Cohort validation pack

UK Biobank

Generated 6 Oct 2026, 10:36 · ID 10

AI inferred

Instructions for reviewers

Review each field against your knowledge of this cohort. Mark Accurate if the value is right, Needs correction if it is wrong or inaccurate (add notes), Not sure if you cannot verify it, or Does not apply if the field is not relevant.
Evidence shown is from our source registry. Fields marked No source yet hold values we could not yet pin to a document — those were AI-inferred and need your input most. Fields marked Searched — not published are ones we looked for and could not find publicly; the note lists where we checked.
Your selections and notes are kept in this browser tab only (not sent to the database). Print or save as PDF when finished, then return it to the DIGIT team.

Overview

114

Total fields

Field-cited

Whole-record source only

AI-inferred, no source yet

Searched — not published

No value held

Needs review

Source coverage

Summary of how well fields in this pack are linked to evidence.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Field-level source coverage Optional	89 of 109 reviewable fields are cited to a source (82%) · 3 with no source yet · 17 searched — not published · 18 with no value held	Computed	No citation linked to this field yet.	Response for Field-level source coverageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Identity and ownership

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Short name Required	UK Biobank	Field-cited	UK Biobank — Official Website https://www.ukbiobank.ac.uk/ Section: Page title “UK Biobank” Page: https://www.ukbiobank.ac.uk/	Response for Short nameAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Full name Required	UK Biobank	Field-cited	UK Biobank — Official Website https://www.ukbiobank.ac.uk/ Section: Page title “UK Biobank” Page: https://www.ukbiobank.ac.uk/	Response for Full nameAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Managing organisation Recommended	UK Biobank Ltd	Field-cited	DPUK Cohort Directory — UK Biobank https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=UK+Biobank Section: Cohort Descriptives “Institution Name \| UK Biobank” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=UK+Biobank	Response for Managing organisationAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Primary site Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: UK Biobank is national and multi-centre; searched UK Biobank website, PLOS 2015 profile, MHQ2 paper, HDRUK Gateway, and DPUK. No single DIGIT site ID is publicly designated as a primary site.	Response for Primary siteAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Website URL Recommended	https://www.ukbiobank.ac.uk/	Field-cited	UK Biobank — Official Website https://www.ukbiobank.ac.uk/ Section: Canonical URL “https://www.ukbiobank.ac.uk/” Page: https://www.ukbiobank.ac.uk/	Response for Website URLAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Catalogue of Mental Health Measures URL Recommended	https://www.cataloguementalhealth.ac.uk/Biobank	Field-cited	Catalogue of Mental Health Measures https://www.cataloguementalhealth.ac.uk Section: Official sitemap study URL “https://www.cataloguementalhealth.ac.uk/Biobank” Page: https://www.cataloguementalhealth.ac.uk/Biobank	Response for Catalogue of Mental Health Measures URLAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Contact name Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: no named cohort contact person on the cited public pages searched (UK Biobank home/apply pages, PLOS papers, HDRUK, DPUK).	Response for Contact nameAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Contact email Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: no public direct cohort contact email identified in cited sources for this seed field.	Response for Contact emailAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Summary and status

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Description Required	Large prospective cohort with over 500,000 participants aged 40-69 at recruitment (2006-2010). Extensive health, genetic, imaging, and biomarker data. Mental Health Questionnaire completed by 157,366 (MHQ1) and 169,253 (MHQ2, 2022).	Field-cited	UK Biobank: An Open Access Resource (PLOS Medicine, 2015) https://doi.org/10.1371/journal.pmed.1001779 Section: Summary Points “UK Biobank is a very large and detailed prospective study with over 500,000 participants aged 40–69 years when recruited in 2006–2010.” Page: https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1001779	Response for DescriptionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Total N Required	503,316	Field-cited	DPUK Cohort Directory — UK Biobank https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=UK+Biobank Section: Cohort Descriptives “#Subjects at Baseline \| 503316” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=UK+Biobank	Response for Total NAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Total N qualifier Recommended	as_of_2024	Field-cited	HDR UK Gateway — UK Biobank Dataset 700 https://healthdatagateway.org/en/dataset/700 Section: Details “Modified 08/10/2024” Page: https://healthdatagateway.org/en/dataset/700 Participant count used as a dated snapshot from HDRUK metadata; qualifier set to as_of_2024.	Response for Total N qualifierAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Year established Recommended	2006	Field-cited	DPUK Cohort Directory — UK Biobank https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=UK+Biobank Section: Cohort Descriptives “Study start date \| 01/01/2006 00:00:00” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=UK+Biobank	Response for Year establishedAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Active cohort Recommended	Yes	Field-cited	DPUK Cohort Directory — UK Biobank https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=UK+Biobank Section: Cohort Descriptives “Is study ongoing? \| Yes” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=UK+Biobank	Response for Active cohortAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Ongoing recruitment Recommended	No	Field-cited	DPUK Cohort Directory — UK Biobank https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=UK+Biobank Section: Cohort Descriptives “Is study still recruiting? \| No” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=UK+Biobank	Response for Ongoing recruitmentAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Refreshed cohort Recommended	Yes	Field-cited	DPUK Cohort Directory — UK Biobank https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=UK+Biobank Section: Cohort Descriptives “How many times followed up? \| 2, with online questionnaires at intervals” Page: https://data.dpuk.ukserp.ac.uk/cohortdirectory/Item?fingerPrintID=UK+Biobank Cohort is periodically reassessed and enhanced over time; meets refreshed definition.	Response for Refreshed cohortAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Recontact success rate Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: public sources searched (UK Biobank pages, PLOS 2015/2025, HDRUK, DPUK) do not publish a cohort-level recontact success percentage.	Response for Recontact success rateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Retention rate Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: no field-ready retention percentage found in searched public sources.	Response for Retention rateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Published references Recommended	doi:10.1371/journal.pmed.1001779, doi:10.1038/s41586-018-0579-z, doi:10.1371/journal.pone.0324189	Field-cited	The UK Biobank Mental Health Enhancement 2022 (PLOS ONE, 2025) https://doi.org/10.1371/journal.pone.0324189 Section: Citation “Citation: Sudlow... doi:10.1371/journal.pmed.1001779 ... Citation: Davis ... doi:10.1371/journal.pone.0324189” Page: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0324189	Response for Published referencesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Notes Recommended	Not MH-specific. MHQ2 (2022): 18% lifetime depression, 4.0% panic disorder, 2.8% specific eating disorder, and 0.4% bipolar I among respondents. Positioned between Group 2 and Group 3.	No source yet	No citation linked to this field yet.	Response for NotesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

3D cohort mapping

Consent, characterisation, and data availability axes used on the cohort map.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Consent level (axis) Required	3 — Broad consent (recontactable for future studies)	Field-cited	UK Biobank: An Open Access Resource (PLOS Medicine, 2015) https://doi.org/10.1371/journal.pmed.1001779 Section: Interactions with Participants “All gave broad consent to use of their anonymised data and samples for any health-related research, to be re-contacted for further substudies, and for UK Biobank to access their health-related records.” Page: https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1001779 Decision tree: identifiable=YES (consent-based cohort), S251/CAG=NO (participant consent model), recontactable=YES (quote), specific interventional trial consent=NO (broad consent resource). => Level 3.	Response for Consent level (axis)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Characterisation depth (axis) Required	3 — Multi-domain MH characterisation	Field-cited	UK Biobank: An Open Access Resource (PLOS Medicine, 2015) https://doi.org/10.1371/journal.pmed.1001779 Section: Summary Points “The study has collected and continues to collect extensive phenotypic and genotypic detail ... including data from questionnaires, physical measures, sample assays, accelerometry, multimodal imaging, genome-wide genotyping and longitudinal follow-up.” Page: https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1001779 L1 routine EHR only? NO. L2 validated MH instruments? YES (PHQ-9/GAD-7/CIDI-SF in MHQ2). L3 multi-domain data? YES (questionnaires, physical, cognitive/imaging/genetic domains). L4 research-grade interview + refreshed? Not evidenced as both true. => Level 3.	Response for Characterisation depth (axis)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data availability (axis) Required	4 — Multi-modal	Field-cited	UK Biobank: An Open Access Resource (PLOS Medicine, 2015) https://doi.org/10.1371/journal.pmed.1001779 Section: Summary Points “...including data from questionnaires, physical measures, sample assays, accelerometry, multimodal imaging, genome-wide genotyping...” Page: https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1001779 Flags set TRUE: questionnaire, cognitive, physical, biosamples, genomic, omics, imaging, wearable, linked_health_records; FALSE: digital_phenotyping. Formula: hasResearch=TRUE, hasBiological=TRUE, hasAdvanced=TRUE => data_availability=4.	Response for Data availability (axis)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Cohort map group (derived) Recommended	Group 1	Internal	Internal catalogue field	—	—
Population type Recommended	General population	Not published	DIGIT Cohort Portfolio Review — population type and engagement classification (Aug 2026) Classified general_population in the DIGIT cohort portfolio review (Aug 2026). General adult population aged 40-69 recruited via NHS registers; mental health measured in a questionnaire subset, not an entry criterion.	Response for Population typeAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Industry engagement status Recommended	Established access process	Not published	DIGIT Cohort Portfolio Review — population type and engagement classification (Aug 2026) UK Biobank operates a mature access management system used routinely by commercial researchers.	Response for Industry engagement statusAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Parent cohort / programme Recommended	No value held	No source yet	No citation linked to this field yet.	Response for Parent cohort / programmeAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
TWiCs eligible Recommended	No	Field-cited	UK Biobank: An Open Access Resource (PLOS Medicine, 2015) https://doi.org/10.1371/journal.pmed.1001779 Section: Interactions with Participants “All gave broad consent... to be re-contacted for further substudies” Page: https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1001779 Broad consent/recontact model supports consent level 3, not specific pre-consent for intervention/randomisation; therefore twics_eligible=FALSE.	Response for TWiCs eligibleAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Data modalities

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Questionnaire / interview Recommended	Yes	Field-cited	UK Biobank: An Open Access Resource (PLOS Medicine, 2015) https://doi.org/10.1371/journal.pmed.1001779 Section: Summary Points “...including data from questionnaires...” Page: https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1001779	Response for Questionnaire / interviewAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Cognitive testing Recommended	Yes	Field-cited	The UK Biobank Mental Health Enhancement 2022 (PLOS ONE, 2025) https://doi.org/10.1371/journal.pone.0324189 Section: Introduction “...enhancements, including via multimodal imaging ..., activity/sleep monitoring, and cognitive testing.” Page: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0324189	Response for Cognitive testingAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Physical measures Recommended	Yes	Field-cited	UK Biobank: An Open Access Resource (PLOS Medicine, 2015) https://doi.org/10.1371/journal.pmed.1001779 Section: Summary Points “...physical measures...” Page: https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1001779	Response for Physical measuresAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Biosamples Recommended	Yes	Field-cited	UK Biobank: An Open Access Resource (PLOS Medicine, 2015) https://doi.org/10.1371/journal.pmed.1001779 Section: Data from the Baseline Assessment “...collection of blood, urine, and saliva...” Page: https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1001779	Response for BiosamplesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Genomic data Recommended	Yes	Field-cited	HDR UK Gateway — UK Biobank Dataset 700 https://healthdatagateway.org/en/dataset/700 Section: Documentation “Genotyping, whole exome sequencing and whole genome sequencing is available for the whole cohort.” Page: https://healthdatagateway.org/en/dataset/700	Response for Genomic dataAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Omics Recommended	Yes	Field-cited	HDR UK Gateway — UK Biobank Dataset 700 https://healthdatagateway.org/en/dataset/700 Section: Documentation “...metabolomic and proteomic data ... have been assayed from the samples provided.” Page: https://healthdatagateway.org/en/dataset/700	Response for OmicsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Imaging Recommended	Yes	Field-cited	HDR UK Gateway — UK Biobank Dataset 700 https://healthdatagateway.org/en/dataset/700 Section: Documentation “Since 2014 we have been undertaking the largest imaging study to date... brain, cardiac and neck to knee MRI, whole body DXA and carotid ultrasound ... retinal images...” Page: https://healthdatagateway.org/en/dataset/700	Response for ImagingAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Wearable / sensor Recommended	Yes	Field-cited	HDR UK Gateway — UK Biobank Dataset 700 https://healthdatagateway.org/en/dataset/700 Section: Documentation “...accelerometer data for 100,000 participants collected 2013-2014.” Page: https://healthdatagateway.org/en/dataset/700	Response for Wearable / sensorAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Digital phenotyping Recommended	No	Field-cited	HDR UK Gateway — UK Biobank Dataset 700 https://healthdatagateway.org/en/dataset/700 Section: Documentation “Questionnaires ... are regularly sent to our participants.” Page: https://healthdatagateway.org/en/dataset/700 No passive smartphone metadata/GPS/call-log digital phenotyping explicitly evidenced in searched public sources; set FALSE per strict definition.	Response for Digital phenotypingAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Linked health records Recommended	Yes	Field-cited	UK Biobank: An Open Access Resource (PLOS Medicine, 2015) https://doi.org/10.1371/journal.pmed.1001779 Section: Data from Longitudinal Follow-Up “Follow-up is conducted chiefly through linkages to routinely available national datasets.” Page: https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1001779	Response for Linked health recordsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Biosample types Recommended	blood, urine, saliva	Field-cited	UK Biobank: An Open Access Resource (PLOS Medicine, 2015) https://doi.org/10.1371/journal.pmed.1001779 Section: Data from the Baseline Assessment “...collection of blood, urine, and saliva...” Page: https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1001779	Response for Biosample typesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Genotyping platform Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: public pages confirm cohort-wide genotyping, but no single canonical platform string was confirmed in the required source set used for this audit.	Response for Genotyping platformAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Imaging modalities Recommended	brain_mri, cardiac_mri, abdominal_mri, dexa, carotid_ultrasound, retinal_imaging	Field-cited	HDR UK Gateway — UK Biobank Dataset 700 https://healthdatagateway.org/en/dataset/700 Section: Documentation “...brain, cardiac and neck to knee MRI, whole body DXA and carotid ultrasound ... retinal images...” Page: https://healthdatagateway.org/en/dataset/700	Response for Imaging modalitiesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Mental health measures Recommended	PHQ-9, GAD-7, AUDIT, CIDI-SF	Field-cited	The UK Biobank Mental Health Enhancement 2022 (PLOS ONE, 2025) https://doi.org/10.1371/journal.pone.0324189 Section: Methods “...such as the PHQ-9 for current depression and CIDI-SF for lifetime panic...” Page: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0324189 GAD-7 and AUDIT are also explicitly listed in abbreviations and repeated-measures section.	Response for Mental health measuresAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Data subcategories

Structured modality and subcategory rows used alongside the high-level data-type flags.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Data modality: Blood sample Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · biosamples · biospecimen type · parent: Biospecimen collection · Blood collected at baseline	Field-cited	UK Biobank: An Open Access Resource (PLOS Medicine, 2015) https://doi.org/10.1371/journal.pmed.1001779 Section: Pilot modality classification “Blood collected at baseline” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: Blood sampleAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: Saliva sample Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · biosamples · biospecimen type · parent: Biospecimen collection · Saliva collected at baseline	Field-cited	UK Biobank: An Open Access Resource (PLOS Medicine, 2015) https://doi.org/10.1371/journal.pmed.1001779 Section: Pilot modality classification “Saliva collected at baseline” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: Saliva sampleAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: Urine sample Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · biosamples · biospecimen type · parent: Biospecimen collection · Urine collected at baseline	Field-cited	UK Biobank: An Open Access Resource (PLOS Medicine, 2015) https://doi.org/10.1371/journal.pmed.1001779 Section: Pilot modality classification “Urine collected at baseline” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: Urine sampleAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: Biospecimen collection Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · biosamples · category marker · Blood, urine and saliva samples	Field-cited	UK Biobank: An Open Access Resource (PLOS Medicine, 2015) https://doi.org/10.1371/journal.pmed.1001779 Section: Pilot modality classification “Blood, urine and saliva samples” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: Biospecimen collectionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: Cognitive assessment data Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · cognitive measures · category marker · Cognitive testing enhancements	Field-cited	UK Biobank: An Open Access Resource (PLOS Medicine, 2015) https://doi.org/10.1371/journal.pmed.1001779 Section: Pilot modality classification “Cognitive testing enhancements” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: Cognitive assessment dataAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: Genotyping array Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · genomics · derived genomic data · Genome-wide genotyping data	Field-cited	HDR UK Gateway — UK Biobank Dataset 700 https://healthdatagateway.org/en/dataset/700 Section: Pilot modality classification “Genome-wide genotyping data” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: Genotyping arrayAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: Whole exome sequencing Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · genomics · derived genomic data · Whole exome sequencing available through UK Biobank	Field-cited	HDR UK Gateway — UK Biobank Dataset 700 https://healthdatagateway.org/en/dataset/700 Section: Pilot modality classification “Whole exome sequencing available through UK Biobank” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: Whole exome sequencingAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: Whole genome sequencing Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · genomics · derived genomic data · Whole genome sequencing available through UK Biobank	Field-cited	HDR UK Gateway — UK Biobank Dataset 700 https://healthdatagateway.org/en/dataset/700 Section: Pilot modality classification “Whole genome sequencing available through UK Biobank” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: Whole genome sequencingAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: Brain MRI Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · imaging · category marker · Brain MRI as part of multimodal imaging	Field-cited	HDR UK Gateway — UK Biobank Dataset 700 https://healthdatagateway.org/en/dataset/700 Section: Pilot modality classification “Brain MRI as part of multimodal imaging” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: Brain MRIAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: Body MRI Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · imaging · imaging modality · Cardiac, abdominal, and neck-to-knee MRI	Field-cited	HDR UK Gateway — UK Biobank Dataset 700 https://healthdatagateway.org/en/dataset/700 Section: Pilot modality classification “Cardiac, abdominal, and neck-to-knee MRI” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: Body MRIAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: Carotid ultrasound Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · imaging · imaging modality · Carotid ultrasound	Field-cited	HDR UK Gateway — UK Biobank Dataset 700 https://healthdatagateway.org/en/dataset/700 Section: Pilot modality classification “Carotid ultrasound” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: Carotid ultrasoundAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: DEXA Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · imaging · imaging modality · Whole-body DEXA	Field-cited	HDR UK Gateway — UK Biobank Dataset 700 https://healthdatagateway.org/en/dataset/700 Section: Pilot modality classification “Whole-body DEXA” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: DEXAAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: Retinal imaging Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · imaging · imaging modality · Retinal imaging	Field-cited	HDR UK Gateway — UK Biobank Dataset 700 https://healthdatagateway.org/en/dataset/700 Section: Pilot modality classification “Retinal imaging” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: Retinal imagingAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: Linked NHS records Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · linked health records · category marker · Linked health-related records	Field-cited	UK Biobank: An Open Access Resource (PLOS Medicine, 2015) https://doi.org/10.1371/journal.pmed.1001779 Section: Pilot modality classification “Linked health-related records” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: Linked NHS recordsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: Linked GP records Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · linked health records · linked record type · parent: Linked NHS records · Linked GP records	Field-cited	UK Biobank: An Open Access Resource (PLOS Medicine, 2015) https://doi.org/10.1371/journal.pmed.1001779 Section: Pilot modality classification “Linked GP records” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: Linked GP recordsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: Linked death registry Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · linked health records · linked record type · parent: Linked NHS records · Death registry linkage	Field-cited	UK Biobank: An Open Access Resource (PLOS Medicine, 2015) https://doi.org/10.1371/journal.pmed.1001779 Section: Pilot modality classification “Death registry linkage” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: Linked death registryAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: Metabolomics Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · omics · derived omics data · Metabolomic assay data	Field-cited	HDR UK Gateway — UK Biobank Dataset 700 https://healthdatagateway.org/en/dataset/700 Section: Pilot modality classification “Metabolomic assay data” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: MetabolomicsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: Proteomics Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · omics · derived omics data · Proteomic assay data	Field-cited	HDR UK Gateway — UK Biobank Dataset 700 https://healthdatagateway.org/en/dataset/700 Section: Pilot modality classification “Proteomic assay data” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: ProteomicsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: Clinical / physical measurements Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · physical measures · category marker · Baseline physical measures	Field-cited	UK Biobank: An Open Access Resource (PLOS Medicine, 2015) https://doi.org/10.1371/journal.pmed.1001779 Section: Pilot modality classification “Baseline physical measures” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: Clinical / physical measurementsAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: Questionnaire / interview data Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · questionnaires · category marker · Baseline and repeat online questionnaires including mental health questionnaires	Field-cited	The UK Biobank Mental Health Enhancement 2022 (PLOS ONE, 2025) https://doi.org/10.1371/journal.pone.0324189 Section: Pilot modality classification “Baseline and repeat online questionnaires including mental health questionnaires” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: Questionnaire / interview dataAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: AUDIT Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · questionnaires · questionnaire instrument · parent: Questionnaire / interview data · AUDIT alcohol-use measure in mental health questionnaire content	Field-cited	The UK Biobank Mental Health Enhancement 2022 (PLOS ONE, 2025) https://doi.org/10.1371/journal.pone.0324189 Section: Pilot modality classification “AUDIT alcohol-use measure in mental health questionnaire content” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: AUDITAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: GAD-7 Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · questionnaires · questionnaire instrument · parent: Questionnaire / interview data · GAD-7 in mental health questionnaire content	Field-cited	The UK Biobank Mental Health Enhancement 2022 (PLOS ONE, 2025) https://doi.org/10.1371/journal.pone.0324189 Section: Pilot modality classification “GAD-7 in mental health questionnaire content” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: GAD-7AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: PHQ-9 Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · questionnaires · questionnaire instrument · parent: Questionnaire / interview data · PHQ-9 in mental health questionnaire content	Field-cited	The UK Biobank Mental Health Enhancement 2022 (PLOS ONE, 2025) https://doi.org/10.1371/journal.pone.0324189 Section: Pilot modality classification “PHQ-9 in mental health questionnaire content” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: PHQ-9AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: CIDI-SF Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · questionnaires · structured interview · parent: Questionnaire / interview data · CIDI-SF modules in mental health questionnaire content	Field-cited	The UK Biobank Mental Health Enhancement 2022 (PLOS ONE, 2025) https://doi.org/10.1371/journal.pone.0324189 Section: Pilot modality classification “CIDI-SF modules in mental health questionnaire content” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: CIDI-SFAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data modality: Accelerometry Recommended Confirm this row is correctly typed as a category marker, named instrument/interview, biospecimen type, assay/data product, imaging modality, sensor stream, or linked-record type; add missing named instruments/sample types where known.	available · wearables · wearable sensor data · Accelerometer data for a large participant subset	Field-cited	HDR UK Gateway — UK Biobank Dataset 700 https://healthdatagateway.org/en/dataset/700 Section: Pilot modality classification “Accelerometer data for a large participant subset” Structured modality row derived from existing sourced cohort modality flags and detail fields; confirm exact release status and availability with cohort owner.	Response for Data modality: AccelerometryAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Consent and use permissions

Specific use permissions separate from the 3D consent-level axis.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Consent/use: Biosample research use Recommended Confirm status, population scope, whether the permission is a DUO-style restriction/permission or a local operational permission, and whether academic and industry/commercial use differ.	permitted · biosample use · local operational permission · Consented participants · Broad consent includes use of samples for health-related research.	Field-cited	UK Biobank: An Open Access Resource (PLOS Medicine, 2015) https://doi.org/10.1371/journal.pmed.1001779 Section: Pilot consent/use permission classification “Broad consent includes use of samples for health-related research.” Structured consent/use row derived from existing sourced consent and access statements. Status captures whether the permission is explicit, restricted, or unknown in public sources.	Response for Consent/use: Biosample research useAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Consent/use: Industry / commercial research considered Recommended Confirm status, population scope, whether the permission is a DUO-style restriction/permission or a local operational permission, and whether academic and industry/commercial use differ.	permitted · commercial use · local operational permission · Approved researchers · Commercial researchers are eligible subject to UK Biobank approval and terms.	Field-cited	UK Biobank: An Open Access Resource (PLOS Medicine, 2015) https://doi.org/10.1371/journal.pmed.1001779 Section: Pilot consent/use permission classification “Commercial researchers are eligible subject to UK Biobank approval and terms.” Structured consent/use row derived from existing sourced consent and access statements. Status captures whether the permission is explicit, restricted, or unknown in public sources.	Response for Consent/use: Industry / commercial research consideredAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Consent/use: Health record linkage permitted Recommended Confirm status, population scope, whether the permission is a DUO-style restriction/permission or a local operational permission, and whether academic and industry/commercial use differ.	permitted · data linkage · local operational permission · Consented participants · Consent includes access to health-related records.	Field-cited	UK Biobank: An Open Access Resource (PLOS Medicine, 2015) https://doi.org/10.1371/journal.pmed.1001779 Section: Pilot consent/use permission classification “Consent includes access to health-related records.” Structured consent/use row derived from existing sourced consent and access statements. Status captures whether the permission is explicit, restricted, or unknown in public sources.	Response for Consent/use: Health record linkage permittedAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Consent/use: Data sharing permitted Recommended Confirm status, population scope, whether the permission is a DUO-style restriction/permission or a local operational permission, and whether academic and industry/commercial use differ.	permitted · data sharing · local operational permission · Approved researchers · Approved researchers access anonymised data under UK Biobank terms.	Field-cited	UK Biobank: An Open Access Resource (PLOS Medicine, 2015) https://doi.org/10.1371/journal.pmed.1001779 Section: Pilot consent/use permission classification “Approved researchers access anonymised data under UK Biobank terms.” Structured consent/use row derived from existing sourced consent and access statements. Status captures whether the permission is explicit, restricted, or unknown in public sources.	Response for Consent/use: Data sharing permittedAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Consent/use: Ethics approval required Recommended Confirm status, population scope, whether the permission is a DUO-style restriction/permission or a local operational permission, and whether academic and industry/commercial use differ.	restricted · governance · duo modifier · Approved researchers · Access requires approval under UK Biobank governance and research ethics commitments.	Field-cited	UK Biobank: An Open Access Resource (PLOS Medicine, 2015) https://doi.org/10.1371/journal.pmed.1001779 Section: Pilot consent/use permission classification “Access requires approval under UK Biobank governance and research ethics commitments.” Structured consent/use row derived from existing sourced consent and access statements. Status captures whether the permission is explicit, restricted, or unknown in public sources.	Response for Consent/use: Ethics approval requiredAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Consent/use: International data sharing / transfer permitted Recommended Confirm status, population scope, whether the permission is a DUO-style restriction/permission or a local operational permission, and whether academic and industry/commercial use differ.	permitted · international transfer · local operational permission · Approved researchers worldwide · UK Biobank permits eligible researchers worldwide subject to application approval.	Field-cited	UK Biobank: An Open Access Resource (PLOS Medicine, 2015) https://doi.org/10.1371/journal.pmed.1001779 Section: Pilot consent/use permission classification “UK Biobank permits eligible researchers worldwide subject to application approval.” Structured consent/use row derived from existing sourced consent and access statements. Status captures whether the permission is explicit, restricted, or unknown in public sources.	Response for Consent/use: International data sharing / transfer permittedAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Consent/use: Participant recontact permitted Recommended Confirm status, population scope, whether the permission is a DUO-style restriction/permission or a local operational permission, and whether academic and industry/commercial use differ.	permitted · recontact · local operational permission · Consented participants · Broad consent includes recontact for further substudies.	Field-cited	UK Biobank: An Open Access Resource (PLOS Medicine, 2015) https://doi.org/10.1371/journal.pmed.1001779 Section: Pilot consent/use permission classification “Broad consent includes recontact for further substudies.” Structured consent/use row derived from existing sourced consent and access statements. Status captures whether the permission is explicit, restricted, or unknown in public sources.	Response for Consent/use: Participant recontact permittedAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Consent/use: Health / medical / biomedical research use Recommended Confirm status, population scope, whether the permission is a DUO-style restriction/permission or a local operational permission, and whether academic and industry/commercial use differ.	permitted · research use · duo permission · DUO:0000002 · Approved researchers · Eligible researchers can apply for health-related public-interest research.	Field-cited	UK Biobank: An Open Access Resource (PLOS Medicine, 2015) https://doi.org/10.1371/journal.pmed.1001779 Section: Pilot consent/use permission classification “Eligible researchers can apply for health-related public-interest research.” Structured consent/use row derived from existing sourced consent and access statements. Status captures whether the permission is explicit, restricted, or unknown in public sources.	Response for Consent/use: Health / medical / biomedical research useAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Consent/use: Approach for trials permitted Recommended Confirm status, population scope, whether the permission is a DUO-style restriction/permission or a local operational permission, and whether academic and industry/commercial use differ.	restricted · trial approach · local operational permission · Consented participants · Recontact is permitted; interventional participation requires study-specific consent.	Field-cited	UK Biobank: An Open Access Resource (PLOS Medicine, 2015) https://doi.org/10.1371/journal.pmed.1001779 Section: Pilot consent/use permission classification “Recontact is permitted; interventional participation requires study-specific consent.” Structured consent/use row derived from existing sourced consent and access statements. Status captures whether the permission is explicit, restricted, or unknown in public sources.	Response for Consent/use: Approach for trials permittedAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Access pathways

One or more routes by which researchers can request or analyse data.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Access pathway: Direct application Recommended Confirm route, access level, environment type, DAC review, collaboration, data sharing agreement, output checking, platform, timeline, cost, URL, and whether multiple routes are possible.	available · access level: controlled · environment: tre sde · DAC review required · data sharing agreement required · output checking required · UK Biobank Access Management System · 45 days · Varies by project · https://www.ukbiobank.ac.uk/use-our-data/apply-for-access/ · Researchers apply directly to UK Biobank for access approval.	Field-cited	UK Biobank — Apply for Access https://www.ukbiobank.ac.uk/use-our-data/apply-for-access/ Section: Pilot data access pathway classification “Researchers apply directly to UK Biobank for access approval.” Structured access pathway row derived from existing sourced access mechanism, TRE, cost, and route fields.	Response for Access pathway: Direct applicationAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Access pathway: Trusted Research Environment Recommended Confirm route, access level, environment type, DAC review, collaboration, data sharing agreement, output checking, platform, timeline, cost, URL, and whether multiple routes are possible.	available · access level: secure environment · environment: tre sde · DAC review required · data sharing agreement required · output checking required · UK Biobank Research Analysis Platform · 45 days · Varies by project · https://www.ukbiobank.ac.uk/use-our-data/apply-for-access/ · Approved researchers can access data through the Research Analysis Platform.	Field-cited	UK Biobank — Apply for Access https://www.ukbiobank.ac.uk/use-our-data/apply-for-access/ Section: Pilot data access pathway classification “Approved researchers can access data through the Research Analysis Platform.” Structured access pathway row derived from existing sourced access mechanism, TRE, cost, and route fields.	Response for Access pathway: Trusted Research EnvironmentAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Field

Current value

Evidence

Source evidence

Response

Notes / correction

Access pathway: Direct application

Recommended

Confirm route, access level, environment type, DAC review, collaboration, data sharing agreement, output checking, platform, timeline, cost, URL, and whether multiple routes are possible.

available · access level: controlled · environment: tre sde · DAC review required · data sharing agreement required · output checking required · UK Biobank Access Management System · 45 days · Varies by project · https://www.ukbiobank.ac.uk/use-our-data/apply-for-access/ · Researchers apply directly to UK Biobank for access approval.

Field-cited

UK Biobank — Apply for Access
https://www.ukbiobank.ac.uk/use-our-data/apply-for-access/
Section: Pilot data access pathway classification
“Researchers apply directly to UK Biobank for access approval.”
Structured access pathway row derived from existing sourced access mechanism, TRE, cost, and route fields.

AccurateNeeds correctionNot sureDoes not apply

Access pathway: Trusted Research Environment

Recommended

Confirm route, access level, environment type, DAC review, collaboration, data sharing agreement, output checking, platform, timeline, cost, URL, and whether multiple routes are possible.

available · access level: secure environment · environment: tre sde · DAC review required · data sharing agreement required · output checking required · UK Biobank Research Analysis Platform · 45 days · Varies by project · https://www.ukbiobank.ac.uk/use-our-data/apply-for-access/ · Approved researchers can access data through the Research Analysis Platform.

Field-cited

UK Biobank — Apply for Access
https://www.ukbiobank.ac.uk/use-our-data/apply-for-access/
Section: Pilot data access pathway classification
“Approved researchers can access data through the Research Analysis Platform.”
Structured access pathway row derived from existing sourced access mechanism, TRE, cost, and route fields.

AccurateNeeds correctionNot sureDoes not apply

Within-cohort coverage

Aggregate counts or percentages showing how broadly data, consent, or access characteristics apply within the cohort.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Coverage: Accelerometer data subset Recommended Confirm numerator, denominator, unit type, exactness qualifiers, denominator type, basis, as-of date/release, source wording, and whether the metric is marginal, joint, conditional, or a release total.	c. 100,000 / 503,316 (19.87% indicative) · unit: participants · denominator: total cohort · basis: collected · status: available · scope: marginal · source value: approximately 100,000 participants · Approximate published subset count.	Field-cited	HDR UK Gateway — UK Biobank Dataset 700 https://healthdatagateway.org/en/dataset/700 Section: Documentation “accelerometer data for 100,000 participants collected 2013-2014” Page: https://healthdatagateway.org/en/dataset/700	Response for Coverage: Accelerometer data subsetAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Coverage: Genotyping/WES/WGS available for whole cohort Recommended Confirm numerator, denominator, unit type, exactness qualifiers, denominator type, basis, as-of date/release, source wording, and whether the metric is marginal, joint, conditional, or a release total.	503,316 / 503,316 (100%) · unit: participants · denominator: total cohort · basis: available to researchers · status: available · scope: marginal · source value: whole cohort · Source describes genotyping, whole-exome, and whole-genome sequencing as available for the whole cohort.	Field-cited	HDR UK Gateway — UK Biobank Dataset 700 https://healthdatagateway.org/en/dataset/700 Section: Documentation “Genotyping, whole exome sequencing and whole genome sequencing is available for the whole cohort.” Page: https://healthdatagateway.org/en/dataset/700	Response for Coverage: Genotyping/WES/WGS available for whole cohortAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Coverage: Mental Health Questionnaire 1 completed Recommended Confirm numerator, denominator, unit type, exactness qualifiers, denominator type, basis, as-of date/release, source wording, and whether the metric is marginal, joint, conditional, or a release total.	157,366 / 503,316 (31.27%) · unit: participants · denominator: total cohort · basis: completed · status: available · release: MHQ1 · scope: marginal · source value: 157,366 of 503,316 participants · Marginal completion count; does not imply overlap with other modalities.	Field-cited	The UK Biobank Mental Health Enhancement 2022 (PLOS ONE, 2025) https://doi.org/10.1371/journal.pone.0324189 Section: UK Biobank mental health questionnaire coverage “Mental Health Questionnaire completed by 157,366 (MHQ1)” Denominator uses total_n=503,316 from existing UK Biobank seed/source set.	Response for Coverage: Mental Health Questionnaire 1 completedAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Coverage: Mental Health Questionnaire 2 completed Recommended Confirm numerator, denominator, unit type, exactness qualifiers, denominator type, basis, as-of date/release, source wording, and whether the metric is marginal, joint, conditional, or a release total.	169,253 / 503,316 (33.63%) · unit: participants · denominator: total cohort · basis: completed · status: available · release: MHQ2 2022 · as of 31 Dec 2022 · scope: marginal · source value: 169,253 of 503,316 participants · Marginal completion count; does not imply overlap with other modalities.	Field-cited	The UK Biobank Mental Health Enhancement 2022 (PLOS ONE, 2025) https://doi.org/10.1371/journal.pone.0324189 Section: UK Biobank mental health questionnaire coverage “Mental Health Questionnaire completed by 169,253 (MHQ2, 2022)” Denominator uses total_n=503,316 from existing UK Biobank seed/source set.	Response for Coverage: Mental Health Questionnaire 2 completedAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Linkage and access

Field	Current value	Evidence	Source evidence	Response	Notes / correction
NHS linkage Recommended	Yes	Field-cited	HDR UK Gateway — UK Biobank Dataset 700 https://healthdatagateway.org/en/dataset/700 Section: Documentation “...linked to their health-related records...” Page: https://healthdatagateway.org/en/dataset/700	Response for NHS linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
GP linkage Recommended	Yes	Field-cited	UK Biobank — Official Website https://www.ukbiobank.ac.uk/ Section: Homepage news “...access to de-identified GP data for all UK Biobank’s 500,000 volunteers...” Page: https://www.ukbiobank.ac.uk/	Response for GP linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Death registry linkage Recommended	Yes	Field-cited	UK Biobank: An Open Access Resource (PLOS Medicine, 2015) https://doi.org/10.1371/journal.pmed.1001779 Section: Data from Longitudinal Follow-Up “Data are already available on over 8,500 deaths...” Page: https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1001779	Response for Death registry linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Education linkage Recommended	No	Not published	Searched — not published UNSOURCEABLE/FALSE: no explicit education data linkage statement found in searched public sources.	Response for Education linkageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data access mechanism Recommended	tre	Field-cited	HDR UK Gateway — UK Biobank Dataset 700 https://healthdatagateway.org/en/dataset/700 Section: Data Access Request “...via our Research Analysis Platform ...” Page: https://healthdatagateway.org/en/dataset/700 Mechanism classified as tre per data-dictionary definitions.	Response for Data access mechanismAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
TRE platform Recommended	UK Biobank Research Analysis Platform	Field-cited	HDR UK Gateway — UK Biobank Dataset 700 https://healthdatagateway.org/en/dataset/700 Section: Data Access Request “Data access is either via data download ... or via our Research Analysis Platform ...” Page: https://healthdatagateway.org/en/dataset/700	Response for TRE platformAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data dictionary URL Recommended	https://biobank.ndph.ox.ac.uk/showcase/	Field-cited	UK Biobank: An Open Access Resource (PLOS Medicine, 2015) https://doi.org/10.1371/journal.pmed.1001779 Section: Online Open Access to Researchers “UK Biobank’s publicly available Data Showcase ...” Page: https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1001779	Response for Data dictionary URLAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data access timeline (days) Recommended	45	Field-cited	HDR UK Gateway — UK Biobank Dataset 700 https://healthdatagateway.org/en/dataset/700 Section: Summary “Lead time 1-2 months” Page: https://healthdatagateway.org/en/dataset/700 Converted to 45 days midpoint for field value.	Response for Data access timeline (days)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Data access cost Recommended	Varies by project (see UK Biobank cost calculator)	Field-cited	UK Biobank — Apply for Access https://www.ukbiobank.ac.uk/use-our-data/apply-for-access/ Section: Apply for access “Use our cost calculator ... Find out how much your analysis could cost before you apply” Page: https://www.ukbiobank.ac.uk/use-our-data/apply-for-access/	Response for Data access costAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Participant profile and dates

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Age distribution Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: searched UK Biobank website, PLOS 2015/2025 papers, HDRUK and DPUK pages; no public whole-cohort age-bin distribution found in cited sources.	Response for Age distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Sex distribution Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: searched UK Biobank website, PLOS 2015/2025 papers, HDRUK and DPUK pages; no public whole-cohort sex split table in cited sources.	Response for Sex distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Ethnicity distribution Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: searched UK Biobank website, PLOS 2015/2025 papers, HDRUK and DPUK pages; no field-ready whole-cohort ethnicity distribution table in cited sources.	Response for Ethnicity distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Smoking status distribution Recommended	never: [object Object]; current: [object Object]; previous: [object Object]; prefer_not_to_say: [object Object]	Field-cited	UK Biobank Showcase — Data-Field 20116 Smoking Status https://biobank.ndph.ox.ac.uk/ukb/field.cgi?id=20116 Section: Data-Field 20116, initial assessment visit (2006-2010) “Instance 0: 501,046 participants; Never 273,220; Previous 172,840; Current 52,929; Prefer not to answer 2,057” Page: https://biobank.ndph.ox.ac.uk/ukb/field.cgi?id=20116 Counts transcribed from the official Instance 0 summary graph; percentages calculated using denominator 501,046.	Response for Smoking status distributionAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Median age Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: source set confirms recruitment age range but no single public median age value for entire cohort was located.	Response for Median ageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Percent female Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: no stable whole-cohort percent female figure with versioned date found in searched public sources.	Response for Percent femaleAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Percent non-white Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: no field-ready whole-cohort non-white percentage in searched public sources.	Response for Percent non-whiteAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Geographic coverage Recommended	national	Field-cited	HDR UK Gateway — UK Biobank Dataset 700 https://healthdatagateway.org/en/dataset/700 Section: Summary/Coverage “Geographic coverage ... United Kingdom” Page: https://healthdatagateway.org/en/dataset/700	Response for Geographic coverageAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Follow-up duration Recommended	>10 years	Field-cited	HDR UK Gateway — UK Biobank Dataset 700 https://healthdatagateway.org/en/dataset/700 Section: Coverage “Follow-up Continuous” Page: https://healthdatagateway.org/en/dataset/700 Mapped to >10 years based on recruitment from 2006 and ongoing linkage/follow-up.	Response for Follow-up durationAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Last data collection date Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: no single cohort-wide last collection date published in the source set.	Response for Last data collection dateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Recruitment start date Recommended	13 Mar 2006	Field-cited	HDR UK Gateway — UK Biobank Dataset 700 https://healthdatagateway.org/en/dataset/700 Section: Coverage “Start date 13/03/2006” Page: https://healthdatagateway.org/en/dataset/700	Response for Recruitment start dateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Recruitment end date Recommended	No value held	Not published	Searched — not published UNSOURCEABLE: public sources describe recruitment window 2006-2010 but no exact end date in cited sources.	Response for Recruitment end dateAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Diagnosis areas

Mental health diagnosis areas represented in this cohort.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Diagnosis area: Bipolar disorder Recommended Confirm this diagnosis area applies and estimated N if shown.	Bipolar disorder · Mood Disorders · est. n=2,013	Field-cited	The UK Biobank Mental Health Enhancement 2022 (PLOS ONE, 2025) https://doi.org/10.1371/journal.pone.0324189 Section: Results “...bipolar affective disorder I (0.4%).” Page: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0324189 estimated_n = round(503316 * 0.004) = 2013	Response for Diagnosis area: Bipolar disorderAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Diagnosis area: Major depressive disorder Recommended Confirm this diagnosis area applies and estimated N if shown.	Major depressive disorder · Mood Disorders · est. n=90,597	Field-cited	The UK Biobank Mental Health Enhancement 2022 (PLOS ONE, 2025) https://doi.org/10.1371/journal.pone.0324189 Section: Results B(1) “Participants were most likely to be positive for lifetime depression (18%)” Page: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0324189 estimated_n = round(503316 * 0.18) = 90597	Response for Diagnosis area: Major depressive disorderAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Diagnosis area: Generalised anxiety disorder Recommended Confirm this diagnosis area applies and estimated N if shown.	Generalised anxiety disorder · Anxiety Disorders · est. n=35,232	Field-cited	The UK Biobank Mental Health Enhancement 2022 (PLOS ONE, 2025) https://doi.org/10.1371/journal.pone.0324189 Section: Results B(1) “...in the MHQ1, the symptom-based definition of lifetime generalised anxiety disorder (GAD) was met by 7%.” Page: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0324189 estimated_n = round(503316 * 0.07) = 35232	Response for Diagnosis area: Generalised anxiety disorderAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Diagnosis area: Panic disorder Recommended Confirm this diagnosis area applies and estimated N if shown.	Panic disorder · Anxiety Disorders · est. n=20,133	Field-cited	The UK Biobank Mental Health Enhancement 2022 (PLOS ONE, 2025) https://doi.org/10.1371/journal.pone.0324189 Section: Results “...panic disorder (4.0%)...” Page: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0324189 estimated_n = round(503316 * 0.04) = 20133	Response for Diagnosis area: Panic disorderAccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Diagnosis area: Eating disorders (anorexia) Recommended Confirm this diagnosis area applies and estimated N if shown.	Eating disorders (anorexia) · Eating Disorders · est. n=8,556	Field-cited	The UK Biobank Mental Health Enhancement 2022 (PLOS ONE, 2025) https://doi.org/10.1371/journal.pone.0324189 Section: Results B(1) “Anorexia nervosa criteria were met by 1.7% of respondents” Page: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0324189 estimated_n = round(503316 * 0.017) = 8556	Response for Diagnosis area: Eating disorders (anorexia)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Diagnosis area: Eating disorders (bulimia) Recommended Confirm this diagnosis area applies and estimated N if shown.	Eating disorders (bulimia) · Eating Disorders · est. n=2,013	Field-cited	The UK Biobank Mental Health Enhancement 2022 (PLOS ONE, 2025) https://doi.org/10.1371/journal.pone.0324189 Section: Results B(1) “...bulimia nervosa by 0.4%...” Page: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0324189 estimated_n = round(503316 * 0.004) = 2013	Response for Diagnosis area: Eating disorders (bulimia)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes
Diagnosis area: Eating disorders (BED) Recommended Confirm this diagnosis area applies and estimated N if shown.	Eating disorders (BED) · Eating Disorders · est. n=1,007	Field-cited	The UK Biobank Mental Health Enhancement 2022 (PLOS ONE, 2025) https://doi.org/10.1371/journal.pone.0324189 Section: Results B(1) “...binge-eating disorder by 0.2%.” Page: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0324189 estimated_n = round(503316 * 0.002) = 1007	Response for Diagnosis area: Eating disorders (BED)AccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Linked sites

Sites contributing participants or data to this cohort.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Linked sites Optional	No value held	No source yet	No citation linked to this field yet.	Response for Linked sitesAccurateNeeds correctionNot sureDoes not apply No response selected	No notes

Verification metadata

Internal catalogue status — for reference only.

Field	Current value	Evidence	Source evidence	Response	Notes / correction
Verification status Recommended	ai_inferred	Internal	Internal catalogue field	—	—
Last verified Recommended	No value held	Internal	Internal catalogue field	—	—
Data source Recommended	No value held	Internal	Internal catalogue field	—	—