Cohort validation pack

REACT

Remote Assessment of Disease and Relapse (RADAR-CNS)

Generated 6 Oct 2026, 10:36 · ID 35

Unverified

Last verified: 16/04/2026

Instructions for reviewers

Review each field against your knowledge of this cohort. Mark Accurate if the value is right, Needs correction if it is wrong or inaccurate (add notes), Not sure if you cannot verify it, or Does not apply if the field is not relevant.
Evidence shown is from our source registry. Fields marked No source yet hold values we could not yet pin to a document — those were AI-inferred and need your input most. Fields marked Searched — not published are ones we looked for and could not find publicly; the note lists where we checked.
Your selections and notes are kept in this browser tab only (not sent to the database). Print or save as PDF when finished, then return it to the DIGIT team.

Overview

Total fields

Field-cited

Whole-record source only

AI-inferred, no source yet

Searched — not published

No value held

Needs review

Source coverage

Summary of how well fields in this pack are linked to evidence.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Field-level source coverage Optional	37 of 67 reviewable fields are cited to a source (55%) · 7 with no source yet · 23 searched — not published · 28 with no value held	Computed	No citation linked to this field yet.	Response for Field-level source coverageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Identity and ownership

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Short name Required	REACT	Field-cited	DIGIT — data-population-plan.md (Group 3 cohort list) Section: Group 3 (16) “McPin, REACT, ZOE Health” Short name REACT is the grant Figure 1 label enumerated alongside other Group 3 cohorts in DIGIT data-population-plan.md. King's College London — RADAR-CNS programme overview https://www.kcl.ac.uk/research/radarcns Section: Heading “RADAR-CNS (Remote Assessment of Disease and Relapse – Central Nervous System)” Page: https://www.kcl.ac.uk/research/radarcns Supplementary context: public programme branding for the same umbrella initiative.	Response for Short nameAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Full name Required	Remote Assessment of Disease and Relapse (RADAR-CNS)	Field-cited	King's College London — RADAR-CNS programme overview https://www.kcl.ac.uk/research/radarcns Section: Heading “RADAR-CNS (Remote Assessment of Disease and Relapse – Central Nervous System)” Page: https://www.kcl.ac.uk/research/radarcns DIGIT cohort row appends (RADAR-CNS) to align short grant label REACT with the public programme title on the KCL overview.	Response for Full nameAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Managing organisation Recommended	King's College London / IMI RADAR-CNS consortium	Field-cited	King's College London — RADAR-CNS programme overview https://www.kcl.ac.uk/research/radarcns Section: Opening “It was jointly led by King's College London and Janssen Pharmaceutica NV, funded by the Innovative Medicines Initiative” Page: https://www.kcl.ac.uk/research/radarcns	Response for Managing organisationAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Primary site Recommended	NIHR Maudsley Biomedical Research Centre (site #1)	Field-cited	Matcham et al. — RADAR-MDD protocol, BMC Psychiatry 2019 https://doi.org/10.1186/s12888-019-2049-z Section: HTML citation metadata “King’s College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC6379954/ primary_site_id=1 (NIHR Maudsley BRC / KCL IoPPN hub) reflects the London academic lead for RADAR-MDD named in the protocol author institutions.	Response for Primary siteAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Website URL Recommended	https://www.radar-cns.org/	Field-cited	RADAR-CNS Programme — Official Website https://www.radar-cns.org/ Section: Consortium reference “https://www.radar-cns.org/” Page: https://www.radar-cns.org/ Shared registry source id 101 (RADAR-CNS programme site) matches cohort website_url.	Response for Website URLAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Catalogue of Mental Health Measures URL Recommended	No value held	No source yet	No citation linked to this field yet.	Response for Catalogue of Mental Health Measures URLAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Contact name Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: no single public cohort contact name for umbrella programme on KCL overview or radar-cns.org landing text reviewed.	Response for Contact nameAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Contact email Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: programme overview pages reviewed do not publish a stable umbrella contact email; RADAR: Engage substudy lists katie.white@kcl.ac.uk for that substudy only (NCT04972474), not adopted as umbrella cohort contact.	Response for Contact emailAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Summary and status

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Description Required	The IMI RADAR-CNS programme (Remote Assessment of Disease and Relapse in Central Nervous System), coordinated from King's College London with EFPIA partners, ran 2016–2022 and developed the open-source RADAR-base platform. It combined active smartphone tasks (validated questionnaires, speech tasks, THINC-IT cognitive screening) with passive smartphone sensors and wrist-worn wearables (e.g. Fitbit) in prospective studies across major depressive disorder (RADAR-MDD), epilepsy, and multiple sclerosis to explore remote relapse monitoring. Named alongside Our Future Health in Group 3 of the programme grant Figure 1.	Field-cited	King's College London — RADAR-CNS programme overview https://www.kcl.ac.uk/research/radarcns Section: Summary “RADAR-CNS was a major new research programme that developed new ways of monitoring major depressive disorder, epilepsy, and multiple sclerosis using wearable devices and smartphone technology.” Page: https://www.kcl.ac.uk/research/radarcns	Response for DescriptionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Total N Required	1,450	Field-cited	King's College London — RADAR-CNS programme overview https://www.kcl.ac.uk/research/radarcns Section: Scale “recruited 1450 individuals with brain disorders and collected over 62 TB of data.” Page: https://www.kcl.ac.uk/research/radarcns KCL summary N used as umbrella programme size; RADAR-MDD component alone targeted 600 (Matcham et al.).	Response for Total NAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Total N qualifier Recommended	approximate	Field-cited	King's College London — RADAR-CNS programme overview https://www.kcl.ac.uk/research/radarcns Section: Scale “recruited 1450 individuals” Page: https://www.kcl.ac.uk/research/radarcns total_n_qualifier=approximate per data-dictionary.md (rounded programme summary, not audited census-by-dataset).	Response for Total N qualifierAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Year established Recommended	2016	Field-cited	King's College London — RADAR-CNS programme overview https://www.kcl.ac.uk/research/radarcns Section: Funding period “The programme ran from 2016 to 2022.” Page: https://www.kcl.ac.uk/research/radarcns	Response for Year establishedAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Active cohort Recommended	No	Field-cited	King's College London — RADAR-CNS programme overview https://www.kcl.ac.uk/research/radarcns Section: Status “Project status: Completed” Page: https://www.kcl.ac.uk/research/radarcns Primary IMI programme concluded 2022; is_active=FALSE while RADAR-base platform continues for derivative studies.	Response for Active cohortAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Ongoing recruitment Recommended	No	Field-cited	Matcham et al. — RADAR-MDD protocol, BMC Psychiatry 2019 https://doi.org/10.1186/s12888-019-2049-z Section: Study design “The study involves no randomisation or intervention, and uses commercially available activity trackers and smartphone sensors.” Page: https://doi.org/10.1186/s12888-019-2049-z Primary RADAR-MDD protocol closed with programme end; ongoing_recruitment=FALSE.	Response for Ongoing recruitmentAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Refreshed cohort Recommended	Yes	Field-cited	Matcham et al. — RADAR-MDD protocol, BMC Psychiatry 2019 https://doi.org/10.1186/s12888-019-2049-z Section: Abstract / follow-up “The wearable device, smartphone sensors and questionnaires will collect data for up to 2-years” Page: https://doi.org/10.1186/s12888-019-2049-z Longitudinal repeated remote assessments on fixed schedule → satisfies periodic re-assessment of participants per data-dictionary.md.	Response for Refreshed cohortAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Recontact success rate Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: recontact success rate not published on sources reviewed.	Response for Recontact success rateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Retention rate Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: retention percentage not extracted in this pass from Matcham/KCL sources reviewed.	Response for Retention rateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Published references Recommended	doi:10.1186/s12888-019-2049-z	Field-cited	Matcham et al. — RADAR-MDD protocol, BMC Psychiatry 2019 https://doi.org/10.1186/s12888-019-2049-z Section: Citation “https://doi.org/10.1186/s12888-019-2049-z” Page: https://doi.org/10.1186/s12888-019-2049-z	Response for Published referencesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Notes Recommended	Programme recruitment target for RADAR-MDD alone was 600 participants (Matcham et al. 2019); KCL reports ~1450 participants across the full RADAR-CNS programme and >62 TB collected. Main IMI programme ended 2022; RADAR-base continues as an open research platform.	Field-cited	King's College London — RADAR-CNS programme overview https://www.kcl.ac.uk/research/radarcns Section: Scale + status “recruited 1450 individuals with brain disorders and collected over 62 TB of data.” Page: https://www.kcl.ac.uk/research/radarcns	Response for NotesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

3D cohort mapping

Consent, characterisation, and data availability axes used on the cohort map.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Consent level (axis) Required	3 — Broad consent (recontactable for future studies)	Field-cited	Matcham et al. — RADAR-MDD protocol, BMC Psychiatry 2019 https://doi.org/10.1186/s12888-019-2049-z Section: Eligibility / Table 1 “Able to give informed consent for participation.” Page: https://doi.org/10.1186/s12888-019-2049-z Step 1 identifiable participants YES. Step 2 S251/CAG-only access NO (prospective consent). Step 3 recontact: recruitment text notes contact from prior research cohorts who consented to research approaches. Step 4 interventional randomised trial consent for main RADAR-MDD observational protocol NO → Level 3 per data-dictionary.md.	Response for Consent level (axis)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Characterisation depth (axis) Required	3 — Multi-domain MH characterisation	Field-cited	Matcham et al. — RADAR-MDD protocol, BMC Psychiatry 2019 https://doi.org/10.1186/s12888-019-2049-z Section: Methods / aRMT “Cognitive function will also be measured using the THINC-IT® app, which has been specifically designed and validated to screen for cognitive dysfunction in depression” Page: https://doi.org/10.1186/s12888-019-2049-z Step 1 validated MH instruments YES (PHQ-8, IDS-SR, CIDI-SF, GAD-7). Step 2 multi-domain beyond symptoms YES (cognition via THINC-IT, speech tasks, passive physiology/behaviour via RMT). Step 3 research-grade SCID-class interview plus active cohort refresh NO → characterisation_depth 3.	Response for Characterisation depth (axis)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data availability (axis) Required	2 — Records + research data	Field-cited	Matcham et al. — RADAR-MDD protocol, BMC Psychiatry 2019 https://doi.org/10.1186/s12888-019-2049-z Section: Data type flags + derivation “Participants will be asked to wear a wrist-worn activity tracker and download several apps onto their smartphones.” Page: https://doi.org/10.1186/s12888-019-2049-z DERIVED: hasResearch=TRUE (questionnaires, cognitive tasks); hasBiological=FALSE; hasAdvanced=TRUE (wearables + passive smartphone sensors). Per data-dictionary.md pseudocode → level 2 (research data without biological archive).	Response for Data availability (axis)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Cohort map group (derived) Recommended	Group 3	Internal	Internal catalogue field	—	—
Population type Recommended	Clinical	Not published	DIGIT Cohort Portfolio Review — population type and engagement classification (Aug 2026) Classified clinical in the DIGIT cohort portfolio review (Aug 2026). RADAR-CNS remote-measurement cohorts recruited on clinical diagnoses; programme completed 2022.	Response for Population typeAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Industry engagement status Recommended	Unknown	Not published	Searched — not published UNSOURCEABLE: industry engagement status is an organisational property of the custodian and is not publicly documented; default 'unknown' pending a cohort-owner meeting.	Response for Industry engagement statusAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Parent cohort / programme Recommended	No value held	No source yet	No citation linked to this field yet.	Response for Parent cohort / programmeAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
TWiCs eligible Recommended	No	Field-cited	Matcham et al. — RADAR-MDD protocol, BMC Psychiatry 2019 https://doi.org/10.1186/s12888-019-2049-z Section: Study design “The study involves no randomisation or intervention” Page: https://doi.org/10.1186/s12888-019-2049-z TWiCs requires consent_level 4 per data-dictionary; umbrella observational consent model → twics_eligible=FALSE.	Response for TWiCs eligibleAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Data modalities

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Questionnaire / interview Recommended	Yes	Field-cited	Matcham et al. — RADAR-MDD protocol, BMC Psychiatry 2019 https://doi.org/10.1186/s12888-019-2049-z Section: aRMT “validated questionnaires to measure depressive symptoms ... measured via the 8-item Patient Health Questionnaire (PHQ8” Page: https://doi.org/10.1186/s12888-019-2049-z	Response for Questionnaire / interviewAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Cognitive testing Recommended	Yes	Field-cited	Matcham et al. — RADAR-MDD protocol, BMC Psychiatry 2019 https://doi.org/10.1186/s12888-019-2049-z Section: aRMT / cognition “Cognitive function will also be measured using the THINC-IT® app, which has been specifically designed and validated to screen for cognitive dysfunction in depression” Page: https://doi.org/10.1186/s12888-019-2049-z	Response for Cognitive testingAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Physical measures Recommended	No	Field-cited	Matcham et al. — RADAR-MDD protocol, BMC Psychiatry 2019 https://doi.org/10.1186/s12888-019-2049-z Section: Wearable / physiology framing “accelerometery and heart rate, which provide information about movement, daytime activity, sedentary activity, physical exercise, step count, sleep efficiency” Page: https://doi.org/10.1186/s12888-019-2049-z Measures derive from consumer wearable and phone sensors rather than research-grade anthropometry/vitals panels in clinic → classify under wearable/digital per data-dictionary boundaries, not has_physical_measures.	Response for Physical measuresAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Biosamples Recommended	No	Field-cited	Matcham et al. — RADAR-MDD protocol, BMC Psychiatry 2019 https://doi.org/10.1186/s12888-019-2049-z Section: Study design “RADAR-MDD is a multi-centre prospective observational cohort study in which 600 individuals with a recent history of MDD will be asked to download several RMT apps and use an activity tracker for up to 2 years of follow-up. The study involves no randomisation or intervention, and uses commercially available activity trackers and smartphone sensors.” Page: https://doi.org/10.1186/s12888-019-2049-z No biosample banking described in reviewed protocol sections → FALSE.	Response for BiosamplesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Genomic data Recommended	No	Field-cited	Matcham et al. — RADAR-MDD protocol, BMC Psychiatry 2019 https://doi.org/10.1186/s12888-019-2049-z Section: Study design “uses commercially available activity trackers and smartphone sensors.” Page: https://doi.org/10.1186/s12888-019-2049-z No genotyping/sequencing component described for RADAR-MDD in reviewed protocol summary → FALSE.	Response for Genomic dataAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Omics Recommended	No	Field-cited	Matcham et al. — RADAR-MDD protocol, BMC Psychiatry 2019 https://doi.org/10.1186/s12888-019-2049-z Section: Study design “uses commercially available activity trackers and smartphone sensors.” Page: https://doi.org/10.1186/s12888-019-2049-z No proteomics/metabolomics/transcriptomics data offering described → FALSE.	Response for OmicsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Imaging Recommended	No	Field-cited	Matcham et al. — RADAR-MDD protocol, BMC Psychiatry 2019 https://doi.org/10.1186/s12888-019-2049-z Section: Study design “activity trackers and smartphone sensors.” Page: https://doi.org/10.1186/s12888-019-2049-z No structural or functional neuroimaging acquisition described → FALSE.	Response for ImagingAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Wearable / sensor Recommended	Yes	Field-cited	Matcham et al. — RADAR-MDD protocol, BMC Psychiatry 2019 https://doi.org/10.1186/s12888-019-2049-z Section: Wearable sensors “The wearable device planned for use in RADAR-MDD is the FitBit Charge 2.” Page: https://doi.org/10.1186/s12888-019-2049-z	Response for Wearable / sensorAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Digital phenotyping Recommended	Yes	Field-cited	Matcham et al. — RADAR-MDD protocol, BMC Psychiatry 2019 https://doi.org/10.1186/s12888-019-2049-z Section: Passive RMT “Passive RMT (pRMT) uses sensors in activity monitors and smartphones to gather data with no input from the wearer” Page: https://doi.org/10.1186/s12888-019-2049-z Includes GPS, accelerometer, communication logs, ambient noise and light per same paragraph → meets passive smartphone/sensor digital phenotyping definition.	Response for Digital phenotypingAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Linked health records Recommended	No	Field-cited	Matcham et al. — RADAR-MDD protocol, BMC Psychiatry 2019 https://doi.org/10.1186/s12888-019-2049-z Section: Remote data collection summary “Research Electronic Data Capture (REDCap) software” Page: https://doi.org/10.1186/s12888-019-2049-z Core protocol emphasises REDCap-delivered research instruments and RMT; no NHS HES/GP administrative linkage described in reviewed sections → FALSE for has_linked_health_records (distinct from research data capture).	Response for Linked health recordsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Biosample types Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: remains NULL — no biosample types in reviewed RADAR-MDD protocol description.	Response for Biosample typesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Genotyping platform Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: remains NULL — genomics not part of reviewed design.	Response for Genotyping platformAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Imaging modalities Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: remains NULL — no imaging modalities.	Response for Imaging modalitiesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Mental health measures Recommended	PHQ-8, GAD-7, IDS-SR, CIDI-SF, RSES, LIDAS, THINC-IT cognitive battery	Field-cited	Matcham et al. — RADAR-MDD protocol, BMC Psychiatry 2019 https://doi.org/10.1186/s12888-019-2049-z Section: Outcome schedule / aRMT / relapse / baseline “Mood, PHQ8 (aRMT)” Page: https://doi.org/10.1186/s12888-019-2049-z mental_health_measures array aggregates instruments named in the protocol: PHQ-8 (table row), GAD-7 (schedule footnote Anxiety GAD7 (R)), IDS-SR and CIDI-SF (relapse section), RSES (aRMT section), LIDAS (baseline enrolment), THINC-IT cognitive battery (dedicated paragraph).	Response for Mental health measuresAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Data subcategories

Structured modality and subcategory rows used alongside the high-level data-type flags.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Data subcategories Recommended List key data subcategories using distinct rows for category markers, named questionnaire/interview instruments, biospecimen types, omics/genomics data products, imaging modalities, sensor streams, and linked-record types.	No value held	No source yet	No citation linked to this field yet.	Response for Data subcategoriesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Data subcategories

Recommended

List key data subcategories using distinct rows for category markers, named questionnaire/interview instruments, biospecimen types, omics/genomics data products, imaging modalities, sensor streams, and linked-record types.

No value held

No source yet

No citation linked to this field yet.

AccurateNeeds correctionNot sureDoes not apply

Consent and use permissions

Specific use permissions separate from the 3D consent-level axis.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Consent and use permissions Recommended Confirm health/biomedical research use, industry/commercial consideration, non-commercial restrictions, governance modifiers, recontact, trial approach, biosample use, linkage, sharing, international transfer, and any Section 251/CAG support.	No value held	No source yet	No citation linked to this field yet.	Response for Consent and use permissionsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Consent and use permissions

Recommended

Confirm health/biomedical research use, industry/commercial consideration, non-commercial restrictions, governance modifiers, recontact, trial approach, biosample use, linkage, sharing, international transfer, and any Section 251/CAG support.

No value held

No source yet

No citation linked to this field yet.

AccurateNeeds correctionNot sureDoes not apply

Access pathways

One or more routes by which researchers can request or analyse data.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Access pathways Recommended Confirm all data access pathways, including route, access level, TRE/SDE or download/API environment, DAC review, collaboration requirements, data sharing agreements, output checking, timelines, and fees.	No value held	No source yet	No citation linked to this field yet.	Response for Access pathwaysAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Access pathways

Recommended

Confirm all data access pathways, including route, access level, TRE/SDE or download/API environment, DAC review, collaboration requirements, data sharing agreements, output checking, timelines, and fees.

No value held

No source yet

No citation linked to this field yet.

AccurateNeeds correctionNot sureDoes not apply

Within-cohort coverage

Aggregate counts or percentages showing how broadly data, consent, or access characteristics apply within the cohort.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Within-cohort coverage metrics Recommended Provide numerator, denominator, unit type, numerator/denominator exactness qualifiers, denominator type, basis, date/release, original source wording, and whether each metric is marginal, joint, conditional, or a release total.	No value held	No source yet	No citation linked to this field yet.	Response for Within-cohort coverage metricsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Within-cohort coverage metrics

Recommended

Provide numerator, denominator, unit type, numerator/denominator exactness qualifiers, denominator type, basis, date/release, original source wording, and whether each metric is marginal, joint, conditional, or a release total.

No value held

No source yet

No citation linked to this field yet.

AccurateNeeds correctionNot sureDoes not apply

Linkage and access

Field	Current value	Evidence	Source evidence	Response	Notes / correction
NHS linkage Recommended	No	Field-cited	Matcham et al. — RADAR-MDD protocol, BMC Psychiatry 2019 https://doi.org/10.1186/s12888-019-2049-z Section: Remote data collection summary “Research Electronic Data Capture (REDCap) software” Page: https://doi.org/10.1186/s12888-019-2049-z Reviewed protocol foregrounds REDCap-delivered research measures and RMT; no NHS HES linkage described → has_nhs_linkage=FALSE.	Response for NHS linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
GP linkage Recommended	No	Field-cited	Matcham et al. — RADAR-MDD protocol, BMC Psychiatry 2019 https://doi.org/10.1186/s12888-019-2049-z Section: Remote data collection summary “Research Electronic Data Capture (REDCap) software” Page: https://doi.org/10.1186/s12888-019-2049-z No GP record linkage described in reviewed sections → has_gp_linkage=FALSE.	Response for GP linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Death registry linkage Recommended	No	Field-cited	Matcham et al. — RADAR-MDD protocol, BMC Psychiatry 2019 https://doi.org/10.1186/s12888-019-2049-z Section: Remote data collection summary “Research Electronic Data Capture (REDCap) software” Page: https://doi.org/10.1186/s12888-019-2049-z No ONS mortality linkage described in reviewed sections → has_death_registry_linkage=FALSE.	Response for Death registry linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Education linkage Recommended	No	Field-cited	Matcham et al. — RADAR-MDD protocol, BMC Psychiatry 2019 https://doi.org/10.1186/s12888-019-2049-z Section: Remote data collection summary “Research Electronic Data Capture (REDCap) software” Page: https://doi.org/10.1186/s12888-019-2049-z No education/DfE administrative linkage described → has_education_linkage=FALSE.	Response for Education linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data access mechanism Recommended	No value held	Not published	Searched — not published UNSOURCEABLE in this pass: access mechanism not standardised on pages reviewed; field left NULL pending RADAR-base / catalogue metadata review.	Response for Data access mechanismAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
TRE platform Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: TRE hosting not specified on KCL overview text reviewed.	Response for TRE platformAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data dictionary URL Recommended	No value held	Not published	Searched — not published UNSOURCEABLE in this pass: no single public data-dictionary URL identified on KCL overview or radar-cns.org text reviewed; candidate RADAR-base docs not pinned to stable URL in extraction.	Response for Data dictionary URLAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data access timeline (days) Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: not stated on sources reviewed.	Response for Data access timeline (days)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data access cost Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: not stated on sources reviewed.	Response for Data access costAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Participant profile and dates

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Age distribution Recommended	No value held	Not published	Searched — not published UNSOURCEABLE in this pass: no Table 1 age percentages extracted to JSON. Searched Matcham et al. 2019 BMC Psychiatry HTML (PMC6379954) methods; KCL programme summary page — no cohort-wide age band percentages suitable for JSON field.	Response for Age distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Sex distribution Recommended	No value held	Not published	Searched — not published UNSOURCEABLE in this pass: sex split not quoted in reviewed KCL summary or Matcham abstract sections used. Searched same sources as age_distribution.	Response for Sex distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Ethnicity distribution Recommended	No value held	Not published	Searched — not published UNSOURCEABLE in this pass: no ethnicity JSON extracted. Searched Matcham 2019 methods pages on PMC HTML; KCL RADAR-CNS overview — no suitable cohort-wide ethnicity percentages.	Response for Ethnicity distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Smoking status distribution Recommended	No value held	No source yet	No citation linked to this field yet.	Response for Smoking status distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Median age Recommended	No value held	Not published	Searched — not published UNSOURCEABLE in this pass: median age not stated in KCL summary or Matcham abstract/table excerpts reviewed.	Response for Median ageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Percent female Recommended	No value held	Not published	Searched — not published UNSOURCEABLE in this pass: sex percentage not extracted from reviewed sections.	Response for Percent femaleAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Percent non-white Recommended	No value held	Not published	Searched — not published UNSOURCEABLE in this pass: diversity percentages not extracted from reviewed sections.	Response for Percent non-whiteAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Geographic coverage Recommended	multi_site	Field-cited	Matcham et al. — RADAR-MDD protocol, BMC Psychiatry 2019 https://doi.org/10.1186/s12888-019-2049-z Section: Design “history of depressive disorder across three sites: London, Amsterdam and Barcelona.” Page: https://doi.org/10.1186/s12888-019-2049-z International multi-centre network, not UK-national → geographic_coverage multi_site per enumerated definition.	Response for Geographic coverageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Follow-up duration Recommended	Up to 24 months (RADAR-MDD); programme 2016–22	Field-cited	Matcham et al. — RADAR-MDD protocol, BMC Psychiatry 2019 https://doi.org/10.1186/s12888-019-2049-z Section: Abstract “collect data for up to 2-years” Page: https://doi.org/10.1186/s12888-019-2049-z King's College London — RADAR-CNS programme overview https://www.kcl.ac.uk/research/radarcns Section: Funding period “The programme ran from 2016 to 2022.” Page: https://www.kcl.ac.uk/research/radarcns Supplementary context for umbrella programme duration alongside per-participant RADAR-MDD follow-up.	Response for Follow-up durationAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Last data collection date Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: exact last collection date not extracted; programme ended 2022 per KCL page.	Response for Last data collection dateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Recruitment start date Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: calendar recruitment open date not pinned from reviewed pages (year_established uses programme start 2016).	Response for Recruitment start dateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Recruitment end date Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: programme-level close date not expressed as SQL DATE beyond 2022 narrative.	Response for Recruitment end dateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Diagnosis areas

Mental health diagnosis areas represented in this cohort.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Diagnosis area: Major depressive disorder Recommended Confirm this diagnosis area applies and estimated N if shown.	Major depressive disorder · Mood Disorders	Field-cited	Matcham et al. — RADAR-MDD protocol, BMC Psychiatry 2019 https://doi.org/10.1186/s12888-019-2049-z Section: Eligibility / Table 1 “Meet DSM-5 diagnostic criteria for diagnosis of non-psychotic MDD within the past 2 years.” Page: https://doi.org/10.1186/s12888-019-2049-z diagnosis_area_id=5 maps to Major depressive disorder per diagnosis_areas seed order.	Response for Diagnosis area: Major depressive disorderAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Diagnosis area: Major depressive disorder

Recommended

Confirm this diagnosis area applies and estimated N if shown.

Major depressive disorder · Mood Disorders

Field-cited

Matcham et al. — RADAR-MDD protocol, BMC Psychiatry 2019
https://doi.org/10.1186/s12888-019-2049-z
Section: Eligibility / Table 1
“Meet DSM-5 diagnostic criteria for diagnosis of non-psychotic MDD within the past 2 years.”
Page: https://doi.org/10.1186/s12888-019-2049-z
diagnosis_area_id=5 maps to Major depressive disorder per diagnosis_areas seed order.

AccurateNeeds correctionNot sureDoes not apply

Linked sites

Sites contributing participants or data to this cohort.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Linked site: NIHR Maudsley Biomedical Research Centre Recommended	NIHR Maudsley Biomedical Research Centre · London	Field-cited	Matcham et al. — RADAR-MDD protocol, BMC Psychiatry 2019 https://doi.org/10.1186/s12888-019-2049-z Section: Design “three sites: London, Amsterdam and Barcelona.” Page: https://doi.org/10.1186/s12888-019-2049-z site_id=1 NIHR Maudsley BRC / KCL hub is the UK site explicitly named in the depression arm; additional EU sites are not mapped to DIGIT site rows in this pass. King's College London — RADAR-CNS programme overview https://www.kcl.ac.uk/research/radarcns Section: Affiliation “NIHR Maudsley Biomedical Research Centre” Page: https://www.kcl.ac.uk/research/radarcns Supplementary evidence that KCL programme leadership sits with NIHR Maudsley BRC network.	Response for Linked site: NIHR Maudsley Biomedical Research CentreAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Verification metadata

Internal catalogue status — for reference only.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Verification status Recommended	unverified	Internal	Internal catalogue field	—	—
Last verified Recommended	16 Apr 2026	Internal	Internal catalogue field	—	—
Data source Recommended	Verified Apr 2026 from KCL RADAR-CNS programme page, Matcham et al. 2019 BMC Psychiatry (PMC6379954), ClinicalTrials.gov API (query RADAR-MDD; NCT04972474 RADAR: Engage), IMI/HDR grant registry source (Figure 1 cohort list), ISRCTN API (query RADAR-MDD; 0 trials). HDR UK web catalogue API was unreachable from the verification environment.	Internal	Internal catalogue field	—	—