Cohort validation pack

Generation Scotland

Generation Scotland: Scottish Family Health Study

Generated 6 Oct 2026, 10:37 · ID 12

Unverified

Instructions for reviewers

Review each field against your knowledge of this cohort. Mark Accurate if the value is right, Needs correction if it is wrong or inaccurate (add notes), Not sure if you cannot verify it, or Does not apply if the field is not relevant.
Evidence shown is from our source registry. Fields marked No source yet hold values we could not yet pin to a document — those were AI-inferred and need your input most. Fields marked Searched — not published are ones we looked for and could not find publicly; the note lists where we checked.
Your selections and notes are kept in this browser tab only (not sent to the database). Print or save as PDF when finished, then return it to the DIGIT team.

Overview

108

Total fields

Field-cited

Whole-record source only

AI-inferred, no source yet

Searched — not published

No value held

Needs review

Source coverage

Summary of how well fields in this pack are linked to evidence.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Field-level source coverage Optional	89 of 103 reviewable fields are cited to a source (86%) · 2 with no source yet · 12 searched — not published · 14 with no value held	Computed	No citation linked to this field yet.	Response for Field-level source coverageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Identity and ownership

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Short name Required	Generation Scotland	Field-cited	Generation Scotland — For Researchers https://generation-scotland.ed.ac.uk/for-researchers Section: Page heading “Generation Scotland” Page: https://generation-scotland.ed.ac.uk/for-researchers	Response for Short nameAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Full name Required	Generation Scotland: Scottish Family Health Study	Field-cited	Smith et al. 2013 — Generation Scotland Cohort Profile (IJE) https://doi.org/10.1093/ije/dys084 Section: Abstract “GS:SFHS is a family-based genetic epidemiology study” Page: https://doi.org/10.1093/ije/dys084	Response for Full nameAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Managing organisation Recommended	University of Edinburgh	Field-cited	Generation Scotland — For Researchers https://generation-scotland.ed.ac.uk/for-researchers Section: For Researchers “We are based at The University of Edinburgh” Page: https://generation-scotland.ed.ac.uk/for-researchers	Response for Managing organisationAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Primary site Recommended	University of Edinburgh (site #12)	Field-cited	Generation Scotland — For Researchers https://generation-scotland.ed.ac.uk/for-researchers Section: For Researchers “We are based at The University of Edinburgh” Page: https://generation-scotland.ed.ac.uk/for-researchers Mapped to site_id=12 (University of Edinburgh).	Response for Primary siteAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Website URL Recommended	https://generation-scotland.ed.ac.uk/	Field-cited	Generation Scotland — For Researchers https://generation-scotland.ed.ac.uk/for-researchers Section: Site content “Generation Scotland” Page: https://generation-scotland.ed.ac.uk/for-researchers Canonical website used in cohort row.	Response for Website URLAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Catalogue of Mental Health Measures URL Recommended	https://www.cataloguementalhealth.ac.uk/GSSFHS	Field-cited	Catalogue of Mental Health Measures https://www.cataloguementalhealth.ac.uk Section: Official sitemap study URL “https://www.cataloguementalhealth.ac.uk/GSSFHS” Page: https://www.cataloguementalhealth.ac.uk/GSSFHS	Response for Catalogue of Mental Health Measures URLAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Contact name Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: public GS pages provide functional contact routes rather than a single named cohort contact for this field.	Response for Contact nameAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Contact email Recommended	No value held	Not published	Searched — not published UNSOURCEABLE for stable cohort-level field: both GenScot@ed.ac.uk and gen.scot@ed.ac.uk appear across pages; left NULL pending owner confirmation of canonical contact mailbox.	Response for Contact emailAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Summary and status

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Description Required	Family-based longitudinal cohort across Scotland combining questionnaire, cognitive, physical and multi-omics data with NHS record linkage and recontact for follow-on studies.	Field-cited	Generation Scotland — For Researchers https://generation-scotland.ed.ac.uk/for-researchers Section: For Researchers “Generation Scotland combines questionnaire data on health and wellbeing across the life course with NHS health record linkage and biological measures” Page: https://generation-scotland.ed.ac.uk/for-researchers	Response for DescriptionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Total N Required	41,211	Field-cited	Generation Scotland Data Explorer Dashboard https://shiny.igc.ed.ac.uk/GS_Data_Explorer/ Section: Cohort Summary “Total Volunteers 41,211” Page: https://shiny.igc.ed.ac.uk/GS_Data_Explorer/	Response for Total NAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Total N qualifier Recommended	approximate	Field-cited	Generation Scotland — For Researchers https://generation-scotland.ed.ac.uk/for-researchers Section: For Researchers “with over 40,000 participants in total” Page: https://generation-scotland.ed.ac.uk/for-researchers Qualifier set to approximate because website narrative uses rounded phrasing while dashboard displays 41,211.	Response for Total N qualifierAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Year established Recommended	2006	Field-cited	Smith et al. 2013 — Generation Scotland Cohort Profile (IJE) https://doi.org/10.1093/ije/dys084 Section: Abstract “from February 2006 to March 2011” Page: https://doi.org/10.1093/ije/dys084 Year established mapped to first recruitment year 2006.	Response for Year establishedAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Active cohort Recommended	Yes	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Future plans “Next Generation Scotland launched in May 2022 to expand the existing cohort” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC11340249/ Ongoing expansion confirms active status.	Response for Active cohortAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Ongoing recruitment Recommended	Yes	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Future plans “Next Generation Scotland launched in May 2022 to expand the existing cohort by a target of 20 000 additional volunteers” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC11340249/	Response for Ongoing recruitmentAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Refreshed cohort Recommended	Yes	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Future plans “To create a larger, richer, longitudinal resource, Next Generation Scotland launched in May 2022 to expand the existing cohort” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC11340249/ New recruitment wave and repeated data collection support is_refreshed=TRUE.	Response for Refreshed cohortAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Recontact success rate Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: no public percentage for successful recontact in searched sources (IJE 2013, BMJ 2024, GS website, DPUK pages).	Response for Recontact success rateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Retention rate Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: no cohort-wide retention percentage published in searched sources.	Response for Retention rateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Published references Recommended	doi:10.1093/ije/dys084, doi:10.1136/bmjopen-2024-084719	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Article header “DOI: 10.1136/bmjopen-2024-084719” Page: https://doi.org/10.1136/bmjopen-2024-084719 Smith et al. 2013 — Generation Scotland Cohort Profile (IJE) https://doi.org/10.1093/ije/dys084 Section: Article metadata “DOI: 10.1093/ije/dys084” Page: https://doi.org/10.1093/ije/dys084	Response for Published referencesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Notes Recommended	Includes original GS:SFHS recruitment plus NextGenScot expansion with continued linkage and recontact studies.	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Data access and collaborations “GS also collaborates with ... DPUK ... CLOSER ... HDR UK Innovation Gateway.” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC11340249/ ClinicalTrials.gov Search: Generation Scotland https://clinicaltrials.gov/search?term=%22Generation%20Scotland%22 Section: Search page capture “ClinicalTrials.gov ... Search for terms” Page: https://clinicaltrials.gov/search?term=%22Generation%20Scotland%22 No cohort registration record found for Generation Scotland in fetched search output; used during join-table reconciliation Phase B. ISRCTN Search: Generation Scotland https://www.isrctn.com/search?q=%22Generation%20Scotland%22 Section: Registry search notes “ISRCTN ... search endpoint returned HTTP 500 at verification time” Page: https://www.isrctn.com/search?q=%22Generation%20Scotland%22 ISRCTN queried but endpoint error prevented result rendering; supplementary web search used to confirm no obvious Generation Scotland trial registration.	Response for NotesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

3D cohort mapping

Consent, characterisation, and data availability axes used on the cohort map.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Consent level (axis) Required	3 — Broad consent (recontactable for future studies)	Field-cited	Smith et al. 2013 — Generation Scotland Cohort Profile (IJE) https://doi.org/10.1093/ije/dys084 Section: Abstract “broad consent from participants to use their data and samples for a wide range of medical research, including commercial research, and for re-contact” Page: https://doi.org/10.1093/ije/dys084 Step 1 identifiable participants=YES. Step 2 S251/CAG model=NO. Step 3 recontactable consent=YES. Step 4 specific interventional randomisation consent=NO. Therefore consent_level=3.	Response for Consent level (axis)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Characterisation depth (axis) Required	3 — Multi-domain MH characterisation	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Baseline data collection “Standardised assessments included the 28-item General Health Questionnaire, Structured Clinical Interview for DSM Disorders, Mood Disorder Questionnaire” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC11340249/ Step 1 validated MH instruments=YES. Step 2 multi-domain data including cognitive and physical assessments=YES. Step 3 SCID present but refreshed diagnostic interview across whole expanded cohort not established as level-4 requirement; score=3.	Response for Characterisation depth (axis)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data availability (axis) Required	4 — Multi-modal	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Abstract - Participants “Genotype array data are available for 20 026 (83%) participants ... blood-based DNA methylation data for 18 869 (78%) participants ... Multimodal brain imaging is available in 1069 individuals.” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC11340249/ Derived by rule: hasResearch=TRUE (questionnaire/cognitive/physical/linkage), hasBiological=TRUE (biosamples/genomic/omics), hasAdvanced=TRUE (imaging). hasAdvanced AND hasBiological => data_availability=4.	Response for Data availability (axis)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Cohort map group (derived) Recommended	Group 1	Internal	Internal catalogue field	—	—
Population type Recommended	General population	Not published	DIGIT Cohort Portfolio Review — population type and engagement classification (Aug 2026) Classified general_population in the DIGIT cohort portfolio review (Aug 2026). Family-based population cohort across Scotland; no health-based entry criteria.	Response for Population typeAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Industry engagement status Recommended	Unknown	Not published	Searched — not published UNSOURCEABLE: industry engagement status is an organisational property of the custodian and is not publicly documented; default 'unknown' pending a cohort-owner meeting.	Response for Industry engagement statusAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Parent cohort / programme Recommended	No value held	No source yet	No citation linked to this field yet.	Response for Parent cohort / programmeAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
TWiCs eligible Recommended	No	Field-cited	Smith et al. 2013 — Generation Scotland Cohort Profile (IJE) https://doi.org/10.1093/ije/dys084 Section: Abstract “broad consent ... for re-contact” Page: https://doi.org/10.1093/ije/dys084 FALSE because consent model is broad/recontact (level 3), not explicit cohort-wide interventional randomisation consent required for TWiCs.	Response for TWiCs eligibleAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Data modalities

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Questionnaire / interview Recommended	Yes	Field-cited	Smith et al. 2013 — Generation Scotland Cohort Profile (IJE) https://doi.org/10.1093/ije/dys084 Section: Abstract “DNA and socio-demographic and clinical data ... detailed data on ... mental health” Page: https://doi.org/10.1093/ije/dys084 TRUE by data-dictionary definition for validated questionnaires/structured instruments.	Response for Questionnaire / interviewAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Cognitive testing Recommended	Yes	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Abstract - Participants “detailed baseline data were collected on ... cognitive function” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC11340249/	Response for Cognitive testingAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Physical measures Recommended	Yes	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Baseline data collection “physical measurements included height, weight, heart rate, systolic and diastolic blood pressure, ECG and body composition analysis” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC11340249/	Response for Physical measuresAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Biosamples Recommended	Yes	Field-cited	Smith et al. 2013 — Generation Scotland Cohort Profile (IJE) https://doi.org/10.1093/ije/dys084 Section: Abstract “Biological samples and anonymized data form a resource” Page: https://doi.org/10.1093/ije/dys084	Response for BiosamplesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Genomic data Recommended	Yes	Field-cited	Generation Scotland — For Researchers https://generation-scotland.ed.ac.uk/for-researchers Section: About Omics Data “genome-wide genotyping data for 83%” Page: https://generation-scotland.ed.ac.uk/for-researchers	Response for Genomic dataAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Omics Recommended	Yes	Field-cited	Generation Scotland — For Researchers https://generation-scotland.ed.ac.uk/for-researchers Section: About Omics Data “DNA methylation for 79% of participants, and proteomic data for 82% of participants” Page: https://generation-scotland.ed.ac.uk/for-researchers	Response for OmicsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Imaging Recommended	Yes	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Abstract - Participants “Multimodal brain imaging is available in 1069 individuals.” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC11340249/	Response for ImagingAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Wearable / sensor Recommended	No	Field-cited	Generation Scotland Data Explorer Dashboard https://shiny.igc.ed.ac.uk/GS_Data_Explorer/ Section: Cohort Summary “Total Volunteers 41,211 ... Genotype Data ... Methylation ... Proteomics” Page: https://shiny.igc.ed.ac.uk/GS_Data_Explorer/ FALSE: reviewed For Researchers, Data Explorer, BMJ update and DPUK pages; no wearable device stream documented.	Response for Wearable / sensorAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Digital phenotyping Recommended	No	Field-cited	Generation Scotland Data Explorer Dashboard https://shiny.igc.ed.ac.uk/GS_Data_Explorer/ Section: For Researchers “Generation Scotland combines questionnaire data ... with NHS health record linkage and biological measures” Page: https://generation-scotland.ed.ac.uk/for-researchers FALSE: no passive smartphone/sensor digital phenotyping described in searched sources.	Response for Digital phenotypingAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Linked health records Recommended	Yes	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Abstract - Participants “Linkage to routine National Health Service datasets has been possible for 93% (n=22 402) of the cohort” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC11340249/	Response for Linked health recordsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Biosample types Recommended	blood, saliva, urine	Field-cited	DPUK Featured Cohort: Generation Scotland https://www.dementiasplatform.uk/research-hub/data-portal/featured-cohort-generation-scotland Section: Cohort overview “providing DNA, blood and other samples” Page: https://www.dementiasplatform.uk/research-hub/data-portal/featured-cohort-generation-scotland Seed uses blood, saliva, urine as publicly documented core sample types.	Response for Biosample typesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Genotyping platform Recommended	Illumina HumanOmniExpressExome	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Genomics “Samples were genotyped using the Illumina HumanOmniExpressExome” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC11340249/	Response for Genotyping platformAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Imaging modalities Recommended	structural_mri, fmri, dwi	Field-cited	DPUK Data Portal Cohort Directory: GS:SFHS https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=GS%3A+SFHS Section: Imaging “Imaging: fMRI-rest, T1-weighted MRI, Diffusion” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=GS%3A+SFHS	Response for Imaging modalitiesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Mental health measures Recommended	GHQ-28, SCID, Mood Disorder Questionnaire	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Baseline data collection “General Health Questionnaire ... Structured Clinical Interview for DSM Disorders ... Mood Disorder Questionnaire” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC11340249/	Response for Mental health measuresAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Data subcategories

Structured modality and subcategory rows used alongside the high-level data-type flags.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Data modality: Blood sample Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · biosamples · biospecimen type · parent: Biospecimen collection · Blood sample resource	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Pilot modality classification “Blood sample resource” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: Blood sampleAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: Saliva sample Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · biosamples · biospecimen type · parent: Biospecimen collection · Saliva sample resource	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Pilot modality classification “Saliva sample resource” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: Saliva sampleAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: Urine sample Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · biosamples · biospecimen type · parent: Biospecimen collection · Urine sample resource	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Pilot modality classification “Urine sample resource” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: Urine sampleAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: Biospecimen collection Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · biosamples · category marker · Blood, saliva, urine and DNA-related sample resources	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Pilot modality classification “Blood, saliva, urine and DNA-related sample resources” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: Biospecimen collectionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: Cognitive assessment data Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · cognitive measures · category marker · Cognitive function data	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Pilot modality classification “Cognitive function data” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: Cognitive assessment dataAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: Genotyping array Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · genomics · derived genomic data · Illumina HumanOmniExpressExome genotyping	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Pilot modality classification “Illumina HumanOmniExpressExome genotyping” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: Genotyping arrayAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: Brain MRI Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · imaging · category marker · Multimodal brain imaging subset	Field-cited	DPUK Data Portal Cohort Directory: GS:SFHS https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=GS%3A+SFHS Section: Pilot modality classification “Multimodal brain imaging subset” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: Brain MRIAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: Diffusion MRI Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · imaging · imaging modality · parent: Brain MRI · Diffusion MRI	Field-cited	DPUK Data Portal Cohort Directory: GS:SFHS https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=GS%3A+SFHS Section: Pilot modality classification “Diffusion MRI” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: Diffusion MRIAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: Functional MRI Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · imaging · imaging modality · parent: Brain MRI · Resting-state fMRI	Field-cited	DPUK Data Portal Cohort Directory: GS:SFHS https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=GS%3A+SFHS Section: Pilot modality classification “Resting-state fMRI” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: Functional MRIAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: Structural MRI Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · imaging · imaging modality · parent: Brain MRI · T1-weighted MRI	Field-cited	DPUK Data Portal Cohort Directory: GS:SFHS https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=GS%3A+SFHS Section: Pilot modality classification “T1-weighted MRI” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: Structural MRIAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: Linked NHS records Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · linked health records · category marker · Routine NHS dataset linkage	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Pilot modality classification “Routine NHS dataset linkage” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: Linked NHS recordsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: Linked GP records Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · linked health records · linked record type · parent: Linked NHS records · General practice linked data	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Pilot modality classification “General practice linked data” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: Linked GP recordsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: Linked death registry Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · linked health records · linked record type · parent: Linked NHS records · NRS deaths data	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Pilot modality classification “NRS deaths data” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: Linked death registryAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: DNA methylation Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · omics · derived omics data · Blood-based DNA methylation data	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Pilot modality classification “Blood-based DNA methylation data” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: DNA methylationAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: Proteomics Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · omics · derived omics data · Proteomics data	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Pilot modality classification “Proteomics data” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: ProteomicsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: Clinical / physical measurements Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · physical measures · category marker · Height, weight, heart rate, blood pressure, ECG and body composition	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Pilot modality classification “Height, weight, heart rate, blood pressure, ECG and body composition” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: Clinical / physical measurementsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: Anthropometry Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · physical measures · clinical physical measure · parent: Clinical / physical measurements · Height and weight	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Pilot modality classification “Height and weight” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: AnthropometryAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: Blood pressure / vitals Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · physical measures · clinical physical measure · parent: Clinical / physical measurements · Systolic and diastolic blood pressure	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Pilot modality classification “Systolic and diastolic blood pressure” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: Blood pressure / vitalsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: Body composition Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · physical measures · clinical physical measure · parent: Clinical / physical measurements · Body composition analysis	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Pilot modality classification “Body composition analysis” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: Body compositionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: Questionnaire / interview data Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · questionnaires · category marker · Health and wellbeing questionnaire data across the life course	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Pilot modality classification “Health and wellbeing questionnaire data across the life course” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: Questionnaire / interview dataAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: GHQ-12 / GHQ Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · questionnaires · questionnaire instrument · parent: Questionnaire / interview data · General Health Questionnaire family instruments · Existing seed stores GHQ-28; grouped under GHQ modality.	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Pilot modality classification “General Health Questionnaire family instruments” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: GHQ-12 / GHQAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: Mood Disorder Questionnaire Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · questionnaires · questionnaire instrument · parent: Questionnaire / interview data · Mood Disorder Questionnaire	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Pilot modality classification “Mood Disorder Questionnaire” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: Mood Disorder QuestionnaireAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: SCID Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · questionnaires · structured interview · parent: Questionnaire / interview data · Structured Clinical Interview for DSM Disorders	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Pilot modality classification “Structured Clinical Interview for DSM Disorders” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: SCIDAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Consent and use permissions

Specific use permissions separate from the 3D consent-level axis.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Consent/use: Biosample research use Recommended Confirm status, population scope, whether the permission is a DUO-style restriction/permission or a local operational permission, and whether academic and industry/commercial use differ.	permitted · biosample use · local operational permission · Participants with samples · Broad consent includes use of data and samples.	Field-cited	Smith et al. 2013 — Generation Scotland Cohort Profile (IJE) https://doi.org/10.1093/ije/dys084 Section: Pilot consent/use permission classification “Broad consent includes use of data and samples.” Structured consent/use row derived from existing sourced consent and access statements. Status captures whether the permission is explicit, restricted, or unknown in public sources.	Response for Consent/use: Biosample research useAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Consent/use: Industry / commercial research considered Recommended Confirm status, population scope, whether the permission is a DUO-style restriction/permission or a local operational permission, and whether academic and industry/commercial use differ.	permitted · commercial use · local operational permission · Consented participants · Cohort profile states consent includes commercial research.	Field-cited	Smith et al. 2013 — Generation Scotland Cohort Profile (IJE) https://doi.org/10.1093/ije/dys084 Section: Pilot consent/use permission classification “Cohort profile states consent includes commercial research.” Structured consent/use row derived from existing sourced consent and access statements. Status captures whether the permission is explicit, restricted, or unknown in public sources.	Response for Consent/use: Industry / commercial research consideredAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Consent/use: Health record linkage permitted Recommended Confirm status, population scope, whether the permission is a DUO-style restriction/permission or a local operational permission, and whether academic and industry/commercial use differ.	permitted · data linkage · local operational permission · Consented participants · NHS linkage possible for a large participant subset.	Field-cited	Smith et al. 2013 — Generation Scotland Cohort Profile (IJE) https://doi.org/10.1093/ije/dys084 Section: Pilot consent/use permission classification “NHS linkage possible for a large participant subset.” Structured consent/use row derived from existing sourced consent and access statements. Status captures whether the permission is explicit, restricted, or unknown in public sources.	Response for Consent/use: Health record linkage permittedAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Consent/use: Data sharing permitted Recommended Confirm status, population scope, whether the permission is a DUO-style restriction/permission or a local operational permission, and whether academic and industry/commercial use differ.	restricted · data sharing · local operational permission · Approved researchers · Data sharing requires access committee approval.	Field-cited	Smith et al. 2013 — Generation Scotland Cohort Profile (IJE) https://doi.org/10.1093/ije/dys084 Section: Pilot consent/use permission classification “Data sharing requires access committee approval.” Structured consent/use row derived from existing sourced consent and access statements. Status captures whether the permission is explicit, restricted, or unknown in public sources.	Response for Consent/use: Data sharing permittedAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Consent/use: Ethics approval required Recommended Confirm status, population scope, whether the permission is a DUO-style restriction/permission or a local operational permission, and whether academic and industry/commercial use differ.	restricted · governance · duo modifier · Commercial and academic users · Access remains subject to Generation Scotland Access Committee review.	Field-cited	Smith et al. 2013 — Generation Scotland Cohort Profile (IJE) https://doi.org/10.1093/ije/dys084 Section: Pilot consent/use permission classification “Access remains subject to Generation Scotland Access Committee review.” Structured consent/use row derived from existing sourced consent and access statements. Status captures whether the permission is explicit, restricted, or unknown in public sources.	Response for Consent/use: Ethics approval requiredAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Consent/use: Participant recontact permitted Recommended Confirm status, population scope, whether the permission is a DUO-style restriction/permission or a local operational permission, and whether academic and industry/commercial use differ.	permitted · recontact · local operational permission · Consented participants · Broad consent includes recontact.	Field-cited	Smith et al. 2013 — Generation Scotland Cohort Profile (IJE) https://doi.org/10.1093/ije/dys084 Section: Pilot consent/use permission classification “Broad consent includes recontact.” Structured consent/use row derived from existing sourced consent and access statements. Status captures whether the permission is explicit, restricted, or unknown in public sources.	Response for Consent/use: Participant recontact permittedAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Consent/use: Health / medical / biomedical research use Recommended Confirm status, population scope, whether the permission is a DUO-style restriction/permission or a local operational permission, and whether academic and industry/commercial use differ.	permitted · research use · duo permission · DUO:0000002 · Consented participants · Broad consent covers wide medical research uses.	Field-cited	Smith et al. 2013 — Generation Scotland Cohort Profile (IJE) https://doi.org/10.1093/ije/dys084 Section: Pilot consent/use permission classification “Broad consent covers wide medical research uses.” Structured consent/use row derived from existing sourced consent and access statements. Status captures whether the permission is explicit, restricted, or unknown in public sources.	Response for Consent/use: Health / medical / biomedical research useAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Consent/use: Approach for trials permitted Recommended Confirm status, population scope, whether the permission is a DUO-style restriction/permission or a local operational permission, and whether academic and industry/commercial use differ.	restricted · trial approach · local operational permission · Consented participants · Recontact is permitted; trial participation would require study-specific consent.	Field-cited	Smith et al. 2013 — Generation Scotland Cohort Profile (IJE) https://doi.org/10.1093/ije/dys084 Section: Pilot consent/use permission classification “Recontact is permitted; trial participation would require study-specific consent.” Structured consent/use row derived from existing sourced consent and access statements. Status captures whether the permission is explicit, restricted, or unknown in public sources.	Response for Consent/use: Approach for trials permittedAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Access pathways

One or more routes by which researchers can request or analyse data.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Access pathway: Direct application Recommended Confirm route, access level, environment type, DAC review, collaboration, data sharing agreement, output checking, platform, timeline, cost, URL, and whether multiple routes are possible.	available on application · access level: controlled · environment: secure download · DAC review required · data sharing agreement required · Generation Scotland Access Request · Charges may apply · https://generation-scotland.ed.ac.uk/for-researchers/access · Applications are reviewed by the Generation Scotland Access Committee.	Field-cited	Generation Scotland — Make an Access Request https://generation-scotland.ed.ac.uk/for-researchers/access Section: Pilot data access pathway classification “Applications are reviewed by the Generation Scotland Access Committee.” Structured access pathway row derived from existing sourced access mechanism, TRE, cost, and route fields.	Response for Access pathway: Direct applicationAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Access pathway: Managed access / DAC Recommended Confirm route, access level, environment type, DAC review, collaboration, data sharing agreement, output checking, platform, timeline, cost, URL, and whether multiple routes are possible.	available on application · access level: controlled · environment: secure download · DAC review required · data sharing agreement required · Generation Scotland Access Committee · Charges may apply · https://generation-scotland.ed.ac.uk/for-researchers/access · Access committee review is required before data release.	Field-cited	Generation Scotland — Make an Access Request https://generation-scotland.ed.ac.uk/for-researchers/access Section: Pilot data access pathway classification “Access committee review is required before data release.” Structured access pathway row derived from existing sourced access mechanism, TRE, cost, and route fields.	Response for Access pathway: Managed access / DACAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Access pathway: Direct application

Recommended

Confirm route, access level, environment type, DAC review, collaboration, data sharing agreement, output checking, platform, timeline, cost, URL, and whether multiple routes are possible.

available on application · access level: controlled · environment: secure download · DAC review required · data sharing agreement required · Generation Scotland Access Request · Charges may apply · https://generation-scotland.ed.ac.uk/for-researchers/access · Applications are reviewed by the Generation Scotland Access Committee.

Field-cited

Generation Scotland — Make an Access Request
https://generation-scotland.ed.ac.uk/for-researchers/access
Section: Pilot data access pathway classification
“Applications are reviewed by the Generation Scotland Access Committee.”
Structured access pathway row derived from existing sourced access mechanism, TRE, cost, and route fields.

AccurateNeeds correctionNot sureDoes not apply

Access pathway: Managed access / DAC

Recommended

Confirm route, access level, environment type, DAC review, collaboration, data sharing agreement, output checking, platform, timeline, cost, URL, and whether multiple routes are possible.

available on application · access level: controlled · environment: secure download · DAC review required · data sharing agreement required · Generation Scotland Access Committee · Charges may apply · https://generation-scotland.ed.ac.uk/for-researchers/access · Access committee review is required before data release.

Field-cited

Generation Scotland — Make an Access Request
https://generation-scotland.ed.ac.uk/for-researchers/access
Section: Pilot data access pathway classification
“Access committee review is required before data release.”
Structured access pathway row derived from existing sourced access mechanism, TRE, cost, and route fields.

AccurateNeeds correctionNot sureDoes not apply

Within-cohort coverage

Aggregate counts or percentages showing how broadly data, consent, or access characteristics apply within the cohort.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Coverage: DNA methylation data Recommended Confirm numerator, denominator, unit type, exactness qualifiers, denominator type, basis, as-of date/release, source wording, and whether the metric is marginal, joint, conditional, or a release total.	18,869 · unit: participants · denominator: unknown · basis: available to researchers · status: available · scope: marginal · source value: 18,869 participants and 78% · Source reports 18,869 participants and 78%; denominator should be confirmed by cohort owner.	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Abstract - Participants “blood-based DNA methylation data for 18 869 (78%) participants” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC11340249/	Response for Coverage: DNA methylation dataAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Coverage: Genotype array data Recommended Confirm numerator, denominator, unit type, exactness qualifiers, denominator type, basis, as-of date/release, source wording, and whether the metric is marginal, joint, conditional, or a release total.	20,026 · unit: participants · denominator: unknown · basis: available to researchers · status: available · scope: marginal · source value: 20,026 participants and 83% · Source reports 20,026 participants and 83%; denominator should be confirmed by cohort owner.	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Abstract - Participants “Genotype array data are available for 20 026 (83%) participants” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC11340249/	Response for Coverage: Genotype array dataAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Coverage: Multimodal brain imaging Recommended Confirm numerator, denominator, unit type, exactness qualifiers, denominator type, basis, as-of date/release, source wording, and whether the metric is marginal, joint, conditional, or a release total.	1,069 · unit: participants · denominator: unknown · basis: available to researchers · status: available · scope: marginal · source value: 1,069 participants · Marginal imaging subset count.	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Abstract - Participants “Multimodal brain imaging is available in 1069 individuals.” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC11340249/	Response for Coverage: Multimodal brain imagingAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Coverage: Routine NHS linkage possible Recommended Confirm numerator, denominator, unit type, exactness qualifiers, denominator type, basis, as-of date/release, source wording, and whether the metric is marginal, joint, conditional, or a release total.	22,402 · unit: participants · denominator: unknown · basis: linked · status: available · scope: marginal · source value: 22,402 participants and 93% · Source reports linkage possible for 22,402 participants and 93%; denominator should be confirmed by cohort owner.	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Abstract - Participants “Linkage to routine National Health Service datasets has been possible for 93% (n=22 402) of the cohort” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC11340249/	Response for Coverage: Routine NHS linkage possibleAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Linkage and access

Field	Current value	Evidence	Source evidence	Response	Notes / correction
NHS linkage Recommended	Yes	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Abstract - Participants “Linkage to routine National Health Service datasets has been possible for 93%” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC11340249/	Response for NHS linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
GP linkage Recommended	Yes	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Table 2 “Summary of linked data sources ... General practice (GP)” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC11340249/	Response for GP linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Death registry linkage Recommended	Yes	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Table 2 “Summary of linked data sources ... Deaths (NRS deaths data)” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC11340249/	Response for Death registry linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Education linkage Recommended	No	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Strengths and limitations “Planned additional linkages include ... education records” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC11340249/ FALSE because education linkage is described as planned, not currently linked.	Response for Education linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data access mechanism Recommended	direct_application	Field-cited	Generation Scotland — Make an Access Request https://generation-scotland.ed.ac.uk/for-researchers/access Section: Approval Process “Upon submission, your application will be reviewed by the Generation Scotland Access Committee” Page: https://generation-scotland.ed.ac.uk/for-researchers/access Mapped to direct_application access model.	Response for Data access mechanismAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
TRE platform Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: no named TRE/SDE platform is stated on the accessed GS pages.	Response for TRE platformAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data dictionary URL Recommended	https://generation-scotland.ed.ac.uk/for-researchers/access	Field-cited	Generation Scotland — Make an Access Request https://generation-scotland.ed.ac.uk/for-researchers/access Section: For Researchers “Make an Access Request” Page: https://generation-scotland.ed.ac.uk/for-researchers/access	Response for Data dictionary URLAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data access timeline (days) Recommended	No value held	Not published	Searched — not published UNSOURCEABLE exact integer: access page states review within 6-8 weeks, but no single day value is published.	Response for Data access timeline (days)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data access cost Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: access page indicates charges may apply and invites contact, but no stable public fee schedule is listed.	Response for Data access costAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Participant profile and dates

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Age distribution Recommended	mean_age_49: 1	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Abstract - Participants “average age at recruitment of 49 years” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC11340249/ Stored as summary JSON {mean_age_49:1.0}.	Response for Age distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Sex distribution Recommended	male: 0.41; female: 0.59	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Abstract - Participants “59% are women” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC11340249/ male proportion derived as remainder 41%.	Response for Sex distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Ethnicity distribution Recommended	No value held	Not published	Searched — not published UNSOURCEABLE as structured JSON in current public extracts. BMJ table provides aggregate ethnicity percentages but not full multi-bin distribution aligned to schema JSON.	Response for Ethnicity distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Smoking status distribution Recommended	No value held	No source yet	No citation linked to this field yet.	Response for Smoking status distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Median age Recommended	49.0	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Abstract - Participants “average age at recruitment of 49 years” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC11340249/	Response for Median ageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Percent female Recommended	59.00	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Abstract - Participants “59% are women” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC11340249/	Response for Percent femaleAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Percent non-white Recommended	1.10	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Table 1 “Ethnicity ... White 94.8% ... Other 1.1%” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC11340249/ percent_non_white mapped to 1.1 based on reported Other category in cohort table.	Response for Percent non-whiteAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Geographic coverage Recommended	national	Field-cited	Generation Scotland — For Researchers https://generation-scotland.ed.ac.uk/for-researchers Section: For Researchers “across Scotland” Page: https://generation-scotland.ed.ac.uk/for-researchers Mapped to controlled value national.	Response for Geographic coverageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Follow-up duration Recommended	19+ years (2006-present)	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Longitudinal data linkage “participants have up to 16-year follow-up data since recruitment in 2006” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC11340249/ Represented as 19+ years (2006-present) at 2026 verification date.	Response for Follow-up durationAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Last data collection date Recommended	No value held	Not published	Searched — not published UNSOURCEABLE exact date: public sources report phases and ongoing/target windows, not a canonical last collection date field.	Response for Last data collection dateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Recruitment start date Recommended	1 Feb 2006	Field-cited	Smith et al. 2013 — Generation Scotland Cohort Profile (IJE) https://doi.org/10.1093/ije/dys084 Section: Abstract “from February 2006 to March 2011” Page: https://doi.org/10.1093/ije/dys084	Response for Recruitment start dateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Recruitment end date Recommended	No value held	Not published	Searched — not published UNSOURCEABLE exact date for combined GS + NextGenScot resource; public pages present phase windows but not a single definitive end date used by schema field.	Response for Recruitment end dateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Diagnosis areas

Mental health diagnosis areas represented in this cohort.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Diagnosis area: Major depressive disorder Recommended Confirm this diagnosis area applies and estimated N if shown.	Major depressive disorder · Mood Disorders · est. n=2,346	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Table 3 “Depression ... Total 2346” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC11340249/ Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Table 3 “Depression ... Total 2346” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC11340249/	Response for Diagnosis area: Major depressive disorderAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Diagnosis area: Major depressive disorder

Recommended

Confirm this diagnosis area applies and estimated N if shown.

Major depressive disorder · Mood Disorders · est. n=2,346

Field-cited

Milbourn et al. 2024 — Generation Scotland Update (BMJ Open)
https://doi.org/10.1136/bmjopen-2024-084719
Section: Table 3
“Depression ... Total 2346”
Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC11340249/
Milbourn et al. 2024 — Generation Scotland Update (BMJ Open)
https://doi.org/10.1136/bmjopen-2024-084719
Section: Table 3
“Depression ... Total 2346”
Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC11340249/

AccurateNeeds correctionNot sureDoes not apply

Linked sites

Sites contributing participants or data to this cohort.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Linked site: University of Edinburgh Recommended	University of Edinburgh · Scotland	Field-cited	Generation Scotland — For Researchers https://generation-scotland.ed.ac.uk/for-researchers Section: For Researchers “We are based at The University of Edinburgh” Page: https://generation-scotland.ed.ac.uk/for-researchers	Response for Linked site: University of EdinburghAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Linked site: University of Glasgow / NHS Greater Glasgow and Clyde Recommended	University of Glasgow / NHS Greater Glasgow and Clyde · Scotland	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Introduction “GS was founded as a multi-institutional, cross-disciplinary collaboration between the Universities of Aberdeen, Dundee, Edinburgh and Glasgow” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC11340249/ Mapped Glasgow institution to site_id=19.	Response for Linked site: University of Glasgow / NHS Greater Glasgow and ClydeAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Linked site: University of Aberdeen / NHS Grampian Recommended	University of Aberdeen / NHS Grampian · Scotland	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Introduction “GS was founded as a multi-institutional, cross-disciplinary collaboration between the Universities of Aberdeen, Dundee, Edinburgh and Glasgow” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC11340249/ Mapped Aberdeen institution to site_id=20.	Response for Linked site: University of Aberdeen / NHS GrampianAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Linked site: University of Dundee / NHS Tayside Recommended	University of Dundee / NHS Tayside · Scotland	Field-cited	Milbourn et al. 2024 — Generation Scotland Update (BMJ Open) https://doi.org/10.1136/bmjopen-2024-084719 Section: Introduction “GS was founded as a multi-institutional, cross-disciplinary collaboration between the Universities of Aberdeen, Dundee, Edinburgh and Glasgow” Page: https://pmc.ncbi.nlm.nih.gov/articles/PMC11340249/ Mapped Dundee institution to site_id=21.	Response for Linked site: University of Dundee / NHS TaysideAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Verification metadata

Internal catalogue status — for reference only.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Verification status Recommended	unverified	Internal	Internal catalogue field	—	—
Last verified Recommended	No value held	Internal	Internal catalogue field	—	—
Data source Recommended	No value held	Internal	Internal catalogue field	—	—