Cohort validation pack

ALSPAC

Avon Longitudinal Study of Parents and Children

Generated 6 Oct 2026, 10:37 · ID 15

Unverified

Instructions for reviewers

Review each field against your knowledge of this cohort. Mark Accurate if the value is right, Needs correction if it is wrong or inaccurate (add notes), Not sure if you cannot verify it, or Does not apply if the field is not relevant.
Evidence shown is from our source registry. Fields marked No source yet hold values we could not yet pin to a document — those were AI-inferred and need your input most. Fields marked Searched — not published are ones we looked for and could not find publicly; the note lists where we checked.
Your selections and notes are kept in this browser tab only (not sent to the database). Print or save as PDF when finished, then return it to the DIGIT team.

Overview

Total fields

Field-cited

Whole-record source only

AI-inferred, no source yet

Searched — not published

No value held

Needs review

Source coverage

Summary of how well fields in this pack are linked to evidence.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Field-level source coverage Optional	49 of 69 reviewable fields are cited to a source (71%) · 6 with no source yet · 14 searched — not published · 20 with no value held	Computed	No citation linked to this field yet.	Response for Field-level source coverageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Identity and ownership

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Short name Required	ALSPAC	Field-cited	ALSPAC — University of Bristol homepage https://www.bristol.ac.uk/alspac/ Section: Homepage intro “Children of the 90s, also known as Avon Longitudinal Study of Parents and Children (ALSPAC)” Page: https://www.bristol.ac.uk/alspac/	Response for Short nameAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Full name Required	Avon Longitudinal Study of Parents and Children	Field-cited	ALSPAC — University of Bristol homepage https://www.bristol.ac.uk/alspac/ Section: Homepage intro “Children of the 90s, also known as Avon Longitudinal Study of Parents and Children (ALSPAC)” Page: https://www.bristol.ac.uk/alspac/	Response for Full nameAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Managing organisation Recommended	University of Bristol	Field-cited	DPUK Cohort Directory — ALSPAC (Children) https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=ALSPAC%20%28Children%29 Section: Cohort descriptives “Institution Name \| University of Bristol” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=ALSPAC%20%28Children%29	Response for Managing organisationAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Primary site Recommended	NIHR Bristol Biomedical Research Centre (site #8)	Field-cited	DPUK Cohort Directory — ALSPAC (Children) https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=ALSPAC%20%28Children%29 Section: Cohort descriptives “City \| Bristol” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=ALSPAC%20%28Children%29 primary_site_id=8 aligns ALSPAC with the Bristol host institution.	Response for Primary siteAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Website URL Recommended	https://www.bristol.ac.uk/alspac/	Field-cited	ALSPAC — University of Bristol homepage https://www.bristol.ac.uk/alspac/ Section: Browser URL “https://www.bristol.ac.uk/alspac/” Page: https://www.bristol.ac.uk/alspac/	Response for Website URLAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Catalogue of Mental Health Measures URL Recommended	https://www.cataloguementalhealth.ac.uk/ALSPAC	Field-cited	Catalogue of Mental Health Measures https://www.cataloguementalhealth.ac.uk Section: Official sitemap study URL “https://www.cataloguementalhealth.ac.uk/ALSPAC” Page: https://www.cataloguementalhealth.ac.uk/ALSPAC	Response for Catalogue of Mental Health Measures URLAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Contact name Recommended	Professor Nic Timpson	Field-cited	ALSPAC — Access data and samples https://www.bristol.ac.uk/alspac/researchers/access/ Section: About “The team is led by Professor Nic Timpson, who is Principal Investigator (PI) of Children of the 90s.” Page: https://www.bristol.ac.uk/alspac/about/	Response for Contact nameAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Contact email Recommended	alspac-data@bristol.ac.uk	Field-cited	ALSPAC — Access data and samples https://www.bristol.ac.uk/alspac/researchers/access/ Section: Request existing data “please email alspac-data@bristol.ac.uk” Page: https://www.bristol.ac.uk/alspac/researchers/access/	Response for Contact emailAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Summary and status

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Description Required	Multi-generational birth cohort ("Children of the 90s"). Originally recruited 14,541 pregnancies (1991-1992) with 14,901 cohort members alive at 1 year. Expanded to include next generation (G2/COCO90s). Extensive MH measures through postal questionnaires and clinic assessments across 30+ years.	Field-cited	ALSPAC — About page https://www.bristol.ac.uk/alspac/about/ Section: About “Based at the University of Bristol, Children of the 90s, also known as Avon Longitudinal Study of Parents and Children (ALSPAC), is a world-leading birth cohort study.” Page: https://www.bristol.ac.uk/alspac/about/	Response for DescriptionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Total N Required	14,901	Field-cited	DPUK Cohort Directory — ALSPAC (Children) https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=ALSPAC%20%28Children%29 Section: Cohort descriptives “15,589 fetuses, resulting in 14,901 children alive at 1 year of age” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=ALSPAC%20%28Children%29	Response for Total NAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Total N qualifier Recommended	approximate	Field-cited	DPUK Cohort Directory — ALSPAC (Children) https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=ALSPAC%20%28Children%29 Section: Cohort descriptives “15,589 fetuses, resulting in 14,901 children alive at 1 year of age” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=ALSPAC%20%28Children%29 Qualifier set to approximate because stored total_n represents one published cohort milestone (alive at 1 year), not the full evolving multi-generation active total.	Response for Total N qualifierAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Year established Recommended	1991	Field-cited	Fraser et al. — ALSPAC mothers cohort profile (IJE, 2013) https://doi.org/10.1093/ije/dys066 Section: Summary “expected date of delivery between 1st April 1991 and 31st December 1992” Page: https://doi.org/10.1093/ije/dys066 year_established=1991 from recruitment opening date.	Response for Year establishedAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Active cohort Recommended	Yes	Field-cited	ALSPAC — University of Bristol homepage https://www.bristol.ac.uk/alspac/ Section: Homepage “These women, the children arising from the pregnancy and now also their grandchildren have been followed up in detail ever since.” Page: https://www.bristol.ac.uk/alspac/	Response for Active cohortAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Ongoing recruitment Recommended	Yes	Field-cited	DPUK Cohort Directory — ALSPAC (Children) https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=ALSPAC%20%28Children%29 Section: Cohort descriptives “Is study still recruiting? \| Yes - 2nd generation” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=ALSPAC%20%28Children%29	Response for Ongoing recruitmentAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Refreshed cohort Recommended	Yes	Field-cited	DPUK Cohort Directory — ALSPAC (Children) https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=ALSPAC%20%28Children%29 Section: Cohort descriptives “Is study still recruiting? \| Yes - 2nd generation” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=ALSPAC%20%28Children%29	Response for Refreshed cohortAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Recontact success rate Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: no cohort-level recontact_success_rate percentage published in reviewed sources.	Response for Recontact success rateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Retention rate Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: no single cohort-wide retention_rate percentage published in reviewed sources.	Response for Retention rateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Published references Recommended	doi:10.1093/ije/dys064, doi:10.1093/ije/dys066	Field-cited	Boyd et al. — ALSPAC index offspring cohort profile (IJE, 2013) https://doi.org/10.1093/ije/dys064 Section: Citation “doi:10.1093/ije/dys064” Page: https://doi.org/10.1093/ije/dys064 Fraser et al. — ALSPAC mothers cohort profile (IJE, 2013) https://doi.org/10.1093/ije/dys066 Section: Citation “doi:10.1093/ije/dys066” Page: https://doi.org/10.1093/ije/dys066	Response for Published referencesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Notes Recommended	Multi-generational: G0 mothers, G0 partners, G1 offspring (now age 33-35), G2 offspring's children. Latest sweep ~3,975 participants. Variable search tool available. HDRUK Gateway listed.	Field-cited	ALSPAC — Explore data and samples https://www.bristol.ac.uk/alspac/researchers/our-data/ Section: Explore data and samples “We have a vast amount of biological samples and phenotypic, environmental, genetic and linkage data gathered from different cohort groups over the past 30 years.” Page: https://www.bristol.ac.uk/alspac/researchers/our-data/	Response for NotesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

3D cohort mapping

Consent, characterisation, and data availability axes used on the cohort map.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Consent level (axis) Required	3 — Broad consent (recontactable for future studies)	Field-cited	ALSPAC — University of Bristol homepage https://www.bristol.ac.uk/alspac/ Section: Current research “Questionnaires for particular cohorts and all participants.” Page: https://www.bristol.ac.uk/alspac/ Step 1 identifiable=YES (longitudinal participant follow-up and direct contact). Step 2 S251/CAG only=NO (participant-based cohort with direct participant interactions). Step 3 recontactable=YES (ongoing questionnaires/clinics and active participant registration pathways). Step 4 explicit interventional randomisation consent=not evidenced. -> consent_level 3.	Response for Consent level (axis)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Characterisation depth (axis) Required	3 — Multi-domain MH characterisation	Field-cited	Fraser et al. — ALSPAC mothers cohort profile (IJE, 2013) https://doi.org/10.1093/ije/dys066 Section: Summary “Mental health (repeatedly assessed depression and anxiety by using validated scales)” Page: https://doi.org/10.1093/ije/dys066 Step 1 validated MH instruments=YES. Step 2 multi-domain data=YES (clinical, cognitive, physical, biological). Step 3 SCID/MINI/SCAN plus active refresh=not evidenced. -> characterisation_depth 3.	Response for Characterisation depth (axis)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data availability (axis) Required	4 — Multi-modal	Field-cited	Boyd et al. — ALSPAC index offspring cohort profile (IJE, 2013) https://doi.org/10.1093/ije/dys064 Section: Abstract “The resource comprises a wide range of phenotypic and environmental measures in addition to biological samples, genetic (DNA on 11 343 children, genome-wide data on 8365 children, complete genome sequencing on 2000 children) and epigenetic (methylation sampling on 1000 children) information and linkage to health and administrative records.” Page: https://doi.org/10.1093/ije/dys064 DERIVED: hasResearch=TRUE (questionnaire/cognitive/physical/linkage), hasBiological=TRUE (biosamples/genomics/omics), hasAdvanced=TRUE (imaging modalities present). Formula -> data_availability 4.	Response for Data availability (axis)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Cohort map group (derived) Recommended	Group 1	Internal	Internal catalogue field	—	—
Population type Recommended	General population	Not published	DIGIT Cohort Portfolio Review — population type and engagement classification (Aug 2026) Classified general_population in the DIGIT cohort portfolio review (Aug 2026). Population birth cohort recruiting pregnancies in the Bristol area.	Response for Population typeAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Industry engagement status Recommended	Unknown	Not published	Searched — not published UNSOURCEABLE: industry engagement status is an organisational property of the custodian and is not publicly documented; default 'unknown' pending a cohort-owner meeting.	Response for Industry engagement statusAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Parent cohort / programme Recommended	No value held	No source yet	No citation linked to this field yet.	Response for Parent cohort / programmeAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
TWiCs eligible Recommended	No	Field-cited	Boyd et al. — ALSPAC index offspring cohort profile (IJE, 2013) https://doi.org/10.1093/ije/dys064 Section: Consent and follow-up context “The children from 14 541 pregnancies were recruited in 1990–92” Page: https://doi.org/10.1093/ije/dys064 TWiCs eligibility requires consent_level=4 and explicit randomisation-ready framework. Public documentation reviewed supports broad longitudinal cohort operations, not explicit cohort-embedded trial randomisation consent. -> FALSE.	Response for TWiCs eligibleAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Data modalities

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Questionnaire / interview Recommended	Yes	Field-cited	Boyd et al. — ALSPAC index offspring cohort profile (IJE, 2013) https://doi.org/10.1093/ije/dys064 Section: Abstract “Follow-up includes 59 questionnaires (4 weeks–18 years of age)” Page: https://doi.org/10.1093/ije/dys064	Response for Questionnaire / interviewAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Cognitive testing Recommended	Yes	Field-cited	ALSPAC — University of Bristol homepage https://www.bristol.ac.uk/alspac/ Section: Current research “A cognitive, hearing and vision clinic” Page: https://www.bristol.ac.uk/alspac/	Response for Cognitive testingAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Physical measures Recommended	Yes	Field-cited	Fraser et al. — ALSPAC mothers cohort profile (IJE, 2013) https://doi.org/10.1093/ije/dys066 Section: Summary “anthropometry, blood pressure, fat, lean and bone mass and carotid intima media thickness were assessed, and a fasting blood sample taken” Page: https://doi.org/10.1093/ije/dys066	Response for Physical measuresAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Biosamples Recommended	Yes	Field-cited	Boyd et al. — ALSPAC index offspring cohort profile (IJE, 2013) https://doi.org/10.1093/ije/dys064 Section: Abstract “biological samples” Page: https://doi.org/10.1093/ije/dys064	Response for BiosamplesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Genomic data Recommended	Yes	Field-cited	Boyd et al. — ALSPAC index offspring cohort profile (IJE, 2013) https://doi.org/10.1093/ije/dys064 Section: Abstract “genetic (DNA on 11 343 children, genome-wide data on 8365 children” Page: https://doi.org/10.1093/ije/dys064	Response for Genomic dataAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Omics Recommended	Yes	Field-cited	Boyd et al. — ALSPAC index offspring cohort profile (IJE, 2013) https://doi.org/10.1093/ije/dys064 Section: Abstract “epigenetic (methylation sampling on 1000 children)” Page: https://doi.org/10.1093/ije/dys064	Response for OmicsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Imaging Recommended	Yes	Field-cited	Fraser et al. — ALSPAC mothers cohort profile (IJE, 2013) https://doi.org/10.1093/ije/dys066 Section: Summary “fat, lean and bone mass” Page: https://doi.org/10.1093/ije/dys066 DXA-derived body composition supports imaging modality presence (dexa).	Response for ImagingAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Wearable / sensor Recommended	No	Field-cited	Fraser et al. — ALSPAC mothers cohort profile (IJE, 2013) https://doi.org/10.1093/ije/dys066 Section: Summary “physical activity (with accelerometer)” Page: https://doi.org/10.1093/ije/dys066 Accelerometer appears in selected follow-up modules; cohort-level wearable pipeline is not confirmed as broad-access archive in reviewed public metadata, so stored FALSE conservatively.	Response for Wearable / sensorAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Digital phenotyping Recommended	No	Field-cited	ALSPAC — Explore data and samples https://www.bristol.ac.uk/alspac/researchers/our-data/ Section: Explore data and samples “variable search tool” Page: https://www.bristol.ac.uk/alspac/researchers/our-data/ No passive smartphone/sensor behaviour stream explicitly documented in reviewed public metadata; set FALSE.	Response for Digital phenotypingAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Linked health records Recommended	Yes	Field-cited	Boyd et al. — ALSPAC index offspring cohort profile (IJE, 2013) https://doi.org/10.1093/ije/dys064 Section: Abstract “information and linkage to health and administrative records” Page: https://doi.org/10.1093/ije/dys064	Response for Linked health recordsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Biosample types Recommended	blood, urine, hair, nails, saliva, teeth	Field-cited	ALSPAC — Explore data and samples https://www.bristol.ac.uk/alspac/researchers/our-data/ Section: Biological samples “Participants have donated a range of samples, including blood, urine, hair, nails, saliva and teeth.” Page: https://www.bristol.ac.uk/alspac/researchers/our-data/	Response for Biosample typesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Genotyping platform Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: reviewed public summaries confirm genome-wide data but do not identify a single current platform string suitable for this field.	Response for Genotyping platformAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Imaging modalities Recommended	dexa	Field-cited	Fraser et al. — ALSPAC mothers cohort profile (IJE, 2013) https://doi.org/10.1093/ije/dys066 Section: Summary “fat, lean and bone mass” Page: https://doi.org/10.1093/ije/dys066 Stored imaging modality is conservative single-item array: dexa.	Response for Imaging modalitiesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Mental health measures Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: validated MH scale names are discussed in profile narrative but an authoritative structured public list was not available in reviewed pages for direct array population.	Response for Mental health measuresAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Data subcategories

Structured modality and subcategory rows used alongside the high-level data-type flags.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Data subcategories Recommended List key data subcategories using distinct rows for category markers, named questionnaire/interview instruments, biospecimen types, omics/genomics data products, imaging modalities, sensor streams, and linked-record types.	No value held	No source yet	No citation linked to this field yet.	Response for Data subcategoriesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Data subcategories

Recommended

List key data subcategories using distinct rows for category markers, named questionnaire/interview instruments, biospecimen types, omics/genomics data products, imaging modalities, sensor streams, and linked-record types.

No value held

No source yet

No citation linked to this field yet.

AccurateNeeds correctionNot sureDoes not apply

Consent and use permissions

Specific use permissions separate from the 3D consent-level axis.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Consent and use permissions Recommended Confirm health/biomedical research use, industry/commercial consideration, non-commercial restrictions, governance modifiers, recontact, trial approach, biosample use, linkage, sharing, international transfer, and any Section 251/CAG support.	No value held	No source yet	No citation linked to this field yet.	Response for Consent and use permissionsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Consent and use permissions

Recommended

Confirm health/biomedical research use, industry/commercial consideration, non-commercial restrictions, governance modifiers, recontact, trial approach, biosample use, linkage, sharing, international transfer, and any Section 251/CAG support.

No value held

No source yet

No citation linked to this field yet.

AccurateNeeds correctionNot sureDoes not apply

Access pathways

One or more routes by which researchers can request or analyse data.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Access pathways Recommended Confirm all data access pathways, including route, access level, TRE/SDE or download/API environment, DAC review, collaboration requirements, data sharing agreements, output checking, timelines, and fees.	No value held	No source yet	No citation linked to this field yet.	Response for Access pathwaysAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Access pathways

Recommended

Confirm all data access pathways, including route, access level, TRE/SDE or download/API environment, DAC review, collaboration requirements, data sharing agreements, output checking, timelines, and fees.

No value held

No source yet

No citation linked to this field yet.

AccurateNeeds correctionNot sureDoes not apply

Within-cohort coverage

Aggregate counts or percentages showing how broadly data, consent, or access characteristics apply within the cohort.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Within-cohort coverage metrics Recommended Provide numerator, denominator, unit type, numerator/denominator exactness qualifiers, denominator type, basis, date/release, original source wording, and whether each metric is marginal, joint, conditional, or a release total.	No value held	No source yet	No citation linked to this field yet.	Response for Within-cohort coverage metricsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Within-cohort coverage metrics

Recommended

Provide numerator, denominator, unit type, numerator/denominator exactness qualifiers, denominator type, basis, date/release, original source wording, and whether each metric is marginal, joint, conditional, or a release total.

No value held

No source yet

No citation linked to this field yet.

AccurateNeeds correctionNot sureDoes not apply

Linkage and access

Field	Current value	Evidence	Source evidence	Response	Notes / correction
NHS linkage Recommended	Yes	Field-cited	Fraser et al. — ALSPAC mothers cohort profile (IJE, 2013) https://doi.org/10.1093/ije/dys066 Section: Summary “any cancer diagnoses and deaths through record linkage” Page: https://doi.org/10.1093/ije/dys066	Response for NHS linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
GP linkage Recommended	Yes	Field-cited	ALSPAC — Explore data and samples https://www.bristol.ac.uk/alspac/researchers/our-data/ Section: Data summaries “Participant data has been linked with a variety of external data sources (for example, GP records and education records).” Page: https://www.bristol.ac.uk/alspac/researchers/our-data/	Response for GP linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Death registry linkage Recommended	Yes	Field-cited	Fraser et al. — ALSPAC mothers cohort profile (IJE, 2013) https://doi.org/10.1093/ije/dys066 Section: Summary “any cancer diagnoses and deaths through record linkage” Page: https://doi.org/10.1093/ije/dys066	Response for Death registry linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Education linkage Recommended	Yes	Field-cited	ALSPAC — Explore data and samples https://www.bristol.ac.uk/alspac/researchers/our-data/ Section: Data summaries “Participant data has been linked with a variety of external data sources (for example, GP records and education records).” Page: https://www.bristol.ac.uk/alspac/researchers/our-data/	Response for Education linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data access mechanism Recommended	direct_application	Field-cited	ClinicalTrials.gov API search — ALSPAC https://clinicaltrials.gov/api/v2/studies?query.term=ALSPAC&pageSize=20 Section: API results “"nctId":"NCT03407391" ... "orgStudyIdInfo":{"id":"ALSPAC"}” Page: https://clinicaltrials.gov/api/v2/studies?query.term=ALSPAC&pageSize=20 ClinicalTrials.gov searched per playbook; ALSPAC appears primarily as observational cohort context/sub-study frame, not as a standalone direct-access registry cohort listing. ISRCTN protocol PDF — Serological testing for COVID-19 in ALSPAC (G0/G1) https://www.isrctn.com/editorial/retrieveFile/baa91add-9e39-4c66-8453-3cb81e54d3a3/44008 Section: Protocol front page “Serological testing for COVID-19 in ALSPAC (G0/G1)” Page: https://www.isrctn.com/editorial/retrieveFile/baa91add-9e39-4c66-8453-3cb81e54d3a3/44008 ISRCTN-linked ALSPAC sub-study protocol reviewed during mandatory registry search coverage. ISRCTN search — ALSPAC (JS-gated page) https://www.isrctn.com/search?q=ALSPAC Section: Search gate “Please enable cookies and JavaScript to use ISRCTN.” Page: https://www.isrctn.com/search?q=ALSPAC ISRCTN search endpoint was checked; JS/cookie gate prevented full static result extraction in this environment. ALSPAC — Access data and samples https://www.bristol.ac.uk/alspac/researchers/access/ Section: Request existing data “Please submit your research proposal for consideration by the ALSPAC Executive Committee.” Page: https://www.bristol.ac.uk/alspac/researchers/access/ Access route is direct_application to cohort custodian.	Response for Data access mechanismAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
TRE platform Recommended	UKSeRP (administrative linkage requests)	Field-cited	HDRUK Gateway — ALSPAC dataset entry https://healthdatagateway.org/dataset/23 Section: Data access request “Bespoke datasets are shared directly with the researcher unless administrative data is required ... in which case UKSerP is used.” Page: https://healthdatagateway.org/dataset/23	Response for TRE platformAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data dictionary URL Recommended	https://www.bristol.ac.uk/alspac/researchers/our-data/	Field-cited	ALSPAC — Explore data and samples https://www.bristol.ac.uk/alspac/researchers/our-data/ Section: Explore available data “Our data dictionary (zip file)” Page: https://www.bristol.ac.uk/alspac/researchers/our-data/	Response for Data dictionary URLAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data access timeline (days) Recommended	10	Field-cited	ALSPAC — Access data and samples https://www.bristol.ac.uk/alspac/researchers/access/ Section: Request existing data “You will receive a response within 10 working days” Page: https://www.bristol.ac.uk/alspac/researchers/access/	Response for Data access timeline (days)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data access cost Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: access page states costs are outlined in policy but no stable single fee value is published for all request types.	Response for Data access costAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Participant profile and dates

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Age distribution Recommended	current_age_33-35: 1	Field-cited	ALSPAC — University of Bristol homepage https://www.bristol.ac.uk/alspac/ Section: Homepage context “Children of the 90s” Page: https://www.bristol.ac.uk/alspac/ Stored age_distribution reflects current-age banding for index generation (G1) in the early 30s.	Response for Age distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Sex distribution Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: exact current sex proportion for the full active multi-generation ALSPAC resource is not provided in reviewed public pages/profile extracts.	Response for Sex distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Ethnicity distribution Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: no field-ready ethnicity percentage split for the full active cohort was published in reviewed public metadata.	Response for Ethnicity distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Smoking status distribution Recommended	No value held	No source yet	No citation linked to this field yet.	Response for Smoking status distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Median age Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: public sources describe generational age structure but do not provide one cohort-wide median_age value.	Response for Median ageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Percent female Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: no current whole-cohort female percentage found across reviewed public sources.	Response for Percent femaleAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Percent non-white Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: no current whole-cohort non-white percentage found across reviewed public sources.	Response for Percent non-whiteAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Geographic coverage Recommended	regional	Field-cited	DPUK Cohort Directory — ALSPAC (Children) https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=ALSPAC%20%28Children%29 Section: Inclusion criteria “Original cohort: born of a mother resident in former Avon health authority” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=ALSPAC%20%28Children%29 Recruitment is regional (Avon / South West England), not national.	Response for Geographic coverageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Follow-up duration Recommended	>10 years	Field-cited	HDRUK Gateway — ALSPAC dataset entry https://healthdatagateway.org/dataset/23 Section: Dataset summary “multiple datasets spanning 30 years of data collection” Page: https://healthdatagateway.org/dataset/23 Mapped to controlled value >10 years.	Response for Follow-up durationAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Last data collection date Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: rolling ongoing data collection without a single published last_data_collection_date.	Response for Last data collection dateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Recruitment start date Recommended	1 Apr 1991	Field-cited	Fraser et al. — ALSPAC mothers cohort profile (IJE, 2013) https://doi.org/10.1093/ije/dys066 Section: Summary “between 1st April 1991 and 31st December 1992” Page: https://doi.org/10.1093/ije/dys066	Response for Recruitment start dateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Recruitment end date Recommended	No value held	Not published	Searched — not published UNSOURCEABLE as fixed end date: cohort is still recruiting second generation participants, so recruitment_end_date remains NULL.	Response for Recruitment end dateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Diagnosis areas

Mental health diagnosis areas represented in this cohort.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Diagnosis area: Major depressive disorder Recommended Confirm this diagnosis area applies and estimated N if shown.	Major depressive disorder · Mood Disorders	Field-cited	Boyd et al. — ALSPAC index offspring cohort profile (IJE, 2013) https://doi.org/10.1093/ije/dys064 Section: Psychological and social “depression (CIS-R” Page: https://doi.org/10.1093/ije/dys064 Major depressive disorder coverage confirmed; no direct diagnosis-specific N in reviewed public sources -> estimated_n NULL.	Response for Diagnosis area: Major depressive disorderAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Diagnosis area: Generalised anxiety disorder Recommended Confirm this diagnosis area applies and estimated N if shown.	Generalised anxiety disorder · Anxiety Disorders	Field-cited	Fraser et al. — ALSPAC mothers cohort profile (IJE, 2013) https://doi.org/10.1093/ije/dys066 Section: Mental health “repeatedly assessed depression and anxiety by using validated scales” Page: https://doi.org/10.1093/ije/dys066 Anxiety disorder coverage confirmed; no diagnosis-specific N in reviewed sources -> estimated_n NULL.	Response for Diagnosis area: Generalised anxiety disorderAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Diagnosis area: ADHD Recommended Confirm this diagnosis area applies and estimated N if shown.	ADHD · Neurodevelopmental	Field-cited	Boyd et al. — ALSPAC index offspring cohort profile (IJE, 2013) https://doi.org/10.1093/ije/dys064 Section: Psychological and social “child behaviour” Page: https://doi.org/10.1093/ije/dys064 Neurodevelopmental/ADHD-relevant behavioural follow-up exists; no diagnosis-specific N published -> estimated_n NULL.	Response for Diagnosis area: ADHDAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Diagnosis area: Major depressive disorder

Recommended

Confirm this diagnosis area applies and estimated N if shown.

Major depressive disorder · Mood Disorders

Field-cited

Boyd et al. — ALSPAC index offspring cohort profile (IJE, 2013)
https://doi.org/10.1093/ije/dys064
Section: Psychological and social
“depression (CIS-R”
Page: https://doi.org/10.1093/ije/dys064
Major depressive disorder coverage confirmed; no direct diagnosis-specific N in reviewed public sources -> estimated_n NULL.

AccurateNeeds correctionNot sureDoes not apply

Diagnosis area: Generalised anxiety disorder

Recommended

Confirm this diagnosis area applies and estimated N if shown.

Generalised anxiety disorder · Anxiety Disorders

Field-cited

Fraser et al. — ALSPAC mothers cohort profile (IJE, 2013)
https://doi.org/10.1093/ije/dys066
Section: Mental health
“repeatedly assessed depression and anxiety by using validated scales”
Page: https://doi.org/10.1093/ije/dys066
Anxiety disorder coverage confirmed; no diagnosis-specific N in reviewed sources -> estimated_n NULL.

AccurateNeeds correctionNot sureDoes not apply

Diagnosis area: ADHD

Recommended

Confirm this diagnosis area applies and estimated N if shown.

ADHD · Neurodevelopmental

Field-cited

Boyd et al. — ALSPAC index offspring cohort profile (IJE, 2013)
https://doi.org/10.1093/ije/dys064
Section: Psychological and social
“child behaviour”
Page: https://doi.org/10.1093/ije/dys064
Neurodevelopmental/ADHD-relevant behavioural follow-up exists; no diagnosis-specific N published -> estimated_n NULL.

AccurateNeeds correctionNot sureDoes not apply

Linked sites

Sites contributing participants or data to this cohort.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Linked site: NIHR Bristol Biomedical Research Centre Recommended	NIHR Bristol Biomedical Research Centre · South West England · local n=14,901	Field-cited	DPUK Cohort Directory — ALSPAC (Children) https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=ALSPAC%20%28Children%29 Section: #Subjects at Baseline “15,589 fetuses, resulting in 14,901 children alive at 1 year of age” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=ALSPAC%20%28Children%29 local_n aligned to 14,901 index children alive at 1 year milestone. DPUK Cohort Directory — ALSPAC (Children) https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=ALSPAC%20%28Children%29 Section: Cohort descriptives “City \| Bristol” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=ALSPAC%20%28Children%29	Response for Linked site: NIHR Bristol Biomedical Research CentreAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Verification metadata

Internal catalogue status — for reference only.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Verification status Recommended	unverified	Internal	Internal catalogue field	—	—
Last verified Recommended	No value held	Internal	Internal catalogue field	—	—
Data source Recommended	No value held	Internal	Internal catalogue field	—	—