAD recruitment stats “50,000 questionnaire responses submitted” Page: https://www.bioresource.nihr.ac.uk/centres-programmes/mental-health-bioresource/ Denominator uses the same page's 91,000+ GLAD consented participants, stored as 91,000 lower bound.	Response for Coverage: Questionnaire responses submittedAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Coverage: Saliva sample kits returned Recommended Confirm numerator, denominator, unit type, exactness qualifiers, denominator type, basis, as-of date/release, source wording, and whether the metric is marginal, joint, conditional, or a release total.	>= 35,000 / >= 91,000 (38.46% indicative) · unit: samples · denominator: consented participants · basis: collected · status: available · release: NIHR BioResource public count · as of 16 Apr 2026 · scope: marginal · source value: 35,000+ returned saliva kits of 91,000+ GLAD participants · Both numerator and denominator are lower-bound public counts; computed percentage should be read as indicative only.	Field-cited	NIHR BioResource — Mental Health BioResource programme page https://www.bioresource.nihr.ac.uk/centres-programmes/mental-health-bioresource/ Section: GLAD recruitment stats “35,000 saliva sample kits returned” Page: https://www.bioresource.nihr.ac.uk/centres-programmes/mental-health-bioresource/ Denominator uses the same page's 91,000+ GLAD consented participants, stored as 91,000 lower bound.	Response for Coverage: Saliva sample kits returnedAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Coverage: Questionnaire responses submitted

Recommended

Confirm numerator, denominator, unit type, exactness qualifiers, denominator type, basis, as-of date/release, source wording, and whether the metric is marginal, joint, conditional, or a release total.

>= 50,000 / >= 91,000 (54.95% indicative) · unit: participants · denominator: consented participants · basis: completed · status: available · release: NIHR BioResource public count · as of 16 Apr 2026 · scope: marginal · source value: 50,000+ questionnaire responses of 91,000+ GLAD participants · Both numerator and denominator are lower-bound public counts; computed percentage should be read as indicative only.

Field-cited

NIHR BioResource — Mental Health BioResource programme page
https://www.bioresource.nihr.ac.uk/centres-programmes/mental-health-bioresource/
Section: GLAD recruitment stats
“50,000 questionnaire responses submitted”
Page: https://www.bioresource.nihr.ac.uk/centres-programmes/mental-health-bioresource/
Denominator uses the same page's 91,000+ GLAD consented participants, stored as 91,000 lower bound.

AccurateNeeds correctionNot sureDoes not apply

Coverage: Saliva sample kits returned

Recommended

>= 35,000 / >= 91,000 (38.46% indicative) · unit: samples · denominator: consented participants · basis: collected · status: available · release: NIHR BioResource public count · as of 16 Apr 2026 · scope: marginal · source value: 35,000+ returned saliva kits of 91,000+ GLAD participants · Both numerator and denominator are lower-bound public counts; computed percentage should be read as indicative only.

Field-cited

NIHR BioResource — Mental Health BioResource programme page
https://www.bioresource.nihr.ac.uk/centres-programmes/mental-health-bioresource/
Section: GLAD recruitment stats
“35,000 saliva sample kits returned”
Page: https://www.bioresource.nihr.ac.uk/centres-programmes/mental-health-bioresource/
Denominator uses the same page's 91,000+ GLAD consented participants, stored as 91,000 lower bound.

AccurateNeeds correctionNot sureDoes not apply

Linkage and access

Field	Current value	Evidence	Source evidence	Response	Notes / correction
NHS linkage Recommended	Yes	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: 2.2. Sign-up process “access to their full medical and health related records” Page: https://doi.org/10.1016/j.brat.2019.103503 UK full medical records access for research implies NHS hospital episode and related secondary care data linkage where consented.	Response for NHS linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
GP linkage Recommended	Yes	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: 2.2. Sign-up process “access to their full medical and health related records” Page: https://doi.org/10.1016/j.brat.2019.103503 Full medical records in UK context includes primary care where available under consent and BioResource governance.	Response for GP linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Death registry linkage Recommended	No	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: Methods (linkage scope) “consent for medical record linkage and recontact” Page: https://doi.org/10.1016/j.brat.2019.103503 ONS mortality linkage not explicitly named in reviewed sections; conservative FALSE pending custodian metadata.	Response for Death registry linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Education linkage Recommended	No	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: Abstract “Participants invited to join the study (via media campaigns) provide demographic, environmental and genetic data, and consent for medical record linkage and recontact.” Page: https://doi.org/10.1016/j.brat.2019.103503 DfE/education administrative linkage not stated in abstract or sign-up overview -> FALSE.	Response for Education linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data access mechanism Recommended	collaboration	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: Access “Researchers wishing to access GLAD Study participants or data are invited to submit a data and sample access request to the NIHR BioResource to request a collaboration” Page: https://doi.org/10.1016/j.brat.2019.103503	Response for Data access mechanismAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
TRE platform Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: Access is NIHR BioResource governed; specific TRE product name for analysis environment not stated in reviewed public summaries.	Response for TRE platformAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data dictionary URL Recommended	https://gladstudy.org.uk/for-researchers/	Field-cited	Catalogue of Mental Health Measures https://www.cataloguementalhealth.ac.uk Section: Data access “Genetic data collected” Page: https://www.cataloguementalhealth.ac.uk/GLAD data_dictionary_url in cohort SQL points to gladstudy.org.uk/for-researchers/ as the study-maintained researcher portal; Catalogue confirms genetic data and linkage flags.	Response for Data dictionary URLAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data access timeline (days) Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: BioResource turnaround not quoted numerically in reviewed public pages.	Response for Data access timeline (days)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data access cost Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: Costs are collaboration-dependent and not published as a fixed tariff in reviewed sources.	Response for Data access costAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Participant profile and dates

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Age distribution Recommended	50+: 0.33; 18-25: 0.15; 26-35: 0.22; 36-50: 0.3	Field-cited	Bright et al. — Participation after re-contact (GLAD subset), BMC Psychiatry 2023 https://doi.org/10.1186/s12888-023-04890-x Section: Abstract / sample frame “The Genetic Links to Anxiety and Depression (GLAD) Study is a large cohort of individuals with lifetime anxiety and/or depression, designed to facilitate re-contact of participants for mental health research.” Page: https://doi.org/10.1186/s12888-023-04890-x JSON age bands retained from prior seed; Apr 2026 pass did not re-extract Table 1 percentages from PDF tables — flagged for human numeric refresh from latest GLAD descriptive tables.	Response for Age distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Sex distribution Recommended	male: 0.24; other: 0.01; female: 0.75	Field-cited	Bright et al. — Participation after re-contact (GLAD subset), BMC Psychiatry 2023 https://doi.org/10.1186/s12888-023-04890-x Section: Introduction (context) “female gender identity (ref: male)” Page: https://doi.org/10.1186/s12888-023-04890-x Participation paper references female majority; JSON sex split retained from prior seed pending re-pull from published Table 1.	Response for Sex distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Ethnicity distribution Recommended	asian: 0.03; black: 0.01; mixed: 0.02; other: 0.01; white: 0.93	Field-cited	Bright et al. — Participation after re-contact (GLAD subset), BMC Psychiatry 2023 https://doi.org/10.1186/s12888-023-04890-x Section: Discussion “certain populations were underrepresented, such as people from ethnic minority backgrounds.” Page: https://doi.org/10.1186/s12888-023-04890-x White majority approximate shares retained from prior seed; confirm against latest GLAD diversity report.	Response for Ethnicity distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Smoking status distribution Recommended	never: 0.506; former: 0.319; current: 0.175	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: Results 3.1, Table 2: Descriptors of GLAD sample, July 2019 “Smoking status: Current 17.5%; Former 31.9%; Never 50.6%” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC6891252/#tbl2 Percentages describe GLAD participants recruited before 25 July 2019 who completed the sign-up questionnaire (27,991 questionnaire completers reported in the surrounding results text). The paper does not publish category counts, so counts were not inferred.	Response for Smoking status distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Median age Recommended	42.6	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: Age distribution JSON “Age (continuous; measured in years)” Page: https://doi.org/10.1186/s12888-023-04890-x DERIVED: weighted midpoints of age_distribution bins (18-25,26-35,36-50,50+) with stated proportions yields ~42.6 years.	Response for Median ageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Percent female Recommended	75.00	Field-cited	Bright et al. — Participation after re-contact (GLAD subset), BMC Psychiatry 2023 https://doi.org/10.1186/s12888-023-04890-x Section: Results narrative “female gender identity (ref: male)” Page: https://doi.org/10.1186/s12888-023-04890-x 75% aligns with female-majority sample described across GLAD papers; use latest descriptive table when available.	Response for Percent femaleAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Percent non-white Recommended	7.00	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: Demographics JSON + discussion “self-identifying as White” Page: https://doi.org/10.1186/s12888-023-04890-x DERIVED: ethnicity_distribution white=0.93 -> approx 7% non-white for percent_non_white field.	Response for Percent non-whiteAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Geographic coverage Recommended	national	Field-cited	GLAD Study — About the Study https://gladstudy.org.uk/about/ Section: Can I take part in GLAD? “Live in the United Kingdom” Page: https://gladstudy.org.uk/about/ UK-wide online recruitment -> geographic_coverage national.	Response for Geographic coverageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Follow-up duration Recommended	2018–present; annual optional questionnaires	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: 2.3.2 “Additional follow-up questionnaires will be sent to participants annually” Page: https://doi.org/10.1016/j.brat.2019.103503	Response for Follow-up durationAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Last data collection date Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: Rolling online recruitment; no single last_data_collection_date published.	Response for Last data collection dateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Recruitment start date Recommended	17 Sept 2018	Field-cited	NIHR Be Part of Research — GLAD (CPMS 40136) https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=21684 Section: Recruitment dates “17 Sep 2018” Page: https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=21684	Response for Recruitment start dateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Recruitment end date Recommended	1 Sept 2028	Field-cited	NIHR Be Part of Research — GLAD (CPMS 40136) https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=21684 Section: Recruitment dates “01 Sep 2028” Page: https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=21684	Response for Recruitment end dateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Diagnosis areas

Mental health diagnosis areas represented in this cohort.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Diagnosis area: Major depressive disorder Recommended Confirm this diagnosis area applies and estimated N if shown.	Major depressive disorder · Mood Disorders	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: Results “The majority of participants reached diagnostic criteria for major depressive disorder” Page: https://doi.org/10.1016/j.brat.2019.103503 Major depressive disorder diagnosis area retained; mutually exclusive estimated_n not published -> NULL.	Response for Diagnosis area: Major depressive disorderAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Diagnosis area: Generalised anxiety disorder Recommended Confirm this diagnosis area applies and estimated N if shown.	Generalised anxiety disorder · Anxiety Disorders	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: Results “Over half the sample screen positively for a lifetime anxiety disorder, with panic disorder being the most common.” Page: https://doi.org/10.1016/j.brat.2019.103503 GAD row retained for GAD caseness; overlapping with MDD -> estimated_n NULL.	Response for Diagnosis area: Generalised anxiety disorderAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Diagnosis area: Social anxiety disorder Recommended Confirm this diagnosis area applies and estimated N if shown.	Social anxiety disorder · Anxiety Disorders	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: Table 1 “Lifetime social phobia \| Lifetime assessment of social phobia” Page: https://doi.org/10.1016/j.brat.2019.103503 Social anxiety disorder coverage confirmed; estimated_n NULL (overlap).	Response for Diagnosis area: Social anxiety disorderAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Diagnosis area: Panic disorder Recommended Confirm this diagnosis area applies and estimated N if shown.	Panic disorder · Anxiety Disorders	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: Results “panic disorder being the most common” Page: https://doi.org/10.1016/j.brat.2019.103503 Panic disorder row retained; estimated_n NULL (overlap).	Response for Diagnosis area: Panic disorderAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Linked sites

Sites contributing participants or data to this cohort.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Linked site: NIHR Maudsley Biomedical Research Centre Recommended	NIHR Maudsley Biomedical Research Centre · London	Field-cited	NIHR Maudsley BRC — GLAD study story https://www.maudsleybrc.nihr.ac.uk/stories-of-research/genetic-links-to-anxiety-and-depression-glad-study/ Section: Operations “Data and sample collection is organised by the BioResource for Mental Health theme at the Maudsley BRC and the central NIHR BioResource.” Page: https://www.maudsleybrc.nihr.ac.uk/stories-of-research/genetic-links-to-anxiety-and-depression-glad-study/	Response for Linked site: NIHR Maudsley Biomedical Research CentreAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Linked site: Queen's University Belfast Recommended	Queen's University Belfast · Northern Ireland	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: Author affiliations “School of Psychology, Queens University Belfast (QUB), Belfast, Northern Ireland, UK” Page: https://doi.org/10.1016/j.brat.2019.103503	Response for Linked site: Queen's University BelfastAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Linked site: University of Edinburgh Recommended	University of Edinburgh · Scotland	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: Author affiliations “Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinurgh, UK” Page: https://doi.org/10.1016/j.brat.2019.103503	Response for Linked site: University of EdinburghAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Linked site: Cardiff University Brain Research Imaging Centre Recommended	Cardiff University Brain Research Imaging Centre · Wales	Field-cited	Davies et al. — GLAD protocol, Behav Res Ther 2019 (PMC full text) https://doi.org/10.1016/j.brat.2019.103503 Section: Author affiliations “Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK” Page: https://doi.org/10.1016/j.brat.2019.103503 Linked to seed site 11 (Cardiff University CUBRIC) as the Cardiff University research infrastructure entry for Wales; Wales GLAD lead (Ian Jones) is based at Cardiff University per protocol author list.	Response for Linked site: Cardiff University Brain Research Imaging CentreAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Verification metadata

Internal catalogue status — for reference only.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Verification status Recommended	unverified	Internal	Internal catalogue field	—	—
Last verified Recommended	No value held	Internal	Internal catalogue field	—	—
Data source Recommended	Verified Apr 2026 from gladstudy.org.uk (home, about), Davies et al. 2019 Behav Res Ther (PMC6891252), Bright et al. 2023 BMC Psychiatry, NIHR Maudsley BRC GLAD story, NIHR Mental Health BioResource pages, NIHR Be Part of Research (trialId=21684); ClinicalTrials.gov v2 search returned no protocol titled GLAD; ISRCTN web UI timed out.	Internal	Internal catalogue field	—	—